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World Journal of Gastroenterology 2007年第28期13卷 3868-3872页

作者： M Vidaurreta ml Maestro S Rafael S Veganzones MT Sanz-Casla J Cerdán M Arroyo Servicio de Análisis Clínicos Hospital Clínico San CarlosMadrid 28040Spain Servicio de Análisis Clínicos Hospital Clínico San CarlosMadrid 28040Spain Servicio de Cirugía General ⅢHospital Clínico San CarlosMadrid 28040Spain

AIM： To determine whether the telomerase activity is related to the Microsatellite instability （MSI） genetic pathway and whether it means a difference in the survival.METHODS： The population consisted of 97 colorectal cancer patients. MSI determination was performed in accordance with the NCI criteria using PCR and Genescan. Telomerase activity was determined by the TRAP-assay, an ELISA procedure based on the amplification of telomeric repeat sequences.RESULTS： 6.2% showed high MSI （MSI-H）, 10.3% showed low MSI （MSI-L） and 83.5% did not show this alteration （MSS）. Positive telomerase activity was detected in 92.8% of the patients. 83.3% of MSI-H tumors showed positive telomerase against 93.8% of MSS tumors. In the overall survival analysis the absence of telomerase activity conferred a better prognosis.CONCLUSION： Previous works have shown that tumors which develop via the MSI pathway present a better prognosis. No link between telomerase activity and MSl status is observed, although sample sizes are small. Patients with telomerase negative tumors had better overall survival than patients with telomerase positive tumors.

关键词： Microsatellite instability Telomerase Colorectal cancer Prognosis

Anterior Cervical Spine Osteosynthesis Complicated by Pharyngoesophageal Perforation

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Open Journal of Modern Neurosurgery 2018年第4期8卷 383-388页

作者： André Tokpa Louis Derou ml Konan Guy Varlet Dominique N’dri-Oka Department of Neurosurgery CHU de Yopougon Abidjan Cote d’Ivoire

Anterior cervical spine surgery for traumatic or degenerative disease is a well-established procedure. However, complications such as pharyngoesophageal perforation can occur. In this study, we report a series of 6 pharyngoesophageal perforations after surgery. Based on the literature review, we analyzed pathogenesis, diagnosis and discussed therapeutic strategies. Three cases occurred after surgeries of traumatic cervical spine whereas the remaining were after surgeries for degenerative cervical myelopathy. The mean duration of surgery was 210 minutes. The symptoms, appearing 48 hours after surgery, were commonly hyperthermia, dysphagia, sore throat and swelling of the incision site. The diagnostic was confirmed after contrast-enhanced esophagography. The treatment strategies consisted of insertion of nasogastric feeding tube, oral intake restriction, intravenous antibiotics administration, wound drainage. Reoperation was necessary in 4 cases with removal of the hardware in three of them. One death occurred by pulmonary embolism in a tetraplegic patient. The occurrence of pharyngoesophageal perforation after cervical spine surgery can be disastrous. It can be avoided by increasing surgeon awareness during the surgical procedure. Early detection, immediate and multidisciplinary therapy are recommended to achieve the best outcomes.

关键词： Cervical Spinal Surgery Osteosynthesis Complications Pharyngo Oesophageal Perforation

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分析化学在工业卫生中的应用

国外医学（卫生学分册） 1991年第2期18卷 69-76页

作者： Langhorst ml Coyne LB 刘海喜李维新

本文综述了1987、1988年分析化学在工业卫生中应用的某些技术问题,也包括1983、1985、1987年此题的综述内容。重点讨论采样、样品处理和各种分析方法,以及有关技术:衍生、剂量计、生物监测、气敏监测器、颗粒物分析和标准气配制等。

关键词：分析化学工业卫生采样样品处理

Medications for diabetic neuropathy

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中华物理医学与康复杂志 2015年第2期37卷 85-85页

作者： Griebeler ml Morey-Vargas OL Brito JP

BACKGROUND AND OBJECTIVE Diabetic neuropathy is a common, long-term complication that can decrease quality of life. While various neuropathic agents are useful for treating this pain, choosing one or the other can be challenging. This systematic review investigated the relative effectiveness of various medications used for the treatment of diabetic *** Databases were reviewed for randomized, controlled trials published between January of 2012 and April of 2014. The trials assessed the efficacy of medications for treating diabetic neuropathy, and compared the medication to placebo or to another *** Sixty-five, randomized, controlled trials, including 27 medications with 12, 632 patients analyzed. By drug class, SNRIs, topical capsaicin, TCAs, and anticonvulsants all resulted in larger and statistically significant reductions in pain, as compared with placebo. Head-to-head trials showed that SNRIs and TCAs reduced pain more than did anticonvulsants and topical capsaicin. Studies that evaluated long-term efficacy found that the aldose reductase inhibitors fidarestat, duloxetine and oxcarbazepine are all more effective than placebo. Indirect and direct comparisons among specific medications revealed greater pain control with carbamazepine, venlafaxine, duloxetine and amitriptyline as compared with *** This systematic review and meta-analysis of pharmacologic interventions for painful diabetic neuropathy found that carbamazepine, venlafaxine, duloxetine and amitriptyline are significantly better than placebo for controlling pain.

关键词：药物治疗糖尿病神经病变随机对照试验醛糖还原酶抑制剂度洛西汀试验评估

Exercise for whiplash associated disorder

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中华物理医学与康复杂志 2015年第5期37卷 364-364页

作者： Ludvigsson ml Peterson G O’Leary S

BACKGROUND AND OBJECTIVE Data suggest that, one year after injury, 50% of people with whiplash associated disorder (WAD) still report neck pain. Despite clinical recommendations, there remains no clinical evidence of benefit for many conservative methods of management of chronic WAD, including neck specific exercise. As chronic neck disorders may have symptoms with both physical and psychosocial contributing factors, this study assessed the effects of incorporating a behavioral approach to neck specific *** Subjects were 216 individuals with chronic WAD, with a mean age of 40.5 years. The subjects were randomized to receive either physiotherapist led neck specific exercise (NSE), twice-weekly, aimed at facilitating activity of the deep cervical muscle layers, or similar exercise combined with behavioral intervention. The behavioral treatment included education concerning pain, as well as activities aimed at pain management and problem solving (NSEB). A third group was prescribed physical activity, to be completed outside of the healthcare system (PPA). The primary outcome measure was the Neck Disability Index (NDI). Other outcome variables included self-reported general health, measured with the Euroqol 5-D instrument, and activity level, measured with the International Physical Activity Questionnaire. Pain was recorded with a pain visual analog scale (VAS).RESULTS At three months, disability levels were found to have significantly improved in both the NSE (P<0.01) and the NSEB (P<0.001) groups, with no improvement observed in the PPA group. At six months, the proportions of responders, as indicated by changes in scores on the NDI, were 21% in the PPA group, 28% in the NSE group and 54% in the NSEB group. Pain bothersomeness was significantly reduced over time in all three groups. Self-efficacy improved only in the NSE *** This study of patients with whiplash associated disorder found that supervised, neck specific exercise may have better

关键词：相关疾病消耗臭氧层物质锻炼 WAD 颈部数据表临床慢性

Effects of a nurse-led heart failure clinic on hospital readmission and mortality in Hong Kong

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Journal of Geriatric Cardiology 2016年第5期13卷 415-419页

作者： Ho Yu Cheng Sek Ying Chair Qun Wang Janet WH Sit Eliza ml Wong Siu Wai Tang The Nethersole School of Nursing: Faculty of Medicine The Chinese University of Hong Kong Hong Kong China Cardiac Rehabilitation Centre Tung Wah Eastern Hospital Hong Kong China

Background Heart failure （HF） is a physically and socially debilitating disease that carries the burden of hospital re-admission and mortality. As an aging society, Hong Kong urgently needs to find ways to reduce the hospital readmission of HF patients. This study evaluates the effects of a nurse-led HF clinic on the hospital readmission and mortality rates among older HF patients in Hong Kong. Methods This study is a retrospective data analysis that compares HF patient in a nurse-led HF clinic in Hong Kong compared with HF patients who did not attend the clinic. The nurses of this clinic provide education on lifestyle modification and symptom monitoring, as well as titrate the medications and measure biochemical markers by following established protocols. This analysis used the socio-demographic and clinical data of HF patients who were aged 〉 65 years old and stayed in the clinic over a six-month period. Results The data of a total of 78 HF patients were included in this data analysis. The mean age of the patients was 77.38 ± 6.80 years. Approximately half of the HF patients were male （51.3%）, almost half were smokers （46.2%）, and the majority received 〈 six years of formal education. Most of the HF patients （87.2%） belonged to classes II and III of the New York Heart Association Functional Classification, with a mean ejection fraction of 47.15± 20.31 ml. The HF patients who attended the clinic （n = 38, 75.13 ± 5.89 years） were significantly younger than those who did not attend the clinic （n = 40, 79.53 ± 6.96 years）（P = 0.04）, and had lower recorded blood pressure. No other statistically significant difference existed between the socio-demographic and clinical characteristics of the two groups. The HF patients who did not attend the nurse-led HF clinic demonstrated a significantly higher risk of hospital readmission [odd ratio （OR）： 7.40; P 〈 0.01] than those who attended after adjusting for the effect of age and blood pressure. In addition, HF patients who att

关键词： Heart failure Hospital readmission Mortality Nurse-led clinic

Ursodeoxycholic acid improves gastrointestinal motility defects in gallstone patients

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World Journal of Gastroenterology 2006年第33期12卷 5336-5343页

作者： A Colecchia G Mazzella L Sandri F Azzaroli M Magliuolo P Simoni ml Bacchi-Reggiani E Roda D Festi Department of Internal Medicine and Gastroenterology University of Bologna Bologna Italy Department of Pharmaceutical Sciences University of Bologna Bologna Italy Department of Cardiovascular Diseases University of Bologna Bologna Italy

AIM: To simultaneously evaluate the presence of defects in gallbladder and gastric emptying, as well as in intestinal transit in gallstone patients (GS) and the effect of chronic ursodeoxycholic acid (UDCA) administration on these parameters and on serum bile acids and clinical outcome in GS and controls (CTR). METHODS: After a standard liquid test meal, gallbla-dder and gastric emptying (by ultrasound), oroileal transit time (OITT) (by an immunoenzymatic technique) and serum bile acids (by HPLC) were evaluated before and after 3 mo of UDCA (12 mg/kg bw/d) or placebo administration in 10 symptomatic GS and 10 matched healthy CTR. RESULTS: OITT was longer in GS than in CTR (P < 0.0001); UDCA significantly reduced OITT in GS (P < 0.0001), but not in CTR. GS had longer gastric half-emptying time (t1/2) than CTR (P < 0.0044) at baseline; after UDCA, t1/2 significantly decreased (P < 0.006) in GS but not in CTR. Placebo administration had no effect on gastric emptying and intestinal transit in both GS and CTR. CONCLUSION: The gallstone patient has simultaneous multiple impairments of gallbladder and gastric emptying, as well as of intestinal transit. UDCA administration restores these defects in GS, without any effect in CTR. These results confirm the pathogenetic role of gastrointestinal motility in gallstone disease and suggest an additional mechanism of action for UDCA in reducing bile cholesterol supersaturation.

关键词： Bile acids Biliary cholesterol Deoxycholic acid Gallbladder emptying Gastric emptying Intestinaltransit Tauroursodeoxycholic acid

一种在表面形成Al_2O_3膜的新型耐热奥氏体不锈钢

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自然杂志 2008年第4期30卷 189-193页

作者： BRADY MP YAMAMOTO Y MAZIASZ PJ SANTELLA ml 韦习成美国橡树岭国家实验室上海大学

一类以在材料表面形成Al2O3膜的奥氏体不锈钢(AFA)的开发正如火如荼地在全球展开。这类合金与传统的、在其表面形成Cr2O3膜的不锈钢相比,在不牺牲其成本、蠕变抗力和可焊性等其它性能的同时具有更高的使用温度和更好的耐环境侵蚀能力。... 详细信息

一类以在材料表面形成Al2O3膜的奥氏体不锈钢(AFA)的开发正如火如荼地在全球展开。这类合金与传统的、在其表面形成Cr2O3膜的不锈钢相比,在不牺牲其成本、蠕变抗力和可焊性等其它性能的同时具有更高的使用温度和更好的耐环境侵蚀能力。作者简要介绍了该合金的开发方法和其抗氧化和蠕变抗力方面的数据。

关键词：奥氏体不锈钢耐热表面处理

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血浆脂联素水平与原发性高血压的关系

中国组织工程研究与临床康复 2007年第21期11卷 4213-4216页

作者：胡明磊胡世红广西医科大学广西壮族自治区南宁市530000 广西医科大学第五附属医院

目的:查明原发性高血压及降压药物对血浆脂联素水平的影响,揭示升高血浆脂联素水平的临床意义。资料来源:应用计算机检索Medline 1996-01/2006-12与脂联素及高血压相关的文献,检索词为“adiponectin,hypertension”,并限定文章语种为Eng... 详细信息

目的:查明原发性高血压及降压药物对血浆脂联素水平的影响,揭示升高血浆脂联素水平的临床意义。资料来源:应用计算机检索Medline 1996-01/2006-12与脂联素及高血压相关的文献,检索词为“adiponectin,hypertension”,并限定文章语种为English。同时检索中国期刊全文数据库1996-01/2006-12有关脂联素的文章,检索词为“脂联素,高血压”,限定文章语种为中文。资料选择:对资料进行初审,选取包括脂联素基因、蛋白、受体及与高血压研究密切相关的文献。涉及到影响血浆脂联素的治疗药物,优先选择临床随机对照试验。排除标准:重复性研究。资料提炼:共收集210篇关于脂联素与高血压的研究文献,其中综述类文献20篇,选择2篇,英文随机对照试验8篇,全部选入。排除与选择标准关系不大的177篇。资料综合:符合标准文章33篇。脂联素是近年发现的脂肪细胞因子之一,具有重要的生理功能影响体内代谢和某些疾病的发生发展。原发性高血压患者血浆脂联素水平降低日益受到重视。已有的研究结果表明,脂联素及其受体可能成为防治高血压等心血管病的新靶点。结论:原发性高血压患者的血浆脂联素水平是降低的,但原发性高血压致血浆脂联素水平降低的确切机制尚未完全阐明。人们正在研究降压药物对血浆脂联素水平的影响,所取得的一些初步结果有待于进一步验证和评价。

关键词：脂联素基因高血压,综述文献

Automated image processing algorithm for Young's fringe pattern analysis

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Chinese Journal of Lasers 1993年第5期 27-37页

作者： Jie Gu, Fang Chen(Deparement of Mechanical Engineering, Oakland Univertsity, Rochester, ml 48309 USA)

An automatic of image processing for the analysis of Young’s fringe pattern is proposed. A Young’s fringe patttern is first FFT treated to get two patterns of 0 degree and 90 degree phase shifted. Regular two pattern shift algorithm is used to calculate the phase of the Young’s pattern. One or two times of phase shift iteration are carried out to improve the phase. Then the phase is least square fitted to get a phase plane. The displacement magnitude and direction are eaasily induced from the phase plane. Because every step is full field treatment, very precise result is achieved. The algorithm is simple and easy to implement. Theory and experiment are presented to prove the proposal. A program is designed to execute the algorithm and the processing is automated by a Personal Computer with an image board.

关键词： FFT phase shift iteration image processing