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Neuralgic amyotrophy with hourglass-like constrictions:A case report

World Journal of Clinical Cases 2024年第34期12卷 6728-6735页

作者： mi-hyeon bang Ha-Lim Song Seok Hahn Wanil Kim Hwan-Kwon Do Department of Physical Medicine and Rehabilitation Haeundae Paik HospitalInje University College of MedicineBusan 48108South Korea Department of Radiology Haeundae Paik HospitalInje University College of MedicineBusan 48108South Korea Division of Biochemistry Department of Convergence Medical ScienceInstitute of Medical ScienceGyeongsang National University College of MedicineJinju 52727South Korea Department of Physical Medicine and Rehabilitation Dongnam Institute of Radiological and Medical SciencesBusan 46033South Korea

BACKGROUND Neuralgic amyotrophy(NA)is a rare disease with sudden upper limb pain followed by affected muscle *** most commonly affected area in NA is the upper part of the brachial plexus,and the paraspinal muscles are rarely affected(1.5%),making these cases difficult to distinguish from cervical *** SUMMARY A 76-year-old male presented to the emergency department with left hip pain *** undergoing left femoral neck fracture surgery,he experienced sudden left shoulder pain for 10 days with subsequent left arm *** spine computed tomography revealed mild right asymmetric intervertebral disc bulging with a decreased C5-6disc *** weeks later,an electrodiagnostic study confirmed brachial plexopathy findings involving the cervical *** resonance neurography was performed for a differential *** enhancement was identified at the upper trunk of the brachial plexus,including the C5 nerve root.A suprascapular nerve hourglass-like focal constriction(HLFC)was also identified,confirming *** being diagnosed with NA,the patient received 15 mg prednisolone,twice daily,for 3 *** therapy was initiated,including left arm strengthening exercises and electrical stimulation *** shoulder muscle strength significantly improved one CONCLUSION NA's unique features like HLFC and paraspinal involvement are crucial for accurate diagnosis,avoiding confusion with cervical radiculopathy.

关键词： Neuralgic amyotrophy Cervical radiculopathy Hourglass-like focal constriction Paraspinal muscle Magnetic resonance neurography Case report

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Low-molecular-weight fucoidan inhibits the proliferation of melanoma via Bcl-2 phosphorylation and PTEN/AKT pathway

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Oncology Research 2024年第2期32卷 273-282页

作者： miNJI PARK CHULHWAN bang WON-SOO YUN YUN-mi JEONG T&R Biofab Co. Ltd.Seongnam-si13487Korea Department of Dermatology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul02706Korea Department of Mechanical Engineering Tech University of KoreaSi-heung City15073Korea

Fucoidan,a sulfate polysaccharide obtained from brown seaweed,has various bioactive properties,including anti-inflammatory,anti-cancer,anti-viral,anti-oxidant,anti-coagulant,anti-thrombotic,anti-angiogenic,and anti-Helicobacter pylori ***,the effects of low-molecular-weight fucoidan(LMW-F)on melanoma cell lines and three dimensional(3D)cell culture models are not well *** study aimed to investigate the effects of LMW-F on A375 human melanoma cells and cryopreserved biospecimens derived from patients with advanced *** wave was used to fragment fucoidan derived from Fucus vesiculosus into smaller *** and live/dead assays showed that LMW-F inhibited cell proliferation in both A375 cells and patientderived melanoma explants in a 3D-printed collagen *** PTEN/AKT pathway was found to be involved in the anti-melanoma effects of *** blot analysis revealed that LMW-F reduced the phosphorylation of Bcl-2 at Thr 56,which was associated with the prevention of anti-apoptotic activity of cancer *** findings suggested that LMW-F could enhance anti-melanoma chemotherapy and improve the outcomes of patients with melanoma resistance.

关键词： Low-molecular-weight fucoidan Melanoma Patient-derived melanoma explants in a 3D-printed collagen scaffold Anti-melanoma effect PTEN-AKT-Bcl-2 network

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Noncommutative analysis of Hermite expansions

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Science China Mathematics 2024年第10期67卷 2331-2356页

作者： bang Xu Department of Mathematics University of HoustonHoustonTX 77204USA Department of Mathematical Sciences Seoul National UniversitySeoul 08826Republic of Korea

This paper is devoted to the study of semi-commutative harmonic analysis associated with Hermite semigroups. In the first part, we establish the noncommutative maximal inequalities for Bochner-Riesz means associated with Hermite operators and then obtain the corresponding pointwise convergence theorems. In particular, we develop a noncommutative version of Stein's theorem of Bochner-Riesz means for Hermite operators. In the second part, we investigate two noncommutative multiplier theorems. Our approach in this part relies on a noncommutative analog of the classical Littlewood-Paley-Stein theory associated with Hermite semigroups.

关键词： noncommutative L_(p)-spaces Hermite semigroup maximal inequalities pointwise convergence multipliers

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A new centrality measure based on neighbor loop structure for network dismantling

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Digital Communications and Networks 2024年第2期10卷 472-480页

作者： Qingxia Liu bang Wang Jiming Qi Xianjun Deng School of Electronic Information and Communications Huazhong University of Science and TechnologyWuhan430074China School of Cyber Science and Engineering Huazhong University of Science and TechnologyWuhan430074China

Nearly all real-world networks are complex networks and usually are in danger of ***,it is crucial to exploit and understand the mechanisms of network attacks and provide better protection for network *** dismantling aims to find the smallest set of nodes such that after their removal the network is broken into connected components of sub-extensive *** overcome the limitations and drawbacks of existing network dismantling methods,this paper focuses on network dismantling problem and proposes a neighbor-loop structure based centrality metric,NL,which achieves a balance between computational efficiency and evaluation *** addition,we design a novel method combining NL-based nodes-removing,greedy tree-breaking and ***,we compare five baseline methods with our algorithm on ten widely used real-world networks and three types of model networks including Erd€os-Renyi random networks,Watts-Strogatz smallworld networks and Barabasi-Albert scale-free networks with different network generation *** results demonstrate that our proposed method outperforms most peer methods by obtaining a minimal set of targeted attack ***,the insights gained from this study may be of assistance to future practical research into real-world networks.

关键词： Complex networks Network dismantling Centrality measure

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Real-Time Object Detection and Face Recognition Application for the Visually Impaired

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Computers, Materials & Continua 2024年第6期79卷 3569-3583页

作者： Karshiev Sanjar Soyoun bang SookheeRyue Heechul Jung Department of Artificial Intelligence Kyungpook National UniversityDaegu41466Republic of Korea Haga Co. Ltd.Daegu38428Republic of Korea

The advancement of navigation systems for the visually impaired has significantly enhanced their mobility by mitigating the risk of encountering obstacles and guiding them along safe,navigable *** approaches primarily focus on broad applications such as wayfinding,obstacle detection,and fall ***,there is a notable discrepancy in applying these technologies to more specific scenarios,like identifying distinct food crop types or recognizing *** study proposes a real-time application designed for visually impaired individuals,aiming to bridge this research-application *** introduces a system capable of detecting 20 different food crop types and recognizing faces with impressive accuracies of 83.27%and 95.64%,*** results represent a significant contribution to the field of assistive technologies,providing visually impaired users with detailed and relevant information about their surroundings,thereby enhancing their mobility and ensuring their ***,it addresses the vital aspects of social engagements,acknowledging the challenges faced by visually impaired individuals in recognizing acquaintances without auditory or tactile signals,and highlights recent developments in prototype systems aimed at assisting with face recognition *** comprehensive approach not only promises enhanced navigational aids but also aims to enrich the social well-being and safety of visually impaired communities.

关键词： Artificial intelligence deep learning real-time object detection application

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Evaluating the role of large language models in inflammatory bowel disease patient information

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World Journal of Gastroenterology 2024年第29期30卷 3538-3540页

作者： Eun Jeong Gong Chang Seok bang Department of Internal Medicine Hallym University College of MedicineChuncheon 24253Gangwon-doSouth Korea

This letter evaluates the article by Gravina et al on ChatGPT’s potential in providing medical information for inflammatory bowel disease *** promising,it highlights the need for advanced techniques like reasoning+action and retrieval-augmented generation to improve accuracy and *** that simple question and answer testing is insufficient,it calls for more nuanced evaluation methods to truly gauge large language models’capabilities in clinical applications.

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel disease Chat generative pre-trained transformer Large language model Artificial intelligence

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Application of extreme gradient boosting in predicting the viscoelastic characteristics of graphene oxide modified asphalt at medium and high temperatures

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Frontiers of Structural and Civil Engineering 2024年第6期18卷 899-917页

作者： Huong-Giang Thi HOANG Hai-Van Thi MAI Hoang Long NGUYEN Hai-bang LY University of Transport Technology Hanoi 100000Vietnam

Complex modulus(G^(*))is one of the important criteria for asphalt classification according to AASHTO M320-10,and is often used to predict the linear viscoelastic behavior of asphalt *** addition,phase angle(φ)characterizes the deformation resilience of asphalt and is used to assess the ratio between the viscous and elastic *** is thus important to quickly and accurately estimate these two *** purpose of this investigation is to construct an extreme gradient boosting(XGB)model to predict G^(*)andφof graphene oxide(GO)modified asphaltat medium and high *** data sets are gathered from previously published experiments,consisting of 357 samples for G^(*)and 339 samples forφ,and the se are used to develop the XGB model using nine inputs representing theasphalt binder *** findings show that XGB is an excellent predictor of G^(*)andφof GO-modified asphalt,evaluated by the coefficient of determination R^(2)(R^(2)=0.990 and 0.9903 for G^(*)andφ,respectively)and root mean square error(RMSE=31.499 and 1.08 for G^(*)andφ,respectively).In addition,the model’s performance is compared with experimental results and five other machine learning(ML)models to highlight its *** the final step,the Shapley additive explanations(SHAP)value analysis is conducted to assess the impact of each input and the correlation between pairs of important features on asphalt’s two physical properties.

关键词： complex modulus phase angle graphene oxide asphalt extreme gradient boosting machine learning

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Prognostic analysis of related factors of adverse reactions to immunotherapy in advanced gastric cancer and establishment of a nomogram model

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1268-1280页

作者： Xu-Xu He bang Du Tao Wu Hao Shen Department of Surgery Fudan University Affiliated Zhongshan Hospital(Qingpu Branch)Shanghai 201700China Department of Surgery Anhui Provincial Red Cross Society HospitalHefei 230031Anhui ProvinceChina Department of General Surgery West China Hospital of Sichuan UniversityChengdu 610044Sichuan ProvinceChina

BACKGROUND Immunotherapy for advanced gastric cancer has attracted widespread attention in recent ***,the adverse reactions of immunotherapy and its relationship with patient prognosis still need further *** order to determine the association between adverse reaction factors and prognosis,the aim of this study was to conduct a systematic prognostic *** comprehensively evaluating the clinical data of patients with advanced gastric cancer treated by immunotherapy,a nomogram model will be established to predict the survival status of patients more *** To explore the characteristics and predictors of immune-related adverse reactions(irAEs)in advanced gastric cancer patients receiving immunotherapy with programmed death protein-1(PD-1)inhibitors and to analyze the correlation between irAEs and patient *** A total of 140 patients with advanced gastric cancer who were treated with PD-1 inhibitors in our hospital from June 2021 to October 2023 were *** were divided into the irAEs group and the non-irAEs group according to whether or not irAEs *** features,manifestations,and prognosis of irAEs in the two groups were collected and analyzed.A multivariate logistic regression model was used to analyze the related factors affecting the occurrence of irAEs,and the prediction model of irAEs was *** receiver operating characteristic(ROC)curve was used to evaluate the ability of different indicators to predict irAEs.A Kaplan-Meier survival curve was used to analyze the correlation between irAEs and *** Cox proportional risk model was used to analyze the related factors affecting the prognosis of *** A total of 132 patients were followed up,of whom 63(47.7%)developed *** looked at the two groups’clinical features and found that the two groups were statistically different in age≥65 years,Ki-67 index,white blood cell count,neutrophil count,and regulatory T cell(Treg)count

关键词： Advanced gastric cancer Prognostic analysis Immunotherapy Nomogram model

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Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3205-3217页

作者： Bing-Chen Zhang Chun-Mei Lai bang-Yue Luo Jing-Wei Shao Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of ChemistryFuzhou UniversityFuzhou 350116China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer Researchthe Tenth Affiliated Hospital of Southern Medical University(Dongguan People’s Hospital)Dongguan 523058China College of Materials and Chemical Engineering MinjiangUniversityFuzhou350108China

Combination immunotherapy has shown promising potential for enhancing the objective response rate compared to immune checkpoint blockade(ICB)***,combination therapy with multi-drugs is limited by the different properties of the agents and inconsistent synergistic targeted ***,based on a universal triterpene template and the anticancer active agent ursolic acid(UA),a cytomembrane-coated biomimetic delivery nanoplatform(UR@M)prepared by the selfassembly of a PD-L1 targeted CRISPR/Cas9 system and UA was designed for hepatocellular carcinoma(HCC)***@M showed enhanced tumor accumulation in vivo with homologous tumor targeting,and CRISPR in the nanosystem exhibited potent gene-editing efficiency of 76.53% in vitro and 62.42% in vivo with no off-target *** activated the natural immune system through the TLR-2-MyD88-TRAF6 pathway,which synergistically enhanced the proliferation of natural killer cells and dendritic cells and realized excellent immune cytotoxic T cell infiltration by combining with the ICB of *** strategy of work along both lines based on innate immune and adaptive immunity displayed a significant effect in tumor ***,the UA-templated strategy“killed three birds with one stone”by establishing a self-assembly nanosystem,inducing tumor cell death,and promoting synergistic immunostimulation for HCC treatment.

关键词： Ursolic acid Self-assembly Biomimetic nanoplatform Hepatocellular carcinoma CRISPR/Cas9 Immune checkpoint blockade Gene therapy Immunotherapy

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Quantum nonlocality evolution for two entangled mesoscopic fields under decoherence

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Communications in Theoretical Physics 2024年第1期76卷 24-28页

作者： Zhao-Song Tan Shou-bang Yang Zhen-Biao Yang Shi-Biao Zheng Fujian Key Laboratory of Quantum Information and Quantum Optics Fuzhou UniversityFuzhouFujian 350116China

Investigation of the nonlocality evolution of entangled mesoscopic fields under decoherence not only is important for understanding the quantum–classical transition,but also has relevance to quantum communication and quantum computation protocols based on continuous *** to previous formulations of Bell inequalities,the system loses nonlocal features far before the disappearance of *** here construct a new version of Bell signal based on rotated and displaced on–off correlations,with which the Bell inequality is violated as long as there remains entanglement and the field state components keep ***,the nonlocal character revealed by our formulation decays much slower compared with those based on previous *** importantly,there exists a wide regime where the Bell inequality is restored with previous formulations but remains to be violated based on our correlation operators.

关键词： entangled mesoscopic fields rotated and displaced on-off correlations Bell inequality nonlocality evolution

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