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Sinonasal teratocarcinosarcoma involving the nasal cavity,unilateral paranasal sinuses,and intracranial invasion:A case report

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World Journal of Clinical Cases 2024年第25期12卷 5784-5790页

作者： Li-Yuan Fu mi-Yang Yang Pei-Yun Ye Zhao-chu Wang chu-Jie Chen Hui Li Shang-Wen Xu Department of Radiology 900th Hospital of Joint Logistics Support ForceFuzhou 350025Fujian ProvinceChina The First Clinical Medical College Fuzong Teaching HospitalFujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina

BACKGROUND Sinonasal teratocarcinosarcoma(SNTCS)is a rare and highly invasive neoplasm originating from the nasal cavity and ***,it exhibits an invasive behavior towards adjacent structures;however,in exceptional instances,it may infiltrate the intracranial *** to the tumor's rarity and lack of distinctive features on computed tomography(CT)and magnetic resonance imaging(MRI)images,SNTCS is often *** SUMMARY In this study,we present a case of SNTCS in a 56-year-old patient who exhibited unexplained cognitive impairment before *** and MRI scans revealed the presence of a mass in the right nasal cavity,with lesions extending to the right ethmoid sinus and right frontal ***,the patient underwent pathological examination for confirmation and received surgical intervention to excise the *** future advancement in our understanding of this disease will significantly contribute to the precise diagnosis and treatment of *** SNTCS is an exceptionally rare malignant tumor that originates from the nasal cavity and paranasal sinuses,presenting a diagnostic challenge due to its nonspecific imaging *** accurately delineates the location,morphological characteristics,size,internal structure,extent of surrounding involvement,and metabolic information of the *** aspects play a pivotal role in the precise localization and qualitative assessment of ***,a definitive diagnosis still requires a pathological biopsy.

关键词： Paranasal sinus Malignant tumor Sinonasal teratocarcinosarcoma Brain invasion Case report

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脾肿大在门静脉高压症外科中的地位

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世界华人消化杂志 2024年第4期32卷 248-253页

作者：董伟褚海波同济大学附属东方医院胶州医院普通外科山东省青岛市266300

脾脏是机体重要的免疫器官,许多功能独一无二,同时兼有代谢和内分泌调节功能.当今,对门静脉高压症脾肿大,有害或者有益仍是个迷,外科的“切”与“保”一直是争论的焦点,并形成两派.鉴于脾肿大在门静脉高压症发展与治疗中所具有的特殊地... 详细信息

脾脏是机体重要的免疫器官,许多功能独一无二,同时兼有代谢和内分泌调节功能.当今,对门静脉高压症脾肿大,有害或者有益仍是个迷,外科的“切”与“保”一直是争论的焦点,并形成两派.鉴于脾肿大在门静脉高压症发展与治疗中所具有的特殊地位与作用,笔者结合自己长期的临床实践与基础研究,在这一领域不断传承与积累,改进与创新,对这一问题作一阐述,以此推动我国脾功能与脾外科的进一步发展.

关键词：脾肿大门静脉高压症外科

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Causal relationships between gut microbiota and dementia:A twosample,bidirectional,Mendelian randomization study

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World Journal of Clinical Cases 2024年第16期12卷 2780-2788页

作者： Zhao-Lin Ren hai-Hong Zhou chu-Pei Chen Hao He Duo-Lao Wang Zhou Liu Department of Neurology The Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina Department of Clinical Medicine Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina Department of Clinical Sciences Liverpool School of Tropical MedicineLiverpool L693BXUnited Kingdom

BACKGROUND Existing evidence suggests that gut microbiota represent a significant environmental risk factor for various forms of dementia,including Alzheimer's dementia,vascular dementia,and dementia in other diseases classified ***,the exact causal relationships between gut microbiota and the different forms of dementia or their subtypes remain *** To investigate putative causal relationships between gut microbiota and dementia or its subtypes using Mendelian randomization(MR)*** A bidirectional,two-sample,MR analysis was conducted utilizing publicly available gut microbiota-related genome-wide association study(GWAS)summary data from the miBioGen consortium alongside GWAS summary statistics for dementia and its subtypes from the FinnGen *** variables were selected according to the fundamental tenets of MR and their strengths were evaluated using the *** MR methods were employed,and the robustness of our findings was *** account for multiple comparisons,we applied the Bonferroni method for P-value *** We identified several gut microbiota taxa exhibiting putative causal relationships with dementia or its subtypes,potentially serving as risk or protective factors for the *** addition,reverse MR analysis indicated that the relative abundance of several gut microbiota taxa might be influenced by dementia or its *** exhaustive sensitivity analysis confirmed the absence of heterogeneity and horizontal *** applying correction for multiple testing,we observed that the order Bacillales(odds ratio:0.830,95%confidence interval:0.740-0.932,P=0.00155,Padjust=0.0311)exhibited a strong association with Alzheimer’s disease-related *** The results suggest that gut microbiota is causally associated with *** findings provide novel insights into the pathophysiology of dementia and have important implications for its treatment and prevention.

关键词： Mendelian randomization FinnGen miBioGen Gut microbiota Dementia Alzheimer’s disease Vascular dementia

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PIM1基因对急性髓系白血病U937细胞增殖、凋亡及JAK2/STAT3信号通路的影响

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中国实验血液学杂志 2024年第3期32卷 663-669页

作者：高鑫储李婧颜宗海安徽医学高等专科学校临床医学院安徽合肥230031 安徽医科大学附属巢湖医院血液科安徽合肥238000

目的:探讨PIM1基因对急性髓系白血病(AML)U937细胞增殖、凋亡的影响,以及对JAK2/STAT3通路的调控作用。方法:收集初诊成人AML患者和单纯缺铁性贫血患者的骨髓单个核细胞,荧光定量PCR检测PIM1 mRNA表达。将AML细胞系U937细胞分为:U937组(... 详细信息

目的:探讨PIM1基因对急性髓系白血病(AML)U937细胞增殖、凋亡的影响,以及对JAK2/STAT3通路的调控作用。方法:收集初诊成人AML患者和单纯缺铁性贫血患者的骨髓单个核细胞,荧光定量PCR检测PIM1 mRNA表达。将AML细胞系U937细胞分为:U937组(U937细胞正常培养)、Si-PIM1组(U937细胞转染含PIM1 mRNA的低表达腺病毒载体)、Si-NC组(U937细胞转染不含PIM1 mRNA的低表达腺病毒载体)、CoA1组(U937细胞中加入浓度为20μmol/L的JAK2激活剂CoA1)、Si-PIM1+CoA1组(U937细胞转染含PIM1 mRNA低表达的腺病毒载体并加入浓度为20μmol/L的CoA1)。培养24 h。荧光定量PCR和蛋白印迹法检测U937细胞PIM1 mRNA和蛋白、JAK2/STAT3通路、细胞周期、凋亡相关蛋白表达;噻唑蓝法检测细胞增殖活性;流式细胞术检测细胞周期变化及凋亡率。结果:AML患者骨髓单个核细胞中PIM1 mRNA表达水平高于单纯缺铁性贫血患者(P0.05)。结论:敲低PIM1基因表达可抑制U937细胞增殖、促进凋亡,缓解ALM进程,且上述作用可能与抑制JAK2/STAT3通路活化有关。

关键词：丝/苏氨酸激酶家族成员1 急性髓系白血病U937细胞增殖凋亡 Janus酪氨酸激酶2/信号转导及转录激活因子3通路

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Correlation function and the inverse problem in the BD interaction

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Chinese Physics C 2024年第5期48卷 117-123页

作者：李海鹏义景宇肖褚文姚德良梁伟红 Eulogio Oset Department of Physics Guangxi Normal UniversityGuilin 541004China School of Physics and Electronics Hunan UniversityChangsha 410082China Guangxi Key Laboratory of Nuclear Physics and Technology Guangxi Normal UniversityGuilin 541004China School of Physics Central South UniversityChangsha 410083China Departamento de Física Teórica and IFIC Centro Mixto Universidad de Valencia-CSIC Institutos de Investigación de PaternaAptdo.2208546071 ValenciaSpain

We study the correlation functions of the B0D+,B+D0 system,which develops a bound state of approximately 40MeV,using inputs consistent with the Tcc(3875)***,we address the inverse problem starting from these correlation functions to determine the scattering observables related to the system,including the existence of the bound state and its molecular *** important output of the approach is the uncertainty with which these observables can be obtained,considering errors in the B0D+,B+D0 correlation functions typical of current values in correlation *** find that it is possible to obtain scattering lengths and effective ranges with relatively high precision and the existence of a bound *** the pole position is obtained with errors of the order of 50%of the binding energy,the molecular probability of the state is obtained with a very small error of the order of 6%.All these findings serve as motivation to perform such measurements in future runs of high energy hadron collisions.

关键词： meson-meson interaction correlation function BD system scattering observables

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Heme oxygenase 1 linked to inactivation of subchondral osteoclasts in osteoarthritis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 513-528页

作者： miao chu Guangdong CHEN Kai CHEN Pengfei ZHU Zhen WANG Zhonglai QIAN Huaqiang TAO Yaozeng XU Dechun GENG Department of Orthopedics the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Orthopedics Yixing People’s HospitalYixing 214200China Department of Orthopedics Hai’an People’s HospitalHai’an 226600China Department of Orthopedics Suzhou Kowloon HospitalShanghai Jiao Tong University School of MedicineSuzhou 215028China

Osteoarthritis(OA)is a chronic progressive osteoarthropathy in the *** activation plays a crucial role in the occurrence of subchondral bone loss in early ***,the specific mechanism of osteoclast differentiation in OA remains *** our study,gene expression profiles related to OA disease progression and osteoclast activation were screened from the Gene Expression Omnibus(GEO)***2R and Funrich analysis tools were employed to find differentially expressed genes(DEGs).Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses demonstrated that chemical carcinogenesis,reactive oxygen species(ROS),and response to oxidative stress were mainly involved in osteoclast differentiation in OA subchondral ***,fourteen DEGs that are associated with oxidative stress were *** first ranked differential gene,heme oxygenase 1(HMOX1),was selected for further *** results showed that osteoclast activation in the pathogenesis of OA subchondral bone is accompanied by the downregulation of *** was revealed to inhibit osteoclastogenesis by targeting HMOX1 and upregulating the expression of antioxidant protein in ***,carnosol was found to alleviate the severity of OA by inhibiting the activation of subchondral osteoclasts in *** research indicated that the activation of osteoclasts due to subchondral bone redox dysplasia may serve as a significant pathway for the advancement of *** HMOX1 in subchondral osteoclasts may offer novel insights for the treatment of early OA.

关键词： Osteoclast Oxidative stress Osteoarthritis(OA) Heme oxygenase 1(HMOX1) Carnosol

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基于低秩重构表示的动态回归迁移模型

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控制与决策 2024年第8期39卷 2511-2520页

作者：霍海丹阎高伟程兰任密蜂肖舒怡太原理工大学电气与动力工程学院太原030024

针对实际流程工业过程存在动态时变和概念漂移特性,导致软测量模型预测精度下降的问题,提出基于低秩重构表示的动态迁移回归模型.为了更好地描述动态过程,在动态内模型偏最小二乘框架下,将高维过程数据映射到低维潜变量空间中,以捕获质... 详细信息

针对实际流程工业过程存在动态时变和概念漂移特性,导致软测量模型预测精度下降的问题,提出基于低秩重构表示的动态迁移回归模型.为了更好地描述动态过程,在动态内模型偏最小二乘框架下,将高维过程数据映射到低维潜变量空间中,以捕获质量变量与潜变量之间的动态相关性.为了减小概念漂移,在获得动态相关性的同时,通过增强不同工况质量变量估计值之间的相关性实现数据的条件分布对齐.在3个公开工业数据集上的实验结果表明:所提出模型的预测精度与静态基模型和动态基模型相比均有所提升,可以有效地提高模型的预测精度和泛化能力.

关键词：软测量动态时变概念漂移动态内模型偏最小二乘条件分布对齐低秩重构

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基于超图正则化的域适应偏最小二乘多工况软测量模型

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控制理论与应用 2024年第3期41卷 396-406页

作者：霍海丹阎高伟王芳任密蜂程兰李荣太原理工大学电气与动力工程学院山西太原030024

针对流程工业中,因多工况导致数据分布变化引起传统软测量模型预测性能恶化问题,本文提出一种基于超图正则化的域适应多工况软测量回归模型框架.首先,采用非线性迭代偏最小二乘回归算法为基模型,在潜变量空间利用历史工况数据重构当前... 详细信息

针对流程工业中,因多工况导致数据分布变化引起传统软测量模型预测性能恶化问题,本文提出一种基于超图正则化的域适应多工况软测量回归模型框架.首先,采用非线性迭代偏最小二乘回归算法为基模型,在潜变量空间利用历史工况数据重构当前工况数据,以增强工况间的相关性,有效减小数据分布差异;同时,对重构系数施加低秩稀疏约束,保留了数据的局部和全局子空间结构;其次,通过超图拉普拉斯正则项对域适应潜变量求解过程进行约束,避免在寻找潜变量过程中破坏数据结构.最后,利用交替方向乘子法优化求解模型参数.在多个数据集上的实验表明,本文方法在多工况环境下可有效提高软测量模型的预测精度和泛化性能.

关键词：多工况超图结构保持域适应软测量

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Chemokine-like factor 1 (CKLF1) is expressed in myocardial ischemia injury in vivo and in vitro

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BIOCELL 2024年第6期48卷 981-990页

作者： JULING FENG HAODONG CHEN YANGBO LIU QIDI AI YANTAO YANG LEI ZHAO SHIFENG chu NAIHONG CHEN School of Pharmacy Department of PharmacyHunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction PiecesHunan University of Chinese MedicineChangsha410208China Department of Pharmacology State Key Laboratory of Bioactive Substances and Functions of Natural MedicinesInstitute of Materia Medica&Neuroscience CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China Department of Diagnostics Research Lab of Translational Medicine Hengyang Medical CollegeUniversity of South ChinaHengyang421001China Department of Gastrointestinal Surgery The First Affiliated HospitalHengyang Medical CollegeUniversity of South ChinaHengyang421001China

Introduction:Chemokine-like factor 1(CKLF1)is a chemokine that is overexpressed in several *** previousﬁndings revealed a signiﬁcant increase in CKLF1 expression in the ischemic brain,suggesting its potential as a therapeutic target for ischemic ***:In this study,we examined the expression dynamics of CKLF1 in both in vivo and in vitro models of ischemic cardiac *** infarction(mi)was induced in vivo by ligation of the left anterior descending artery(LAD)of the rat *** levels of CKLF1,Creatine Kinase MB Isoenzyme(CK-MB),and Lactate dehydrogenase(LDH)in the serum were detected using Enzyme-linked immunosorbent assay(ELISA).The expression of CKLF1 in the infarcted area was detected by immunohistochemistry,immunoﬂuorescence,quantitative PCR(qPCR),and Western blotting(WB).H9C2 and AC16 cardiomyocytes cultured in vitro were subjected to oxygen and glucose deprivation(OGD).LDH was used to detect cell damage,and CKLF1 expression was detected by qPCR and ***:CKLF1 mRNA and protein expression were signiﬁcantly increased in h9c2 cells at 1.5 h and in AC16 cells at 4 h after *** serum CK-MB in rats increased signiﬁcantly on theﬁrst day after infarction,while the LDH concentration increased signiﬁcantly on the third day after ***1 blood levels signiﬁcantly increased on theﬁrst day following mi in ***1 expression notably increased in the infarct area on days 1,3,and 7 *** mi tissue,CKLF1 colocalizes with cardiomyocytes,macrophages,and ***:CKLF1 was substantially expressed during myocardial ischemia injury both in vivo and in vitro and was colocalized with macrophages and neutrophils,indicating that CKLF1 is expected to be a biomarker and a drug target for the treatment of myocardial infarction.

关键词： Chemokine-like factor 1 Overexpression Myocardial infarction

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基于复合控制策略的激光光束指向控制系统研究

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陕西科技大学学报 2024年第4期42卷 154-159页

作者：孙昕霍子民储海荣中国科学院长春光学精密机械与物理研究所吉林长春130033 中国科学院大学北京100049

激光光束指向控制系统是通过对激光光束偏转执行机构的控制,实现激光光束稳定指向目标的系统.当激光光束指向控制系统被应用于恶劣环境时,应考虑环境对系统造成的不利影响,消除激光光束的指向误差.激光光束指向控制系统采用了基于比例-... 详细信息

激光光束指向控制系统是通过对激光光束偏转执行机构的控制,实现激光光束稳定指向目标的系统.当激光光束指向控制系统被应用于恶劣环境时,应考虑环境对系统造成的不利影响,消除激光光束的指向误差.激光光束指向控制系统采用了基于比例-微分-积分(PID)控制器和滑模控制器的控制策略,用于提高其动态和静态性能.最后,将PID控制器和滑模控制器在不同状态下的优势相结合,提出了复合控制策略.通过实验对比分析,复合控制策略比单一控制策略具有更好的控制性能,可以满足不同工况下的激光光束指向作业.

关键词：激光光束指向控制系统比例-微分-积分控制器滑模控制器复合控制策略

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