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Probiotic mixture VSL#3 prevents ulcerative colitis-associated carcinogenesis in mice and cells by regulating the inflammatory and Wnt/β-catenin pathway

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Chinese Medical Journal 2022年第19期135卷 2357-2359页

作者： Wenbin Li Yanan Wang Chunsaier Wang Hongying Wang Yiming Ma Hong Yang Xinhua Zhao Xiaomin Hu John Y.Kao Jiaming Qian chung Owyang Jingnan Li Department of Gastroenterology Key Laboratory of Gut Microbiota Translational Medicine ResearchPeking Union Medical Cllege HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100730China Department of Gastroenterology Bejing HospitalNational Center of GerontologyInstitute of Geriatic MedicineChinese Academy of Medical ScienceBejing 100730China National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100021China Department of Central Laboratory Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CllegeBejing 100730China Department of Internal Medicine Division of GastroenterologyUniversity of Michigan Health SystemAnn ArborMIUSA.

To the Editor:Increasing attention is being paid to preventing ulcerative colitis(UC)-associated *** intestinal microbiota plays an important role in maintaining the intestinal barrier and immune *** mixture VSL#3,that was bought from Sigma-Tau pharmaceuticals(De Simone Formulation)in May 2015,is a mixture of Lactobacillus casei,***,***,*** ***,Bifidobacterium longum,***,*** and Streptococcus salivarius andcontains 4.5 billion live bacterialcolonies.i Previous studies have shown that VSL#3 can help induce and maintain UC *** effects of probiotics on UC-associated carcinogenesis are difficult to observe clinically;therefore,mouse models are often used to study this *** studies have shown that azoxymethane(AOM)combined with dextran sulfate sodium(DSS)can quickly induce a UC-associated carcinogenesis model.

关键词： carcinogenesis function. mixture

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Protection against microcystin-LR-Induced Toxicity by Sulforaphane through Activation of the Nrf2-Mediated Defensive Response

Protection against Microcystin-LR-Induced Toxicity by Sulfor...

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庆祝中国藻类学会成立30周年暨第十五次学术讨论会

作者： Nanqin Gan~1,Lixin mi~2,Xiaoyun Sun~1,Guofei Dai~1,Fung-Lung chung~2,Lirong Song~(1*) 1 State Key Laboratory of Freshwater Ecology and Biotechnology,Institute of Hydrobiology,CAS, People’s Republic of China 2 Department of Oncology,Lombardi Comprehensive Cancer Center, Georgetown University,Washington,DC 20057.

＜正＞BACKGROUND:microcystin（MC）,a cyclic nonribosomal peptide,is mainly produced by the bloom-forming cyanobacerium microcystis,which has become an environmental hazard *** in freshwater is known to be very toxic for plants,animals,and *** term consumption of MC-containing water may induce liver damage,liver cancer,and even human ***,in addition to removal or neutralization of MC in drinking water,novel strategies that prevent health damages are urgently ***（SFN）,a natural-occurring isothiocyanate from cruciferous vegetables,has been reported to reduce and eliminate toxicities from xenobiotics and carcinogens.

关键词： microcystin-LR(MC-LR) Sulforaphane(SFN) NF-E2-related factor 2(Nrf2) PhaseⅡenzymes Glutathione(GSH) Chemoprevention

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Improvement of Renewable Bioenergy Production in microbial Fuel Cells with Saponin Supplementation

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Journal of Sustainable Bioenergy Systems 2021年第2期11卷 82-93页

作者： Skylar Choi Yongjin Park Immanuel H. Anaborne Jin Sik Song Ji Woo Han So Hyun Jeon Jaewoo Kim James Kim Jinkwon Lee Paul S. chung Horace Greeley High School Chappaqua NY USA Deerfield Academy Deerfield MA USA Oakton High School Vienna VA USA School of Arts & Sciences University of Virginia Charlottesville VA USA School of Arts & Sciences Emory University Atlanta GA USA Bachelor of Science Villanova University Villanova PA USA College of Letters & Sciences University of California Los Angeles Los Angeles CA USA School of Arts & Sciences University of Michigan Ann Arbor MI USA Division of Biological Sciences Revelle College University of California San Diego CA USA Fuzbien Technology Institute Rockville MD USA

microbial fuel cell (MFC) is one of renewable biofuel production technology that directly converts biomass to electricity. Cellulosic biomass is particularly attractive renewable resources for its low cost and abundance and neutral carbon balance. However, methanogenesis remains as a major factor limiting MFC performance. The current study reports that saponin addition at 0.05% w/v dose to anolyte in MFCs inhibited methanogenesis and improves power generation and cellulose fermentation. Mediator-less two chamber H-type MFCs were prepared using rumen fluid as anode inocula at 20% v/v of anolyte to convert finely ground pine tree (Avicel) at 2%, w/v to electricity. Saponin was added to the anode of MFC at 0.005% or 0.05% v/v dosage for treatment. MFC power and current across an external resistor were measured daily for 10d. On d10, collected gases from anode compartment were measured for total gas volume and analyzed for gas composition on gas chromatography. Supplementation of saponin to MFC at 0.005% did not have any effects on electricity generation or biogas production and composition. Saponin at 0.05% dose reduced 10%mily:Verdana;"> of methane prod

关键词： microbial Fuel Cells Saponin Bioenergy

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Patients with breath test positive are necessary to be identified from irritable bowel syndrome:a clinical trial based on microbiomics and rifaximin sensitivity

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Chinese Medical Journal 2022年第14期135卷 1716-1727页

作者： Zuojing Liu Shiwei Zhu Meibo He Mo Li Hui Wei Lu Zhang Qinghua Sun Qiong Jia Nan Hu Yuan Fang Lijin Song Chen Zhou Heqing Tao John Y Kao Huaiqiu Zhu chung Owyang Liping Duan Department of Gastroenterology Peking University Third HospitalHaidian DistrictBeijing 100191China Department of Ultrasound Peking University Third HospitalHaidian DistrictBeijing 100191China Institute of Systems Biomedicine School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Department of Biomedical Engineering College of EngineeringPeking UniversityBeijing 100187China Division of Gastroenterology Department of Internal MedicineUniversity of Michigan Health System6520 MSRB ISPC 56821150 West Medical Center DriveAnn ArborMI 48109USA

Background:As a non-invasive and effective diagnostic method for small intestinal bacterial overgrowth(SIBO),wild-use of breath test(BT)has demonstrated a high comorbidity rate in patients with diarrhea-predominant irritable bowel syndrome(IBS-D)and *** overlapping with SIBO respond better to rifaximin therapy than those with IBS-D *** microbiota plays a critical role in both of these two *** aimed to determine the microbial difference between IBS-D overlapping with/without SIBO,and to study the underlying mechanism of its sensitivity to ***:Patients with IBS-D were categorized as BT-negative(IBSN)and BT-positive(IBSP).Healthy volunteers(BT-negative)were enrolled as healthy *** patients were clinically evaluated before and after rifaximin treatment(0.4 g bid,4 weeks).Blood,intestine,and stool samples were collected for cytokine assessment and gut microbial ***:Clinical complaints and microbial abundance were significantly higher in IBSP than in *** contrast,severe systemic inflammation and more active bacterial invasion function that were associated with enrichment of opportunistic pathogens were seen in *** symptoms of IBSP patients were relieved in different degrees after therapy,but the symptoms of IBSN rarely *** also found that the presence of IBSN-enriched genera(Enterobacter and Enterococcus)are unaffected by rifaximin ***:IBS-D patients overlapping with SIBO showed noticeably different fecal microbial composition and function compared with IBS-D *** better response to rifaximin in those comorbid patients might associate with their different gut microbiota,which suggests that BT is necessary before IBS-D diagnosis and use of ***:Chinese Clinical Trial Registry,ChiCTR1800017911.

关键词： Irritable bowel syndrome Small intestinal bacterial overgrowth Breath test Gut microbiota Rifaximin

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Cultured circulating tumor cells and their derived xenografts for personalized oncology

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Asian Journal of Urology 2016年第4期3卷 240-253页

作者： Ruoxiang Wang Gina CYChu Stefan Mrdenovic Alagappan A.Annamalai Andrew E.Hendifar Nicholas N.Nissen James S.Tomlinson michael Lewis Nallasivam Palanisamy Hsian-Rong Tseng Edwin M.Posadas michael R.Freeman Stephen J.Pandol Haiyen E.Zhau Leland W.K.chung Uro-Oncology Research Department of MedicineSamuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA Uro-Oncology Research Department of SurgerySamuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA Department of Surgery West Los Angeles VA HospitalGreater Los Angeles Veterans Affairs Healthcare SystemLos AngelesCAUSA Department of Pathology West Los Angeles VA HospitalGreater Los Angeles Veterans Affairs Healthcare SystemLos AngelesCAUSA Henry Ford Health System DetroitMIUSA Department of Molecular and Medical Pharmacology University of California Los AngelesLos AngelesCAUSA

Recent cancer research has demonstrated the existence of circulating tumor cells(CTCs)in cancer patient’s *** identified,CTC biomarkers will be invaluable tools for clinical diagnosis,prognosis and *** this review,we propose ex vivo culture as a rational strategy for large scale amplification of the limited numbers of CTCs from a patient sample,to derive enough CTCs for accurate and reproducible characterization of the biophysical,biochemical,gene expressional and behavioral properties of the harvested *** of tumor cell heterogeneity,it is important to amplify all the CTCs in a blood sample for a comprehensive understanding of their role in cancer *** analyzing critical steps and technical issues in ex vivo CTC culture,we developed a cost-effective and reproducible protocol directly culturing whole peripheral blood mononuclear cells,relying on an assumed survival advantage in CTCs and CTC-like cells over the normal cells to amplify this specified cluster of cancer cells.

关键词： Cancer metastasis Peripheral blood Circulating tumor cell ex vivo culture

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长期热处理引起无毛鼠皮肤形成皱纹和氧化性损伤

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热处理技术与装备 2012年第6期33卷 63-63页

作者： mi Hee Shin Jo -Eun Seo Yeon Kyung Kim Kyu Han Kim Jin Ho chung

前面我们已经指出热振动能够引起皮肤细胞中母体金属蛋白酶的出现，这些结果也关系到长期热处理引起皮肤起皱纹。最近的研究中，我们检查到长期热处理（43℃，30min，3次／周，6周）在无毛鼠的皮肤形起皱纹。我们发现无毛鼠的皮肤经6周... 详细信息

前面我们已经指出热振动能够引起皮肤细胞中母体金属蛋白酶的出现，这些结果也关系到长期热处理引起皮肤起皱纹。最近的研究中，我们检查到长期热处理（43℃，30min，3次／周，6周）在无毛鼠的皮肤形起皱纹。我们发现无毛鼠的皮肤经6周一个周期反复热处理后引起皮肤起皱纹。在组织结构上无毛鼠的皮肤经热处理导致MMP-13蛋白质和mRNA的出现明显增加，但不是MMP-2和-9。我们还要指出长期热处理会降低抗氧化剂（过氧化氢酶）和过氧化物歧化酶（SOD）。另外，承受长期热振动后在老鼠皮肤上增加氧化性损伤。

关键词：皮肤细胞氧化性损伤热处理老鼠皱纹无毛过氧化物歧化酶 MMP-13

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Electrostatic spraying for flne-tuning particle dimensions to enhance oral bioavailability of poorly water-soluble drugs

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Asian Journal of Pharmaceutical Sciences 2024年第5期 141-153页

作者： Jung Suk Kim Seunghyun Cheon mi Ran Woo Sanghyun Woo Jee-Eun chung Yu Seok Youn Kyung Taek Oh Soo-Jeong Lim Sae Kwang Ku Bao Loc Nguyen Jong Oh Kim Sung Giu Jin Han-Gon Choi College of Pharmacy Hanyang University School of Pharmacy Sungkyunkwan University College of Pharmacy Chung-Ang University Department of Bioscience and biotechnology Sejong University Department of Anatomy and Histology College of Korean Medicine Daegu Haany University College of Pharmacy Yeungnam University Department of Pharmaceutical Engineering Dankook University

While spray-drying has been widely utilized to improve the bioavailability of poorly water-soluble drugs, the outcomes often exhibit suboptimal particle size distribution and large particle sizes, limiting their effectiveness. In this study, we introduce electrostatic spraying as an advanced technology tailored for poorly water-soluble drugs, enabling the fabrication of nanoparticles with flne and uniform particle size distribution. Regorafenib(1 g), as a model drug, copovidone(5 g), and sodium dodecyl sulfate(0.1 g) were dissolved in 200 ml ethanol and subjected to conventional-spray-dryer and electrostatic spray dryer. The electrostatic spray-dried nanoparticles(ESDN) showed smaller particle sizes with better uniformity compared to conventional spray-dried nanoparticles(CSDN). ESDN demonstrated signiflcantly enhanced solubility and rapid release in water. In vitro studies revealed that ESDN induced apoptosis in HCT-116 cells to a greater extent, exhibiting superior cytotoxicity compared to CSDN. Furthermore, ESDN substantially improved oral bioavailability and antitumor efflcacy compared to CSDN. These flndings suggest that ESD shows potential in developing enhanced drug delivery systems for poorly water-soluble drugs, effectively addressing the limitations associated with CSD methods.

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Effects of 2-Bromopropane on Mouse Embryo Development in vitro

Effects of 2-Bromopropane on Mouse Embryo Development in vit...

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中国实验动物学会第六届学术年会

作者： Cheng-Zhe Jiang, Jeong-Doo Her, Moon-Koo chung, Jong-Choon Kim (Korea Institute of Toxicology, P.O. Box 123, Yuseong, Daejeon,Korea College of Veterinary Medicine, Chonnam National University, Gwangju, Korea)

Recently we have demonstrated that a 12-day s.c. dose of 2-Bromopropane(2-BP) to pregnant mice during pregnancy resulted in significant developmental toxicity at dose levels of above 1250 mg/kg/day. However, the cause and effect relationship between maternal and developmental toxicities could not be elucidated in the previous study. The present study was conducted to determine the relationship between maternal and developmental toxicities of 2-BP using a whole embryo culture technique. ICR mouse embryos were explanted on gesta-tional day 8.5 and cultured for 48 hrs in the immediately centrifuged and heat-inactivated rat serum containing 0, 2.5, 5 or 10 mg2-BP/ml. After 48 hrs in culture, the growth and development of embryos we recompared and each embryo was evaluated for the presence of any malformations . Atabove 5 mg/ml of culture medium, decreases in developmental score and protein content and an increase in the incidence of morphological alterations were observed. Characteristic malformations included microcephaly, shortened proscencephalon, open anterior neuropore, open cranial neuropore, kinked somite, and abnormal axial rotation. There were no adverse effects on embryonic growth and development at aconcentration level of 2.5 mg 2-BP/mi of culture medium. The results showed that exposure of 2-BP to mouse embryos caused a direct developmental toxicity.

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汉语方位短语中的概念及介词共现模式研究

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语料库语言学 2016年第2期3卷 25-49,114-115页

作者：赵逢毅钟晓芳台湾工业技术研究院台湾政治大学

中文的方位短语主要可以由前饰词(如,以、之)与后缀词(如,边、面、头)组合而成,结合了明确的方向指引(如,前后、上下、左右、里外等)。这样的组成会避免在实际使用上不存在的组合逻辑,而此现象在方位短语的构成中同样可见。本研究旨在... 详细信息

中文的方位短语主要可以由前饰词(如,以、之)与后缀词(如,边、面、头)组合而成,结合了明确的方向指引(如,前后、上下、左右、里外等)。这样的组成会避免在实际使用上不存在的组合逻辑,而此现象在方位短语的构成中同样可见。本研究旨在分析从Sketch Engine中提取出的中文方位名词短语的概念合成模式,并使用具有知识层级架构的中文同义词词林(梅家驹等1983)来计算方位短句里所包含的知识概念组成模式,试图从统计方法上寻得在十亿字中文语料库里诠释方位词组组合模式的实证信息。本研究运用互信息法(Point-wise Mutual Information,Pmi)计算两个概念间的相关性,并使用多变量互信息法(Multivariate Mutual Information,Mmi)(Cruys 2011)计算3个概念间的相关性,最后亦针对方位短语中适用的介词及适用的方位词构词进行分析。本研究的统计结果除了能了解所选语料库使用方位名词的情况外,亦能从单一及成对出现的语境概念内容(描述人、物、时空等)在同义词词林中第一阶层的名词,分析各种方位短语使用前饰词与后缀语的搭配方式。期盼本研究能对方位词汇的分析提供参考模式。

关键词：中文方位词同义词词林互信息多变量互信息介词

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使用70kV管电压CT脑血管成像的实验设计:改善血管增强效果同时减少对比剂用量和辐射剂量

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国际医学放射学杂志 2015年第4期 394-394页

作者： E.S.Cho T.S.chung S.J.Ahn K.H.Chong J.H.Baek S.H.suh 刘学焕 Department of Radiology Yonsei University College of Medicine Gangnam Severance Hospital

摘要目的与使用120 k V管电压的扫描方案比较,确定使用70 k V管电压进行CT脑血管成像的可行性,并确定70 k V管电压方案可能降低的对比剂(CM)用量。方法设置

关键词：管电压辐射剂量对比剂脑血管 CT

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