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Postoperative subacute static progressive stretch does not increase the risk of distal lower limb venous thromboembolism

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Chinese Journal of Traumatology 2023年第3期26卷 178-182页

作者： Jun-Kun Zhu Feng-Feng Wu Rui-Feng Yang Fen-Fen Xu Ya-Li Lin miao-fang ye Orthopedics Rehabilitation Department Lishui Central HospitalLishuiZhejiang Province323020China Rehabilitation Department Huzhou Central HospitalHangzhou310020China Orthopedics and Trauma Department Lishui Central HospitalLishuiZhejiang Province323020China

Purpose:Static progressive stretch(SPS)can be applied to treat chronic joint ***,the impacts of subacute application of SPS to the distal lower limbs,where deep vein thrombosis(DVT)is common,on venous thromboembolism remain *** study aims to explore the risk of venous thromboembolism events following subacute application of ***:A retrospective cohort study was conducted on patients diagnosed with DVT following a lower extremity orthopedic surgery before being transferred to the rehabilitation ward from May 2017 to May *** with unilateral lower limb comminuted para-articular fractures,transferred to rehabilitation ward for further treatment within 3 weeks after operation,followed up more than 12 weeks since initial manual physiotherapy,and diagnosed DVT by ultrasound before rehabilitation course were included in the *** with polytrauma,without evidence of previous peripheral vascular disease or incompetence,had medication for thrombosis treatment or prophylaxis before the operation,detected with paralysis due to nervous system impairment,infected after operation during the regime,or with acute progression of DVT were *** included patients were randomized to the standard physiotherapy and the SPS integrated groups for *** DVT and pulmonary embolism data were collected during the physiotherapy course to compare the *** 28.0 and GraphPad Prism 9 were used for data ***<0.05 was set significant ***:In total of 154 patients with DVT participating in this study,75 of them were treated with additional SPS for postoperative *** participants in the SPS group showed improved range of motion(12.3°±6.7°).However,in the SPS group,there was no difference in thrombosis volume between the start and termination(p=0.106,p=0.787,respectively),although difference was seen intra-therapy(p<0.001).Contingency analysis revealed the pulmonary embolism incidence(OR=0.

关键词： Trauma Deep vein thrombosis Rehabilitation Musculoskeletal manipulations Physical therapy modalities

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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao fang Junfan fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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三叶青黄酮对结肠癌SW620细胞增殖凋亡的影响

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中国中西医结合消化杂志 2016年第12期24卷 902-905页

作者：吴晓尉杨妙芳余纳叶院宁汪芳裕南京军区南京总医院消化内科江苏南京210002

[目的]观察三叶青黄酮对结肠癌SW620细胞增殖凋亡的作用并探讨可能的机制。[方法]采用体外细胞培养技术,MTT法观察三叶青黄酮对SW620细胞增殖的影响,流式细胞术分析细胞凋亡率,Western Blotting检测Cle-caspase3、Cle-caspase9、Bax、Bc... 详细信息

[目的]观察三叶青黄酮对结肠癌SW620细胞增殖凋亡的作用并探讨可能的机制。[方法]采用体外细胞培养技术,MTT法观察三叶青黄酮对SW620细胞增殖的影响,流式细胞术分析细胞凋亡率,Western Blotting检测Cle-caspase3、Cle-caspase9、Bax、Bcl-2蛋白表达改变。[结果]三叶青黄酮能显著地抑制SW620细胞增殖,并且具有剂量和时间依赖性。三叶青黄酮能显著地促进SW620细胞凋亡,并且呈剂量依赖性上调Cle-caspase3、Clecaspase9、Bax表达,下调Bcl-2表达。[结论]三叶青黄酮对人结肠癌SW620细胞具有抑制增殖和促进凋亡的作用。

关键词：三叶青黄酮结肠癌增殖凋亡

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Dexmedetomidine Promotes Angiogenesis and Vasculogenic Mimicry in Human Hepatocellular Carcinoma through α^(2)-AR/HIF-1α/VEGFA Pathway

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Biomedical and Environmental Sciences 2022年第10期35卷 931-942页

作者： fang Tao LIN Li ye Zhi Jian fang Lian SHI Shuai YU Ke Da miao Hui Hui LI Tian Zuo Department of Anesthesiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Anesthesiology The Affiliated Jinhua Hospital of Wenzhou Medical UniversityJinhua 321000ZhejiangChina IVF centre The Affiliated Jinhua Hospital of Wenzhou Medical UniversityJinhua 321000ZhejiangChina

Objective Dexmedetomidine(DEX),the most specificα^(2)-adrenergic receptor agonist widely used for its sedative and analgesic properties,has been reported to upregulate HIF-1αexpression to protect hypoxic and ischemic ***,it is largely unclear whether DEX can also upregulate Hypoxiainducible factor-1 alpha(HIF-1α)expression and its downstream vascular endothelial growth factor-A(VEGFA)in cancer tissues with oxygen-deficient tumor *** We used SMMC-7721 cells,MHCC97-H cells,and a mouse model of orthotopic hepatic carcinoma to explore the effect of DEX on angiogenesis and vasculogenic mimicry(VM)and its *** normoxic(20%O^(2))and hypoxic(1%O^(2))conditions,DEX was used to intervene cells,and yohimbine was used to rescue *** The results showed that DEX promoted angiogenesis and VM in human liver cancer cells within a certain dose range,and the addition of yohimbine inhibited this *** could activate HIF-1α/VEGFA pathway,which was further verified by silencing HIF-1α.Consistently,in vivo results also showed that DEX can up-regulate HIF-1α/VEGFA expression,and enhance the number of VM channels and microvessel density(MVD).Conclusion We believe that HIF-1α/VEGFA might be an important signaling pathway by which DEX promotes angiogenesis and VM formation in human hepatocellular carcinoma,whereasα^(2)-adrenergic receptor mediation might be the critical mechanisms.

关键词： Hepatocellular carcinoma Dexmedetomidine Yohimbine α^(2)-adrenergic receptor HIF-1a VEGFA Vascular mimicry Angiogenesis

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Serum triglycerides concentration in relation to total and cardiovascular mortality in an elderly Chinese population

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Journal of Geriatric Cardiology 2022年第8期19卷 603-609页

作者： Chao-Ying miao Xiao-Fei ye Wei ZHANG Chang-Sheng SHENG Qi-fang HUANG Ji-Guang WANG School of Public Health Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Cardi-ovascular Medicine the Shanghai Institute of HypertensionRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

OBJECTIVE To investigate serum triglycerides in relation to all-cause,cardiovascular,and non-cardiovascular mortality in an elderly Chinese *** The study participants(n=3565)were elderly(≥60 years)community dwellers living in a suburban town of *** was defined as a serum triglycerides concentration≥2.30 mmol/L(definite)and≥1.70 mmol/L(borderline),*** The prevalence of definite and borderline hypertriglyceridemia at baseline was 7.5%and 29.5%,*** was higher in women(n=1982,9.0%and 33.8%,respectively)than men(n=1583,6.2%and 27.9%,respectively),in obese and over-weight participants(n=1566,10.5%and 36.4%,respectively)than normal weight participants(n=1999,5.6%and 27.1%,respect-ively),and in diabetic participants(n=177,11.9%and 39.0%,respectively)than non-diabetic participants(n=3388,7.5%and 30.8%,respectively).During a median of 7.9 years follow-up,all-cause,cardiovascular and non-cardiovascular deaths occurred in 529,216 and 313 participants,*** analyses according to the quintile distributions of serum triglycerides concentration,the sex-and age-standardized mortality rate was lowest in the middle quintile for all-cause,cardiovascular and non-cardiovascu-lar mortality(18.6,7.8 and 11.9 per 1000 person-years,respectively,versus 21.5,10.5 and 12.7 per 1000 person-years,respectively,in the two lower quintiles and 21.7,9.5 and 14.0 per 1000 person-years,respectively,in the two higher quintiles).The fully adjus-ted hazard ratios(95%CI)for the middle quintile versus the combined two lower with two higher quintiles were 0.85(95%CI:0.67-1.07,P=0.17),0.81(95%CI:0.54-1.19,P=0.28)and 0.87(95%CI:0.64-1.17,P=0.35)for all-cause,cardiovascular and non-cardiovascular mortality,*** Our study showed high prevalence of hypertriglyceridemia,especially when defined as borderline and in obese and overweight participants,and mildly but non-significantly elevated risks of cardiovascular mort

关键词： cardiovascular mortality Serum

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An algorithm based on evidence theory and fuzzy entropy to defend against SSDF

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Journal of Systems Engineering and Electronics 2020年第2期31卷 243-251页

作者： ye fang BAI Ping TIAN Yuan College of Information and Communication Engineering Harbin Engineering UniversityHarbin 150001China

In cognitive radio networks, spectrum sensing is one of the most important functions to identify available spectrum for improving the spectrum utilization. Due to the open characteristic of the wireless electromagnetic environment, the wireless network is vulnerable to be attacked by malicious users(MUs), and spectrum sensing data falsification(SSDF) attack is one of the most harmful attacks on spectrum sensing performance. In this article,an algorithm based on the evidence theory and fuzzy entropy is proposed to resist SSDF attacks. In this algorithm, secondary users(SUs) obtain the corresponding degree of membership function and basic probability assignment function based on the local energy detection result. The new conflicting coefficient is calculated based on the evidence distance and classical conflicting coefficient, and the conflicting weight of the evidence is *** fuzzy weight is calculated by the fuzzy entropy. The credibility weight is obtained by updating the credibility. On this basis, the probability assignment function of the evidence is corrected, and the final result is obtained by using the fusion formula. Simulation results show that the proposed algorithm has a higher detection probability and lower false alarm probability than other *** can effectively defend against SSDF attacks and improve the performance of spectrum sensing.

关键词： cooperative spectrum sensing evidence theory fuzzy entropy spectrum sensing data falsification(SSDF)

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Boundary Shift of Potential Suitable Agricultural Area in Farming-grazing Transitional Zone in Northeastern China under Background of Climate Change During 20th Century

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Chinese Geographical Science 2013年第6期23卷 655-665页

作者： ye Yu fang Xiuqi School of Geography Beijing Normal University Key Laboratory of Environment Change and Natural Disaster Ministry of EducationBeijing Normal University

Climate change affected the agricultural expansion and the formation of farming-grazing transitional patterns during historical periods. This study analyzed the possible range of the boundary shift of the potential suitable agriculture area in the farming-grazing transitional zone in the northeastern China during the 20th century. Based on modem weather data, 1 km-resolution land cover data, historical climatic time series, and estimation by using similar historical climatic scenes, the following was concluded： 1） The climate conditions of suitable agriculture areas in the farming-grazing transitional zone in the northeastern China between 1971 and 2000 required an average annual temperature above 1℃ or ≥ 0℃ accumulated temperature above 2500℃-2700℃, and annual precipitation above 350 mm. 2） The northern boundary of the potential suitable agriculture area during the relatively warmer period of 1890-1910 was approximately located at the position of the 1961-2000 area. The northern boundary shifted back to the south by 75 km on average during the colder period of the earlier 20th century, whereas during the modem warm period of the 1990s, the area shifted north by 100 km on average. 3） The western and eastern boundaries of the suitable agricul^re area during the heaviest drought periods between 1920s and 1930s had shifted northeast by 250 km and 125 km, respectively, contrasting to the boundaries of 1951-2008. For the wettest period, that is, the 1890s to the 1910s, the shift of western and eastern boundaries was to the southwest by 125 km and 200 km, respectively, compared with that in the 1951-2008 period. This study serves as a reference for identifying a climatically sensitive area and planning future land use and agricultural production in the study area.

关键词： land cover changes farming-grazing transitional zone climate change agricultural production

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Representations of Frobenius-type Triangular Matrix Algebras

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Acta Mathematica Sinica,English Series 2017年第3期33卷 341-361页

作者： fang LI Chang ye Department of Mathematics Zhejiang University Hangzhou 310027 P. R. China

The aim of this paper is mainly to build a new representation-theoretic realization of finite root systems through the so-called Frobenius-type triangular matrix algebras by the method of reflection functors over any field. Finally, we give an analog of APR-tilting module for this class of algebras. The major conclusions contains the known results as special cases, e.g., that for path algebras over an algebraically closed field and for path algebras with relations from symmetrizable cartan matrices. Meanwhile, it means the corresponding results for some other important classes of algebras, that is, the path algebras of quivers over Frobenius algebras and the generalized path algebras endowed by Frobenius algebras at vertices.

关键词： Frobenius-type triangular matrix algebras reflection functor locally free module rootsystem APR-tilting module

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Fractional Dynamics of Fluid-Conveying Pipes Made of Polymer-Like Materials

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Acta Mechanica Solida Sinica 2018年第2期31卷 243-258页

作者： ye Tang Tianzhi Yang Bo fang School of Mechanical and Automotive Engineering Anhui Polytechnic University School of Aerospace Engineering Shenyang Aerospace University Department of Mechanics Tianjin University School of Astronautics Harbin Institute of Technology

The fluid-conveying pipes made of polymer-like materials are widely applied in engineering fields. However, the fractional dynamics of fluid-solid interaction remain unknown. In this work, the fractional dynamics of the pipes subjected to the excitation of supporting foun- dation are studied. A new nonlinear, fractional-order dynamic model is presented. The method of multiple scales is adopted directly to solve the model for the case of primary resonances. Numerical results are presented to show the effects of fractional order, foundation vibration, and other physical parameters on the steady-state response and stability.

关键词： Fluid-conveying pipes Fractional dynamics Method of multiple scales Polymer- like materials

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Constructed TiO_(2)/WO_(3)heterojunction with strengthened nano-trees structure for highly stable electrochromic energy storage device

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Journal of Advanced Ceramics 2023年第3期12卷 634-648页

作者： Lili Zhao Zhuoan Cai Xiaoyang Wang Wenbo Liao Simin Huang Lingyun ye Jilie fang Chunxing Wu Hao Qiu Lei miao School of Chemical Engineering and Energy Technology Dongguan University of TechnologyDongguan 523808China Guangxi Key Laboratory of Information Materials Engineering Research Center of Electronic Information Materials and DevicesMinistry of EducationSchool of Materials Science and EngineeringGuilin University of Electronic TechnologyGuilin 541004China Guangdong Provincial Key Laboratory of Distributed Energy Systems Dongguan 523808China

Tungsten trioxide(WO_(3))has been widely regarded as a prospective bifunctional material due to its electrochromic and pseudocapacitive properties,while still facing the dilemma of inadequate cycle stability and trapping-induced ***,inspired by the trees-strengthening approach,a unique titanium dioxide(TiO_(2))nanorod arrays strengthened WO_(3)nano-trees(TWNTs)heterojunction was rationally designed and *** sharp contrast to the transmittance modulation(ΔT)attenuation of primary WO_(3)nano-trees during cycling,the TWNTs film showed not only excellent electrochromic performance but also fascinating cycle stability(77.35%retention of the initialΔT after 10,000 cycles).Besides,the trapping-induced degradation could be easily rejuvenated by a potentiostatic de-trapping *** electrochromic energy storage device(EESD)was further assembled based on the TWNTs film to deliver excellentΔT(up to 79.5%at 633 nm),fast switching speed(tc/tb=1.9 s/14.8 s),extremely high coloration efficiency value(443.4 cm^(2)·C^(−1)),and long-term cycle stability(over 10,000 charge/discharge cycles).This innovative study provided in-depth insights into the electrochromism nature and a significant step in the realization of stable electrochromic-energy storage application,paving the way for multifunctional smart windows as well as next-generation optoelectronic devices.

关键词： electrochromic(EC) WO_(3)nano-trees cycle stability TiO_(2)nanorod arrays(TiO_(2)NRAs) energy storage

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