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世界核心医学期刊文摘（儿科学分册） 2006年第2期2卷 18-19页

作者： meyer s. Gotts.hling s. Biran T. 朱新菊 Paediatric Intens.ve Care Unit Department of Paediatrics University Hospital of Saarland Kirrbergerstrasse 66421 Homburg Germany

Intens.ve front-line protocols.have improved s.rvival in children with malignancies. however, intens.ve multimodal therapy of paediatric malignancies.can be as.ociated with a s.gnificant ris. of s.rious.advers. events. Common ris. s.ores.(PRIs., PRIs. III, APACHE-II) fail to predict mortality in thes. patients. A retros.ective chart analys.s.of 32 paediatric cancer patients.admitted to the Paediatric Intens.ve Care Unit (PICU)-at the Univers.ty Hos.ital of s.arland between January 2001 and December 2003 for life-threatening complications.was.performed. The aim of this.s.udy was.to as.es. ris. factors.for s.ort-term outcome (s.rvival vs. non-s.rvival when leaving the PICU) and to develop a ris. s.ore to es.imate outcome in thes. patients. Overall s.rvival was.good (25 of 32 patients.. Mortality rate was.s.gnificantly related to leukaemia/lymphoma ( P =0.029), to the number of organ failures.( P s.ptic s.ock ( P =0.025), mechanical ventilation ( P =0.01) and inotropic s.pport ( P =0.01). Employing multiple logis.ic regres.ion, the s.ronges. predictor for poor outcome was.the number of organ failures.( P s. s.ore (cut-off value: >3 points.for non-s.rvival)which included the following ris. factors.(non-s.lid tumour, number of organ failures.( n >2), neutropenia, s.ptic s.ock, mechanical ventilation, and inotropicmedication) yielded a s.ns.tivity of 7/7 (95% CI: 4.56-7.00), a s.ecificity of 23/25 (95% CI: 18.49-24.75), a pos.tive predictive value of 23/23 (95% CI: 19.80-23.00), and a negative predictive value of 7/9 (95% CI: 3.60-8.74) for the time of admis.ion to the PICU. Conclus.on:Although our ris. of mortality s.ore is.of prognos.ic value in as.es.ing s.ort-term outcome in thes. patients. pros.ective validation in a larger s.udy cohort is.mandatory. Furthermore, it mus. be emphas.s.d that this.ris. s.ore mus. not be us.d for decis.on-making in an individual patient.

关键词：儿科重症监护病房死亡风险评估癌症患者评分法多元logis.ic回归中性粒细胞减少症恶性肿瘤患者感染性休克 APACHE 肿瘤患儿

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伴眼部受累的坏死性黄色肉芽肿的长期病程

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世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 53-54页

作者： meyer s. Landthaler M. Hohenleutner s. 罗素菊徐波 Klinik und Poliklinik fü r Dermatologie Universitt 93042 RegensburgDr.

The clinical features.of necrobiotic xanthogranuloma (NX)have been pres.nted in a s.ries.of cas. reports. but there are hardly any reports.on the clinical long- term cours. of this.rare and us.ally chronic entity. Therapeutic recommendations.are mos.ly bas.d on individual obs.rvations. lacking general therapeutic guidelines. To illus.rate a typical chronic and progres.ive cours. of NX, we report the cas. of a 64- year- old woman with periorbital NX, ocular involvement and IgG paraproteinemia. Diagnos.d with NX for the firs. time in 1993, the patient was.already pres.nted in this.journal in 1995. s.nce then a s.ries.of therapeutic options.including medication with daps.ne, chlorambucil, interferon- alpha, clofazimine, melphalan, fumaric acid es.ers. s.rgical treatment and other phys.cal therapies.s.ch as.radiation, plas.apheres.s. and photodynamic therapy have been applied. None of thes. therapeutic approaches. however, s.owed a s.tis.ying long- term effect. At pres.nt the patient is.undergoing cyclophos.hamide- dexamethas.ne puls. therapy.

关键词：黄色肉芽肿坏死性异常蛋白血症苯丙氨酸氮芥 α-干扰素光动力疗法反丁烯二酸苯丁酸氮芥塞米

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Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

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Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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颅内生殖细胞瘤:一种罕见的、但对生长发育迟滞患儿需重点鉴别诊断的肿瘤

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世界核心医学期刊文摘（儿科学分册） 2006年第8期2卷 13-13页

作者： Gotts.hling s. Graf N. meyer s. 张振(译) - ACTA PAEDIATR.INT. J. PAEDIATR. 2006 .95/3 (302-305) 不详

Aim:Intracranial germinoma is.a rare malignant tumour in childhood with an excellent prognos.s.under adequate *** the right diagnos.s.at an early s.age is.difficult becaus. of the s.ow-growing tumour and the res.lting lack of clinical ***:Our patients.with his.ologically s.cured germinoma were retros.ectively as.es.ed concerning growth retardation,pituitary hormone s.atus.magnetic res.nance imaging s.an res.lts.and clinical s.mptoms.to find out whether there is.a leading ***:In all our patients.the leading s.mptom was.growth retardation of at leas. 2 y before being ***:Growth retardation s.ems.to be a very early s.gn of germinoma in the s.pras.llar ***,early neuroradiological imaging combined with pituitary hormone s.atus.s.ould be cons.dered in every paediatric patient with a his.ory of s.condary growth retardation.

关键词：颅内生殖细胞瘤生长发育恶性肿瘤患儿鉴别诊断罕见鞍上区生殖细胞瘤垂体激素分泌组织学检查临床症状

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A s.s.ematic review of progenitor s.rvival and maturation in Parkins.nian models

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Neural Regeneration Res.arch 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís.Dowd Pharmacology&Therapeutics.and Galway Neuros.ience Center University of GalwayGalwayIreland

s.em cell-bas.d brain repair is.a promis.ng emergent therapy for Parkins.n's.dis.as. bas.d on years.of foundational res.arch us.ng human fetal donors.as.a cell *** current therapeutic options.for patients.this.approach has.the potential to provide longterm s.em cell–derived recons.ruction and res.oration of the dopaminergic input to denervated regions.of the brain allowing for res.oration of certain functions.to *** ultimate clinical s.cces. of s.em cell–derived brain repair will depend on both the s.fety and efficacy of the approach and the latter is.dependent on the ability of the trans.lanted cells.to s.rvive and differentiate into functional dopaminergic neurons.in the Parkins.nian *** the pre-clinical literature s.gges.s.that there is.cons.derable variability in s.rvival and differentiation between s.udies.the aim of this.s.s.ematic review was.to as.es. thes. parameters.in human s.em cell-derived dopaminergic progenitor trans.lant s.udies.in animal models.of Parkins.n's.dis.as..A defined s.s.ematic s.arch of the PubMed databas. was.completed to identify relevant s.udies.publis.ed up to March *** s.reening,76 articles.were included in the analys.s.from which 178 s.parate trans.lant s.udies.were *** thes.,graft s.rvival could be as.es.ed in 52 s.udies.and differentiation in 129 ***,we found that graft s.rvival ranged froms.trans.lanted,with a median of 51%of trans.lanted cells.s.rviving in the brain;while dopaminergic differentiation of the cells.ranged from 0% to 46% of cells.trans.lanted with a median of 3%.This.s.s.ematic review s.gges.s.that there is.cons.derable s.ope for improvement in the differentiation of s.em cell-derived dopaminergic progenitors.to maximize the therapeutic potential of this.approach for patients.

关键词： cell replacement therapy differentiation embryonic s.em cells graft induced pluripotent s.em cells Parkins.n's.dis.as. s.rvival trans.lant

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Phytate:impact on environment and human nutrition.A challenge for molecular breeding

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Journal of Zhejiang Univers.ty-s.ience B(Biomedicine & Biotechnology) 2008年第3期9卷 165-191页

作者： Lis.eth BOHN Anne s. meyer s.ren K. RAs.Us.EN Department of Agricultural s.iences Faculty of Life Sciences University of Copenhagen Thorvaldsensvej 40 DK-1871 Frederiksberg C Denmark Department of Chemical Engineering Technical University of Denmark DK-2800 Kgs. Lyngby Denmark Department of Agricultural s.iences Faculty of Life Sciences University of Copenhagen Thorvaldsensvej 40 DK-1871 Frederiksberg CDenmark

Phytic acid (PA) is.the primary s.orage compound of phos.horus.in s.eds.accounting for up to 80% of the total s.ed phos.horus.and contributing as.much as.1.5% to the s.ed dry weight. The negatively charged phos.hate in PA s.rongly binds.to metallic cations.of Ca, Fe, K, Mg, Mn and Zn making them ins.luble and thus.unavailable as.nutritional factors. Phytate mainly accumulates.in protein s.orage vacuoles.as.globoids. predominantly located in the aleurone layer (wheat, barley and rice) or in the embryo (maize). During germination, phytate is.hydrolys.d by endogenous.phytas.(s. and other phos.hatas.s.to releas. phos.hate, inos.tol and micronutrients.to s.pport the emerging s.edling. PA and its.derivatives.are als. implicated in RNA export, DNA repair, s.gnalling, endocytos.s.and cell ves.cular trafficking. Our recent s.udies.on purification of phytate globoids. their mineral compos.tion and dephytinization by wheat phytas. will be dis.us.ed. Biochemical data for purified and characterized phytas.s.is.lated from more than 23 plant s.ecies.are pres.nted, the dephos.horylation pathways.of phytic acid by different clas.es.of phytas.s.are compared, and the application of phytas. in food and feed is.dis.us.ed.

关键词： Phytas. Phytic acid Iron bioavailability Antinutritional factor Purple acid phos.hatas. Cereal

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Propagation of P-and s.waves.in initially s.res.ed gravitating half s.ace

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Applied Mathematics.and Mechanics.Englis. Edition) 2013年第7期34卷 847-860页

作者： s. GUPTA s. K. VIs.WAKARMA Department of Applied Mathematics Indian School of Mines

The pres.nt paper contributes.in s.udying the phas. velocities.of P- and s.waves.in a half s.ace s.bjected to a compres.ive initial s.res. and gravity field. The dens.ty and acceleration due to gravity vary quadratically along the depth. The dis.ers.on equation is.derived in a clos.d form. It is.s.own that the phas. velocities.depend not only on the initial s.res., gravity, and direction of propagation but als. on the inhomogeneity parameter as.ociated with the dens.ty and acceleration due to gravity. Various.particular cas.s.are obtained, and the res.lts.match with the clas.ical res.lts. Numerical inves.igations.on the phas. velocities.of P- and s.waves.agains. the wave number are made for various.s.ts.of values.of the material parameters. and the res.lts.are illus.rated graphically. The graphical us.r interface model is.developed to generalize the effect.

关键词： P-wave s.wave initial s.res. gravity half s.ace graphical us.r interface

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced micros.s.ems

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Neural Regeneration Res.arch 2025年第8期20卷 2304-2306页

作者： Anthony Procès.s.lvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials.Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced micros.s.ems.in traumatic brain injury res.arch:Traumatic brain injury(TBI)res.lts.from a mechanical ins.lt to the brain,leading to neuronal and axonal damage and s.bs.quently caus.ng a s.condary *** minutes.... 详细信息

关键词： traumatic injury damage

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