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Application of texture signatures based on multiparameter-magnetic resonance imaging for predicting microvascular invasion in hepatocellular carcinoma:Retrospective study

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1309-1318页

作者： Hai-Yang Nong Yong-Yi Cen mi Qin Wen-Qi Qin You-Xiang Xie Lin Li Man-Rong Liu ke Ding Department of Radiology The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Radiology The Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Radiology The First Affiliated Hospital of Guangxi University of Traditional Chinese MedicineNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Hepatobiliary Surgery The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Ultrasound The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina

BACkGROUND Despite continuous changes in treatment methods,the survival rate for advanced hepatocellular carcinoma(HCC)patients remains low,highlighting the importance of diagnostic methods for *** To explore the efficacy of texture analysis based on multi-parametric magnetic resonance(MR)imaging(MRI)in predicting microvascular invasion(MVI)in preoperative *** This study included 105 patients with pathologically confirmed HCC,categorized into MVI-positive and MVI-negative *** employed Original Data Analysis,Principal Component Analysis,Linear Discriminant Analysis(LDA),and Non-LDA(NDA)for texture analysis using multi-parametric MR images to predict preoperative *** effectiveness of texture analysis was determined using the B11 program of the MaZda4.6 software,with results expressed as the misjudgment rate(MCR).RESULTS Texture analysis using multi-parametric MRI,particularly the mi+pa+F dimensionality reduction method combined with NDA discrimination,demonstrated the most effective prediction of MVI in *** accuracy in the pulse and equilibrium phases was 83.81%.MCRs for the combination of T2-weighted imaging(T2WI),arterial phase,portal venous phase,and equilibrium phase were 22.86%,16.19%,20.95%,and 20.95%,*** area under the curve for predicting MVI positivity was 0.844,with a sensitivity of 77.19%and specificity of 91.67%.CONCLUSION Texture analysis of arterial phase images demonstrated superior predictive efficacy for MVI in HCC compared to T2WI,portal venous,and equilibrium *** study provides an objective,non-invasive method for preoperative prediction of MVI,offering a theoretical foundation for the selection of clinical therapy.

关键词： Magnetic resonance imaging Hepatocellular carcinoma Texture analysis microvascular invasion

Biological characteristics and clinical management of uveal and conjunctival melanoma

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Oncology Research 2024年第8期32卷 1265-1285页

作者： SNJEŽANA kAŠTELAN ANA DIDOVIĆpaVIČIĆ DARIA paŠALIĆ TAMARA NIkUŠEVA-MARTIĆ SAmiRČANOVIĆ PETRA kOVAČEVIĆ SUZANA kONJEVODA School of Medicine University of ZagrebZagreb10000Croatia Department of Ophthalmology Clinical Hospital DubravaZagreb10000Croatia Department of Ophthalmology Zadar General HospitalZadar23000Croatia Department of Medical Chemistry Biochemistry and Clinical ChemistrySchool of MedicineUniversity of ZagrebZagreb10000Croatia Department of Biology and Genetics School of MedicineUniversity of ZagrebZagreb10000Croatia School of Medicine University of SplitSplit21000Croatia Department of Health Studies University of ZadarZadar23000Croatia

Uveal and conjunctival melanomas are relatively rare tumors;nonetheless,they pose a signiﬁcant risk of mortality for a large number of affected *** pathogenesis of melanoma at different sites is very similar,however,the prognosis for patients with ocular melanoma remains unfavourable,primarily due to its distinctive genetic proﬁle and tumor *** of considerable advances in understanding the genetic characteristics and biological behaviour,the treatment of uveal and conjunctival melanoma remains a formidable *** enhance the prospect of success,collaborative efforts involving medical professionals and researchers in theﬁelds of ocular biology and oncology are *** data show a lack of well-designed randomized clinical trials and limited beneﬁts in current forms of treatment for these *** advancements in the development of effective melanoma therapeutic strategies,all current treatments for uveal melanoma(UM)and conjunctival melanoma(CoM)remain unsatisfactory,resulting in a poor long-term *** trials offer hope for positive outcomes in advanced and metastatic tumors.A more comprehensive understanding of the genetic and molecular abnormalities involved in the development and progression of ocular melanomas opens the way for the development of personalized therapy,with various potential therapeutic targets currently under *** comprehension of the molecular pathogenesis of UM and CoM and their speciﬁcities may aid in the development of new and more effective systemic therapeutic agents,with the hope of improving the prognosis for patients with metastatic disease.

关键词： Uveal melanoma Conjunctival melanoma Genetic characteristics Immune checkpoint inhibitors Target molecular inhibitors

A new route to weak force sensing beyond SQL:Squeezed magnons in cavity magnomechanics

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 166-167页

作者： S.k.Özdemir Department of Engineering Science and Mechanics and Materials Research Institute(MRI)The Pennsylvania State UniversityUniversity ParkPA 16802USA

Quantum mechanics imposes limits on measurement accuracy through quantum noise which typically has two components:First is the shot noise originating from vacuum fluctuations and referred to as the imprecision *** is ... 详细信息

关键词： quantum typically vacuum

SARS-CoV-2 breakthrough infections following inactivated vaccine vaccination induce few neutralizing antibodies against the currently emerging Omicron XBB variants

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Virologica Sinica 2024年第1期39卷 173-176页

作者： Fan Shen Chun Liang Cui-Xian Yang Ying Lu An-Qi Li Ying Duan mi Zhang c Ren-Rong Tian a Xing-Qi Dong Yong-Tang Zheng Wei pang key Laboratory of Bioactive Peptides of Yunnan Province/key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunming650223China University of Chinese Academy of Sciences Beijing100049China Yunnan Provincial Infectious Disease Hospital Kunming650399China Department of pathogen Biology and Immunology Faculty of Basic Medical ScienceKunming Medical UniversityKunming650500China

Dear Editor,COVID-19 inactivated vaccines have been extensively administered ***,the majority of the Chinese population has experiencedbreakthrough infections from SARS-CoV-2 ancestral,Delta or Omicronvariants over the past three years,particularly during the wave of Omicron BA.5 and BA.7 variants at the end of 2022(Zhu et al.,2023).Subsequently,new Omicron variants,such as BQ.1,BQ.1.1,XBB,XBB.1/XBB.1.9,and XBB.1.5/XBB.1.9.1,are emerging in China(Yueetal.,2023;Zhu et al.,2023).Therefore,it is an urgentneed and a publichealth imperative to assess the extent of the immunoprotection established in this population.

关键词： breakthrough neutral Omi

Exploring the synergy of the eyebrain connection:neuromodulation approaches for neurodegenerative disorders through transcorneal electrical stimulation

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Neural Regeneration Research 2024年第10期19卷 2097-2098页

作者： Antara Verma Stephen k.Agadagba Leanne Lai-Hang Chan Department of Electrical Engineering City University of Hong KongKowloonHong Kong Special Administrative RegionChina Centre for Eye and Vision Research Ltd. Hong Kong Special Administrative RegionChina Pennsylvania State University University ParkPAUSA

The connection and interaction between the eye and the brain are crucial to understanding brain disorders(Marchesi et al.,2021).Both the eye and the brain have a limited regenerative capacity as there are few progenitor cells,and nerve cells do not ***,neurodegeneration implicates irreversible damage to the central nervous system,as observed in several neurodegenerative diseases(Marchesi et al.,2021).

关键词： stimulation degenerative

四元Gd_(55-x)Zr_(x)Al_(23)Ni_(22)非晶合金的凝固形成机理和微观力学性能研究

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中国科学：技术科学 2024年第7期54卷 1357-1367页

作者：武博文胡亮糜晓磊魏炳波西北工业大学物理科学与技术学院西安710072

本文研究了不同成分Gd_(55-x)Zr_(x)Al_(23)Ni_(22)(x=0,15,25,35,45,55)非晶合金的凝固形成机理和微观力学性能变化规律.实验发现,由于Zr-Gd体系中存在不互溶间隙,液态四元Gd-Zr-Al-Ni合金在深过冷条件下发生亚稳相分离.只有当Zr与Gd... 详细信息

本文研究了不同成分Gd_(55-x)Zr_(x)Al_(23)Ni_(22)(x=0,15,25,35,45,55)非晶合金的凝固形成机理和微观力学性能变化规律.实验发现,由于Zr-Gd体系中存在不互溶间隙,液态四元Gd-Zr-Al-Ni合金在深过冷条件下发生亚稳相分离.只有当Zr与Gd不共存时,液态三元Gd_(55)Al_(23)Ni_(22)和Zr_(55)Al_(23)Ni_(22)合金可以快速凝固形成单相非晶.在530 k的过冷度下,液态Zr_(45)Gd_(10)Al_(23)Ni_(22)合金发生形核长大型亚稳相分离,并凝固为球状结构双相非晶.液态Gd_(55-x)Zr_(x)Al_(23)Ni_(22)(x=15,25,35)合金分别在189,336和438 k过冷度时发生调幅分解型亚稳相分离,均形成网状结构双相非晶.随着非晶AM-Zr相体积分数增加,非晶合金的平均硬度从3.95 Gpa提高到7.95 Gpa,弹性模量由58.27 Gpa增大到101.37 ***元素含量的升高使非晶合金的抗磨系数由5.2×10^(10)pa增加到3.81×10^(11)pa,表观摩擦系数从0.11减小到0.05.

关键词：快速凝固亚稳相分离双相非晶微观力学性能

高校竞技健美操运动员落地偏侧性和稳定性的生物力学研究

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中国运动医学杂志 2024年第4期43卷 266-274页

作者：王莉莉 Wan Ahmad Munsif Bin Wan pa 王宇轩李风雷颉梦宁许春莲马来西亚国立大学教育学院吉隆坡43600 东华理工大学体育学院南昌330032 南昌交通学院体育学院南昌330100

目的:分析竞技健美操运动员落地动作的生物力学特征,比较优势侧和非优势侧生物力学指标的偏侧性,探究影响落地稳定性的关键偏侧性因素。方法:以26名高校女性健美操运动员为研究对象,同步采集40 cm高台垂直双脚落地动作中的下肢运动学和... 详细信息

目的:分析竞技健美操运动员落地动作的生物力学特征,比较优势侧和非优势侧生物力学指标的偏侧性,探究影响落地稳定性的关键偏侧性因素。方法:以26名高校女性健美操运动员为研究对象,同步采集40 cm高台垂直双脚落地动作中的下肢运动学和动力学数据,比较优势侧和非优势侧的触地时刻关节角度、关节活动度(ROM)、地面反作用力(GRF)、负载率、压力中心(COP)位移和包络面积的差异,计算对称指数(代表偏侧性),并采用多元逐步回归方法分析指标偏侧性和COP包络面积的关系。结果:与非优势侧相比,优势侧在触地时刻具有更大的膝外旋和髋外展角(P<0.05),在落地过程中具有较大的踝屈伸、髋屈伸、髋内收-外展及较小的踝旋转ROM(P<0.05);优势侧的伸膝力矩峰值大于非优势侧(P<0.01);垂直方向负载率和伸膝力矩峰值的对称指数与COP包络面积呈显著正相关(P<0.05);垂直方向负载率、伸膝力矩峰值和膝关节旋转角度的对称指数可以解释COP包络面积差异的83.6%。结论:竞技健美操运动员落地动作存在肢体间的偏侧性,垂直方向负载率和伸膝力矩峰值的偏侧性越大,则落地稳定性越差。此外,垂直方向负载率、伸膝力矩峰值和膝关节旋转角度的对称指数可以作为落地稳定性的预测因子。

关键词：健美操落地生物力学偏侧性稳定性

A review of public health guidelines for postpartum physical activity and sedentary behavior from around the world

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Journal of Sport and Health Science 2024年第4期13卷 472-483,F0003页

作者： kelly R.Evenson Wendy J.Brown Alison k.Brinson Emily Budzynski-Seymour Melanie Hayman Department of Epidemiology Gillings School of Global Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599-8050USA Faculty of Health Sciences and Medicine Bond UniversityGold CoastQLD 4226Australia School of Human Movement and Nutrition Sciences The University of QueenslandBrisbaneQLD 4072Australia Department of Anthropology University of North Carolina at Chapel HillChapel HillNC 27599-3115USA Carolina Population Center University of North Carolina at Chapel HillChapel HillNC 27599-8120USA Faculty of Sport Health and Social SciencesSolent UniversitySouthamptonSO140YNUK Appleton Institute School of HealthMedical and Applied SciencesCentral Queensland UniversityRockhamptonQLD 4701Australia

Background:The period following pregnancy is a critical time window when future habits with respect to physical activity(pa) and sedentary behavior(SB) are established;therefore,it warrants *** purpose of this scoping review was to summarize public health-oriented country-specific postpartum pa and SB guidelines ***:To identity guidelines published since 2010,we performed a(a) systematic search of 4 databases(CINAHL,Global Health,PubMed,and SPORTDiscus),(b) structured repeatable web-based search separately for 194 countries,and(c) separate web-based *** the most recent guideline was included for each ***:We identified 22 countries with public health-oriented postpartum guidelines for pa and 11 countries with SB *** continents with guidelines included Europe(n=12),Asia(n=5),Oceania(n=2),Africa(n=1),North America(n=1),and South America(n=1).The most common benefits recorded for pa included weight control/management(n=10),reducing the risk of postpartum depression or depressive symptoms(n=9),and improving mood/well-being(n=8).Postpartum guidelines specified exercises to engage in,including pelvic floor exercises(n=17);muscle strengthening,weight training,or resistance exercises(n=13);aerobics/general aerobic activity(n=13);walking(n=11);cycling(n=9);and swimming(n=9).Eleven guidelines remarked on the interaction between pa and breastfeeding;several guidelines stated that pa did not impact breast milk quantity(n=7),breast milk quality(n=6),or infant growth(n=3).For SB,suggestions included limiting long-term sitting and interrupting sitting with ***:Country-specific postpartum guidelines for pa and SB can help promote healthy behaviors using a culturally appropriate context while providing specific guidance to public health practitioners.

关键词： Breastfeeding Caesarean section Guidelines Postnatal Recommendations

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翻译在藏传佛教中国化进程中的重要作用

攀登（藏文版） 2024年第2期 148-155页

作者：交巴草中国民族语文翻译中心(局)

佛教通过翻译在传入吐蕃过程中,汲取了苯教的部分教义,形成了具有藏族文化特色的藏传佛教。藏传佛教在迅速发展过程中推崇佛经翻译事业起到了重要的推动作用。新时代时期,积极推进藏传佛教中国化是藏传佛教健康传承的必经之路。在坚持... 详细信息

佛教通过翻译在传入吐蕃过程中,汲取了苯教的部分教义,形成了具有藏族文化特色的藏传佛教。藏传佛教在迅速发展过程中推崇佛经翻译事业起到了重要的推动作用。新时代时期,积极推进藏传佛教中国化是藏传佛教健康传承的必经之路。在坚持藏传佛教中国化方向进程中,加强汉藏翻译,一方面使藏传佛教教义教规的翻译呈现社会主义发展内涵,适应社会主义社会的时代要求。另一方面引进宗教中国化的理论,以社会主义核心价值观为引领,使藏传佛教浸润中国特色,弘扬先进思想。

关键词：翻译藏传佛教新时代中国化