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Effects of cross-anisotropy and stress-dependency of pavement layers on pavement responses under dynamic truck loading

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Journal of Rock Mechanics and Geotechnical Engineering 2016年第3期8卷 366-377页

作者： Rafiqul A.Tarefder mesbah u.ahmed Asifur Rahman Department of Civil Engineering University of New Mexico

Previous studies by the authors have determined pavement responses under dynamic loading consid- ering cross-anisotropy in one layer only, either the cross-anisotropic viscoelastic asphalt concrete （AC） layer or the cross-anisotropic stress-dependent base layer, but not both. This study evaluates pavement stress-strain responses considering cross-anisotropy in all layers, i.e. AC, base and subbase, using finite element modeling （FEM） technique. An instrumented pavement section on Interstate 1-40 near Albuquerque, New Mexico was used in ABAQuS framework as model geometry. Field asphalt cores were collected and tested in the laboratory to determine the cross-anisotropy （n-values） defined by horizontal to vertical modulus ratio, and other viscoelastic parameters as inputs of the model incorporated through user defined material interface （uMAT） functionality in ABAQuS. Field base and subbase materials were also collected and tested in the laboratory to determine stress-dependent nonlinear elastic model parameters, as inputs of the model, again incorporated through uMAT. The model validation task was carried out using field-measured deflections and strain values under falling weight deflectometer （FWD） loads at the instrumented section. The validated model was then subjected to an actual truck loading for studying cross-anisotropic effects. It was observed that horizontal tensile strain at the bottom of the AC layer and vertical strains in all layers decreased with an increase in n-value of the asphalt layer, from n （ 1 （anisotropy） to n - 1 （isotropy）. This indicates that the increase in horizontal modulus caused the decrease in layer strains. It was also observed that if the base and subbase layers were considered stressdependent instead of linear elastic unbound layers, the horizontal tensile strain at the bottom of the asphalt layer increased and vertical strains on top of the base and subbase also increased.

关键词： Cross-anisotropyViscoelastic behaviorStress-dependent behaviorFinite element modeling (FEM)

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Induction of sub-G0 arrest and apoptosis by seed extract of Moringa peregrina（Forssk.） Fiori in cervical and prostate cancer cell lines

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Journal of Integrative Medicine 2019年第6期17卷 410-422页

作者： Maged Mohamed Maher Abou-Hashem Dina Mohamed Abo-elmatty Noha Mostafa mesbah ahmed Mohamed Abd EL-Mawgoud Faculty of Pharmacy Pharmacognosy DepartmentZagazig UniversityZagazig 44511Egypt Faculty of Pharmacy Biochemistry DepartmentSuez Canal UniversityIsmailia 41522Egypt Egyptian International Pharmaceuticals Industries Company Tenth of Ramadan City 44629Egypt

Objective: This study investigated cytotoxicity and induction of apoptosis in human cervical cancer cells(HELA) and prostate cancer cells(PC-3) using the most active fraction of Moringa peregrina seed ***: Dried and powdered seeds were extracted using 95% ethanol. The total ethanolic extract was further dissolved in distilled water and separated into petroleum ether, chloroform, ethyl acetate and aqueous extracts. Based on the results of in vitro anticancer studies of all extracts, the most highly active extract was selected for evaluation of apoptosis induction and cell cycle analysis on HELA and PC-3 cells at its half maximal inhibitory concentration using flow cytometry;DNA fragmentation by agarose gel electrophoresis and the expression of protein were measured by Western ***: The chloroform fraction from the ethanolic extract of M. peregrina(CFEE) was the most active antitumor fraction. The selectivity index, determined using the normal Vero cell line, indicated that CFEE had a high degree of selectivity against HELA and PC-3 cells. CFEE induced apoptosis, confirmed by cell cycle arrest at sub-G0 phase and DNA fragmentation. CFEE induced an increase in mRNA expression of caspase-3, a decrease in Bcl-2 mRNA expression, and decreased ATP levels. CFEE increased protein expression of caspase-3 and decreased protein expression of poly-ADP-ribose polymerase-1(PARP-1).Flow cytometric analysis showed an appreciable increase in the number of cells in the early apoptotic stage in CFEE-treated HELA and PC-3 cells. CFEE treatment significantly increased lipid peroxidation(malondialdehyde level) in HELA and PC-3 ***: Seed extract of M. peregrina displayed a significant antitumor effect through apoptosis induction in HELA and PC-3 cells.

关键词： Moringa peregrina Fractionation Antiproliferation Apoptosis

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