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Association between hepatocellular carcinoma and tumor necrosis factor alpha polymorphisms in South Korea

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World Journal of Gastroenterology 2015年第46期21卷 13064-13072页

作者： Suk Pyo Shin nam Keun kim Ju Hwan kim Ju Ho Lee Jung Oh kim Sung Hwan Cho Hana Park mi na kim Kyu Sung Rim Seong Gyu Hwang Department of Internal Medicine CHA Bundang Medical CenterCHA University Institute of Gastroenterology CHA Bundang Medical CenterCHA University Department of Biomedical Science College of Life ScienceCHA University Institute for Clinical Research CHA Bundang Medical CenterCHA University Department of Internal Medicine CHA Gangnam Medical CenterCHA University

AIM: To investigate associations between the tumor necrosis factor alpha(TNF-α)-1031 T>C,-863 C>A,-857 C>T,-308 G>A,and-238 G>A polymorphisms and HCC in ***: Hepatocellular carcinoma(HCC) cases were diagnosed at CHA Bundang Medical Center from June 1996 to August 2008. The association between TNF-α polymorphisms and HCC was analyzed in 157HCC patients and 201 controls using a polymerase chain reaction-restriction fragment length polymorphism assay. We investigated five TNF-α polymorphisms,which are TNF-α-1031 T>C,-863 C>A,-857 C>T,-308 G>A,and-238 G>A. The TNF-α genotype frequencies,genotype combinations and haplotypes were analyzed to disclose the association with ***: None of the TNF-α polymorphisms was significantly associated with HCC. However,nine genotype combinations had associations with increased likelihood of HCC. Among them,TNF-α-1031/-857/-238 TT/CC/GA(AOR = 18.849,95%CI: 2.203-161.246,P = 0.007),TNF-α-1031/-308/-238 TT/GG/GA(AOR = 26.956,95%CI: 3.071-236.584,P = 0.003),and TNF-α-1031/-238 TT/GA(AOR = 21.576,95%CI: 2.581-180.394,P = 0.005) showed marked association with HCC. There were five haplotypes of TNF-α polymorphisms which were significantly associated with HCC. They are TNF-α-1031/-863/-857/-308/-238 T-C-C-G-A(OR = 25.824,95%CI: 1.491-447.223,P = 0.0005),TNF-α-1031/-857/-308/-238 T-C-G-A(OR = 12.059,95%CI: 2.747-52.950,P nations and haplotypes are associated with HCC. In addition,HCC Okuda stage Ⅲ cases with the TNF-α-1031 TT genotype may have a better pr

关键词： Tumor necrosis factor-alpha Polymorphism Single nu

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol na J.Jay Liu Young-Ju kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

Orange-emitting bimetallic nanoclusters combined with cyan-emitting Fe@TAOH as white light-emitting materials

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Chinese Chemical Letters 2022年第1期33卷 298-303页

作者： Wenying mi na Shao College of Chemistry Beijing Normal UniversityBeijing 100875China

White-light-emitting diodes(WLEDs)possess many merits,such as high efficiency and *** cost-effective,environmentally friendly,high-performance luminophores to achieve high-quality,full-spectrum,white lighting is of great importance to the construction and progress of *** this work,solid-state,highly luminescent orange-emitting nanoclusters(MgCl_(2)-Lys-Ag/Au NCs)were prepared via the salt-induced precipitation of Lys-Ag/Au NCs from solution,which showed a high absolute quantum yield of 44.5%.A cyan-emitting metal-organic framework(MOF)-like nanomaterial(named Fe@TAOH)was also prepared by the self-assembly of the coordination compound of Fe^(3+)and TAOH acted upon by H_(3)PO_(4) via H-bonding andπ-πstacking interactions,which showed an emission peak at 485 nm and an absolute quantum yield of 21.7%.The potential application of the two facile-synthesis,low toxicity,and highly luminescent materials in WLEDs was *** WLEDs was constructed by coating powdered Fe@TAOH and MgCl_(2)-Lys-Ag/Au NCs samples on commercial GaN LED chip with 365 nm emissions,and it exhibited acceptable white light characteristics with a CIE color coordinates and a color rendering index(CRI)of(0.28,0.34)and 79.6,respectively,implying good prospects in the field of WLEDs.

关键词： Metal nanoclusters Salt-mediated precipitation Fe@TAOH MOFs Self-assembly White light-emitting materials

Photodegradation of Hexafluoropropylene Oxide Trimer Acid under UV Irradiation

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Journal of Environmental Sciences 2020年第11期32卷 132-140页

作者： Chen Li na mi Zhanghao Chen Cheng Gu State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China

As a novel alternative to traditional perfluoroalkyl substances(PFASs),including perfluorooctanoic acid(PFOA)and perfluorooctane sulfonate(PFOS),hexafluoroproplyene oxide trimer acid(HFPO-TA)has been detected worldwide in surface ***,recent researches have demonstrated that HFPO-TA has stronger bioaccumulation potential and higher hepatotoxicity than *** treat these contaminants *** and PFOS,some photochemical techniques by adding exogenous substances had been ***,there is still no report for the behavior of HFPO-TA itself under direct UV *** current study investigated the photo-transformation of HFPO-TA under UV irradiation in aqueous *** 72 hr photoreaction,75%degradation ratio and 25%defluorination ratio were achieved under ambient *** active species,i.e.,hydrated electrons and active hydrogen atoms,generated from water splitting played dominant roles in degradation of HFPO-TA,which was confirmed by different effects of reaction atmospheres and quenching experiments.A possible degradation pathway was proposed based on the products identification and theoretical *** general,HFPO-TA would be transformed into shorter-chain PFASs,including hexafluoropropylene oxide dimer acid(HFPODA),perfluoropropionic acid(PFA)and trifluoroacetate(TFA).This research provides basic information for HFPO-TA photodegradation process and is essential to develop novel remediation techniques for HFPO-TA and other alternatives with similar structures.

关键词： HFPO-TA Photo-reductive Hydrated electrons Active hydrogen atoms Degradation pathway

Impacts of Types and Degree of Obesity on Non-Alcoholic Fatty Liver Disease and Related Dyslipidemia in Chinese School-Age Children?

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Biomedical and Environmental Sciences 2011年第1期24卷 22-30页

作者： MENG LingHui LUO na mi Jie Department of Epidemiology Capital Institute of Pediatrics Beijing 100020 China Graduate SchoolPeking Union Medical College Beijing 100730 China Primary and middle School Students Health CareCenter affiliated to the Education Committee of Haidian District Beijing 100081 China

Objective To explore the impacts of types and degree of obesity on non‐alcoholic fatty liver disease （naFLD） and related lipids disturbance in Chinese school‐age children. Methods A total of 1 452 school‐age Children of 7 to 17 years were recruited in Beijing with representative cluster sampling method. Data of anthropometric measurements including weight, height and waist circumference were collected from March to May of 2007. Body mass index（Bmi）was calculated. Blood samples were obtained and lipid profiles including triglyceride （TG）, total cholesterol （TC）, high‐density lipoprotein cholesterol （HDL‐C） and low‐density lipoprotein cholesterol （LDL‐C） were measured, while glutamate‐pyruvate transaminase （ALT） and glutamic‐oxalacetic transaminase （AST） were determined to evaluate liver function. The liver was also scanned by sonography, and abnormal hepatic sonograms were documented. naFLD was diagnosed according to the criteria recommended by the Fatty Liver and Alcoholic Liver Disease Study Group under the Chinese Liver Disease Association. Analysis of covariance （ANOVA）, Chi‐square test for trend and binary logistic regression analysis were performed. Results The dyslipidemia and ultrasonographic fatty liver deteriorated with the degree of obesity defined either by Bmi or waist circumference. Compared with Bmi, waist circumference contributed more to the development of dyslipidemia, fatty liver and naFLD. The highest levels of TG, TC, LDL‐C, and lowest level of HDL‐C were seen in the mixed obese group followed by abdominal obese, peripheral obese and non‐obese ones. Adjusted for gender and age, the odds ratios （ORs） and their 95% confidence intervals of peripheral obesity, abdominal obesity and mixed obesity were 0, 10.93 （0.98‐121.96） and 79.16 （10.95‐572.44） for predicting naFLD; 12.61 （1.24‐127.78）, 19.39 （5.23‐71.85）, and 93.21 （29.56‐293.90） for predicting ultrasonographic fatty liver; 1.78 （0.59‐5.44）, 3.01 （1.91‐4.77）, and 4.64 （3.52‐6.12） for predicting d

关键词： Obesity type Degree of obesity Dyslipidemia naFLD School‐age Children

Visible-light-activated N-doped CQDs/g-C3N4/Bi2WO6 nanocomposites with different component arrangements for the promoted degradation of hazardous vapors

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Journal of Materials Science & Technology 2020年第5期40卷 168-175页

作者： mi Gyeong kim Wan-Kuen Jo Department of Environmental Engineering Kyungpook National University 80 University RoadBukguDaegu702-701Republic of Korea

To investigate whether the arrangement of componentsin multi-composite photocatalysts may affect their photocatalytic properties,due to different charge-transfer routes,two ternary-nanocomposite photocatalysts with different component arrangements,comprising N-doped carbon quantum dots(NCQDs),g-C3N4(CN),and Bi2WO6(BWO)(hereafter referred to as NCQDs/CN/BWO),were developed,and the photocatalytic degradation of model hazardous vapors under visible-light illumination was *** I NCQDs/CN/BWO,which was developed by the combination of NCQDs/BWO and CN,exhibited photocatalytic ability superior to that of type II NCQDs/CN/BWO,which was developed by the combination of CN/BWO and NCQDs;the superior photocatalytic ability corresponded to the dual properties of NCQDs:charge mediation and upconversion ***,the photocatalytic ability of NCQDs/CN/BWO was greater than those of the reference catalysts;in addition,this photocatalyst exhibited outstanding photochemical ***,the effects of CN/(BWO+CN)weight ratio of the CN/BWO dual nanocomposites and the NCQDs/(BWO+CN+NCQDs)weight percentage of NCQDs/CN/BWO ternary nanocomposites on the pollutant removal efficiency were *** plausible mechanisms over the two NCQDs/CN/BWO photocatalysts for the degradation of hazardous vapors were *** component arrangement approach proposed herein afforded a technique toward the perceptive development of novel multi-component heterostructures for the photocatalytic degradation of hazardous vapors.

关键词： Component arrangement Charge-transfer route NCQDs dual role Charge mediator Upconversion photoluminescence

Effective Denoising Architecture for Handling Multiple Noises

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Computer Systems Science & Engineering 2023年第3期44卷 2667-2682页

作者： na Hyoun kim namgyu kim The Graduate School of Business IT of Kookmin University Seoul02707Korea

Object detection,one of the core research topics in computer vision,is extensively used in various industrial *** there have been many studies of daytime images where objects can be easily detected,there is relatively little research on nighttime *** the case of nighttime,various types of noises,such as darkness,haze,and light blur,deteriorate image ***,an appropriate process for removing noise must precede to improve object detection *** there are many studies on removing individual noise,only a few studies handle multiple noises *** this paper,we pro-pose a convolutional denoising autoencoder(CDAE)-based architecture trained on various types of *** also present various composing modules for each noise to improve object detection performance for night *** the exclusively dark(ExDark)Image dataset,experimental results show that the Sequentialfiltering architecture showed superior mean average precision(mAP)compared to other architectures.

关键词： Object detection computer vision nighttime multiple noises convolutional denoising autoencoder

Bee wax coated water-soluble fraction of bee venom improved altered glucose homeostasis in streptozotocin-induced diabetic rats

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Journal of Traditional Chinese Medicine 2019年第6期39卷 842-852页

作者： Rangachari Balamurugan Jeong Hwa kim mi-na Jo Chenglian Xue Jin kyu Park Jae Kwon Lee Department of Beesen Lab 204Beesen Co.Ltd.Bioventure TownYuseong Daero 1662Dae Jeon 34054Republic of Korea Department of Biology Education College of EducationChungbuk National UniversityCheongju 28644Republic of Korea

OBJECTIVE:To evaluate the anti-diabetic efficacy of orally administered bee wax coated water-soluble fraction of bee venom(BWCBVA)drug over orally administered bee wax(BW)and intraperitoneally administered whole bee venom(BV)in streptozotocin(STZ)-induced diabetic ***:Diabetes induced by intraperitoneal administration of 60 mg/kg STZ was treated with BWCBVA,BW,and BV for 21 *** biochemical,protein and histological changes,and physical characteristics of BWCBVA were then ***:The BWCBVA group shows significantly decreased blood glucose level as compared to the BW and intraperitoneally administered whole BV treated ***,BWCBVA significantly normalizes the serum biochemical parameters and increases the body ***,administration of BWCBVA significantly reverses the altered liver expression of phosphatidylinositide 3-kinases-p85 and liver *** analysis of the pancreas an increase in the islet cell numbers and decrease inβ-cell ***-administering BWCBVA 0.25 mg/kg with nifedipine(6.8 mg/kg)and nicorandil(13.8 mg/kg)to the diabetic rats results in insulin secretion through enhanced calcium ion *** performance liquid chromatography and gas chromatography was performed to identify the pharmacologically important compounds present in ***:Our results indicate that BWCBVA,an orally administered colon specific drug delivery system,can be effective in treating diabetes mellitus.

关键词： Diabetes Mellitus Waxes Bee venoms Streptozotocin

Recombinant human fibroblast growth factor-2 promotes nerve regeneration and functional recovery after mental nerve crush injury

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Neural Regeneration Research 2017年第4期12卷 629-636页

作者： Sung Ho Lee Wei-Peng Jin na Ri Seo Kang-mi Pang Bongju kim Soung-min kim Jong-Ho Lee Dental Research Institute Department of Oral and Maxillofacial Surgery Seoul National University School of Dentistry Seoul Korea Dental Life Science Research Institute Clinical Translational Research Center for Dental Science Seoul National University Dental Hospital Seoul Korea Dental Research Institute Seoul National University Seoul Korea

Several studies have shown that fibroblast growth factor-2 （FGF2） can directly affect axon regeneration after peripheral nerve damage. In this study, we performed sensory tests and histological analyses to study the effect of recombinant human FGF-2 （rhFGF2） treatment on damaged mental nerves. The mental nerves of 6-week-old male Sprague-Dawley rats were crush-injured for 1 minute and then treated with 10 or 50 μg/mL rhFGF2 or PBS in crush injury area with a mini Osmotic pump. Sensory test using von Frey filaments at 1 week revealed the presence of sensory degeneration based on decreased gap score and increased difference score. However, at 2 weeks, the gap score and difference score were significantly rebounded in the mental nerve crush group treated with 10 μg/mL rhFGF2. Interestingly, treatment with 10 μg/mL rhFGF had a more obviously positive effect on the gap score than treatment with 50 μg/mL rhFGF2. In addition, retrograde neuronal tracing with Dil revealed a significant increase in nerve regeneration in the trigeminal ganglion at 2 and 4 weeks in the rhFGF2 groups （10 μg/mL and 50 μg/mL） than in the PBS group. The 10 μg/mL rhFGF2 group also showed an obviously robust regeneration in axon density in the mental nerve at 4 weeks. Our results demonstrate that 10 μg/mL rhFGF induces mental nerve regeneration and sensory recovery after mental nerve crush injury.

关键词： nerve regeneration mental nerve fibroblast growth factor crush injury sensory neuron functionalrecovery neural regeneration