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Blockage of ATPase-mediated energy supply inducing metabolic disturbances in algal cells under silver nanoparticles stress

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Journal of Environmental Sciences 2023年第9期131卷 141-150页

作者： Ruohua Qu mi chen Jingfu Liu Qiting Xie Na Liu Fei Ge Department of Environment College of Environment and ResourcesXiangtan UniversityXiangtan 411105China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Adenosine triphosphate(ATP)generation of aquatic organisms is often subject to nanoparticles(NPs)stress,involving extensive reprogramming of gene expression and changes in enzyme activity accompanied by metabolic disturbances.However,little is known about the mechanism of energy supply by ATP to regulate the metabolism of aquatic organisms under NPs stress.Here,we selected extensively existing silver nanoparticles(AgNPs)to investigate their implications on ATP generation and relevant metabolic pathways in alga(Chlorella vulgaris).Results showed that ATP content significantly decreased by 94.2%of the control(without AgNPs)in the algal cells at 0.20 mg/L AgNPs,which was mainly attributed to the reduction of chloroplast ATPase activity(81.4%)and the downregulation of ATPase-coding genes atpB and atpH(74.5%-82.8%)in chloroplast.Molecular dynamics simulations demonstrated that AgNPs competed with the binding sites of substrates adenosine diphosphate and inorganic phosphate by forming a stable complex with ATPase subunit beta,potentially resulting in the reduced binding efficiency of substrates.Furthermore,metabolomics analysis proved that the ATP content positively correlated with the content of most differential metabolites such as D-talose,myo-inositol,and L-allothreonine.AgNPs remarkably inhibited ATPinvolving metabolic pathways,including inositol phosphate metabolism,phosphatidylinositol signaling system,glycerophospholipid metabolism,aminoacyl-tRNA biosynthesis,and glutathione metabolism.These results could provide a deep understanding of energy supply in regulating metabolic disturbances under NPs stress.

关键词： Adenosine triphosphate Metabolomics Molecular dynamics simulations Nanoparticles Algae

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"Cusp-overlap" technique simplifies the implantation of Chinese domestic transcatheter valve in transcatheter aortic valve implantation

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Chinese Medical Journal 2021年第8期134卷 976-977页

作者： mi chen Li-Zhong Sun Department of Cardiac Surgery Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Department of Cardiac Surgery University Hospital of ZurichUniversity of ZurichZurich 8091Switzerland

Currently,transcatheter aortic valve implantation(TAVI)has become a feasible interventional technique for severe aortic stenosis in patients who deemed inoperable or are at high surgical risk.In China,the TAVI technique started from 2010.Until now two domestic devices J Valve(Jie cheng Medical Technologies,Suzhou,China)and Venus AValve(Venus MedTech,Hangzhou,China)have been allowed access into the market in 2017,since then most centers began to set up TAVI programs.Venus A-Valve is the only transfemoral transcatheter valve in China which approximately has been implanted 4000 times,till VitaFlow(microPort,Shanghai,China)and SAPIEN 3(Edwards Lifesciences,Irvine,CA,USA)entered the market in China a few months ago.

关键词： transcatheter Irvine implantation

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Research on Greenway Route Selection of Traditional Villages Based on GIS: A Case Study of Xingtai County, China

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Journal of Geographic Information System 2022年第4期14卷 315-331页

作者： Huixuan chen mi chen Yu Li Dandan Zhang National Key Laboratory Cultivation Base of Urban Environmental Process and Digital Simulation Capital Normal University Beijing China Beijing Laboratory of Water Safety Capital Normal University Beijing China School of Resources Environment and Tourism Capital Normal University Beijing China National Institute of Natural Hazards Ministry of Emergency Management of the People’s Republic of China (MEMC) Beijing China Land Satellite Remote Sensing Application Center The Ministry of Natural Resources Beijing China

Greenway is a green linear corridor connecting scenic spots, residential areas, nature reserves, road traffic, etc. Rational greenway route selection can not only attract tourists to increase the income of local villages, but also arouse people’s awareness of the protection of traditional villages. This paper took Xingtai County, Hebei Province, China as an example to practice greenway route selection in the county territory. Eight factors were selected for greenway route planning, namely elevation, water body, mountain, ecological protection redline, cultural relics protection units, population density, road traffic network, and important transportation hub. These eight factors were assigned in the GIS platform, and the suitability evaluation system of each factor was constructed. The analytic hierarchy process (AHP) and entropy weight method were combined to calculate the weight of these eight factors. The raster calculator was used to weight and overlay the suitability evaluation system of each factor, and the comprehensive suitability evaluation map of greenway route selection was obtained. Based on an important transport hub, along with the water body and the road traffic, the final selection greenway route of traditional villages in Xingtai county was formed. The results of the research can provide a certain reference for the greenway route selection at the county scale.

关键词： Greenway Route Selection Suitability Evaluation AHP Entropy Weight Method GIS

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失落的乡土:旅游飞地效应下传统村落发展迷思

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黑龙江生态工程职业学院学报 2024年第3期37卷 49-52页

作者：陈密暨南大学深圳旅游学院旅游管理系广东深圳518000

基于旅游飞地理论,以广西壮族自治区桂林市雁山区大埠乡大岗埠传统村落为个案,运用田野调查和口述史的研究方法,在实地调研过程中追溯大岗埠传统村落旅游发展过程中飞地现象的成因,从空间、社会文化、经济三个方面探究旅游飞地对传统村... 详细信息

基于旅游飞地理论,以广西壮族自治区桂林市雁山区大埠乡大岗埠传统村落为个案,运用田野调查和口述史的研究方法,在实地调研过程中追溯大岗埠传统村落旅游发展过程中飞地现象的成因,从空间、社会文化、经济三个方面探究旅游飞地对传统村落可持续发展的影响,通过进一步讨论分析得出破解旅游飞地消极效应的对策,为缓解当地社区和旅游景区之间的矛盾冲突提出建议,助力大岗埠传统村落振兴发展。

关键词：旅游飞地传统村落地中海俱乐部

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基于马斯定律优化VRLA电池快充参数

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电池 2024年第3期54卷 379-382页

作者：汤秀芬米晨宁夏大学电子与电气工程学院宁夏银川750021 宁夏大学资产与实验室管理处宁夏银川750021

分析阀控式铅酸(VRLA)电池充电时遵循的马斯定律,提出在充电过程中加入负脉冲放电去极化,减少过电势,既能提高电池初始充电可接受电流,又能提高充电可接受率的脉冲快速充电方法。制作用于12 V/20 Ah以下VRLA电池的脉冲快速充电电路,通... 详细信息

分析阀控式铅酸(VRLA)电池充电时遵循的马斯定律,提出在充电过程中加入负脉冲放电去极化,减少过电势,既能提高电池初始充电可接受电流,又能提高充电可接受率的脉冲快速充电方法。制作用于12 V/20 Ah以下VRLA电池的脉冲快速充电电路,通过多次充电实验,确定具体的充电阶段和优化的充电参数。VRLA电池脉冲快速充电电路通过第一阶段较大电流恒流充电,在较短的时间内尽量充入较多的电量,第二阶段优化充电参数的脉冲循环快速充电,可减小电池的浓差极化,充电效率大为提高,从而达到快速、无损充电的目的。

关键词：阀控式铅酸(VRLA)电池马斯定律脉冲快速充电参数优化负脉冲放电

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A novel ground surface subsidence prediction model for sub-critical mining in the geological condition of a thick alluvium layer

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Frontiers of Earth Science 2015年第2期9卷 330-341页

作者： Zhanqiang CHANG Jinzhuang WANG mi chen Zurui AO Qi YAO College of Resource Environment & Tourism Capital Normal University Beijing 100048 China Institute of Earth Sciences and Mapping China University of Mining and Technology Beijing 100083 China

A substantial number of the coal mines in China are in the geological condition of thick alluvium layer. Under these circumstances, it does not make sense to predict ground surface subsidence and other deformations by using conventional prediction models. This paper presents a novel ground surface subsidence prediction model for sub-critical mining in the geological condition of thick alluvium layer. The geological composition and mechanical properties of thick alluvium is regarded as a random medium, as are the uniformly distributed loads on rock mass; however, the overburden of the rock mass in the bending zone is looked upon as a hard stratum controlling the ground surface subsidence. The different subsidence and displacement mechanisms for the rock mass and the thick alluvium layer are respectively considered and described in this model, which indicates satisfactory performances in a practical prediction case.

关键词： ground surface subsidence thick alluviumlayer sub-critical mining prediction model

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溴莫尼定联合噻吗洛尔治疗青光眼的效果分析

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中国社区医师 2024年第6期40卷 32-34页

作者：陈弥常德市第一人民医院眼科湖南常德415000

目的:分析溴莫尼定联合噻吗洛尔治疗青光眼的效果。方法:选取2022年4月—2023年4月常德市第一人民医院收治的82例青光眼患者作为研究对象,采用随机数字表法分为观察组和对照组,各41例。对照组采用噻吗洛尔治疗,观察组在对照组基础上联... 详细信息

目的:分析溴莫尼定联合噻吗洛尔治疗青光眼的效果。方法:选取2022年4月—2023年4月常德市第一人民医院收治的82例青光眼患者作为研究对象,采用随机数字表法分为观察组和对照组,各41例。对照组采用噻吗洛尔治疗,观察组在对照组基础上联合溴莫尼定治疗。比较两组治疗效果。结果:治疗1周后,两组眼压低于治疗前,差异有统计学意义(P<0.05),但两组比较,差异无统计学意义(P=0.135);治疗后2、3、4周后,两组眼压低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.026)。治疗后,两组睫状后动脉(PCA)和视网膜中央动脉(CRA)血管阻力指数低于治疗前,且观察组低于对照组,两组PCA和CRA收缩期峰值血流速度、舒张末期血流速度快于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率低于对照组,差异有统计学意义(P=0.034)。结论:溴莫尼定联合噻吗洛尔治疗青光眼的效果显著,能够降低眼压,改善眼底血流动力学,且不良反应发生率低。

关键词：溴莫尼定噻吗洛尔青光眼

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Bioactive biodegradable polycitrate nanoclusters enhances the myoblast differentiation and in vivo skeletal muscle regeneration via p38 MAPK signaling pathway

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Bioactive Materials 2020年第3期5卷 486-495页

作者： Yi Guo min Wang Juan Ge Wen Niu mi chen Wei cheng Bo Lei Frontier Institute of Science and Technology Xi'an Jiaotong UniversityXi'an710054China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi'an Jiaotong UniversityXi'an710054China National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710000China Instrument Analysis Center Xi'an Jiaotong UniversityXi'an710054China Department of Biomedical Engineering University of MichiganAnn ArborMI48109United States

Complete skeletal muscle repair and regeneration due to severe large injury or disease is still a challenge.Biochemical cues are critical to control myoblast cell function and can be utilized to develop smart biomaterials for skeletal muscle engineering.Citric acid-based biodegradable polymers have received much attention on tissue engineering,however,their regulation on myoblast cell differentiation and mechanism was few investigated.Here,we find that citrate-based polycitrate-polyethylene glycol-polyethylenimine(POCG-PEI600)nanoclusters can significantly enhance the in vitro myoblast proliferation by probably reinforcing the mitochondrial number,promote the myotube formation and full-thickness skeletal muscle regeneration in vivo by activating the myogenic biomarker genes expression of Myod and Mhc.POCG-PEI600 nanoclusters could also promote the phosphorylation of p38 in MAP kinases(MAPK)signaling pathway,which led to the promotion of the myoblast differentiation.The in vivo skeletal muscle loss rat model also confirmed that POCG-PEI600 nanoclusters could significantly improve the angiogenesis,myofibers formation and complete skeletal muscle regeneration.POCG-PEI600 nanocluster could be also biodegraded into small molecules and eliminated in vivo,suggesting their high biocompatibility and biosafety.This study could provide a bioactive biomaterial-based strategy to repair and regenerate skeletal muscle tissue.

关键词： Bioactive biomaterials Citrate nanopolymer Myoblast differentiation Skeletal muscle regeneration

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Stackelberg微分博弈下的鲁棒最优投资-再保险问题

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吉林大学学报（理学版） 2024年第2期62卷 273-284页

作者：颜炳文陈密刘海燕福建师范大学数学与统计学院福州350117 福建省分析数学及应用重点实验室福州350117

考虑一个以模糊厌恶再保险公司为领导者,模糊中立保险公司为追随者的Stackelberg随机微分博弈问题.通过求解拓展的HJB(Hamilton-Jacobi-Bellman)方程组,给出时间一致性均值-方差准则下的鲁棒最优投资-再保险策略以及相应的值函数.最后,... 详细信息

考虑一个以模糊厌恶再保险公司为领导者,模糊中立保险公司为追随者的Stackelberg随机微分博弈问题.通过求解拓展的HJB(Hamilton-Jacobi-Bellman)方程组,给出时间一致性均值-方差准则下的鲁棒最优投资-再保险策略以及相应的值函数.最后,通过数值例子和敏感性分析说明最优策略与主要参数之间的关系.

关键词：比例再保险常系数方差弹性模型 Stackelberg微分博弈时间一致性均值-方差框架模糊厌恶

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损失依赖保费下的稳健最优投资和再保险策略

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兰州文理学院学报（自然科学版） 2024年第2期38卷 8-14页

作者：苏毅明陈密福建师范大学数学与统计学院福建福州350117 福建省分析数学及应用重点实验室福建福州350117

探究了在最大化终端期望指数效用准则下保险人的稳健最优投资和再保险问题.其中,保险人采用了损失依赖保费原则,而再保险人由于信息不对称仍采用期望保费原则,风险投资由GBM模型刻画.通过动态规划原理处理稳健优化问题后可得到稳健最优... 详细信息

探究了在最大化终端期望指数效用准则下保险人的稳健最优投资和再保险问题.其中,保险人采用了损失依赖保费原则,而再保险人由于信息不对称仍采用期望保费原则,风险投资由GBM模型刻画.通过动态规划原理处理稳健优化问题后可得到稳健最优投资和再保险策略以及相应的值函数.最后,用数值模拟验证参数对最优策略的影响.

关键词：再保险和投资损失依赖保费指数效用最大化不确定模型

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