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Pathophysiology of insulin resistance and steatosis in patients with chronic viral hepatitis

World Journal of Gastroenterology 2011年第36期17卷 4055-4062页

作者： metin Basaranoglu Gkcen Basaranoglu Division of Gastroenterology and Hepatology Teaching and ConsultingAnkara Yüksek Ihtisas Hospital Gastroenterology ClinicSihhiyeAnkara 06100Turkey Department of Anaesthesiology Bezmialem Vakif UniversityFatihIstanbul 34590Turkey

Chronic hepatitis due to any cause leads to cirrhosis and end-stage liver disease.A growing body of literature has also shown that fatty liver due to overweight or obesity is a leading cause of *** to the obesity epidemic,fatty liver is now a significant problem in clinical *** has an impact on the acceleration of liver damage in patients with chronic hepatitis due to other *** association between hepatitis C virus (HCV) infection,steatosis and the onset of insulin resistance has been *** resistance is one of the leading factors for severe fibrosis in chronic HCV ***,hyperinsulinemia has a deleterious effect on the management of chronic *** to therapy is increased by decreasing insulin resistance by weight loss or the use of thiazolidenediones or *** underlying mechanisms of this complex interaction are not fully understood.A direct cytopathic effect of HCV has been *** genomic structure of HCV (suggesting that some viral sequences are involved in the intracellular accumulation of triglycerides),lipid metabolism,the molecular links between the HCV core protein and lipid droplets (the core protein of HCV and its transcriptional regulatory function which induce a triglyceride accumulation in hepatocytes) and increased neolipogenesis and inhibited fatty acid degradation in mitochondria have been investigated.

关键词： Adipocytokines Fatty acids Hepatitis B virus Hepatitis C virus Inducible nitric oxide synthase Insulin resistance Signal transduction and activator of transcription-3 Steatosis Sterol regulatory elementbinding protein-1c Suppressors of cytokine signaling Tumor necrosis factor-α

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A Modified Gravity Theory: Null Aether

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Communications in Theoretical Physics 2019年第3期71卷 312-326页

作者： metin Gürses ?etin ?entürk Department of Mathematics Faculty of Sciences Bilkent University Department of Physics Faculty of Sciences Bilkent University Department of Aeronautical Engineering University of Turkish Aeronautical Association

General quantum gravity arguments predict that Lorentz symmetry might not hold exactly in nature. This has motivated much interest in Lorentz breaking gravity theories recently. Among such models are vector-tensor theories with preferred direction established at every point of spacetime by a fixed-norm vector field. The dynamical vector field defined in this way is referred to as the "aether". In this paper, we put forward the idea of a null aether field and introduce, for the first time, the Null Aether Theory(NAT) — a vector-tensor theory. We first study the Newtonian limit of this theory and then construct exact spherically symmetric black hole solutions in the theory in four dimensions, which contain Vaidya-type non-static solutions and static Schwarzschild-(A)dS type solutions, Reissner-Nordstr?m-(A)dS type solutions and solutions of conformal gravity as special cases. Afterwards, we study the cosmological solutions in NAT:We find some exact solutions with perfect fluid distribution for spatially flat FLRW metric and null aether propagating along the x direction. We observe that there are solutions in which the universe has big-bang singularity and null field diminishes asymptotically. We also study exact gravitational wave solutions — AdS-plane waves and pp-waves — in this theory in any dimension D ≥ 3. Assuming the Kerr-Schild-Kundt class of metrics for such solutions, we show that the full field equations of the theory are reduced to two, in general coupled, differential equations when the background metric assumes the maximally symmetric form. The main conclusion of these computations is that the spin-0 aether field acquires a "mass" determined by the cosmological constant of the background spacetime and the Lagrange multiplier given in the theory.

关键词： Aether theory Newtonian limit black holes cosmological solutions Kerr-Schild-Kundt class of metrics Ads-plane waves pp-waves

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Monodisperse Nickel Nanoparticles Supported on SiO_(2) as an Effective Catalyst for the Hydrolysis of Ammonia-Borane

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Nano Research 2010年第9期3卷 676-684页

作者： Önder metin SaimÖzkar Shouheng Sun Department of Chemistry Middle East Technical University06531AnkaraTurkey Department of Chemistry Brown UniversityProvidenceRhode Island 02912USA

Monodisperse Ni nanoparticles(NPs)have been synthesized by the reduction of nickel(Ⅱ)acetylacetonate with the borane–tributylamine complex in a mixture of oleylamine and oleic *** Ni NPs are an active catalyst for the hydrolysis of the ammonia–borane(AB,H3N⋅BH3)complex under ambient conditions and their activities are dependent on the chemical nature of the oxide support that they were deposited *** various oxides(SiO_(2),Al_(2)O_(3),and CeO_(2))tested,SiO_(2)was found to enhance Ni NP catalytic activity due to the etching of the 3.2 nm Ni NPs giving Ni(Ⅱ)ions and the subsequent reduction of Ni(Ⅱ)that led to the formation of 1.6 nm Ni NPs on the SiO_(2)*** kinetics of the hydrolysis of AB catalyzed by Ni/SiO_(2)was shown to be dependent on catalyst and substrate concentration as well as *** Ni/SiO_(2)catalyst has a turnover frequency(TOF)of 13.2 mol H_(2)⋅(mol Ni)^(–1)⋅min^(–1)—the best ever reported for the hydrolysis of AB using a nickel catalyst,an activation energy of 34 kJ/mol±2 kJ/mol and a total turnover number of 15,400 in the hydrolysis of *** is a promising candidate to replace noble metals for catalyzing AB hydrolysis and for hydrogen generation under ambient conditions.

关键词： Nickel nanoparticles supported catalyst hydrogen storage hydrolysis of ammonia-borane

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Stress analysis of functionally graded rotating discs: analytical and numerical solutions

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Acta Mechanica Sinica 2011年第6期27卷 950-955页

作者： Hasan Callioglu Numan Behll Bektas metin Sayer Department of Mechanical Engineering Pamukkale University

This study deals with stress analysis of annular rotating discs made of functionally graded materials（FGMs）.Elasticity modulus and density of the discs are assumed to vary radially according to a power law function,but the material is of constant Poisson＇s ratio.A gradient parameter n is chosen between 0 and *** n = 0,the disc becomes a homogeneous isotropic *** and radial stress distributions and displacements on the disc are investigated for various gradient parameters n by means of the diverse elasticity modulus and density by using analytical and numerical ***,a homogenous tangential stress distribution and the lowest radial stresses along the radius of a rotating disc are approximately obtained for the gradient parameter n = 1.0 compared with the homogeneous,isotropic case n = *** means that a disc made of FGMs has the capability of higher angular rotations compared with the homogeneous isotropic disc.

关键词： Functional graded materials Stress analysis Analytical analysis Finite element analysis (FEA)

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Impact of different sampling rates on precise point positioning performance using online processing service

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Geo-Spatial Information Science 2021年第2期24卷 302-312,I0008页

作者： Serdar Erol Reha metin Alkan İ.Murat Ozulu Veli Ilçi Department of Geomatics Engineering Istanbul Technical UniversityIstanbulTurkey Department of Technical Programs Hitit UniversityÇorumTurkey Department of Geomatics Engineering Ondokuz Mayıs UniversitySamsunTurkey

In this study,the effect of different sampling rates(*** recording interval)on the Precise Point Positioning(PPP)solutions in terms of accuracy was *** this purpose,a field test was carried out inÇorum province,Turkey,on 11 September *** this context,a Geodetic Point(GP)was established and precisely coordinated.A static GNSS measurement was occupied on the GP for about 4-hour time at 0.10 second(s)/10 Hz measurement intervals with the Trimble R10 geodetic grade GNSS *** original observation file was converted to RINEX format and then decimated into the different data sampling rates as 0.2 s,0.5 s,1 s,5 s,10 s,30 s,60 s,and 120 *** these RINEX observation files were submitted to the Canadian Spatial Reference System-Precise Point Positioning(CSRS-PPP)online processing service the day after the data collection date by choosing both static and kinematic processing *** this way,PPP-derived static coordinates,and the kinematic coordinates of each measurement epoch were *** PPP-derived coordinates obtained from each decimated sampling intervals were compared to known coordinates of the GP for northing,easting,2D position,and height *** to the static and kinematic processing results,high data sampling rates did not change the PPP solutions in terms of accuracy when compared to the results obtained using lower sampling *** results of this study imply that it was not necessary to collect GNSS data with high-rate intervals for many surveying projects requiring cm-level accuracy.

关键词： Precise Point Positioning(PPP) online GNSS postprocessing service high-rate GNSS sampling rate monitoring structure behavior

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Assessing the publication output in the field of forensic science and legal medicine using Web of Science database from 2011 to 2020

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Forensic Sciences Research 2022年第4期7卷 748-760页

作者： Bedirhan Sezer Öner metin Orbay Department of Forensic Medicine Faculty of MedicineAmasya UniversityAmasyaTurkey Department of Mathematics and Science Faculty of EducationAmasya UniversityAmasyaTurkey

The aim of this study was ***,it analyzed the characteristics of the publication outputs for the Legal Medicine(LM)category using the Web of Science(WoS)database during ***,it discussed the distribution of the papers for the 25 most productive countries/regions in terms of quality and quantity,such as the h-index and GDP per ***,it investigated the trend and temporal stability of the journal impact factor(JIF)and determined the percentage of the journal *** findings suggested that the number of papers,the average number of pages of the papers,the average number of cited references in the papers,the average number of authors per paper,the percentage of open access papers,as well as international and domestic collaboration tended to increase ***,the productivity was limited when compared to the whole WoS database,since there was no significant change in the number of the *** countries/regions with the highest number of publications were not those that made the most impact in terms of the widespread impact of the *** level of international cooperation and the funding for the research had dramatic impact on the visibility of *** average JIF has increased significantly while the journal self-citation rates have decreased in a similar *** journals have had very stable(have not fluctuated)impact factors over *** the period studied,the journals with the higher impact factors(Q1,Q2)published many more papers than journals with the lower impact factors(Q3,Q4).

关键词： Bibliometrics citation analysis forensic science legal medicine Web of Science

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A Biomimetic Climbing Robot Based on the Gecko

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Journal of Bionic Engineering 2006年第3期3卷 115-125页

作者： Carlo Menon metin Sitti Carnegie Mellon University Pittsburgh Pennsylvania 15213-389 USA

The excellent climbing performance of the gecko is inspiring engineers and researchers for the design of artificial systems aimed at moving on vertical surfaces. Climbing robots could perform many useful tasks such as surveillance, inspection, repair, cleaning, and exploration. This paper presents and discusses the design, fabrication, and evaluation of two climbing robots which mimic the gait of the gecko. The first robot is designed considering macro-scale operations on Earth and in space. The second robot, whose motion is controlled using shape memory alloy actuators, is designed to be easily scaled down for micro-scale applications. Proposed bionic systems can climb up 65 degree slopes at a speed of 20 mm·s^-1.

关键词： gecko robotics biomimetics climbing space memory alloy

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Temperature and Thickness Effects on Electrical Properties of InP Films Deposited by Spray Pyrolysis

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Chinese Physics Letters 2009年第1期26卷 260-263页

作者： Refik Kayah Mehmet An Mustafa Oztas metin Bedir Funda Aksoy Department of Physics Arts and Sciences Faculty Nigde University Nigde Turkey Department of Physics Arts and Sciences Faculty Erciyes University Kayseri Turkey Department if Physics and Engineering Engineering Faculty Gaziantep University Gaziantep Turkey

InP film samples are prepared by spray pyrolysis technique using aqueous solutions of InCl3 and Na2HPO4, which are atomized with compressed air as carrier gas onto glass substrates at 500° C with different thicknesses of the films. The structural properties of the samples are determined by x-ray diffraction （XRD）. It is found that the crystal structure of the InP films is polycrystalline hexagonal. The orientations of all the obtained films are along the c-axis perpendicular to the substrate. The electrical measurements of the samples are obtained by dc four-probe technique on rectangular-shape samples. The effects of temperature on the electrical properties of the InP films are studied in detail.

关键词： THIN-FILMS BEAM EPITAXY SOLAR-CELLS GROWTH-RATE DEPENDENCE

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Mallory-Denk Bodies in chronic hepatitis

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World Journal of Gastroenterology 2011年第17期17卷 2172-2177页

作者： metin Basaranoglu Nesrin Turhan Abdullah Sonsuz Gkcen Basaranoglu Gastroenterology and Hepatology ConsultingEndoscopyAnkara Yüksek Ihtisas HospitalAnkara06420Turkey Department of Pathology Ankara Yüksek Ihtisas HospitalAnkara06420Turkey Gastroenterology Cerrahpasa Medical FacultyUniversity of IstanbulIstanbul34500Turkey Department of Anaesthesiology Vakif Gureba University HospitalIstanbul34500Turkey

Mallory-Denk Bodies(MDB) are important as investigators,suggesting MDB as an indicator of the histologic severity of chronic hepatitis,causes of which include hepatitis C,primary biliary cirrhosis(PBC),and nonalcoholic fatty liver disease(NAFLD).Matteoni et al scored MDB in patients with NAFLD as none,rare and many,and reported that MDB plays a prominent role in this classification scheme in an earlier classification *** this study,we evaluated 258 patients with chronic hepatitis due to metabolic,autoimmune and viral *** biopsy samples were evaluated with hematoxylin and eosin,periodic acid-Schiff-diastase,Gordon and Sweet's reticulin,Masson's trichrome,and iron *** staging and grading were ***,MDB were evaluated and discussed for each *** examined patients with nonalcoholic steatohepatitis(NASH;50 patients),alcoholic hepatitis(10 patients),PBC(50 patients),Wilson disease(WD;20 patients),hepatitis B(50 patients),hepatitis C(50 pati-ents) and hepatocellular carcinoma(HCC;30 patients).Frequency of MDB was as follows;NASH:10 patients with mild in 60% and moderate in 40% and observed in every stage of the disease and frequently seen in zone ***:11 patients with mild in 10%,moderate in 70%,and cirrhosis in 20%,and frequently seen in zone ***:16 patients with moderate and severe in 60% and cirrhosis in 40% and frequently seen in zone *** B:3 patients with mild in 66% and severe in 34%.Hep C:7 patients with mild in 40% and moderate in 60% and observed in every ***:3 patients with hep B in 2 *** found that there is no relationship between MDB and any form of chronic hepatitis regarding histologic severity such as alcoholic steatohepatitis and NAFLD and variable zone distribution by etiology.

关键词： Non-alcoholic fatty liver disease MalloryDenk Bodies Hepatitis B and C Hepatocellular carcinoma Primary biliary cirrhosis Wilson disease

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Inhomogeneous Quantum Invariance Group of Multi-Dimensional Multi-parameter Deformed Boson Algebra

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Chinese Physics Letters 2012年第1期29卷 8-10页

作者： Azmi Ali Altintas metin Arik Ali Serdar Arikan Emre Dil Faculty of Engineering Okan UniversityTuzlaIstanbulTurkey Department of Physics Boğazici UniversityBebekIstanbulTurkey Department of Physics Sakarya UniversityEsentepeSakaryaTurkey

We investigate the inhomogeneous invariance quantum group of the d-dimensional d-parameter deformed boson *** is found that the homogeneous part of this quantum group is given by the𝑑-parameter deformed general linear *** construct the d-matrix which collects all information about the non-commuting structure of the quantum group for the two-dimensional case.

关键词： group. algebra. parameter

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