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Mechanokinetics of receptor-ligand interactions in cell adhesion

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Acta Mechanica Sinica 2015年第2期31卷 248-258页

作者： Ning Li Shouqin Lü Yan Zhang mian Long Key Laboratory of Microgravity(National Microgravity Laboratory) Center of Biomechanics and Bioengineeringand Beijing Key Laboratory of Engineered Construction and MechanobiologyInstitute of MechanicsChinese Academy of Sciences

Receptor-ligand interactions in blood flow are crucial to initiate such biological processes as inflammatory cascade,platelet thrombosis,as well as tumor *** mediate cell adhesion,the interacting receptors and ligands must be anchored onto two apposing surfaces of two cells or a cell and a substratum,i.e.,two-dimensional（2D）binding,which is different from the binding of a soluble ligand in fluid phase to a receptor,i.e.,three-dimensional（3D） *** numerous works have been focused on3 D kinetics of receptor-ligand interactions in the immune system,2D kinetics and its regulations have been less understood,since no theoretical framework or experimental assays were established until *** only does the molecular structure dominate 2D binding kinetics,but the shear force in blood flow also regulates cell adhesion mediated by interacting receptors and ***,we provide an overview of current progress in 2D binding and regulations,mainly from our *** issues of theoretical frameworks,experimental measurements,kinetic rates and binding affinities,and force regulations are discussed.

关键词： Receptor-ligand interactions Selectins β_2 integrins 2D binding kinetics

Interpretation of appropriate places: State ceremonies and the imperial main halls of the Tang and Song dynasties

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Frontiers of Architectural Research 2022年第6期11卷 1007-1029页

作者： mian Guo Yang Shen School of Archaeology and Museology Peking UniversityBeijing 100871China School of Architecture Southeast UniversityNanjing 210096China Member of Key Scientific Research Base of Traditional Wooden Architecture(Southeast University) State Administration for Cultural HeritageNanjing 210096China

This paper aims to inquiry on the dialectical relationships between Chinese architecture’s form and function in the horizon of long-term historical evolution,by clarifying how the histories of imperial main halls and state ceremonies relate to and interact with each other during the Tang and Song *** imperialmain halls are themost archetypical and accomplished ones among traditional Chinese buildings,and their function is primarily ritual rather than *** these magnificent buildings are indisputably considered the crowning achievement of Chinese architectural history,how the built space cooperates with ritual practices did not receive deserved *** the thorough reading of voluminous official ritual documents and comprehensive utilization of archaeological discoveries together with visual materials,the research presents a broad understanding of the asynchronous developments of the ground-level architectural arrangement and the ritual configuration across these *** specifically depicted are details of how architecture engaged in the ritual narration and was used as an apparatus to articulate emperor-courtier relationships.

关键词： Ritual function Architecture and ritual Chinese architecture Architectural meaning Form and function

Optimal non-fragile controller realization algorithm and application to control problems

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Journal of Harbin Institute of Technology(New Series) 2010年第1期17卷 89-94页

作者： mian Ashfaq Ahmad 王道波 Ahmad mian Ilyas 王宏强 College of Automation Engineering Nanjing University of Aeronautics and Astronautics College of Automation Engineering Nanjing University of Aeronautics and Astronautics Dept.of Electrical and Electronic Engineering Imperial College London

To reduce the fragility encountered in controller implementation, which is a measure of extent to describe small perturbations in controller parameters caused by rounding-off errors or component tolerances, and keep the system stability and performance, approaches of weighted eigenvalue sensitivity and stability radii comparison were used for computation and reduction of controller fragility. An algorithm has been derived for the efficient reduction of controller fragility, which used eigenstructure decomposition to obtain the suboptimal solution. The algorithm was tested for different control problems through reducing their fragility by a large margin. Different canonical forms were analyzed for fragility, including controllable canonical form, observable canonical form, modal canonical form, balanced realization and optimal (non-fragile) form. Different realizations were implemented through C language Matlab EXecutable (CMEX) S-function discrete state space block. Double precision calculations were performed. Open and closed loop controller realizations were compared with simulink state space (optimal) block. Results of comparison indicate that the optimal non-fragile controller realization shows better results both in open loop and closed loop realization.

关键词： controller fragility eigenstructure decomposition controller realizations

EFFECTS OF SURFACE WAVES AND MARINE SOIL PARAMETERS ON SEABED STABILITY

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Applied Mathematics and Mechanics(English Edition) 2001年第8期22卷 904-916页

作者： LIN mian(林缅) LI Jia-chun(李家春) Institute of Mechanics CAS Beijing 100080 P R China Institute of Mechanics CAS Beijing 100080 P R China

Based on the Yamamoto's soil model by considering the Coulomb friction effects, the wave-induced seabed instability has been investigated. An analytical solution is derived for soil response of a finite depth seabed tinder surface water wave. The effects of wave parameters and soil characteristics on the seabed instability are addressed for three types of soil. Finally, the roles of Coulomb friction stability are then analyzed as well.

关键词： seabed instability shear failure liquefaction

Sludge-based biochar adsorbent:pore tuning mechanisms,challenges,and role in carbon sequestration

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Biochar 2023年第1期5卷 1419-1441页

作者： Md Manik mian Wenya Ao Shubo Deng State Key Joint Laboratory of Environment Simulation and Pollution Control(SKLESPC) Beijing Key Laboratory for Emerging Organic Contaminants ControlSchool of EnvironmentTsinghua UniversityBeijing 100084China

Sludge biochar,a carbonized product of raw sludge,contains porous architectures that can act as epicenters for adsorbing external molecules through physical or chemical *** biochar also immobilizes innate micropollutants,which is advantageous over conventional sludge disposal *** date,numerous strategies have been discovered to improve sludge biochar morphology,but the influential factors,pore tuning mechanisms,and process feasibility remain *** knowledge gap limits our ability to design a robust sludge-based ***,we present state-of-the-art sludge biochar synthesis methods with insight into structural and chemical transformation *** and novel concepts for improving sludge biochar porous architecture are *** the first time,sludge biochar properties,adsorption performances,and techno-economic perspectives were compared with commercial activated carbon(AC)to reveal the precise challenges in sludge biochar *** importantly,sludge biochar role in carbon sequestration is detailed to demonstrate the environmental significance of this ***,the review concludes with an overview of prospects and an outlook for developing sludge biochar-based research.

关键词： Sludge-based adsorbent Micropores Feasible methods Challenges Carbon sequestration

Tribocorrosion behavior of antibacterial Ti-Cu sintered alloys in simulated biological environments

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Rare Metals 2022年第6期41卷 1921-1932页

作者： Jia-Qi Zhang Shuang Cao Ying Liu mian-mian Bao Jing Ren Sheng-Yi Li Er-Lin Zhang Jian-Jie Wang Departments of Immunology College of Basic MedicineJiamusi UniversityJiamusi 154007China Key Laboratory for Anisotropy and Texture of Materials School of Materials Science and EngineeringEducation Ministry of ChinaNortheastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China

Ti-Cu alloys have strong antibacterial proper-ties,high strength and excellent corrosion resistance,which might be used in orthopedic and dental *** this paper,the tribocorrosion behaviors of Ti-Cu alloy with different Cu contents were investigated in four simulated biological environments compared with *** results showed that Ti-Cu sintered alloy exhibited higher corro-sion resistance,lower coefficient friction and wear loss than cp-Ti in all tested solutions due to the formation of fine and homogeneously distributed Ti_(2)Cu phase,espe-cially in solution with lower F ion and *** Cu content and extrusion process improved the corrosion resistance and the wear resistance because of high Ti_(2)Cu phase fraction and fine grain ***,aggressive solution,such as the solution with lower F ion and pH,accelerated wear in comparison with other solutions for cp-Ti and Ti-Cu sintered *** electron microscope(SEM)surface morphology demonstrated that the wear mecha-nism of cp-Ti during tribocorrosion process was mainly abrasive wear and adhesive wear while that of Ti-Cu alloy was abrasive *** summary,Ti-Cu sintered alloys showed much better tribocorrosion property than cp-Ti,which shows great potential application in condition for wear and corrosion resistance.

关键词： Ti-Cu alloys Tribocorrosion Corrosion Wear In vitro Antibacterial metal alloy

Two new species of the genus Wieseria (Nematoda:Enoplaida:Oxystominidae) from the Jiaozhou Bay

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Acta Oceanologica Sinica 2018年第10期37卷 157-160页

作者： HUANG mian SUN Jing HUANG Yong College of Life Sciences Liaocheng University

Two new species of free-living marine nematodes of the genus Wieseria are described from the sublittoral sediment of the Jiaozhou Bay in Qingdao. Wieseria sinica sp. nov. is characterized by having short labial and cephalic setae in a backward direction; oblong amphidial foveas with double contour; arcuate spicules with alea; ring-like guberculum; and clavated tail. Wieseria tenuisa sp. nov. is characterized by its very large ＂a＂ value （133.6）, long labial setae in a forward direction; spicules with alea and hooked proximal end; rodlike gubernaculums; and relatively longer clavated tail （7.9 a.b.d, long）. It differs from Wieseria sinica sp. nov. mainly by the longer labial setae, slightly straight spicules with hooked proximal end, and its thinner body. Amended dichotomous key to male species of Wieseria is provided.

关键词： Wieseria sinica sp. nov. Wieseria tenuisa sp. nov. free-living marine nematode taxonomy

Two new species of free-living nematodes from the East China Sea

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Acta Oceanologica Sinica 2018年第10期37卷 148-151页

作者： SUN Yan HUANG mian HUANG Yong College of Life Sciences Liaocheng University

Two new species of free-living marine nematodes of the genera Hopperia and Nemanema are described from the sublittoral sediment of the East China Sea. Hopperia macramphida sp. nov. is characterized by having large amphidial fovea with five turns; arcuate spicules with enlarged proximal end and central internal lamella extending one third of spicule length from proximal end; gubernaculum with bent apophyses, six papilliform precloacal supplements; and conico-cylindrical tail with swollen tip and terminal setae. Nernanema minutum sp, nov. is characterized by relatively smaller body size in the genus; large oval amphidial fovea; conical tail; slender spicules with alae and hooked proximal end; ring-like gubernaculum; and papilliform precloacal supplements with three short setae. An updated dichotomous key is provided for the 17 species of Hopperia.

关键词： Hopperia macramphida sp. nov. Nemanema minium sp. nov. marine nematode taxonomy

Daptonema parabreviseta sp. nov.(Xyalidae, Nematoda) from the Jiaozhou Bay of the Yellow Sea, China

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Journal of Oceanology and Limnology 2019年第1期37卷 273-277页

作者： HUANG mian SUN Jing HUANG Yong College of Life Sciences Liaocheng University Key Laboratory of Ecology and Biodiversity of Shandong Colleges and University

A new species of free-living marine nematode of the genus Daptonema Cobb, 1920 is described from the sublittoral sediment of the Jiaozhou Bay, Qingdao. Daptonema parabreviseta sp. *** characterized by having narrowed anterior end; small funnel-shaped buccal cavity; short cephalic setae;spicules with bulbiform proximal end and pointed distal end; gubercunalum tubular shape with a blunt dorsal apophysis. The female genital system presents a spacious postvulval sac. The new species closely resembles Daptonema brevisetosum Thanh & Gagarin, 2009. However, it differs from Daptonema brevisetosum by having relatively narrowed head(10 μm vs 20 μm); spicules with bulbiform proximal end and pointed distal end, not bifurcated at distal end. Female genital system with a spacious postvulval sac(vs absent).

关键词： new species free-living marine nematode taxonomy