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Panhypopituitarism caused by a suprasellar germinoma: A case report

World Journal of Clinical Cases 2024年第10期12卷 1844-1850页

作者： Jelena Roganovic Lea Saric Silvije Segulja Ana Dordevic mia Radosevic Department of Pediatrics Clinical Hospital Centre RijekaRijeka 51000Croatia Faculty of Medicine University of RijekaRijeka 51000Croatia Faculty of Health Sciences University of RijekaRijeka 51000Croatia Department of Business Development Jadran Galenski LaboratorijRijeka 51000Croatia

BACKGROUND Suprasellar germinomas are rare intracranial tumors frequently associated with permanent endocrine disorders.We present the clinical picture,treatment,and complications of suprasellar germinoma at pediatric age which,besides being lifethreatening,has lifelong endocrinological consequences.CASE SUMMARY A 12-year-old female patient was presented having had intensive headaches for three weeks and visual disturbances for six months.An ophthalmological examination revealed bilateral papilledema and a marked loss of vision.Emergency brain magnetic resonance imaging(MRI)showed a suprasellar tumor,involving the infundibulum and the optic chiasm,extending to the third ventricle.Laboratory tests confirmed decreased levels of thyroxine,cortisol,gonadotropins,and insulin-like growth factor 1.Maximal tumor reduction was performed,and immunohistopathology established the diagnosis of suprasellar germinoma.MRI of the spine and cerebrospinal fluid cytology confirmed the localized disease.Adjuvant chemotherapy and radiotherapy were performed according to the SIOP CNS GCT II protocol.A post-treatment MRI showed no residual tumor,but pituitary function had not recovered.Three and a half years after the end of the treatment,the patient is in a complete remission,requiring hormonal replacement therapy,continuous education,and psychological support.CONCLUSION This complex case highlights the importance of timely diagnosis,a multidisciplinary approach,and close follow-up in children with suprasellar germinomas.

关键词： Germinoma Germ cell tumor Suprasellar tumor Hypopituitarism Management Pediatrics Case report

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Nitrate reduction capacity of the oral microbiota is impaired in periodontitis:potential implications for systemic nitric oxide availability

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International Journal of Oral Science 2024年第1期16卷 52-61页

作者： Bob T.Rosier William Johnston Miguel Carda-Diéguez Annabel Simpson Elena Cabello-Yeves Krystyna Piela Robert Reilly Alejandro Artacho Chris Easton mia Burleigh Shauna Culshaw Alex Mira Department of Genomics and Health FISABIO FoundationCenter for Advanced Research in Public HealthValenciaSpain Department of Biological and Biomedical Sciences Glasgow Caledonian UniversityGlasgowUK Oral Sciences University of Glasgow Dental SchoolSchool of MedicineDentistry and NursingCollege of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowUK Sport and Physical Activity Research Institute University of the West of ScotlandBlantyreScotland Instituto de Biomedicina de Valencia Consejo Superior de Investigaciones Científicas(IBV-CSIC)ValenciaSpain CIBER Center for Epidemiology and Public Health MadridSpain

The reduction of nitrate to nitrite by the oral microbiota has been proposed to be important for oral health and results in nitric oxide formation that can improve cardiometabolic conditions. Studies of bacterial composition in subgingival plaque suggest that nitrate-reducing bacteria are associated with periodontal health, but the impact of periodontitis on nitrate-reducing capacity(NRC)and, therefore, nitric oxide availability has not been evaluated. The current study aimed to evaluate how periodontitis affects the NRC of the oral microbiota. First, 16S rRNA sequencing data from five different countries were analyzed, revealing that nitratereducing bacteria were significantly lower in subgingival plaque of periodontitis patients compared with healthy individuals(P < 0.05 in all five datasets with n = 20–82 samples per dataset). Secondly, subgingival plaque, saliva, and plasma samples were obtained from 42 periodontitis patients before and after periodontal treatment. The oral NRC was determined in vitro by incubating saliva with 8 mmol/L nitrate(a concentration found in saliva after nitrate-rich vegetable intake) and compared with the NRC of 15healthy individuals. Salivary NRC was found to be diminished in periodontal patients before treatment(P < 0.05) but recovered to healthy levels 90 days post-treatment. Additionally, the subgingival levels of nitrate-reducing bacteria increased after treatment and correlated negatively with periodontitis-associated bacteria(P < 0.01). No significant effect of periodontal treatment on the baseline saliva and plasma nitrate and nitrite levels was found, indicating that differences in the NRC may only be revealed after nitrate intake. Our results suggest that an impaired NRC in periodontitis could limit dietary nitrate-derived nitric oxide levels, and the effect on systemic health should be explored in future studies.

关键词： impaired intake nitrate

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Integrated proteomic profiling identifies amino acids selectively cytotoxic to pancreatic cancer cells

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The Innovation 2024年第3期5卷 138-145页

作者： Alfred Akinlalu Zachariah Flaten Komila Rasuleva Md Saimon mia Aaron Bauer Santhalingam Elamurugan Nega Ejjigu Sudipa Maity Amara Arshad Min Wu Wenjie Xia Jia Fan Ang Guo Sijo Mathew Dali Sun Department of Electrical and Computer Engineering University of Denver2155 E Wesley AvenueDenverCO 80210USA Biomedical Engineering Program North Dakota State University1401 Centennial BoulevardEngineering AdministrationRoom 203FargoND 58102USA Department of Pharmaceutical Sciences School of PharmacyNorth Dakota State University1001 S.1401 Albrecht Boulevard Sudro HallFargoND 58102USA Materials and Nanotechnology Program North Dakota State University1410 North 14th AvenueCIE 201FargoND 58102USA Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang 325000China Department of Aerospace Engineering Iowa State UniversityAmesIA 50011USA Center for Cellular and Molecular Diagnostics Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Department of Biochemistry and Molecular Biology Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Knoebel Institute for Healthy Aging University of Denver2155 E Wesley AvenueDenverCO 80210USA

Pancreatic adenocarcinoma(PDAC)is one of the most deadly cancers,characterized by extremely limited therapeutic options and a poor prognosis,as it is often diagnosed during late disease stages.Innovative and selective treatments are urgently needed,since current therapies have limited efficacy and significant side effects.Through proteomics analysis of extracellular vesicles,we discovered an imbalanced distribution of amino acids secreted by PDAC tumor cells.Our findings revealed that PDAC cells preferentially excrete proteins with certain preferential amino acids,including isoleucine and histidine,via extracellular vesicles.These amino acids are associated with disease progression and can be targeted to elicit selective toxicity to PDAC tumor cells.Both in vitro and in vivo experiments demonstrated that supplementation with these specific amino acids effectively eradicated PDAC cells.Mechanistically,we also identified XRN1 as a potential target for these amino acids.The high selectivity of this treatment method allows for specific targeting of tumor metabolism with very low toxicity to normal tissues.Furthermore,we found this treatment approach is easy-to-administer and with sustained tumor-killing effects.Together,our findings reveal that exocytosed amino acids may serve as therapeutic targets for designing treatments of intractable PDAC and potentially offer alternative treatments for other types of cancers.

关键词： finding identif selectivity

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The Influence of Rice Husk Ash on Mechanical Properties of the Mortar and Concrete: A Critical Review

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Open Journal of Civil Engineering 2024年第1期14卷 65-81页

作者： Md Jahangir Alam Mithun Biswas Mohammad Biplab mia Shahin Alam Md Mosabber Hossain College of Civil and Transportation Engineering Hohai University Nanjing China School of Civil Engineering Chang’an University Xi’an China

Increasing the population and infrastructure in both emerging and developed countries requires a considerable amount of cement, which significantly affects the environment. The primary materials of concrete (‘cement’) production emit a large quantity of CO2 into the environment. Also, the cost of conventional building materials like cement gives motivation to find geopolymer waste materials for concrete. To reduce harmful effects on the environment and cost of traditional concrete substance, alternative waste materials like rice husk ash (RHA), ground granulated blast-furnace (GGBS), fly ash (FA), and metakaolin (MK) can be used due to their pozzolanic behavior. RHA waste material with a high silica concentration obtained from burning rice husks can possibly be used as a supplementary cementitious material (SCM) in the manufacturing of concrete, and its strong pozzolanic properties can contribute to the strength and impermeability of concrete. This review paper highlights a summary of the positive effect of using RHA as a partial substitute for cement in building construction, as well as its optimal inclusion of enhanced mechanical properties like compressive strength, flexural strength, and split tensile strength of mortar and concrete.

关键词： Cement Rice Husk Ash RHA Properties Mechanical Properties Carbon Di-oxide Emission and Greenhouse Gas

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Designing an Effective Method for Automatic Electric Vehicle Charging Stations in a Static Environment

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Journal of Power and Energy Engineering 2024年第1期12卷 15-28页

作者： Md. Robiul Islam Maisha Islam Tania Sarkar Hanif mia Md. Asadullah Department of Electrical Engineering Hohai University Nanjing China Institute of Science Trade & Technology (ISTT) Dhaka Bangladesh

This article outlines an Effective Method for Automatic Electric Vehicle Charging Stations in a Static Environment. It consists of investigated wireless transformer structures with various ferrite forms. WPT technology has rapidly advanced in the last few years. At kilowatt power levels, the transmission distance grows from a few millimeters to several hundred millimeters with a grid to load efficiency greater than 90%. The improvements have made the WPT more appealing for electric vehicle (EV) charging applications in both static and dynamic charging scenarios. Static and dynamic WEVCS, two of the main applications, are described, and current developments with features from research facilities, academic institutions, and businesses are noted. Additionally, forthcoming concepts based WEVCS are analyzed and examined, including “dynamic” wireless charging systems (WCS). A dynamic wireless power transfer (DWPT) system, which can supply electricity to moving EVs, is one of the feasible alternatives. The moving secondary coil is part of the dynamic WPT system, which also comprises of many fixed groundside (primary) coils. An equivalent circuit between the stationary system and the dynamic WPT system that results from the stationary system is demonstrated by theoretical investigations. The dynamic WPT system’s solenoid coils outperform circular coils in terms of flux distribution and misalignment. The WPT-related EV wireless charging technologies were examined in this study. WPT can assist EVs in overcoming their restrictions on cost, range, and charging time.

关键词： Dynamic Wireless Power Transfer (DWPT) Wireless Charging System (WCS) Electric Vehicle (EV) Dynamic Performance

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东京也将建成纽约式的高线公园

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商业周刊（中文版） 2024年第9期 34-36页

作者： mia Glass 孟洁冰(译) 不详

东京即将建造类似于纽约高线公园的高架步行道,标志着这座城市对汽车至上地位的重视发生了初步转变。日本首都东京中心地带的一条主要高速道路计划把部分路段迁移至地下,这个项目将削弱东京高速道路(又称KK线)的重要地位。在讨论是否拆... 详细信息

东京即将建造类似于纽约高线公园的高架步行道,标志着这座城市对汽车至上地位的重视发生了初步转变。日本首都东京中心地带的一条主要高速道路计划把部分路段迁移至地下,这个项目将削弱东京高速道路(又称KK线)的重要地位。在讨论是否拆除KK线的事宜后,东京于2021年决定将这条长2公里的道路改造为空中步行道。该项目将于2029年部分开放,计划于2030年代或2040年代全部完工。

关键词：高速道路高线公园道路改造东京纽约步行

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餐桌上的冬天每一口都是温暖的味道

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芭莎珠宝 2022年第6期 208-211页

作者： mia 不详

想不想在跨年时刻欣赏绵延相连的黄浦江与外滩万国风情美如画卷般的精彩交汇?这种城中别具一格的云上至潮体验值得你来解锁!

关键词：美如画解锁云上

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走!一起去寻春

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芭莎珠宝 2023年第2期 172-175页

作者： mia 不详

“一年四季春为首,莫负春日好时光。”春意益然的景象正向你款款而来。本期《芭莎珠宝》特地为你精选了四家值得打卡的珍藏级酒店,在这个万物伊始的好时节,捕捉到那份灵动的春之景,浅尝一口春之味,让你的美好生活自此新生!北京宝格丽酒... 详细信息

“一年四季春为首,莫负春日好时光。”春意益然的景象正向你款款而来。本期《芭莎珠宝》特地为你精选了四家值得打卡的珍藏级酒店,在这个万物伊始的好时节,捕捉到那份灵动的春之景,浅尝一口春之味,让你的美好生活自此新生!北京宝格丽酒店,第一口春天,在这份意式菜单里!

关键词：酒店美好生活春意四家

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Neuro faces of beneficial T cells:essential in brain,impaired in aging and neurological diseases,and activated functionally by neurotransmitters and neuropeptides

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Neural Regeneration Research 2023年第6期18卷 1165-1178页

作者： mia Levite Faculty of Medicine The Hebrew University of JerusalemCampus Ein KaremJerusalemIsrael Institute of Gene Therapy The Hadassah University Hospital-Ein KaremJerusalemIsrael

T cells are essential for a healthy life,performing continuously:immune surveillance,recognition,protection,activation,suppression,assistance,eradication,secretion,adhesion,migration,homing,communications,and additional tasks.This paper describes five aspects of normal beneficial T cells in the healthy or diseased brain.First,normal beneficial T cells are essential for normal healthy brain functions:cognition,spatial learning,memory,adult neurogenesis,and neuroprotection.T cells decrease secondary neuronal degeneration,increase neuronal survival after central nervous system(CNS) injury,and limit CNS inflammation and damage upon injury and infection.Second,while pathogenic T cells contribute to CNS disorders,recent studies,mostly in animal models,show that specific subpopulations of normal beneficial T cells have protective and regenerative effects in seve ral neuroinflammatory and neurodegenerative diseases.These include M ultiple Sclerosis(MS),Alzheimer’s disease,Parkinson’s disease,Amyotrophic Lateral Sclerosis(ALS),stro ke,CNS trauma,chronic pain,and others.Both T cell-secreted molecules and direct cell-cell contacts deliver T cell neuroprotective,neuro regenerative and immunomodulato ry effects.Third,normal beneficial T cells are abnormal,impaired,and dysfunctional in aging and multiple neurological diseases.Different T cell impairments are evident in aging,brain tumors(mainly Glioblastoma),seve re viral infections(including COVID-19),chro nic stress,major depression,schizophrenia,Parkinson’s disease,Alzheimer’s disease,ALS,MS,stro ke,and other neuro-pathologies.The main detrimental mechanisms that impair T cell function are activation-induced cell death,exhaustion,senescence,and impaired T cell stemness.Fo urth,several physiological neurotransmitters and neuro peptides induce by themselves multiple direct,potent,beneficial,and therapeutically-relevant effects on normal human T cells,via their receptors in T cells.This scientific field is called "Nerve-Driven Immunity".The main neurotransmitters and neuropept

关键词： aging dopamine glutamate nerve-driven immunity neurological diseases neuropeptides neurotransmitters Personalized Adoptive Neuro-Immunotherapy T cells

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文学即人学文学即梦呓阿雷奥拉：“人化”的动物和“动物化”的人们

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世界博览 2023年第20期 61-63+60页

作者：刘晗 mia

他是《百年孤独》的作者马尔克斯最爱的作家，这位出身卑微的“草根”在公共场所屡出精彩言论，成为墨西哥文化的代言人……从进化史的角度看，没有动物就不可能有人类，它们诸多的生存本领都为人类社会的行为提供了可循之据：壁虎用分...

他是《百年孤独》的作者马尔克斯最爱的作家，这位出身卑微的“草根”在公共场所屡出精彩言论，成为墨西哥文化的代言人……从进化史的角度看，没有动物就不可能有人类，它们诸多的生存本领都为人类社会的行为提供了可循之据：壁虎用分身法迷惑对方，狐狸的装死术可谓高超，章鱼忽明忽暗的变色本事赶超变色龙，叶海马、竹节蝗和枯叶蝶的模仿技艺可谓出神入化，它们与周遭植物化为一体，扑朔迷离。适者生存的丛林法则照见出生存之艰的同时，也暴露出人性的本质。

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