检索结果-南通市图书馆

Probe stiffness regulates receptor-ligand bond lifetime under force

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2011年第5期54卷 923-929页

作者： ZHANG Yan LüShouQin &LONG mian Key Laboratory of Microgravity Institute of MechanicsChinese Academy of SciencesBeijing 100190China National Microgravity Laboratory and Center of Biomechanics and Bioengineering Institute of MechanicsChinese Academy of SciencesBeijing 100190China

Receptor-ligand bond dissociation under applied force is crucial to elucidate its biological functionality when the molecular bond is usually connected to a mechanical probe. While the impact of probe stiffness, k, on bond rupture force has recently at- tracted more and more attention, the mechanism of how it affects the bond lifetime, however, remains unclear. Here we quanti- fied the dissociation lifetime of selectin-ligand bond using an optical trap assay with low stiffness ranging from 3.5×10^-3 to 4.7×10^-2 pN/nm. Our results indicated that bond lifetime yielded distinct distributions with different probe stiffness, implying the stochastic feature of bond dissociation. It was also found that the mean lifetime varied with probe stiffness and that the catch bond nature was visualized at k≥3.0×10^-2 pN/nm. This work furthered the understanding of the forced dissociation of se- lectin-ligand bond at varied probe stiffness, which is physiologically relevant to the tethered rolling of leukoeytes under blood flow.

关键词： probe stiffness bond lifetime optical trap

Monoterpene and tetrahydronaphthene derivatives from Senecio argunensis

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2009年第5期20卷 598-600页

作者： Chao Feng Zhang Ning Li Lin Li mian Zhang Research Department of Pharmacognosy China Pharmaceutical University Nanjing 210038 China

Two new compounds, senarguines A and B, were isolated from Senecio argunensis. They were respectively identified as （Z）-3- ethylidene-9-hydroxyl-9-methyl-6,7-dioxaspiro [4.4] nonane-5,8-dione （1） and 3,6,6-trimeth... 详细信息

关键词： Compositae Senecio argunensis Senarguine A Senarguine B

First record of Theloderma pyaukkya Dever, 2017(Anura: Rhacophoridae) in China, with range extension of Theloderma moloch(Annandale, 1912) to Yunnan

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2020年第5期41卷 576-580页

作者： Li-Na Du Shuo Liu mian Hou Guo-Hua Yu Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Guangxi Normal University) Ministry of EducationGuilinGuangxi 541004China Guangxi Key Laboratory of Rare and Endangered Animal Ecology College of Life ScienceGuangxi Normal UniversityGuilinGuangxi 541004China Kunming Natural History Museum of Zoology Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Institute of Continuing Education Sichuan Normal UniversityChengduSichuan 610068China

DEAR EDITOR,Theloderma pyaukkya is recorded for the first time in China based on a specimen collected from western ***,the specimen shows good agreement with the original description of ***,and phylogenetically is clu... 详细信息

关键词： Morphological record extension

Visual programming language environment for different IoT and robotics platforms in computer science education

在线全文

学校读者我要写书评

暂无评论

CAAI Transactions on Intelligence Technology 2018年第2期3卷 119-130页

作者： Gennaro De Luca Zhongtao Li Sami mian Yinong Chen School of Computing Informatics and Decision Systems Engineering Arizona State University Tempe AZ 85287-8809 USA School of Information Science and Engineering University of Jinan Shandong People's Republic of China

This study presents the authors＇ recent research and application of a new visual programming language and its development environment： VIPLE （Visual IoT/Robotics Programming Language Environment） at Arizona State University （ASU）. ASU VIPLE supports a variety of loT devices and robots based on an open architecture. Based on computational thinking, VIPLE supports the integration of engineering design process, workflow, fundamental programming concepts, control flow, parallel computing, event-driven programming, and service-oriented computing seamlessly into a wide range of curricula, such as introduction to computing, introduction to engineering, service-oriented computing, and software integration. It is actively used at ASU in several sections of FSE 100： Introduction to Engineering and in CSE 446： Software Integration and Engineering, as well as in several other universities worldwide.

关键词：工作流程编程概念计算机技术人工智能

Clinical significance and role of up-regulation of SERPINA3 expression in endometrial cancer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2019年第15期7卷 1996-2002页

作者： mian-Li Zhou Fang-Shan Chen Hui Mao Department of Gynecology and Obstetrics Traditional Chinese Medicine Hospital Affiliated to Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND Serpin peptidase inhibitor,clade A member 3(SERPINA3)belongs to the serpin family with an inhibitory activity against *** aberrant expression has been observed in a wide range of tumor ***,its clinical significance and biological function in endometrial cancer have been rarely *** designed a study to determine the levels of SERPINA3 and its significance in patients with endometrial *** To investigate the clinical significance and role of SERPINA3 expression in endometrial cancer *** Eighty endometrial tissue samples collected from patients with endometrial cancer were included in an observation group and 80 paraffin-embedded tissues samples collected from patients with normal endometrial tissues undergoing myomectomy were employed as a control group between January 2014 and December *** expression of SERPINA3 mRNA was detected by quantitative polymerase chain reaction(PCR)for all endometrial tissues included in the *** The positive expression rate of SERPINA3 protein in endometrial cancer cells was 71.25%in the observation group,which was significantly higher than that in the control group(31.25%;P0.05).However,it was associated with pathological grade,clinical stage,vascular invasion,and lymph node metastasis(P<0.05).Pathological grade,clinical stage,vascular invasion,and lymph node metastasis were independent prognostic factors for endometrial *** The follow-up study of SERPINA3 can be used as a prognostic biomarker for endometrial cancer and as one of the targets for bio-targeted therapy for endometrial cancer.

关键词： Serpin peptidase inhibitor,clade A member 3 Endometrial cancer Quantitative polymerase chain reaction Expression

Bombyx mori nucleopolyhedrovirus induces BmFABP1 downregulation to promote viral proliferation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2023年第6期30卷 1595-1606页

作者： Xiong Wang Guangyu Ma Feifei Ren mian Muhammad Awais Jingchen Sun College of Animal Science Guangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular BreedingSouth China Agricultural UniversityGuangzhouChina

Fatty acid binding proteins (FABPs) play an important role as endogenous cytoprotectants. However, studies on FABPs in invertebrates are scarce. Previously, we discovered Bombyx mori fatty acid binding protein 1 (BmFABP1) through co-immunoprecipitation. Here, we cloned and identified BmFABP1 from BmN cells. The results of immunofluorescence indicated that BmFABP1 was localized in the cytoplasm. The tissue expression profile of silkworms showed that BmFABP1 was expressed in all tissues except hemocytes. The expression level of BmFABP1 gradually decreases in BmN cells and B. mori larvae after infection with B. mori nucleopolyhedrovirus (BmNPV). Upregulation of BmFABP1 expression through overexpression or WY14643 treatment significantly inhibited the replication of BmNPV, while downregulation of BmFABP1 expression by RNA interference promoted the replication of BmNPV. The same results were obtained in experiments on silkworm larvae. These results suggest that BmNPV induces BmFABP1 downregulation to promote its proliferation and that BmFABP1 has a potential anti-BmNPV role. This is the first report on the antiviral effect of BmFABP1 in silkworms and provides new insights into the study of the FABP protein family. Also, it is important to study BmNPV resistance in silkworms to breed transgenic silkworms with BmNPV resistance.

关键词： antiviral BmFABP1 BmNPV Bombyx mori

The effect of the differential rotation of the earth inner core on the free core nutation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geodesy and Geodynamics 2019年第2期10卷 146-149页

作者： mian Zhang Chengli Huang Key Laboratory of Planetary Sciences Shanghai Astronomical ObservatoryChinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences

Seismic observations shows that the inner core rotates faster than the mantle and the rotation axis of the inner core may not align with the rotation axis of the mantle. Free core nutation reflects core's information. We discuss the effect of the inner core's differential rotation on free core nutation from two aspects: rotation speed and deflection angle. Our result shows it is in accordance with the observations when the inner core's rotation speed doesn't exceed 10° faster than mantle's per year, and the deflection angle is less than 1°,if the rotation speed and the deflection angle are respectively considered separately.

关键词： Inner core Differential rotation Free core nutation

Effect of Heat Treatment on Microstructure and Property of Al-Sn-Pb Bearing Material

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2006年第2期13卷 73-76页

作者： XU Guang-ming LI Bao-mian CUI Jian-zhong Key Laboratory of Electromagnetic Processing of Materials Ministry of Education Northeastern University Shenyang 110004 Liaoning China

AlSn8Pb2Si2.5Cu0.8Cr0.2 is a bush material with high hardness, and the main elements tin and plumbum mainly exist along the grain boundary, resulting in bad plasticity and confectioning. It is found that the continuous tin and lead distributing along grain boundary are broken by cold-rolling, and their shape is spheroidized and uniform through annealing at constant temperature. The continuous precipitated phase composed of tin and lead doesn＇t exist along grain boundary. The properties of bush material are greatly increased.

关键词： bush material cold-rolling annealing spheroidization

Social Polyandry and Multiple Paternity in the Omei Treefrog in the Southwest China

在线全文

学校读者我要写书评

暂无评论

Asian Herpetological Research 2017年第1期18卷 48-54页

作者： Hui WANG Zhenhua LUO Jian CHEN mian ZHAO Hua WU Institute of Evolution and Ecology School of Life Sciences Central China Normal University 152 Luoyulu Hongshan District Wuhan 430079 China

Group spawning, polyandry reproductive behaviors, and multiple paternity are increasingly reported in anuran species. The Omei treefrog （Rhacophorus omeimontis）, endemic to subtropical and mountainous forests of central and southwestern China, is a polyandrous lek-patterned breeder commonly showing multiple males-one female matings during the breeding season. To detect the traits of social and genetic polyandry in this species and explore the relationships between these traits, we investigated the breeding behaviors of a population of R. omeimontis in the Fengtongzhai National Nature Reserve, Baoxing County, Sichuan, China. We conducted paternity analyses using six microsatellite genetic markers. A total of 30 matings were recorded in the field （four monogamous pairs and 26 spawning groups）. Our results revealed high proportions of social polyandry （86.7%） and multiple paternity （70.0%） and the numbers of joining males and genetic fathers among matings ranged from 1 to 8 and from 1 to 4, respectively. There was a significantly positive correlation between the intensities of social and genetic polyandry, indicating that multiple males-one female breeding behaviors could be an important promoter of multiple paternity. We considered the intense social polyandry and multiple paternity as consequences of intense male-male competition under a male-biased sex ratio and genetic benefits pursuing of the females. However, the proportion of genetic fathers in a spawning decreased with the increase of joining male number and most of their offspring belonged to a few males. This might be caused by a ＂making the best of a bad lot＂ reproductive strategy of the inferior male individuals.

关键词： Genetic polyandry multiple patemity Rhacophorus omeimontis social polyandry