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Correlation of serum bilirubin level with nerve defect, oxidative stress and adhesion molecules in patients with cerebral infarction

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Journal of Hainan Medical University 2017年第24期23卷 113-116页

作者： Pei Pei mi wei Department of Neurology Huangshi Central Hospital in Hubei ProvinceHuangshiHubei Province435000 Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention HuangshiHubei Province435000 Function Department Huangshi Maternity and Children's Health Hospital in Hubei ProvinceHuangshiHubei Province435000

Objective: To study the correlation of serum bilirubin level with nerve defect, oxidative stress and adhesion molecules in patients with cerebral infarction. Methods: A total of 85 patients who were diagnosed with acute cerebral infarction in Huangshi Central Hospital between August 2014 and March 2017 were selected as the ACI group of the research, and 62 healthy volunteers who received physical examination in Huangshi Central Hospital over the same period were selected as control group. The levels of bilirubin and the contents of nerve defect markers, oxidative stress indexes and adhesion molecules in serum as well as the expression of oxidative stress indexes in peripheral blood were measured. Results: Serum TBIL, IBIL, NSE, sTRAIL, sFas, GFAP, S100B, MDA, AOPP, FKN, sICAM-1, sVCAM-1, ALCAM and PECAM-1 contents as well as peripheral blood Nrf-2 and HO-1 mRNA expression of ACI group were greatly higher than those of control group, serum SOD content was greatly lower than that of control group, and DBIL level was not different from that of control group;serum TBIL and IBIL levels of ACI patients were positively correlated with serum NSE, sTRAIL, sFas, GFAP, S100B, MDA, AOPP, FKN, sICAM-1, sVCAM-1, ALCAM and PECAM-1 contents as well as peripheral blood Nrf-2 and HO-1 mRNA expression, and negatively correlated with serum SOD content. Conclusion: The increase of serum TBIL and IBIL levels in patients with cerebral infarction is related to the degree of nerve defect, the activation of oxidative stress and the increased generation of adhesion molecules.

关键词： Acute cerebral infarction Bilirubin Oxidative stress Adhesion molecule

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Anatomic relationship of the internal jugular vein and the common carotid artery in Chinese people

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Chinese Medical Journal 2010年第22期123卷 3226-3230页

作者： QIN Xiao-hui ZHANG Hong mi wei-dong Anesthesia and Operation Center Chinese People's LiberationArmy General Hospital Beijing 100853 China

Background Variations in position and relationship between the internal jugular vein （IJV） and the common carotid artery （CCA） may lead to inadvertent artery puncture which could be disastrous during central venous access. We demonstrated the anatomic relationship of the IJV with CCA in order to find the optimal site and avoid damage of CCA. Methods Two hundred and twenty surgical patients were enrolled. We analyzed the distance and relationship between the IJV and CCA at three cross sections （upper border of the thyroid cartilage, cricoid cartilage and second tracheal ring） by ultrasonography and then measured the diameters of the IJV and CCA and the distances from the IJV and CCA to the skin. Results Twenty patients were excluded on the basis of exclusion criteria. From up to down at bilateral neck, the IJV became gradually more superficial while the CCA became deeper. The diameter of the IJV became gradually larger while that of the CCA gradually smaller. The IJV from lateral to the CCA gradually moved to the front of the CCA, so the percent overlap of the IJV and CCA was gradually increased. Compared with the left side at the same transverse scan level, the distance between the CCA and IJV was wider at the right side and the right IJV was wider. The IJV location in 11 patients was medial to the CCA at one or more transverse scan levels. The angle between the IJV and CCA was significantly small in elderly patients. The CCA had already furcated at the level of the upper border of the thyroid cartilage in seven patients at the right side and in 12 patients at the left side. Conclusions There are variations in the position and relationship between the IJV and CCA. It is relatively more difficult to puncture at the left side of the neck, at a lower position or in elderly patients. On the contrary, it is relatively easier to puncture at the right side, at the level of the cricoid cartilage or in younger patients.

关键词： central venous jugular veins carotid artery ultrasonography

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考虑设施失效及客户重指派的网络选址模型及求解

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上海交通大学学报 2014年第5期48卷 725-729页

作者：周娜朱伟宓为建上海海事大学物流工程学院上海201306 河南工程学院管理工程学院郑州451191

基于无容量约束且固定费用的设施选址模型,综合考虑系统运作成本及其可靠性,提出了考虑失效概率及对客户多层级重指派的非线性混合整数规划模型,并用优化的拉格朗日松弛算法对线性处理后的模型进行求解.结果表明:拉格朗日松弛算法适用... 详细信息

基于无容量约束且固定费用的设施选址模型,综合考虑系统运作成本及其可靠性,提出了考虑失效概率及对客户多层级重指派的非线性混合整数规划模型,并用优化的拉格朗日松弛算法对线性处理后的模型进行求解.结果表明:拉格朗日松弛算法适用于中等规模的选址问题;相对于客户的多层级重指派,其设施失效概率对网络选址的影响较大.

关键词：设施选址可靠性非线性混合整数规划拉格朗日松弛算法

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EIM-Based Grid Model and Graphics Exchange Format

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China Standardization 2011年第4期56卷 72-74页

作者： Xin Yaozhong mi weimin Li wei

With the rapid development of electric power system and the unceasing expansion of power grid, the operation and conlrol of large power grid needs the support of on-line safe and stable analysis. In recent years, rene... 详细信息

关键词：图形交换格式网格模型 EIM 可再生能源电力系统稳定分析大电网

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社会正义视角下的“道德绑架”问题分析

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伦理学研究 2022年第3期 126-133页

作者：弭维天津大学法学院

对“道德绑架”问题的既有研究通常忽视了纷争背后所隐藏的社会正义意蕴,而多从一般的权利义务理论出发去理解。“逼迫让座”与“逼迫捐款”是最常见的“道德绑架”形式,它们涉及的是社会资源和个人财富的分配和使用原则问题。基于社会... 详细信息

对“道德绑架”问题的既有研究通常忽视了纷争背后所隐藏的社会正义意蕴,而多从一般的权利义务理论出发去理解。“逼迫让座”与“逼迫捐款”是最常见的“道德绑架”形式,它们涉及的是社会资源和个人财富的分配和使用原则问题。基于社会正义视角的分析研究,有助于探求这些纷争频发的真正根源以及各方所诉诸的道德理由,进而通过对相关法律权利和道德义务之边界的辨别去评析这些理由的合理性与不合理性。其中,“慈善”是不是一种义务引发了最多的争论,这是“道德绑架”现象背后蕴含的最深刻的也最难以解决的一种道德分歧,具有高度普遍性。通过对既有的关于个人财产权、法律义务和道德义务、市场的道德性质等问题的基础理论进行反思与批评,慈善可以被证成为一种义务,而不只是一种恩惠。同时,政治共同体对同胞之爱的需求也要求公民应在保证个人权利的基础上去促进社会的慈善行为。

关键词：道德绑架社会正义法律权利慈善义务

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继承与革新:边沁学说的方法论基础

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山东大学学报（哲学社会科学版） 2010年第5期 17-23页

作者：弭维山东大学威海分校法学院

边沁是英国近代最重要思想家之一,其研究领域覆盖了伦理学、政治哲学和法学。他以自然科学和心理学为基础,从观察"实际的人"出发,继承并改造了英国道德哲学中的情感主义学说和功利原则,将之系统化,为近代功利主义和法律实证主义的形成... 详细信息

边沁是英国近代最重要思想家之一,其研究领域覆盖了伦理学、政治哲学和法学。他以自然科学和心理学为基础,从观察"实际的人"出发,继承并改造了英国道德哲学中的情感主义学说和功利原则,将之系统化,为近代功利主义和法律实证主义的形成奠定了重要的思想基础,也为英国的政治和法律改革提供了明晰简单的原则。并以其"穷尽方法"、"细节方法"和"审查方法"为法律和道德的哲学证成提供了新的方法。

关键词：功利原则穷尽方法细节方法审查方法

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基于酸碱相互作用制备染料杂化的聚磷腈微粒及其乳化性能

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高分子学报 2018年第5期28卷 639-647页

作者：焦密密魏玮姜新罗静朱叶刘晓亚江南大学合成与生物胶体教育部重点实验室化学与材料工程学院无锡214122

利用罗丹明B(RhB)通过酸碱相互作用对聚(环三膦腈-co-4,4′-二羟基二苯砜)(PZS)微粒进行表面改性,得到一种染料杂化的聚磷腈胶体粒子(PZS@RhB),对其结构、形貌、亲-疏水性及pH响应性进行了表征;进一步以PZS@RhB微粒为颗粒乳化剂,研究了... 详细信息

利用罗丹明B(RhB)通过酸碱相互作用对聚(环三膦腈-co-4,4′-二羟基二苯砜)(PZS)微粒进行表面改性,得到一种染料杂化的聚磷腈胶体粒子(PZS@RhB),对其结构、形貌、亲-疏水性及pH响应性进行了表征;进一步以PZS@RhB微粒为颗粒乳化剂,研究了其乳化性能,并探讨了乳液的破乳条件及机理.结果表明:PZS微粒表面吸附RhB后,疏水性增加,且RhB结构中的羧基赋予了微粒pH响应性;当水相中PZS@RhB微粒的质量浓度达到14 mg/mL时,可乳化甲苯形成较为细腻的W/O型乳液;乳液呈现出显著的pH响应性,当增加水相pH至强碱性(pH≥10.11)时,乳液可发生相反转,由W/O型转变为O/W型;此外,通过向乳液中加入三乙胺,可有效破环PZS微粒与RhB之间的酸碱相互作用,从而方便实现乳液的破乳.

关键词：聚磷腈微粒酸碱相互作用 pH响应 Pickering乳液相反转破乳

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KLF16 promotes pancreatic adenocarcinoma cell proliferation and migration by positively regulating SMAD6

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2157-2169页

作者： wei mi Zhi Zheng Jiong-Di Lu Shu-Quan Duan Jie Zhang Hai-Qiao Zhang Yi-Xuan Ding Jie Yin Feng Cao Jun Zhang Fei Li Department of General Surgery Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of General Surgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Digestive minimally Invasive Surgery The Second Affiliated Hospital of Baotou Medical CollegeBaotou 014030Inner Mongolia Autonomous RegionChina Department of Radiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Pancreatic adenocarcinoma(PAAD)is a cancerous tumor with an extremely poor 5-year survival *** exploration of biomarkers for the diagnosis and treatment of PAAD is crucial in clinical ***üppel-like factors(KLFs)are involved in a variety of biological functions in *** to multiple studies,KLF16 behave as an oncogene in prostate,breast and gastric ***,no research has been done on the significance of KLF16 in *** To explore the molecular mechanisms of KLF16 in *** KLF16 was identified in the tumor specimens and normal tissues by GEPIA database and verified by quantitative real-time PCR(qRT-PCR).Knockdown or exogenous expression of KLF16,combined with in vitro and in vivo assays,was performed to show the functional significance of *** molecular mechanism of KLF16 was demonstrated by qRT-PCR,western blotting,immunoprecipitation assay and flow *** We showed that KLF16 was highly expressed in PAAD patients based on the GEPIA ***16 silencing suppressed while KLF16 overexpression promoted the malignant function of PAAD *** on RNA sequencing,we discovered that KLF16 potentiated the expression of SMAD6 in PAAD ***6 transcript abundance was increased and positively correlated with KLF16 expression in PAAD *** addition,inhibiting SMAD6 was able to mitigate the effects of KLF16 overexpression on PAAD cell processes,suggesting the importance of SMAD6 in the development of KLF16-triggered *** KLF16/SMAD6 axis might be explored as a therapeutic target for PAAD therapy.

关键词： KLF16 Pancreatic adenocarcinoma SMAD6 Tumorigenesis Therapeutic target

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Influence of ultrasonic treatment on formation of primary Al_3Zr in Al-0.4Zr alloy

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Transactions of Nonferrous Metals Society of China 2017年第5期27卷 977-985页

作者： Feng WANG Brunel Centre for Advanced Solidification Technology Brunel University London Uxbridge London UB8 3PH UK Tomsk State University Tomsk 634050 Russia Diamond Light Source Ltd Harwell Science & Innovation Campus Didcot OX11 0DE UK School of Engineering University of Hull Hull East Yorkshire HU6 7RX UK

The effect of ultrasonic treatment on the formation of primary Al3Zr was investigated by applying ultrasound to an Al?0.4Zr *** temperature ranges were selected,i.e.,830to790°C(above liquidus),790to750°C(cross liquidus)and750to710°C(below liquidus)for *** the scanning electron microscopy,both the size and morphology of the primary Al3Zr particles were *** was found that the size was significantly reduced and the morphology changed from large throwing-star shape to small compact tablet *** mechanisms for refinement of primary Al3Zr were *** is suggested that sonocrystallization theory via activation of aluminium oxide particles is responsible for the refinement of primary Al3Zr when ultrasonic melt treatment(UST)is applied within the fully liquid *** refinement of primary Al3Zr particles when UST is applied in the slurry(growth stage)is due to the sonofragmentation.

关键词： ultrasonic treatment aluminium alloy primary Al3Zr intermetallic refinement crystal morphology

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Contrast enhancement in retinal image via multi-scale geometrical analysis

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Optoelectronics Letters 2006年第3期2卷 229-232页

作者： FENG Peng PAN Ying-jun wei Biao JIN wei mi De-ling Department of Opto-Electronics Engineering University of Chongqing Chongqing 400030 China

We present a new multi-scale geometrical analysis method for ophthalmic image contrast enhancement based on the contourlet transform. The contourlet transform has better performance in representing edges than wavelets due to its anisotropy and directionality,and is therefore well-suited for multiscale edge enhancement. We modify the contourlet coefficients in corresponding subband and take the noise into account for mere precise reconstruction and better visualization. We compare this approach with enhancement based on the ourvelet transform,and the traditional Histogram Stretching （HS）. Our findings are that contourlet based enhancement out-performs other enhancement methods on low contrast and dynamic range images,and can clearly identify the vessels and nerves in an ophthalmic image.

关键词：视网膜图象对比度子波各向异性

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