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The role of the C-terminal tail of the human β2-adrenoceptor in stimulation of glucose uptake in CHO cells.

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The role of the C-terminal tail of the human β2-adrenocepto...

Noninvasive markers of liver steatosis and fibrosis after liver transplantation-Where do we stand?

第十五届国际药理学大会

作者： mia Nevzorova Bronwyn A Evans Roger J Summers Tore Bengtsson Department of Physiology The Wenner - Gren Institute. Stockholm University 10691 Stockholm Sweden Department of Pharmacology Monash UniversityVIC 3800Australia Department of Pharmacology Monash UniversityVIC 3800Australia Department of Physiology The Wenner - Gren InstituteStockholm University 10691 Stockholm Sweden

＜正＞Glucose homeostasis is maintained by insulin, which stimulates glucose uptake in adipose tissue and skeletal *** increase glucose uptake, utilizing components of the insulin ***, activation of β2 - AR increases glucose uptake in L6 muscle cells by activation of cAMP, PI3K and Gi, The β2 - AR C - terminal tail contains PKA and GRK phosphorylation sites, which when phos-phorylated cause desensitization of the receptor, coupling to Gi, and activation of PI3K and MAPK. In this study we transfected CHO cells with human β2- AR （wild type （WT） or truncated at amino acids 344 or 349） and measured glucose uptake and cAMP accumulation, In CHO cells expressing WT β2- AR, glucose uptake was increased by isoprenaline, insulin and 8 - bromo - cAMP, In cells expressing truncated receptors （349 or 344） insulin and 8 - bromo - cAMP increased glucose uptake to the same degree as in the wild type β2 - AR - CHO cells, but isoprenaline - stimulated glucose uptake was significantly reduced, suggesting that C - terminal PKA and GRK phosphorylation sites are important for β2 - AR stimulated glucose uptake, cAMP responses to forskolin or isoprenaline were not significantly changed between the wild type and truncated receptors.

关键词： glucose uptake β2- adrenoceptor signal transduction

来源： cnki会议评论

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World Journal of Transplantation 2021年第3期11卷 37-53页

作者： Ivana Mikolasevic Sanja Stojsavljevic Filip Blazic Maja Mijic Delfa Radic-Kristo Toni Juric Nadija Skenderevic mia Klapan Andjela Lukic Tajana Filipec Kanizaj Department of Gastroenterology Clinical Hospital Centre RijekaRijekaCroatiaDepartment of GastroenterologyClinical hospital MerkurZagrebCroatiaFaculty of MedicineUniversity of RijekaRijekaCroatia Department of Gastroenterology University Hospital Center“Sestre Milosrdnice”Zagreb 10000Croatia Department of Gastroenterology University Hospital Center RijekaRijeka 51000Croatia Department of Gastroenterology University Hospital MerkurZagreb 10000Croatia Department of Hematology University Hospital MerkurZagrebCroatiaFaculty of MedicineUniversity of ZagrebZagrebCroatia School of Medicine School of MedicineRijeka 51000Croatia Department of Gastroenterology University Hospital MerkurZagrebCroatiaFaculty of MedicineUniversity of ZagrebZagrebCroatia

In the last two decades,advances in immunosuppressive regimens have led to fewer complications of acute rejection crisis and consequently improved shortterm graft and patient *** parallel with this great success,long-term posttransplantation complications have become a focus of interest of doctors engaged in transplant *** syndrome(MetS)and its individual components,namely,obesity,dyslipidemia,diabetes,and hypertension,often develop in the post-transplant setting and are associated with immunosuppressive *** fatty liver disease(NAFLD)is closely related to MetS and its individual components and is the liver manifestation of ***,it is not surprising that MetS and its individual components are associated with recurrent or“de novo”NAFLD after liver transplantation(LT).Fibrosis of the graft is one of the main determinants of overall morbidity and mortality in the post-LT *** the assessment of post-LT steatosis and fibrosis,we have biochemical markers,imaging methods and liver *** of the significant economic burden of post-LT steatosis and fibrosis and its potential consequences,there is an unmet need for noninvasive methods that are efficient and *** scores can overestimate fibrosis and are not a good method for fibrosis evaluation in liver transplant recipients due to frequent post-LT *** elastography with controlled attenuation parameter is a promising noninvasive method for steatosis and *** this review,we will specifically focus on the evaluation of steatosis and fibrosis in the post-LT setting in the context of de novo or recurrent NAFLD.

关键词： Steatosis Fibrosis Noninvasive methods Transient elastography Transplantation Nonalcoholic fatty liver disease

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蓝水园·蓝之谜——吴巍空间设计案例赏析

家具与室内装饰 2020年第3期27卷 88-91页

作者： mia 不详

善,是宇宙最好的能量,也是吴巍DESIGN始终坚守的本心。设计师吴巍秉持对待万事万物皆为善意的基础,以“创新·艺术·生活”三者相融的设计理念,打造科学、时尚、舒适的理想空间。同时,吴巍Design更懂得追溯客户的本心与梦想,贴身式服务... 详细信息

善,是宇宙最好的能量,也是吴巍DESIGN始终坚守的本心。设计师吴巍秉持对待万事万物皆为善意的基础,以“创新·艺术·生活”三者相融的设计理念,打造科学、时尚、舒适的理想空间。同时,吴巍Design更懂得追溯客户的本心与梦想,贴身式服务,为客户打造理想居所。为业主提供最优质的空间解决方案,赋予每一座建筑独特的灵魂。

关键词：空间设计案例赏析理想空间设计理念本心

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Anisotropic leaky-like perturbation with subwavelength gratings enables zero crosstalk

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Light(Science & Applications) 2023年第6期12卷 1153-1161页

作者： Md Faiyaz Kabir Md Borhan mia Ishtiaque Ahmed Nafiz Jaidye Syed Z.Ahmed Sangsik Kim Department of Electrical and Computer Engineering Texas Tech UniversityLubbockTX 79409USA Department of Physics and Astronomy Texas Tech UniversityLubbockTX 79409USA School of Electrical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141South Korea

Electromagnetic coupling via an evanescent field or radiative wave is a primary characteristic of light,allowing optical signal/power transfer in a photonic circuit but limiting integration density.A leaky mode,which combines both evanescent field and radiative wave,causes stronger coupling and is thus considered not ideal for dense *** we show that a leaky oscillation with anisotropic perturbation rather can achieve completely zero crosstalk realized by subwavelength grating(SWG)*** oscillating fields in the SWGs enable coupling coefficients in each direction to counteract each other,resulting in completely zero *** experimentally demonstrate such an extraordinarily low coupling between closely spaced identical leaky SWG waveguides,suppressing the crosstalk by≈40 dB compared to conventional strip waveguides,corresponding to≈100 times longer coupling *** leaky-SWG suppresses the crosstalk of transverse–magnetic(TM)mode,which is challenging due to its low confinement,and marks a novel approach in electromagnetic coupling applicable to other spectral regimes and generic devices.

关键词： crosstalk coupling enable

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企业集团内部创新架构与创新绩效

经济管理 2022年第8期44卷 95-115页

作者：徐飞杨冕安徽师范大学经济管理学院安徽芜湖241000 武汉大学经济与管理学院湖北武汉430072

集团化经营是企业应对复杂多变环境的关键举措,集团内部组织架构直接关系企业集团成功实践。集团分散式创新架构强调去中心化的个体自发参与创新活动,而集中式创新架构则由个别节点开展封闭的创新活动。虽然一些知名企业集团已经从封闭... 详细信息

集团化经营是企业应对复杂多变环境的关键举措,集团内部组织架构直接关系企业集团成功实践。集团分散式创新架构强调去中心化的个体自发参与创新活动,而集中式创新架构则由个别节点开展封闭的创新活动。虽然一些知名企业集团已经从封闭的集中式创新走向开放的分散式创新,但既有研究关于两种集团内部创新架构的创新绩效研究不足,导致难以指导企业集团创新实践。为此,本研究从集团微观组织角度识别集团创新架构特征,并基于2007—2017年A股上市公司进行实证检验,重点讨论企业集团创新绩效。研究发现:企业集团分散式创新对于组织创新绩效更有利,包括组织的专利申请和专利授权绩效;增强企业集团盈利能力和国家创新驱动政策实施可以削弱集中式创新负面影响;企业集团分散式创新对于东部地区企业的组织创新绩效影响更明显,即发达地区更需要注重集团内部分散式创新;集团创新架构会通过影响创新策略和产品市场竞争力而影响创新绩效,具体表现为集团分散式创新更加有利于实质性创新和提升产品市场竞争力,进而显著增加分散式创新绩效。本研究表明,企业集团不仅要重视与外部组织开放协作,更要重视内部创新架构设计,构建成员企业积极参与的内部分散式创新网络。本研究丰富了企业集团组织研究,拓展了企业集团创新架构以及创新绩效研究。

关键词：企业集团创新架构分散式创新集中式创新创新绩效

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葡萄次生代谢UDP-糖基转移酶研究进展

园艺学报 2010年第1期37卷 141-150页

作者：王军于淼林木遗传育种与生物技术教育部重点实验室哈尔滨150040 东北林业大学林学院哈尔滨150040

UDP-糖基转移酶催化糖基转移反应,将糖基从活化的供体分子转移到受体分子上,从而调节受体分子在细胞内和机体内的性质,如生物活性、溶解性、可转运性。糖苷化是葡萄次生代谢很普遍的修饰反应,在次生代谢产物合成、贮存方面发挥重要功能... 详细信息

UDP-糖基转移酶催化糖基转移反应,将糖基从活化的供体分子转移到受体分子上,从而调节受体分子在细胞内和机体内的性质,如生物活性、溶解性、可转运性。糖苷化是葡萄次生代谢很普遍的修饰反应,在次生代谢产物合成、贮存方面发挥重要功能。综述了与葡萄次生代谢产物生物合成相关的UDP-糖基转移酶的生化及分子生物学研究进展,并对今后这一领域需要进一步研究的问题作了讨论。

关键词：葡萄次生代谢 UDP-糖基转移酶生化及分子生物学

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餐桌上的冬天每一口都是温暖的味道

芭莎珠宝 2022年第6期 208-211页

作者： mia 不详

想不想在跨年时刻欣赏绵延相连的黄浦江与外滩万国风情美如画卷般的精彩交汇?这种城中别具一格的云上至潮体验值得你来解锁!

关键词：美如画解锁云上

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对待“摩托车返乡大军”不应止于服务

摩托车信息 2018年第2期 48-49页

作者： mia

2018年2月1日是今年春运大幕拉开的第一天，作为春运中最特殊的一个群体，浩浩荡荡的摩托车返乡大军像往年一样“全副武装”，陆续出发。

关键词：摩托车服务春运

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外国人心仪的中国城市

财会月刊 2014年第30期 98-99页

作者： mia

中国浓厚的历史文化、独特的城市风景,都吸引着世界各国的朋友前来一睹风貌,世界正在走向中国。那么,中国大大小小的城市有很多,到底哪一些才是他们眼中最美的呢?发展商业之首选:义乌、上海、鄂尔多斯Kantako来自马里,现居浙江义乌,从... 详细信息

中国浓厚的历史文化、独特的城市风景,都吸引着世界各国的朋友前来一睹风貌,世界正在走向中国。那么,中国大大小小的城市有很多,到底哪一些才是他们眼中最美的呢?发展商业之首选:义乌、上海、鄂尔多斯Kantako来自马里,现居浙江义乌,从事商品出口贸易。义乌,位于浙江省中部,"小商品海洋,购物者天堂"是义乌的代名词。这是一座具有悠久历史和深厚文化底蕴的城市,越王勾践卧薪尝胆之地。这里也是全球最大的小商品集散中心,被联合国、世界银行等国际权威

关键词：中国城市外国人历史古迹历史文化名城