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Effect of dissolved-oxygen on the flotation behavior of pyrite at high altitude area

International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2148-2158页

作者： yan miao Guangke Ye Guofan Zhang School of Minerals Processing and Bio-engineering Central South UniversityChangsha 410083China

With the continuous development of mineral resources to high altitude areas,the study of sulfide ore flotation in unconventional systems has been *** is a consensus that moderate oxidation of sulfide ore is beneficial to flotation,but the specific suitable dissolved oxygen value is inconclusive,and there are few studies on sulfide ore flotation under low dissolved oxygen environment at high *** this paper,we designed and assembled an atmosphere simulation flotation equipment to simulate the flotation of pyrite at high altitude by controlling the partial pressure of N_(2)/O_(2) and dissolved oxygen under atmospheric conditions.X-ray photoelectron spec-troscopy(XPS),atomic force microscope(AFM),Fourier transform infrared spectrometer(FT-IR),UV-vis spectrophotometer,zeta po-tential,and contact angle measurements were used to reveal the effects of surface oxidation and agent adsorption on pyrite at high altitude(4600 m dissolved oxygen(DO)=4.0 mg/L).The results of pure mineral flotation indicated that the high altitude and low dissolved oxy-gen environment is favorable for pyrite *** angle measurements and XPS analysis showed that the high altitude atmosphere nslows down the oxidation of pyrite surface,facilitates S_(n)^(2-)/S^(0) production and enhances surface *** calcula-tions and zeta potential analysis showed that the influence of atmosphere on the form of pyrite adsorption is small,and the different atmo-spheric conditions are consistent with dixanthogen electrochemical adsorption,with lower Zeta potential under high altitude atmosphere and significant potential shift after sodium isobutyl xanthate(SIBX)*** results of FT-IR,UV-vis,and AFM analysis showed that SIBX adsorbed more on the surface of pyrite under high altitude atmosphere and adsorbed on the surface in a mesh structure com-posed of column/*** results of the experimental study revealed the reasons for the easy flotation of sul

关键词： high altitude dissolved-oxygen pyrite flotation oxidation

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Strengthening pharmacotherapy research for COVID-19-induced pulmonary fibrosis

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World Journal of Clinical Cases 2024年第5期12卷 875-879页

作者： yan-miao Liu Jing Zhang Jing-Jing Wu Wei-Wei Guo Fu-Shan Tang The First Clinical Institute Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Key Laboratory of Clinical Pharmacy in Zunyi City Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Department of Respiratory Medicine Central Hospital in Jinchang CityJinchang 737102Gansu ProvinceChina Department of Clinical Pharmacy Key Laboratory of Basic Pharmacology of Guizhou Province and School of PharmacyZunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina

The global spread of severe acute respiratory syndrome coronavirus 2 has resulted in a significant number of individuals developing pulmonary fibrosis(PF),an irreversible lung *** condition can manifest within a short inter-val following the onset of pneumonia symptoms,sometimes even within a few *** lung transplantation is a potentially lifesaving procedure,its limited availability,high costs,intricate surgeries,and risk of immunological rejection present significant *** optimal timing of medication administration for coronavirus disease 2019(COVID-19)-induced PF remains *** this,it is crucial to explore pharmacotherapy interventions,involving early and preventative treatment as well as pharmacotherapy options for advanced-stage ***,studies have demonstrated disparities in anti-fibrotic treatment based on race and gender *** mutations may also impact therapeutic *** research efforts on pharmacotherapy interventions,while considering relevant pharmacological factors and optimizing the timing and dosage of medication administration,will lead to enhanced,personalized,and fair treatment for individuals impacted by COVID-19-related *** measures are crucial in lessening the burden of the disease on healthcare systems and improving patients'quality of life.

关键词： COVID-19 Pulmonary fibrosis Pharmacotherapy intervention Medication administration Timing Dosage

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Impacts of cold exposure on energy metabolism

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Frigid Zone Medicine 2024年第2期4卷 65-71页

作者： miao yan Shanjie Wang Shaohong Fang Mingyan E Bo Yu Department of Cardiology Second Affiliated Hospital of Harbin Medical UniversityHarbin 150001China The Key Laboratory of Myocardial Ischemia Chinese Ministry of EducationHarbin 150001China Department of Thoracic Radiotherapy Harbin Medical University Cancer HospitalHarbin 150081China

Cold stimulation has been shown to regulate glucose,lipid,and amino acid metabolism,while also increasing heat production and energy expenditure in the *** energy metabolism is a key factor in the onset and progression of chronic metabolic conditiones such as diabetes,obesity,and cardiovascular *** research has unveiled the myriad pathways through which cold stimulation affects human energy *** article provides an overview of how cold stimulation affects energy metabolism across the three major metabolic ***,it explores the implications and potential therapeutic applications of cold stimulation in the prevention and treatment of various metabolic diseases.

关键词： cold stimulation energy metabolism glucose metabolism lipid metabolism amino acid metabolism chronic metabolic diseases

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民主正义论:从中国出发的世界性民主话语重构

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哲学动态 2024年第3期 5-18,125,126页

作者：王菁闫苗西南交通大学马克思主义学院

国际话语体系建构面临融通本土性与全球性、特殊性与普遍性的难题,从中国出发重构“世界性”民主话语是突破这一困境的可行路径。“民主正义”通过嵌入“正义”之公正良善的实质价值重构民主认知,成为世界性民主话语的核心概念之一。民... 详细信息

国际话语体系建构面临融通本土性与全球性、特殊性与普遍性的难题,从中国出发重构“世界性”民主话语是突破这一困境的可行路径。“民主正义”通过嵌入“正义”之公正良善的实质价值重构民主认知,成为世界性民主话语的核心概念之一。民主正义论的建构需要遵循四个步骤。首先,确立世界性民主话语的内涵。其次,对“民主正义”给予规范性论证,强化民主正义论的价值理性、客观伦理和实践建构的理论特质。再次,阐释民主正义的建构原则,包括平等参与、保存生命和需要。最后,根据其伦理论证和建构原则明确民主正义的具体范畴:责任民主、治理民主和发展民主。民主正义论是从中国的民主具体实践场域和运行成效中生成的新概念和新范畴,可以全面彰显中国民主对于人类政治文明发展的意义。

关键词：民主正义世界性民主话语

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基于Nrf2/HO-1信号通路探究胃复春胶囊辅助治疗重症肺炎合并应激性胃溃疡临床研究

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世界华人消化杂志 2024年第3期32卷 228-235页

作者：苗燕燕孙康舟山市中医医院急诊科浙江省舟山市316000

背景重症肺炎合并应激性溃疡发病机制并未完全阐述,尚无特效治疗方案,预后普遍较差,明确其发病机制,确定治疗靶点有望控制病情进展,促使疾病转归.目的探讨基于核因子E2相关因子2/血红素氧合酶-1(nuclear factor erythroid 2 related fac... 详细信息

背景重症肺炎合并应激性溃疡发病机制并未完全阐述,尚无特效治疗方案,预后普遍较差,明确其发病机制,确定治疗靶点有望控制病情进展,促使疾病转归.目的探讨基于核因子E2相关因子2/血红素氧合酶-1(nuclear factor erythroid 2 related factor 2/heme oxygenase-1,Nrf2/HO-1)信号通路探究胃复春胶囊辅助治疗重症肺炎合并应激性胃溃疡效果.方法收集2021-01/2023-01舟山市中医医院108例重症肺炎合并应激性胃溃疡患者临床资料进行回顾性分析,根据治疗方案分为对照组(n=54)和研究组(n=54),分别采取奥美拉唑、奥美拉唑+胃复春胶囊,连续治疗1 wk.统计2组治疗总有效率、临床症状缓解时间、不良反应、复发率及治疗前后生长抑素(somatostatin,SS)、血管活性肠肽(vasoactive intestinal peptide,VIP)、胃泌素(gastrin,GAS)、Nrf2/HO-1信号通路相关mRNA、蛋白表达、氧化应激指标[丙二醛(malondialdehyde,MDA)、一氧化氮(nitric oxide,NO)、8-羟基脱氧鸟苷酸(8-Hydroxy-2'-deoxyguanine,8-OHdG)].结果研究组治疗总有效率较对照组高,临床症状缓解时间较对照组短(P<0.05);治疗1 wk后研究组VIP、GAS、SS含量及其差值均高于对照组(P<0.05);治疗1 wk后研究组Nrf2、HO-1 mRNA、蛋白及NO含量均高于对照组,MDA、8-OHdG含量低于对照组,差值均高于对照组(P<0.05);2组不良反应及复发率比较差异无统计学意义.结论胃复春胶囊辅助治疗重症肺炎合并应激性胃溃疡效果确切,有利于增加胃肠激素含量,缩短症状缓解时间,且安全性高,可能机制与上调Nrf2/HO-1信号通路有关.

关键词：重症肺炎应激性胃溃疡胃复春胶囊奥美拉唑 Nrf2/HO-1信号通路

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Alteration of ascending colon mucosal microbiota in patients after cholecystectomy

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2436-2450页

作者： miao-yan Fan Qiao-Li Jiang Meng-yan Cui Meng-Qi Zhao Jing-Jing Wang Ying-Ying Lu Department of Gastroenterology Jiading Branch of Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201803China Shanghai Key Laboratory of Pancreatic Diseases Institute of Translational MedicineShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China

BACKGROUND Cholecystectomy is a successful treatment option for gallstones,although the inci-dence of colorectal cancer(CRC)has notably increased in post-cholecystectomy(PC)***,it remains uncertain whether the altered mucosal micro-biota in the ascending colon is *** total,30 PC patients and 28 healthy controls underwent colonoscopies to collect mucosal biopsy *** patients were divided based on their clinical ***,16S-rRNA gene sequencing was used to analyze the amplicon,alpha diversity,beta diversity,and composition of the bacterial ***-tionally,the Phylogenetic Investigation of Communities by Reconstruction of Unobserved States(PICRUSt)database,sourced from the Kyoto Encyclopedia of Genes and Genomes,was used to predict the functional capabilities of the *** PC patients were comparable with healthy ***,PC patients older than 60 years had a distinct composition compared to those under 60 years *** richness was considerably higher at the phylum level in PC ***,Parabacteroides,and Bilophila were more abundant in the PC group than in the control ***,PC patients exhibited greater enrichment in metabolic pathways,specifically those related to lipopolysaccharide biosynthesis and vancomycin group antibiotic production,than *** This study indicated that the mucosal microbiota in PC patients was altered,perhaps offering new perspectives on the treatment possibilities for CRC and diarrhea following cholecystectomy.

关键词： Post-cholecystectomy Ascending colon Mucosal Microbiota Colorectal cancer Diarrhea

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全球价值链参与、数字化能力与企业韧性

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技术经济与管理研究 2024年第6期 46-51页

作者：刘琳缪言天津师范大学经济学院天津300387

在国际环境不确定性风险日益增加的背景下,增强韧性对企业发展具有重要意义。将企业韧性刻画为稳健性和敏捷性两个维度,实证检验参与全球价值链和数字化能力对企业韧性的影响。研究发现,全球价值链参与对企业韧性有双重影响。GVC企业受... 详细信息

在国际环境不确定性风险日益增加的背景下,增强韧性对企业发展具有重要意义。将企业韧性刻画为稳健性和敏捷性两个维度,实证检验参与全球价值链和数字化能力对企业韧性的影响。研究发现,全球价值链参与对企业韧性有双重影响。GVC企业受冲击后保持运营的概率更小,销售额下降更大,稳健性越弱,但更有能力调整其生产或服务,创新业务模式,敏捷性较高。国家工业实力强可减轻对GVC企业的冲击,增强其稳健性。具备数字化能力的企业受冲击后稳健性强,数字化对商业模式调整影响显著,但对生产服务转变影响不明显。在高收入国家和低技术制造业中,数字化对企业韧性的影响更为显著。

关键词：全球价值链数字化企业韧性

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Aptamer-Based Cell-Surface Profiling with Single-Cell Resolution Enables Precise Cancer Characterization

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CCS Chemistry 2024年第1期6卷 196-207页

作者： Liujun Xu Yawei Feng Tong Wang Shenhuan Li Kangli Xu Yue Sun Yi Luo Yishan Ye yan miao Yun Dong Zhenzhen Guo Qing Zhang Benshang Li He Huang Xue-Qiang Wang Liping Qiu Weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyAptamer Engineering Center of Hunan ProvinceHunan UniversityChangshaHunan 410082 The Key Laboratory of Zhejiang Province for Aptamers and Theranostics Zhejiang Cancer HospitalHangzhou Institute of MedicineChinese Academy of SciencesHangzhouZhejiang 310022 Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineCollege of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240 Bone Marrow Transplantation Center The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003 Institute of Hematology Zhejiang UniversityHangzhou 310003 Department of Hematology and Oncology Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200127

Molecular profiling of cell-surface proteins is a powerful strategy for precise cancer *** mass cytometry(MC)enables synchronous detection of over 40 cellular parameters,its full potential in disease classification is challenged by the limited types of recognition probes currently *** this work,we synthesize a panel of heavy isotopeconjugated aptamers to profile cancer-associated signatures on the surface of hematological malignancy(HM)*** on 15 molecular signatures,we performed cell-surface profiling that allowed the precise classification of 8 HM cell *** with machine-learning technology,this aptamer-based MC platform also achieved multiclass identification of HM subtypes in clinical sampleswith 100%accuracy in the training cohort and 80%accuracy in the test ***,we report an effective and practical strategy for precise cancer classification at the singlecell level,paving the way for its clinical use in the near future.

关键词： molecular profiling cancer diagnosis mass cytometry aptamers machine learning

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Avoiding misdiagnosis of multilocular thymic cysts as malignant tumors on computer tomography

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World Journal of Clinical Cases 2024年第19期12卷 3671-3675页

作者： Yu-Hong Zhang yan-miao Liu Kai-Li Shen Jing-Jing Wu Fu-Shan Tang Key Laboratory of Clinical Pharmacy in Zunyi City Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Department of Traditional Chinese Medicine Central Hospital in Jinchang CityJinchang 737102Gansu ProvinceChina The First Clinical Institute Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Department of Clinical Pharmacy Key Laboratory of Basic Pharmacology of Guizhou Province and School of PharmacyZunyi Medical UniversityZunyi 563006Guizhou ProvinceChina

This editorial provides insights from a case report by Sun et al published in the World Journal of Clinical *** case report focuses on a case where a multilocular thymic cyst(MTC)was misdiagnosed as a thymic tumor,resulting in an unnecessary surgical *** MTCs and thymic tumors are rare conditions that heavily rely on radiological imaging for accurate ***,the similarity in their imaging presentations can lead to misinterpretation,resulting in unnecessary surgical *** to the ongoing lack of comprehensive knowledge about MTCs and thymic tumors,we offer a summary of diagnostic techniques documented in recent literature and examine potential causes of *** computer tomography(CT)values surpass 20 Hounsfield units and display comparable morphology,there is a risk of misdiagnosing MTCs as thymic *** various differential diagnostic methods like biopsy,molecular biology,multi-slice CT,CT functional imaging,positron emission tomography/CT molecular functional imaging,magnetic resonance imaging and radiomics,proves advantageous in reducing clinical misdiagnosis.A deeper understanding of these conditions requires increased attention and exploration by healthcare ***,the continued advancement and utilization of various diagnostic methods are expected to enhance precise diagnoses,provide appropriate treatment options,and improve the quality of life for patients with thymic tumors and MTCs in the *** advancement and utilization of various diagnostic methods are expected to enhance precise diagnoses,provide appropriate treatment options,and improve the quality of life for patients with thymic tumors and MTCs in the future.

关键词： Thymic tumor Multilocular thymic cyst Misdiagnosis Differential diagnosis Imaging manifestation Computed tomography

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数据要素对劳动和资本的配置效应:机理分析与实证检验

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中南财经政法大学学报 2024年第1期 148-160页

作者：曾晶余泳泽缪言南京财经大学国际经贸学院江苏南京210023 天津师范大学经济学院天津300387

本文通过构建包含互联网平台主体的新凯恩斯DSGE模型,探究了数据要素变革劳动和资本要素配置的机理,并利用动态面板模型实证检验了数据要素成本、数字化技术创新与数据要素质量影响就业、投资和资本装备率的真实效应。研究表明:数据要... 详细信息

本文通过构建包含互联网平台主体的新凯恩斯DSGE模型,探究了数据要素变革劳动和资本要素配置的机理,并利用动态面板模型实证检验了数据要素成本、数字化技术创新与数据要素质量影响就业、投资和资本装备率的真实效应。研究表明:数据要素成本降低使得完全竞争条件下的产品价格走低,价格效应短期挤出劳动,长期挤入资本,提升资本装备率;数字化技术创新提高了全要素生产率,要素重组升级引致效率变革,通过替代效应促进就业、降低投资,降低资本装备率;数据质量改进通过协同效应稳定和扩大就业,阻止资本无边界的扩张,降低资本装备率。本文厘清了数据要素对劳动和资本单个要素及其比例关系的配置效应和作用机理,为制定数字经济背景下的就业与投资政策提供了决策参考。

关键词：数据要素劳动要素资本要素资本装备率价格效应替代效应协同效应

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