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Prevalence and Risk.Factors for Albuminuria among HIV Ivorian Children, Using the Dipstick.Method

Open Journal of Nephrology 2018年第1期8卷 1-9页

作者： Tia Weu Melanie messou k. eugene Lagou Delphine Amelie Cisse Lassina Grinmaud Mylene Coulibaly Pessa Albert N’Zoue k.nga Sita Department of Nephrology CHU Yopougon Abidjan C&ocirc te d’Ivoire CePReF Abidjan C&ocirc te d’Ivoire Department of Paediatrics Chu Treichville Abidjan C&ocirc te d’Ivoire

Context: Human immunodeficiency virus (HIV) infected children are at risk.of developing chronic k.dney disease defined by decreased glomerular filtration rate and or proteinuria. Studies on the prevalence of and risk.factors for proteinuria among HIV-infected children in sub-Saharan Africa are scarce and in Cote d’Ivoire, there is paucity of reported data. We determined the prevalence of and the risk.factors for proteinuria among HIV-infected Ivorian children in both ART (antiretroviral therapy)-na?ve and ART-exposed children. Method: It was a cross-sectional bi-centric study, conducted from July 2013 to April 2014. Each child’s urine was tested for proteinuria and microalbuminuria using multi test strips and mitral test, respectively. Proteinuria was defined as of significant of 1+ and above on the dipstick.or the presence of microalbuminuria ≥ 20 mg/l. Results: Of the 155 HIV-infected children enrolled, there were 78 boys. Sixty seven point seven percent were treated with antiretroviral and 74.1% had treatment duration of less than 5 years. In the first dipstick.test, the prevalence of proteinuria was 29% which persisted in 9.7% after 24 hour urinary protein examination. It was significantly different between the 2 groups treated and na?ve (2.8% versus 24%). The advanced CDC clinical stage emerged as the main independent determinant of proteinuria. Conclusion: Proteinuria is common in HIV-infected Ivorian children. Screening for proteinuria in HIV-infected children will help in early and treatment, and thus prevention and progression to chronic k.dney disease to end-stage k.dney disease.

关键词： Prevalence Proteinuria HIV Ivorian Child Antiretroviral Therapy

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Assessment of the Efficacy of Rifaximin in the Management of Irritable Bowel Syndrome (IBS)

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Open Journal of Gastroenterology 2017年第10期7卷 261-270页

作者： Stanislas A. Doffou k.ssi Henriette Anzouan-k.cou eugene k. messou Demba A. Bangoura Dimitri H. k.uamé k.uame M. Alassan Constant Assi Fulgence Mamert Y. Bathaix Alain k. Attia Marie-Jeanne k. Lohoues Yopougon University Hospital Abidjan C&ocirc te d’Ivoire Treichville University Hospital Abidjan C&ocirc te d’Ivoire Cocody University Hospital Abidjan C&ocirc te d’Ivoire

The aim of our study was to assess in our context, the efficacy of Rifaxim in improving the symptoms of irritable bowel syndrome particularly in its diarrheal (IBS-D) or mixed (IBS-DC) component and therefore assess its impact on patients’ quality of life. Patients and methods: This was an uncontrolled, non-comparative prospective cohort study of a single group of patients. Patients recruitment was done in two University Hospitals for 6 months (September 2015-February 2016). Were included ambulatory patients, male or female, aged 18 - 75 years, with diarrheic IBS (IBS-D) or mixed IBS (IBS-DC) diagnosed according to Rome III criteria and who agreed to participate in the study. Each patient received 400mg Rifaximin × 2/d for 15 days. The overall assessment of the efficacy of treatment at D15 (end of treatment) and D30 (2 week. post-treatment) was the primary criterion of judgment. The statistical tests used were the Chi-square test and Fisher’s exact test for the qualitative variables and Student’s test for the quantitative variables. Results: A total number of 30 patients (16 women) with an average age of 44.5 ± 13.9 years were included. The overall assessment of symptoms by the patient with the Lik.rt scale found 28 (93.3%) patients, 12 (40%) patients and 10 patients (33.3%) for a scale ≥2 at D0, D15 and D30 respectively. The assessment of the intensity of pain or abdominal discomfort found at D0, D15 and D30 respectively: 27(90%), 13(43.4%) and 6(20.1%) patients who had an EVA score > 2. The mean score for Francis to assess the improved quality of life was 247.1 ± 97.4 at D0, 99.8 ± 63.1 at D15 and 128.8 ± 70.6 at D30. Conclusion: There is a good overall improvement of symptoms in our patients suffering from IBS-D or mixed (IBS-DC) on Rifaximin with improvement of the quality of life.

关键词： Rifaximin Irritable Bowel Diarrhea Quality of Life

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