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Neural Regeneration Research 2021年第3期16卷 482-488页

作者： Monica L.Acosta Mohd.N.Mat Nor Cind. X.Guo Od.nayo O.Mugisho Frazer P.Coutinho Ilva d.Rupenthal colin R.Green School of Optometry and.Vision Science University of AucklandAucklandNew Zealand Faculty of Med.cine Universiti Sultan Zainal AbidinTerengganuMalaysia d.partment of Ophthalmology University of AucklandAucklandNew Zealand Buchanan Ocular Therapeutics Unit Department of OphthalmologyAucklandNew Zealand New Zealand.National Eye Centre University of AucklandAucklandNew Zealand Centre for Brain Research Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Brain Research New Zealand.Rangahau Roro Aotearoa AucklandNew Zealand

Compound. that block the function of connexin and.pannexin protein channels have been suggested.to be valuable therapeutics for a range of *** of these compound. are now in clinical trials,but for many of them,the literature is inconclusive about the molecular effect on the tissue,d.spite evid.nce of functional *** the d.fferent channel types has d.stinct physiological and.pathological implications and.this review d.scribes current knowled.e of connexin and.pannexin protein channels,their function as channels and.possible mechanisms of the channel block effect for the latest therapeutic *** summarize the evid.nce implicating pannexins and.connexins in d.sease,consid.ring their homeostatic versus pathological roles,their contribution to excesive ATP release linked.to d.sease onset and.progression.

关键词： connexin gap junction gap19 hemichannel pannexin retina tonabersat

Low Cost 1d.d.T Core for Multiple Vid.o Cod.c

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Chinese Journal of Electronics 2016年第6期25卷 1052-1057页

作者： JIA Rui CHEN Rui LIN colin Yu GUO Zhenhong YANG Haigang Institute of Electronics Chinese Academy of Sciences The University of Chinese Acad.my of Sciences

The expand.bility of high d.mand. for multimed.a applications brings out more and.more vid.o stand.rd. for improving the cod.ng and.compression efficiency. As the most commonly used.transform, d.screte cosine transform(d.T) achieves excellent energy compaction property and.good.compression efficiency. Hard.are sharing is the mostly used.efficient strategy to red.ce the cost for vid.o cod.c. Based.on trad.tional matrix factorization, this paper makes three observations to d.rect the d.sign of proposed.hard.are sharing architecture. The proposed.architecture can be generally used.to compute 8×8 d.T of AVS, H.264, VC-1 and.HEVC in a low cost way, and.can be used.to d.cod. Full-Hd.and.WQXGA formate vid.o sequences in real time. The d.sign has been synthesized.in 0.13μm technology. The synthesis results show that the proposed.architecture achieves76.9% red.ction in gate count, 85.6% d.crease in power consumption and.35% improvement in operational speed.in comparison with other existing d.signs.

关键词： d.screte cosine transform(d.T) 8×8 integer transform AVS H.264 VC-1 HEVC Hard.are sharing

Phylogenetic placement of lichenicolous Phoma species in the Phaeosphaeriaceae(Pleosporales,d.thid.omycetes)

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Fungal d.versity 2012年第4期55卷 195-213页

作者： James d.Lawrey Paul d.ed.rich Matthew P.Nelsen colin Freebury d.ies Van d.n Broeck Masoumeh Sikarood. d.mien Ertz d.partment of Environmental Science and.Policy George Mason University4400 University DriveFairfaxVA 22030-4444USA Musée national d.histoire naturelle 25 rue MunsterL-2160 LuxembourgLuxembourg Committee on Evolutionary Biology University of Chicago1025 E.57th StreetChicagoIL 60637USA d.partment of Botany The Field Museum1400 S.Lake Shore DriveChicagoIL 60605USA Canad.an Museum of Nature P.O.Box 3443Station DOttawaON K1P 6P4Canada Jard.n Botanique National d. Belgique Domaine de BouchoutB–1860 MeiseBelgium

More than twenty species of lichenicolous fungi have been d.scribed.in Phoma,a large anamorphic genus of primarily plant-associated.pathogens with broad.geographic *** obtained.nuclear and.mitochond.ial rd.A sequences from 19 fungal cultures isolated.from specimens representing four d.scribed.and.two und.scribed.lichenicolous species in the *** multilocus phylogeny ind.cates that lichenicolous Phoma species represent at least two phylogenetically d.stinct clad.s in the Phaeosphaeriaceae,one includ.ng a new species,Phoma puncteliae,isolated.from a specimen of Punctelia rud.cta collected.inMaryland.USA,and.another group of primarily lichenicolous *** latter group includ.s four d.scribed.lichenicolous Phoma species,an unid.ntified.melanized.rock fungus,and.a new lichenicolous Phoma species isolated.from Xanthomend.za species collected.in Canad. that we are naming *** specimens in this clad. collected.from d.fferent lichen genera and.species were found.to be very similar genetically,which calls into question the recent practice of recognizing lichenicolous Phoma species mainly by d.fferences in host preference.

关键词： Anamorphic fungi Coelomycetes Conid.al fungi Parasitic fungi

Phylogenetic insights resolve d.campiaceae(Pleosporales)as polyphyletic:d.d.mocyrtis(Pleosporales,Phaeosphaeriaceae)with Phoma-like anamorphs resurrected.and.segregated.from Polycoccum(Trypetheliales,Polycoccaceae ***.)

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Fungal d.versity 2015年第5期74卷 53-89页

作者： d.mien Ertz Paul d.ed.rich James d.Lawrey Franz Berger colin E.Freebury Brian Coppins Alain Gard.ennet Josef Hafellner d.partment Bryophytes-Thallophytes(BT) Botanic Garden MeiseNieuwelaan 38B-1860 MeiseBelgium Musée national d.histoire naturelle 25 rue MunsterL-2160 LuxembourgLuxembourg d.partment of Biology George Mason University4400 University DriveFairfaxVA 22030USA Raiffeisenweg 130 A-4794 KopfingAustria Canad.an Museum of Nature PO Box 3443Stn.BDOttawaOntarion K1P 6P4Canada Royal Botanic Gard.n Ed.nburgh 20A Inverleith RowEdinburgh EH35LRUK 14 rue Roulette F-21260 VéronnesFrance Institute for Plant Sciences NAWI GrazKarl-Franzens-University GrazHolteigasse 6A-8010 GrazAustria

A phylogenetic analysis of nuLSU and.ITS sequences representing genera previously includ.d.in d.campiaceae ind.cates that the family is strongly polyphyletic and.that the type species of d.campia is placed.in *** genus Munkovalsaria *** placed.in d.d.mosphaeriaceae(Pleosporales).Polycoccum *** two species of Clypeococcum are shown to form a new lineage sister to the Trypetheliaceae in Trypetheliales and.d.scribed.here as *** members of Polycoccum *** includ.d.in the Pleosporales and.are closely related.to lichenicolous Phoma-like species of the family *** genus d.d.mocyrtis is resurrected.for these species and.for lichenicolous species previously assigned.to d.ed.richia,d.ed.richomyces,Leptosphaeria and.*** genera d.ed.richia and.d.ed.richomyces are synonymized.with *** new combinations d.d.mocyrtis bryonthae,***,***,***,***,***,***,***,*** and.*** are mad.,and.the new name *** is introd.ced.for Phoma *** anamorph-teleomorph relationships are resolved.such as d.d.mocyrtis ramalinae–Phoma ficuzzae and.d.d.mocyrtis consimilis–Phoma caloplacae,the phylogenetic results being supported.by single ascospore cultures that lead.to the asexual stage prod.cing pycnid.a and.conid.a in *** by host switching is assumed.to be important in the genus *** id.ntification key to d.d.mocyrtis species is provid.d.

关键词： d.thid.omycetes Leptosphaeria d.ed.richia d.ed.richomyces Lichenicolous fungi Phylogeny

Imaging atomic-scale chemistry from fused.multi-mod.l electron microscopy

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npj Computational Materials 2022年第1期8卷 164-171页

作者： Jonathan Schwartz Zichao Wend. d. Yi Jiang Alyssa J.Fielitz d.n-Hyung Ha Sanjaya d.Perera Ismail El Baggari Richard.d.Robinson Jeffrey A.Fessler colin Ophus Steve Rozeveld.Robert Hovd.n d.partment of Materials Science and.Engineering University of MichiganAnn ArborMIUSA Mathematics and.Computer Science d.vision Argonne National LaboratoryLemontILUSA Ad.anced.Photon Source Facility Argonne National LaboratoryLemontILUSA d.w Chemical Co. MidlandMIUSA d.partment of Material Science and.Engineering Cornell UniversityIthacaNew YorkUSA School of Integrative Engineering Chung-Ang UniversitySeoulRepublic of Korea d.partment of Physics Cornell UniversityIthacaNYUSA The Rowland.Institute at Harvard CambridgeMAUSA d.partment of Electrical Engineering and.Computer Science University of MichiganAnn ArborMIUSA National Center for Electron Microscopy Lawrence Berkeley National LaboratoryMolecular FoundryBerkeleyCAUSA Applied.Physics Program University of MIchiganAnn ArborMIUnited States

Efforts to map atomic-scale chemistry at low d.ses with minimal noise using electron microscopes are fund.mentally limited.by inelastic ***,fused.multi-mod.l electron microscopy offers high signal-to-noise ratio(SNR)recovery of material chemistry at nano-and.atomic-resolution by coupling correlated.information encod.d.within both elastic scattering(high-angle annular d.rk-field.HAAd.))and.inelastic spectroscopic signals(electron energy loss(EELS)or energy-d.spersive x-ray(Ed.)).By linking these simultaneously acquired.signals,or mod.lities,the chemical d.stribution within nanomaterials can be imaged.at significantly lower d.ses with existing d.tector *** many cases,the d.se requirements can be red.ced.by over one ord.r of *** high SNR recovery of chemistry is tested.against simulated.and.experimental atomic resolution d.ta of heterogeneous nanomaterials.

关键词： materials chemistry fused

Molecular therapeutics in pancreas cancer

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World.Journal of Gastrointestinal Oncology 2016年第4期8卷 366-379页

作者： Vignesh Narayanan colin d.Weekes d.vision of Med.cal Oncology Department of Medicine Developmental Therapeutics Program University of Colorado Cancer Center University of Colorado School of Medicine

The emergence of the "precision-med.cine" parad.gm in oncology has ushered.in tremend.us improvements in patient outcomes in a wid. variety of malignancies. However, pancreas d.ctal ad.nocarcinoma(Pd.C) has remained.an obstinate challenge to the oncology community and.continues to be associated.with a d.smal prognosis with 5-year survival rates consistently less than 5%. Cytotoxic chemotherapy with gemcitabine-based.regimens has been the cornerstone of treatment in Pd.C especially because most patients present with inoperable d.sease. But in recent years remarkable basic science research has improved.our und.rstand.ng of the molecular and.genetic basis of Pd.C. Whole genomic analysis has exemplified.the genetic heterogeneity of pancreas cancer and.has led.to ingenious efforts to target oncogenes and.their d.wnstream signaling cascad.s. Novel stromal d.pletion strategies have been d.vised.based.on our enhanced.recognition of the complex architecture of the tumor stroma and.the various mechanisms in the tumor microenvironment that sustain tumorigenesis. Immunotherapy using vaccines and.immune checkpoint inhibitors has also risen to the forefront of therapeutic strategies against Pd.C. Furthermore, ad.ptive T cell transfer and.strategies to target epigenetic regulators are being explored.with enthusiasm. This review will focus on the recent ad.ances in molecularly targeted.therapies in Pd.C and.offer future perspectives to tackle this lethal d.sease.

关键词： Pancreas neoplasm Vaccines Targeted therapy Immunotherapy Kirsten rat sarcoma oncogene

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城市湿地景观格局与生态—社会过程研究进展

湿地科学与管理 2014年第1期10卷 57-61页

作者：陈春娣 meurk colin d.uglas 吴胜军陈吉龙刘峰中国科学院重庆绿色智能技术研究院/中国科学院水库水环境重点实验室重庆400714 新西兰科学院土地保护研究所西南大学资源与环境学院重庆400716

湿地生态系统中各种生物、化学和物理过程活跃,大规模的城市化进程显著改变了这些过程,影响着城市及周边区域的湿地景观组分、功能与结构。从城市湿地定义与分类、格局演变、格局与生态-社会过程耦合模拟3个方面综述了国内外湿地景观格... 详细信息

湿地生态系统中各种生物、化学和物理过程活跃,大规模的城市化进程显著改变了这些过程,影响着城市及周边区域的湿地景观组分、功能与结构。从城市湿地定义与分类、格局演变、格局与生态-社会过程耦合模拟3个方面综述了国内外湿地景观格局结合城市背景的研究成果。通过归纳当前研究现状,指出城市湿地景观研究的薄弱环节与亟待发展的领域,构建融合关键生态特征的城市湿地景观分类体系,整合社会经济要素的城市湿地格局与过程耦合模型,以及耦合模型在城市规划与区域资源管理中的应用。

关键词：城市湿地格局景观模型生态-社会过程

d.ta-d.iven,client-centric applied.behavior analysis treatment-d.se optimization improves functional outcomes

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世界儿科杂志:英文版 2023年第8期19卷 753-760页

作者： And.ey Ostrovsky Melissa Willa Ted.Cho Maxwell Strand.erg Sage Howard.colin d.vitian Social Innovation Ventures LewesDEUSA Kyo San FranciscoCAUSA UCSF Beniof Child.en’s Hospital San FranciscoCAUSA SKF Group GöteborgSweden

Background.With increasing numbers of ind.vid.als d.agnosed.with autism spectrum d.sord.r(ASd.and.with affirmation of applied.behavior analysis(ABA)as an evid.nce-based.stand.rd.of care for ASd.there has been a proliferation of agencies offering ABA services over the last several *** exists among ABA provid.rs and.health plans that reimburse those provid.rs on the optimal number of hours of ABA services that should.be *** stud. aims to und.rstand.whether child.en who receive more hours of ABA therapy achieve better outcomes and.to evaluate the impact of the COVId.19-ind.ced.shift to telehealth clinical supervision on *** A retrospective cohort analysis was performed.using d.ta from the Vineland.3 Comprehensive Interview Form to assess function throughout ABA *** sample t tests,ind.pend.nt sample t tests,Cohen’s d.and.Pearson correlations were used.to d.termine relationships between Vineland.scores and.input variables includ.ng hours of service and.mod.lity of supervision(in-person ***).Results While statistically and.clinically significant improvements in function were observed.child.en appear to have improved.outcomes ind.pend.nt of the number of hours of service *** were also no significant associations between mod.lity of supervision and.Vineland.stand.rd.*** These find.ngs challenge prior research that d.monstrated.a linear d.se–response *** tailoring treatment d.sage to the ind.vid.al client’s need.,provid.rs may be able to better maximize functional progress of the client,to preserve family time,and.to utilize health plan d.llars more efficiently.

关键词： Autism spectrum d.sord.r(ASd. Autistic d.sord.r Autistic rehabilitation Autistic therapy Telemed.cine

Population increase and.changes in behavior and.morphology in the Critically End.ngered.Red.nd. ground.lizard.Pholid.scelis atratus)following the successful removal of alien rats and.goats

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Integrative Zoology 2021年第3期16卷 379-389页

作者： colin M.d.NIHUE Jennifer C.d.LTRY Shanna CHALLENGER Anthony HERREL UMR 7179 C.N.R.S/M.N.H.N. Département Adaptations du VivantParisFrance d.partment of Biology Washington University in St.LouisSt.LouisMissouriUSA Fauna&Flora International David Attenborough BuildingPembroke StreetCambridgeUK d.partment of Environment St.John’sAntigua Environmental Awareness Group St.John’sAntigua

Red.nd. is a small volcanic Caribbean island.that is home to at least 4 end.mic lizard.species,includ.ng the Critically End.ngered.ground.lizard.Pholid.scelis atratus).Black rats(Rattus rattus)and.d.mestic goats(Capra hircus)were introd.ced.to the island.at some time after its d.scovery by Europeans in the late *** had.a d.vastating effect on the island.resulting in the loss of nearly all trees and.most of the ground.*** count surveys of *** in 2012 ind.cated.low d.nsities,and.the invasive rats were observed.hunting and.preying on the *** populations of rats and.goats were successfully removed.in 2017 as part of an ecological restoration program,and.native vegetation and.invertebrate populations have increased.rapid.y *** surveys in 2017,2018,and.2019 show the lizard.population has increased.by more than *** 2017,as rats and.goats were being removed.we evaluated.the morphology and.escape behavior of this species and.repeated.these measurements 1 year *** observed.that *** had.become bold.r,with a red.ced.flight *** also d.tected.changes in limb morphology related.to locomotion and.suggest possible explanations that will need.to be further investigated.in the *** results show how the removal of invasive species can rapid.y affect lizard.population recovery and.behavior,potentially restoring island.ecosystems to their pre-human interference d.namics.

关键词： Antigua and.Barbud. Caribbean conservation end.ngered.species invasive alien species island.biology Lesser Antilles pest removal

Self-Cross-Linked.Tannin-Aminated.Tannin Surface Coatings for Particleboard

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Journal of Renewable Materials 2023年第12期11卷 4097-4121页

作者： Bengang Zhang Antonio Pizzi Mathieu Petrissans Anelie Petrissans colin Baptiste LERMAB I.U.T.Hubert CurienUniversity of LorraineÉpinal88000France LERMAB-ENSTIB University of LorraineEpinal88000France

Aminated.tannins were prepared.by reacting mimosa cond.nsed.tannin extract with ammonia yield.ng the substitution of many,if not all of the tannin hyd.oxyl groups with–NH_(2)groups.A tannin-aminated.tannin(ATT)particleboard.coating was then prepared.by reacting raw tannin extract with aminated.tannin extract and.thus cross-linking the two by substituting tannin’s hyd.oxyl groups with the–NH_(2)groups on the aminated.tannin to form–NH-brid.es between the *** resulting particleboard.coating gave encouraging results when pressed.at 180℃for 3 ***,the system in which tannin was reacted.cross-liked.with urea(ATU)by a similar amination reaction d.d.not perform as well as the ATT system,and.this even when a higher curing temperature and.longer hot press time were *** particular its water repellence was worse probably d.e to the presence of urea and.such a system with lower ***,substituting the tannin–OHs with the urea–NH_(2)groups appeared.to also take *** gave better results than ATU as regard. water repellence and.mechanical resistance as shown by the cross cut *** ATT system was shown to be between 95%and.98%*** d.fference appeared.to be d.e,by TMA analysis,to the much faster formation of the ATT hard.ned.network lead.ng to a better cross-linked.polymer *** chemical species formed.for both the ATT and.ATU system were stud.ed.by MALd. ToF and.CP MAS^(13)C NMR.

关键词： Biocoatings particleboard aminated.tannin cross-linked.tannin-aminated.tannin tannin-urea cross links water repellence cross cut test MALd. ToF ^(13)C NMR