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Journal of Traditional Chinese Medicine 2018年第5期38卷 769-772页

作者： JiEun Lee Seung-Yeon Cho Seong-Uk Park Woo-Sang Jung Sang-Kwan Moon Jung-mi Park Chang-Nam ko Ki-Ho Cho Seungwon Kwon Department of Cardiology and Neurology College of Korean Medicine Kyung Hee University

OBJECTIVE: To show whether Danggui Sini plus Wuzhuyu Shengjiang Tang(DSWST) has any transient effect on erythrocyte deformability in normal ***: A total of 25 subjects [mean age(27.8± 1.8) years] was enrolled in this study. The study was designed as a cross-over trial in which the subjects took part for 2 d. On the first day, blood samples were collected at baseline and 1-2 h after administration of water, whereas, on the second day, instead of water, the subjects were administered DSWST after the baseline blood sampling. The blood samples collected at baseline and after the administration water or DSWST, were examined for erythrocyte ***: The elongation index increased significantly after 2 h(P = 0.009) compared to the baseline after DSWST intake. However, after water intake, there was no significant differenceobserved. When comparing the percent change of erythrocyte deformability between DSWST and water, we found that after 2 h of administration,DSWST improved erythrocyte deformability significantly compared to water(P < 0.001).CONCLUSION: DSWST has a transient effect on erythrocyte deformability in normal subjects.

关键词： Erythrocyte deformability Peptide elongation factors Raynaud disease Coldness of hands and feet Cross-over studies Danggui Sini plus Wuzhuyu Shengjiang Tang

Uhwang Chungsim Won Decreases Blood Oxygen Level-Dependent fMRI Signal Response to A Motor Stimulation Task

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Chinese Journal of Integrative Medicine 2015年第7期21卷 493-499页

作者： Woo-Sang Jung Jong-Man Ryu Young-Jee Kim Seong-Uk Park Geon-Ho Jahng Jung-mi Park Sang-Kwan Moon Chang-Nam ko Ki-Ho Cho Department of Cardiovascular&Neurologic Diseases(Stroke Center) College of Oriental MedicineKyung Hee University Department of Radiology College of MedicineKyung Hee University

Objectives： TO evaluate the effect of Uhwang Chungsim Won [UC, Niuhuang Qingxin Pill （牛黄清心丸] on the blood oxygen level-dependent （BOLD） functional magnetic resonance imaging （fMRI） signal response to a motor stimulation task using a hand grasping paradigm. Methods： Ten healthy right-handed male volunteers were recruited. Their BOLD fMRI signal characteristics during hand grasping were determined before and 1 h after consuming UC. Results： With the administration of UC, BOLD responses to the right hand motor task showed a decrease in both hemispheres including the right cerebellar culmen, right and left medial frontal gyrus, right parahippocampal gyrus, right and left sublobar insula, right and left posterior cingulate, left precuneus, and right precentral gyrus. Decreased BOLD responses to the left hand motor task were shown in the right lingual gyrus, right cerebellar culmen, left superior temporal gyrus, right and left middle frontal gyrus, and right precentral gyrus after UC administration. Increased BOLD responses to the left hand motor task were shown in the left and right posterior cingulate, while there was no increased response to the right hand motor task after UC administration. Conclusions： UC administration significantly decreased fMRI BOLD signal responses to hand grasping in most of the brain areas including the primary motor cortex, but it is not clear whether these decreased responses were caused by a decrease in neuronal activities or by an increase in cerebral blood flow due to the cerebral vasodilatory effects of UC. Further studies using positron emission tomography or single photon emission computed tomography are needed to fully elucidate these findings.

关键词： Uhwang Chungsim Won Niuhuang Qingxin Pfll pharmacological fMRI cerebral blood flow

Predictive proteomic biomarkers for inflammatory bowel disease-associated cancer:Where are we now in the era of the next generation proteomics?

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World Journal of Gastroenterology 2014年第37期20卷 13466-13476页

作者： Jong-min Park Na Young Han Young-min Han mi Kyung Chung Hoo Keun Lee Kwang Hyun ko Eun-Hee Kim Ki Baik Hahm CHA Cancer Prevention Research Center CHA University Gachon University College of Pharmacy Digestive Disease Center CHA University Bundang Medical Center

Recent advances in genomic medicine have opened up the possibility of tailored medicine that may eventually replace traditional “one-size-fits all” approaches to the treatment of inflammatory bowel disease (IBD). In addition to exploring the interactions between hosts and microbes, referred to as the microbiome, a variety of strategies that can be tailored to an individual in the coming era of personalized medicine in the treatment of IBD are being investigated. These include prompt genomic screening of patients at risk of developing IBD, the utility of molecular discrimination of IBD subtypes among patients diagnosed with IBD, and the discovery of proteome biomarkers to diagnose or predict cancer risks. Host genetic factors influence the etiology of IBD, as do microbial ecosystems in the human bowel, which are not uniform, but instead represent many different microhabitats that can be influenced by diet and might affect processes essential to bowel metabolism. Further advances in basic research regarding intestinal inflammation may reveal new insights into the role of inflammatory mediators, referred to as the inflammasome, and the macromolecular complex of metabolites formed by intestinal bacteria. Collectively, knowledge of the inflammasome and metagenomics will lead to the development of biomarkers for IBD that target specific pathogenic mechanisms involved in the spontaneous progress of IBD. In this review article, our recent results regarding the discovery of potential proteomic biomarkers using a label-free quantification technique are introduced and on-going projects contributing to either the discrimination of IBD subtypes or to the prediction of cancer risks are accompanied by updated information from IBD biomarker research.

关键词： Inflammatory bowel disease Biomarker Proteomics Tailored medicine Colitic cancer

Effect of Digitalization on Serbian Tax Administration Reform

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Belt and Road Initiative Tax Journal 2020年第2期1卷 24-29页

作者： RadeŠević Saša Dulić miško Marković Goran Nikolić Transformation Sector Tax Administration of the Republic of Serbia ICT Sector Tax Administration of the Republic of Serbia Department in ICT Sector Tax Administration of the Republic of Serbia

This article introduces the digitalization trends in the Republic of Serbia and its impact on transformation processes within Serbian Tax Administration,with short overview of a case study—unified collection.

关键词： Digitalization Modernization Tax administration reform Serbia

A Comparison of Brain Activity between Healthy Subjects and Stroke Patients on fMRI by Acupuncture Stimulation

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Chinese Journal of Integrative Medicine 2013年第4期19卷 269-276页

作者： Seung-Yeon Cho mia Kim Jong Joo Sun Geon-Ho Jahng Hengjun J Kim Seong-Uk Park Woo-Sang Jung Chang-Nam ko Jung-mi Park Department of Cardiology and Neurology of korean Medicine College of Korean MedicineKyung Hee UniversitySeoulKorea Department of Radiology Kyung Hee University Hospital at GangdongCollege of MedicineKyung Hee UniversitySeoulKorea Division of Magnetic Resonance Research Korea Basic Science InstituteCheongwongunChungbukKorea

Objective： To investigate brain activity patterns during acupuncture in stroke patients, and to compare the result with normal subjects using functional magnetic resonance imaging （fMRI）. Methods： A total of 11 stroke patients with motor weakness and 10 healthy subjects were studied, fMRI was performed during acupuncture on the left side at points Quchi （Llll） and Zusanli （ST36）. Data were analyzed using statistical parametric maps of brain activation induced by acupuncture stimulation. Results： The results showed that stimulation of both LI11 and ST36 produced significantly different brain activation patterns between the two groups. The normal group showed a greater overall activation than the stroke group. In the normal group, parts of the frontal lobe, parietal lobe, sub-lobar, cerebellum and midbrain regions were activated by acupuncture at the left LI11. On the other hand, only the right side of the inferior parietal Iobule region was activated in the stroke patients. When the left ST36 was stimulated in the normal group, both sides of the frontal lobe, parietal lobe, temporal lobe, and sub-lobar, and the left side of occipital lobe, and the right side of cerebellum and midbrain regions were activated. For the same stimulation in the stroke group, only both sides of the inferior parietal Iobule and cerebellum regions were activated （P〈0.05, cluster level）. Deactivation pattern was not noted during any acupuncture stimulation in both groups. Conclusion： Brain signal activations during the same acupuncture were different between the healthy and the stroke patients, and the effects showed a correlation of different acupuncture points.

关键词： acupuncture functional magnetic resonance imaging stroke LI11 ST36 basal ganglia

Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells

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Cellular & Molecular Immunology 2021年第6期18卷 1395-1411页

作者： Jin-Kwan Lee Seo-Young koo Hye-mi Nam Jee-Boong Lee Jiwon ko Kyung-Mo Kim Eun-Ji Park Tae Jin Kim Ho Lee Heounjeong Go Chang-Woo Lee Research Institute Curogen TechnologySuwonSouth Korea Department of Molecular Cell Biology Samsung Medical CenterSungkyunkwan University School of MedicineSuwonSouth Korea MOGAM Institute for Biomedical Research GyeonggiSouth Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea Department of Immunology Sungkyunkwan University School of MedicineSeoulSouth Korea Department of Cancer Biomedical Science Graduate School of Cancer Science and PolicyResearch InstituteNational Cancer CenterGyeonggiSouth Korea

The homeostatic balance between effector T cells and regulatory T cells(Tregs)is crucial for adaptive immunity;however,epigenetic programs that inhibit phosphorylation to regulate Treg development,peripheral expression,and suppressive activity are ***,we found that the Ssu72 phosphatase is activated by various T-cell receptor signaling pathways,including the T-cell receptor and IL-2R pathways,and localizes at the cell *** of Ssu72 in T cells disrupts CD4+T-cell differentiation into Tregs in the periphery via the production of high levels of the effector cytokines IL-2 and IFNγ,which induce CD4+T-cell activation and differentiation into effector cell *** also found a close correlation between downregulation of Ssu72 and severe defects in mucosal tolerance in ***,Ssu72 forms a complex with PLCγ1,which is an essential effector molecule for T-cell receptor signaling as well as Treg development and ***72 deficiency impairs PLCγ1 downstream signaling and results in failure of Foxp3 ***,our studies show that the Ssu72-mediated cytokine response coordinates the differentiation and function of Treg cells in the periphery.

关键词： Ssu72 Regulatory T cells FoxP3 T cell receptor Autoimmunity

Comparative effects of artemisia vulgaris and charcoal moxa stimulating Zhongwan(CV 12) on body temperature in healthy participants:a cross-over single-blind randomized study

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Journal of Traditional Chinese Medicine 2015年第5期35卷 551-557页

作者： Ho-Yeon Go Ju Ah Lee Sunyoung Park Sunju Park Jeong-Su Park Chunhoo Cheon Seong-Gyu ko Kyung-Hwan kong Chan-yong Jun Jong-hyeong Park mi-Ran Shin Se-Hoon Lee Department of Internal Medicine College of Korean MedicineSemyung University Department of Public Health The Catholic University of Korea Medical Research Division Korea Institute of Oriental Medicine Department of Physiology College of Korean MedicineSemyung University Department of Preventive Medicine College of Korean MedicineDaejeon University Center for Clin ical Research and Genomics College of Oriental Medicine and Institu te of Oriental MedicineKyung Hee University Department of Internal Medicine College of Korean MedicineGachon University Department of Sasang Constitutional Medicine College of Korean MedicineSemyung University

OBJECTIVE:To evaluate the efficacy,safety,satisfaction,discomfort and patient preference of moxa cones of artemisia vulgaris and charcoal ***:This comparative study of moxibustion treatment with Artemisia vulgaris and charcoal moxa cone stimulating Zhongwan(CV 12) is a cross-over single-blinded,randomized clinical trial.A total of 40 healthy subjects(24 males and 16females) participated in this *** subjects dropped out of the ***-eight subjects were treated with Artemisia vulgaris and charcoal moxa cones for 30 min in a cross-over *** treatment,the patients underwent a 30 minute waiting period,and then the temperatures at Tanzhong(CV 17),Zhongwan(CV 12) and Guanyuan(CV 4) were measured using digital infrared thermal ***:After the use of Artemisia vulgaris moxa,the patients' body temperatures were slightly lowered at Tanzhong(CV 17),Zhongwan(CV 12)and Guanyuan(CV 4),but the changes were not statistically *** the use of charcoal moxa,the patients' body temperatures were somewhat increased at Zhongwan(CV 12) and Guanyuan(CV 4),but the changes were not statistically *** Artemisia vulgaris moxa use,the body temperature difference between Zhongwan(CV 12) and Guanyuan(CV 4)was significantly *** charcoal moxa use,the body temperature difference between Tanzhong(CV 17) and Zhongwan(CV 12) was significantly decreased in males and in the whole *** change was caused by the difference in the moxibustion type and by gender ***:This pilot study found that moxibustion did not raise the body temperature,but temperature differences between acupoints were *** large-scale randomized controlled trials are needed for the effect of moxibustion on body temperature.

关键词： Moxibustion Point CV12(Zhongwan) Artemisia Body temperature Cross-over studies Single-blind method Randomized controlled trial

Undiagnosed Borrmann type Ⅱ gastric cancer due to necrosis and regenerative epithelium

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World Journal of Gastroenterology 2014年第28期20卷 9621-9625页

作者： Joon Hur Jae Hyuck Chang Byung Kee Kim Hoon Young ko Jong Hwan Lee Soo Jeong Kim mi Ae Song Tae Ho Kim Chang Whan Kim Sok Won Han Division of Gastroenterology Department of Internal MedicineBucheon St.Mary’s HospitalThe Catholic University of KoreaCollege of Medicine Department of Clinical Pathology Bucheon St.Mary’s HospitalThe Catholic University of KoreaCollege of Medicine

Endoscopic biopsy is essential to the proper diagnosis and treatment of gastric ***,the results of endoscopic biopsy are not always the same as what is expected based on gross endoscopic *** results of endoscopic biopsy can be negative for malignancy in Borrmann typeⅣadvanced gastric cancer(AGCa)or gastric ***,in the case of typeⅡAGCa,repeated biopsies negative for malignancy have not been reported.A 49-year-old male patient underwent esophagogastroduodenoscopy three times due to large gastric ulcer suspected to be Borrmann typeⅡ***,three repeat endoscopic biopsies with multiple specimens showed necrosis and superficial regenerative epithelium without malignant *** patient underwent laparoscopic distal gastrectomy with D2 lymph node *** surgical specimen revealed that the mucosal layer was completely replaced with regenerative epithelium without cancer cells.

关键词： Endoscopy Biopsy Stomach neoplasm Stomach ulcer Regeneration

Safe drug treatment and procedure for herpes zoster in pregnancy:a case report

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Chinese Medical Journal 2020年第16期133卷 1999-2000页

作者： Ji Yeong Kim You Ri ko Sung Eun Sim Sua Oh mi Hyeon Lee Hue Jung Park Department of Anesthesiology and Pain Medicine Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

To the Editor:A first infection of varicella-zoster virus(VZV)during pregnancy can cause serious systemic disease to both mother and the *** this maternal herpes zoster(HZ)does not increase fetal mortality,and the transmission of varicella-zoster virus to the fetus rarely *** HZ infection has a minimal effect on the fetus,maternal HZ can cause significant complications for the mother.

关键词： zoster mother pregnancy fetal

Active case-finding for tuberculosis by mobile teams in Myanmar:yield and treatment outcomes

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Infectious Diseases of Poverty 2017年第1期6卷 683-690页

作者： Ohnmar Myint Saw Saw Petros Isaakidis Mohammed Khogali Anthony Reid Nguyen Binh Hoa Thi Thi Kyaw ko ko Zaw Tin mi mi Khaing Si Thu Aung National Tuberculosis Programme Corner of Mingyi Road and Minglar StreetPathein townshipAyeyarwaddy RegionMyanmar Department of Medical Research YangonMyanmar Medecins sans Frontieres Operational Research UnitLuxembourgLuxembourg National Tuberculosis Programme HanoiVietnam Centre for Operational Research International Union Against Tuberculosis and Lung DiseaseParisFrance TB Unit WHO Country Office for MyanmarYangonMyanmar

Background:Since 2005,the Myanmar National Tuberculosis Programme(NTP)has been implementing active case finding(ACF)activities involving mobile teams in hard-to-reach *** study revealed the contribution of mobile team activities to total tuberculosis(TB)case detection,characteristics of TB patients detected by mobile teams and their treatment ***:This was a descriptive study using routine programme data between October 2014 and December *** team activities were a one-stop service and included portable digital chest radiography(CXR)and microscopy of two sputum *** algorithm of the case detection included screening patients by symptoms,then by CXR followed by sputum microscopy for *** patients were started on treatment and followed until a final outcome was ***:A total of 9349 people with symptoms suggestive of TB were screened by CXR,with an uptake of 96.6%.Of those who were meant to undergo sputum smear microscopy,51.4%had sputum ***,504 TB patients were identified by the mobile teams and the overall contribution to total TB case detection in the respective townships was 25.3%.Among total cases examined by microscopy,6.4%were sputum smear positive *** success rate was high as 91.8%in study townships compared to national rate 85%(2014 cohort).Conclusions:This study confirmed the feasibility and acceptability of ACF by mobile teams in hard-to-reach contexts,especially when equipped with portable,digital CXR machines that provided immediate ***,the follow-up process of sputum examination created a significant barrier to confirmation of the *** order to optimize the ACF through mobile team activity,future ACF activities were needed to be strengthened one stop service including molecular diagnostics or provision of sputum cups to all presumptive TB cases prior to CXR and testing if CXR suggestive of TB.

关键词： Mobile team Active case finding Chest X-ray Treatment outcomes