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Identification of major sources controlling groundwater geochemistry in Mount Makabaï in the Far-North of Cameroon(the northernmost part of the Pan-African Belt)

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Acta Geochimica 2023年第2期42卷 266-289页

作者： merlin gountiédedzo DésiréTsozué Amidou Kpoumié Aubin Nzeugang Nzeukou Department of Life and Earth Sciences Higher Teachers’Training CollegeUniversity of MarouaP.O.Box.55MarouaCameroon Department of Earth Sciences Faculty of ScienceUniversity of MarouaP.O.Box.814MarouaCameroon

The present work focuses on the volcanic basement rock geochemistry of Mount Makabaï(MarouaCameroon city)in relation to groundwater *** were centered on an approach involving an association of several methods such as geological cartography,hydrogeology,and *** rock samples,four disturbed soil samples,three undisturbed soil samples,and 20 samples of groundwater in 10 wells were collected during fieldwork and prepared for laboratory *** exhibit porphyritic,aphyric,and subaphiric *** phenocryst phases are mainly olivine,clinopyroxene,and *** on whole rock major element chemical compositions,the Makabaï samples,plotted on Na_(2)O+K_(2)O versus SiO_(2)diagram,are mugearite,hawaiite,and *** ratio of(MgO+CaO)/(Na_(2)O+K_(2)O)exceeds unity and shows dominance of alkaline Earth metals(MgO:2.99-4.48%;CaO:6.19-9.80%)relatively to alkali metals(Na_(2)O:2.27-4.46%;K_(2)O:2.09-2.51%).Exchangeable base contents are high,mostly represented by Ca and Mg,whose contents vary from 14.6 to 35.28 cmol(+)kg^(-1)and from 3.28 to9.48 cmol(+)kg^(-1)*** CECclayis likewise high,fluctuating between 116.80 and181.38 cmol(+)kg^(-1),values in line with the presence of 2:1 clay minerals represented in the study area by *** the water samples,the Ca2+and Na+contents are generally higher than K^(+)and Mg^(2+),reflecting the relative abundance of Na_(2)O and CaO oxides to K_(2)O and MgO oxides in rocks where different waters were *** waters of Makabaï are acidic to neutral(6.3≤pH≤7.4)and weakly to highly mineralized(110.0≤EC≤1190.0μS/cm).Hydro-geochemical classification by using the Piper diagram revealed two water types:(1)CaMg-HCO_(3)(40%)and(2)CaMg-Cl or CaMg-SO4(60%).The average content of ions in all the analyzed samples was HCO_(3)^(-)>>NO_(3)^(-)>SO_(4)^(2-)>Cl-for anions and Ca^(2+)>>Mg^(2+)>Na^(+)>K^(+)for *** mechanisms governing ionic constituents of groundwater in

关键词： Mount Makabaï-Maroua city Far-North Cameroon Bedrock minerals Groundwater-rock-soil interaction Crystalline basement

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Petrography and Geochemical Characterization of Dolerites from Figuil (Northern Cameroon) and Léré(Southwestern Chad)

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International Journal of Geosciences 2020年第7期11卷 459-482页

作者： Moussa Ngarena Klamadji merlin gountié dedzo Rigobert Tchameni Daouda Dawaï Département des Sciences de la Vie et de la Terre Faculté des Sciences Techniques et de la Technologie Université de Pala Pala Tchad Department of Life and Earth Sciences High Teachers’ Training College University of Maroua Maroua Cameroon Department of Earth Sciences Faculty of Science University of Ngaoundéré Ngaoundéré Cameroon Department of Earth Sciences Faculty of Science University of Maroua Maroua Cameroon

This work presents the petrographic and geochemical data of the dolerite dykes crosscutting the Pan-African basement of Figuil (North-Cameroon) and Léré (South-West Chad) in order to approach their petrogenesis and their emplacement context. Two groups of dolerites have been highlighted by petrographic and geochemical studies. These groups were discriminated by their TiO2, Fe2O3, REE, Ba, Nb, Zr, La and Hf contents which are relatively higher in group I;group II, on the other hand, has higher MgO, Mg#, Sc, Ni and Cr contents. The mineralogical assemblage of these dolerites is made up by plagioclases, pyroxenes, olivine, oxides, amphibole, biotite and sometimes pyrite, calcite, apatite, epidote and chlorite. The behaviour of the major and trace elements suggest that studied dolerites have an evolution dominated by fractional crystallization. Most dolerite samples show higher REE concentrations and (La/Yb)N > 8.7, (Tb/Yb)N > 1.9 and Dy/Yb > 2 ratios characterizing a garnet-bearing mantle. The difference in incompatible elements between the two groups is explained by the degree of partial melting of the same source which becomes more important over time. Low (Ce/Yb)N values (3.3 - 11.58) also suggest relatively low partial melting degree of the source. Fractional crystallization process was possibly combined with minor crustal contamination as shown by enrichment of Th/Yb from group II to Group I that might be due to turbulent magma emplacement. The chemical compositions of these dolerites are similar to that of continental tholeiites with slightly moderate negative Nb-Ta anomalies which are attributed to crustal contamination of magmas. As other dolerites of Cameroon, continental tholeiitic signature of the studied dolerites is evidenced in geotectonic discrimination diagrams with Group II dolerite compositions falling within the field of tholeiitic ba

关键词： Doleritic Dykes Pan-African Basement Continental Tholeiites North-Cameroon South-West of Chad

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Fractional Crystallization and Crustal Contamination of Doleritic and Trachytic Dykes Crosscutting the Cretaceous Sedimentary Basins from Figuil (North Cameroon) and Léré(South-Western Chad): Geodynamic Implications

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Journal of Geoscience and Environment Protection 2021年第12期9卷 190-210页

作者： Moussa Ngarena Klamadji merlin gountié dedzo Rigobert Tchameni Djamilatou Diddi Hamadjoda Pierre Christel Biakan à Nyotok Gervais Onana Département des Sciences de la Vie et de la Terre Faculté des Sciences Techniques et de la Technologie Université de Pala Pala Tchad Department of Life and Earth Sciences High Teachers’ Training College University of Maroua Maroua Cameroon Department of Earth Sciences Faculty of Science University of Ngaoundéré Ngaoundéré Cameroon Department of Earth Sciences Faculty of Sciences University of Maroua Maroua Cameroon

Magmatism in the Cretaceous sedimentary basins of the Figuil and Léré regions constitutes one of the fundamental parameters in the reconstruction of the history of the Cretaceous sedimentary basins. The main objective of this paper is to constrain the petrogenetic processes of hypovolcanic rocks and to determine their geodynamic context of emplacement. The petrographic study of mafic hypovolcanic and trachytic rocks was carried out under a polarizing microscope on thin sections. For the geochemical study, the major oxides and some trace elements were analyzed by ICP-AES. Trace and rare earth elements were analyzed by ICP-MS. The dolerites of the Cretaceous sedimentary basins are composed of dykes of amphibole bearing dolerites, biotite and pyroxene bearing dolerite, pyroxene bearing dolerites and trachytes. The dykes are in the order of 20 to 100 m wide by several kilometers long and oriented from N23°E to N90°E. The textures of these rocks are sub-ophitic to intergranular for dolerites and trachytic for evolved rocks (trachytes). The geochemical study shows that the dolerites are basaltic in composition with alkaline to subalkaline character. The sampled dykes have an evolution dominated by fractional with the minor impact of the crustal assimilation characterized by low Rb/Y ratios for dolerites (0.36 - 0.97) and high values of Rb/Y for the Pan-African granitoids’ samples (1.95 - 4.01). The nature of doleritic and t

关键词： Dolerites Trachyte Sedimentary Basins Continental Tholeiites Figuil and Léré

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Granitic inselbergs of Lara(Panafrican Chain,Far-North Cameroon):Assets for the implementation of geotourism in Mountainous region

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Journal of Mountain Science 2022年第11期19卷 3192-3212页

作者： ZANGMO TEFOGOUM Ghislain NOUHOU DAMA Zouyane Hyacinthe gountiÉdedzo merlin MAFO DONGMO Irène Department of Earth Sciences de la Terre Faculty of ScienceUniversity of MarouaP.O.Box 814 MarouaCameroon Department of Life and Earth Sciences High Teacher Training CollegeUniversity of MarouaP.O.Box 55MarouaCameroon

The locality of Lara(Far-North Region,Cameroon)is made up of a pediplain strewn with coalescent *** interaction of internal and external geological processes has contributed to transform the latter into inselbergs,whose geotouristic values are yet to be *** and laboratory work enabled us to select the geomorphosites through their aesthetic value(particular size and shape)and,geomorphological and geological ***,it permitted to study and map the geomorphosites using Optic Microscope,Google Earth,GIS software and many other ***,four inselbergs have been selected and studied in the locality of *** petrographic study of these inselbergs shows that granites are the main components of inselbergs and they present a fine to coarse-grained texture,materialized by quartz,micas,plagioclases and alkali feldspars(white and pink in colour).Inselbergs exhibit vertical and parallel networks of diaclases giving them a stratified appearance in some *** addition,on some inselberg limbs and piedmonts,are built tors which contribute to their *** tops of inselbergs,are embellished by several alluring pedestal *** their flanks,shelters of various shapes and sizes(about 12 m length)have developed through the heaps of blocks *** the ten shelters selected,some have a fairly high cultural value as they are sacred places for the local ***,Lara's granitic inselbergs include enclaves(cognate enclaves and xenocrysts)that also significantly improve their geoheritage *** are landforms with high education and aesthetic value that attracted a larger local and foreign population of about 863 visitors between *** constitute an exceptional geoheritage that could attract more tourists in the locality of Lara;but the promotion of geotourism is needed through interpretative panels,marketing of geomorphosites through leaflets,web,media,and geotours,to mention a few.

关键词： Lara Inselbergs Granite geoheritage Geotouristic activities

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Biallelic variants in RBM42 cause a multisystem disorder with neurological,facial,cardiac,and musculoskeletal involvement

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Protein & Cell 2024年第1期15卷 52-68页

作者： Yiyao Chen Bingxin Yang Xiaoyu merlin Zhang Songchang Chen Minhui Wang Liya Hu Nina Pan Shuyuan Li Weihui Shi Zhenhua Yang Li Wang Yajing Tan Jian Wang Yanlin Wang Qinghe Xing Zhonghua Ma Jinsong Li He-Feng Huang Jinglan Zhang Chenming Xu Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China bstetrics and Gynecology Hospital Institute of Reproduction and DevelopmentFudan UniversityShanghai 200011China Intermational Peace Matermity and Child Health Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200030China Shanghai Key Laboratory of Embryo Original Diseases Shanghai 200030China State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCAS Center for Excellence in Molecular Cell ScienceUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of Rice Biology the Key Laboratory of Molecular Biology of Crop Pathogens and InsectsInstitute of BiotechnologyZhejiang UniversityHangzhou 310058China Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of MedicineHoustonTX 77030USA Children's hospital of Fudan University Shanghai 201102China School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024ZhejiangChina Research Units of Embryo Original Diseases Chinese Academy of Medical Sciences(No.2019RU056)Shanghai 200011China

Here,we report a previously unrecognized syndromic neurodevelopmental disorder associated with biallelic loss-of-function variants in the RBM42 *** patient is a 2-year-old female with severe central nervous system(CNs)abnormalities,hypotonia,hearing loss,congenital heart defects,and dysmorphic facial *** whole-exome sequencing(WEs)reveals that the patient has two compound heterozygous variants,c.304C>T(p.R102*)and c.1312G>A(p.A438T),in the RBM42 gene which encodes an integral component of splicing complex in the RNA-binding motif protein *** p.A438T variant is in the RRM domain which impairs RBM42 pro-tein stability in ***,p.A438T disrupts the interaction of RBM42 with hnRNP K,which is the causa-tive gene for Au-Kline syndrome with overlapping disease characteristics seen in the index *** human R102*or A438T mutant protein failed to fully rescue the growth defects of RBM42 ortholog knockout△FgRbp1 in Fusarium while it was rescued by the wild-type(WT)human RBM42.A mouse model carying Rbm42 compound heterozygous variants,c.280C>T(p.Q94*)and c.1306_1308delinsACA(p.A436T),demonstrated gross fetal develop-mental defects and most of the double mutant animals died by ***-seq data confirmed that Rbm42 was involved in neurological and myocardial functions with an essential role in alternative splicing(As).Overall,we present clinical,genetic,and functional data to demonstrate that defects in RBM42 constitute the underlying etiology of a new neurodevelopmental disease which links the dysregulation of global AS to abnormal embryonic development.

关键词： RBM42 gene RNA-binding protein neurodevelopmental disorder Au-Kline syndrome alternative splicing

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Study of Multi-Origin Hazards and Assessment of Associated Risks in the Lefo Caldera (Bamenda Volcano, Cameroon Line)

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International Journal of Geosciences 2014年第11期5卷 1300-1314页

作者： Zangmo Tefogoum Ghislain Nkouathio David Guimolaire Kagou Dongmo Armand gountie dedzo merlin Kamgang Pierre Department of Earth Sciences Faculty of Sciences University of Maroua Maroua Cameroon Department of Earth Sciences Faculty of Sciences University of Dschang Dschang Cameroon Department of Life and Earth Science High Teacher Training College University of Maroua Maroua Cameroon Department of Earth Sciences Faculty of Science University of Yaounde 1 Yaounde Cameroon

The Bamenda Volcano (BV) (2621 m) is a stratovolcano situated in the Cameroon Line (CL). BV includes Mount Lefo (2534 m) which is situated on its southern slopes and contains one elliptical caldera (3 × 4 km). This caldera is propitious to farming and breeding activity. Despite these profitable assets, Lefo caldera (LC) is an amphitheater of the occurrence of multi-origin hazards that have direct or indirect impacts on the biodiversity and human patrimony. The most present hazards are those of meteorological origin. Numerous combined factors (steepest slopes, heavy rainfalls, weathered state of volcanic products…) rule these hazards. These factors gave rise to the occurrence of landslides, gullies erosion and rock falls which occur precisely on caldera northern and eastern rims. Hazards of anthropogenic origin are based on the destruction of the vegetation cover by the population for dealing, firewood and building issues. Moreover, during the breeding activity, the cattle covers the caldera throughout the day;this unevens the topography and destroys the meadow. Hazards of volcanological origin are not yet occurring in LC;but the recent Lake Monoun (1984) and Nyos (1986) CO2 eruptions, mount Cameroon eruptions (1999 and 2000) and mount Oku Lake event (2011) which are close to the BV and, the age of 0 Myr of basalt, constitutes a subject of controversy toward the reactivation of the Cameroonian hotspot faults. The assessment of risks in LC was based on the average income of breeding activity and house investment. The economy of LC is valued at about US$527472.527. The level of such risk will be important in case of loss of human beings and the destruction of geomorphosites’ values. In order to reduce the level of looses in this zone, hazard and risks maps are provided in this paper as well as some recommendations.

关键词： Hazards Risk Anthropogenic Activities Lefo Caldera

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Classic Ehlers-Danlos syndrome and cardiac transplantation-Is there a connection?

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World Journal of Cardiology 2020年第8期12卷 368-372页

作者： merlin G Butler Departments of Psychiatry and Behavioral Sciences University of Kansas Medical CenterKansas CityKS 66160United States

Ehlers-Danlos syndrome(EDS)is a heterogeneous group of connective tissue disorders comprised of several *** EDS is an autosomal dominant disorder with stretchable skin,delayed wound healing with poor scarring,joint hypermobility with subluxations or dislocations,easy bruisability,hernias,aneurysms and cardiac *** in genomics technology using next-generation sequencing has led to the discovery of causative genes for connective tissue disorders,hereditary cardiomyopathies and cardiovascular diseases including several genes for connective tissue disorders.A 55 year-old male exhibited thin stretchable skin,atrophic scars,easy bruising,joint pain and dislocations requiring multiple knee surgeries and a Beighton hyperflexibility score of 6 out of *** was found to have a heterozygous missense COL5A1 gene variant involving exon 3 at nucleotide c:305T>A with an amino acid position change at ***102Asn consistent with classic *** had a heart transplant at 43 years of age due to cardiac failure of unknown *** patient with classic EDS is brought to medical attention and should be of interest to cardiologists,heart transplant specialists and surgeons,particularly in individuals with unexplained cardiac failure and then diagnosed prior to surgical intervention to avoid poor wound healing,scarring and other tissue involvement(e.g.,vascular anomalies,blood pressure instability,aneurysms)as components of EDS.

关键词： Ehlers-Danlos syndrome Next-generation sequencing Surgical complications Beighton hypermobility scale Cardiac failure and transplantation

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Spontaneous Abortions in the Second Trimester of Pregnancy: Research and Analysis of Factors Associated at Laquintinie Hospital in Douala

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Open Journal of Obstetrics and Gynecology 2024年第8期14卷 1130-1143页

作者： Henri Essome Moustapha Bilkissou merlin Boten Bounyom Sandrine Ngoumi Ingrid Doriane Ofakem Ilick Astrid Ndolo Kondo Fulbert Mangala Nkwele Michel Roger Ekono Alphonse Ngalame Nyong Robert Tchounzou Junie Ngaha Yaneu Marga Vanina Ngono Akam Gervais Mounchikpou Ngouhouo Grâce Tocki Toutou Théophile Nana Njamen Pascal Foumane Training Teaching and Research Unit in Gynecology Obstetrics and Reproduction Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Laquintinie Hospital Douala Cameroon Faculty of Health Sciences of Bamenda University of Bamenda Bamenda Cameroon Institute of Health Sciences of the University of the Mountains of Bangant Bangant Cameroon Faculty of Health Sciences of Buea University of Buea Buea Cameroon Faculty of Medicine and Biomedical Sciences of Yaound University of Yaound 1 Yaound Cameroon Faculty of Medicine and Pharmaceutical Sciences of Sangmlima University of Ebolowa Ebolowa Cameroon

Introduction: Spontaneous abortion of the second trimester is an interruption of pregnancy with complete expulsion or not of the product of conception between 15 and 28 weeks of pregnancy without any maneuvers. The objective of our study was to determine the factors associated with second trimester spontaneous abortions at Laquintinie Hospital in Douala. Methodology for this purpose: We conducted a case-control study from January to May 2019 on pregnant women who may or may not have had spontaneous second trimester abortions. Results: In total we recorded 1609 pregnancies and recruited 184 patients, including 46 cases and 138 controls;which gave a frequency of spontaneous abortion in the second trimester of pregnancy of 2.85%. A correlative analysis showed that spontaneous abortions in the second trimester were associated with housewife status (OR = 2.89;CI = 1.21 - 6.79;p = 0.010), gestation > 5 (OR = 4.09;CI = 1.02 - 17.66;p = 0.040), multiparity (OR = 3.81;CI = 1.59 - 9.16;p = 0.002), history of endouterine maneuvers (OR = 5.64;CI = 2.43 - 13 .03;p = 0.000), malaria in pregnancy (OR = 3.99;CI = 1.1 - 14.76;p = 0.030), incompleteness on the second trimester ultrasound (OR = 2.37;CI = 1.18 - 4.70;p = 0.010), jolts when traveling (OR = 46.04;CI = 17.29 - 123.66;p = 0.000), long car journeys (OR = 7.05;CI = 1.99 - 27.77;p = 0.000). After logistic regression eliminating the confounding factors, only the following were associated with abortions: Multiparity (OR = 13.90;CI = 2.96 - 65.18;p = 0.000), endo uterine maneuvers (OR = 3.69;CI = 1. 01 - 13.44;p = 0.047), jolts when traveling (OR = 72.63;CI = 19.47 - 270.96;p = 0.000), long car journeys (OR = 15.41;CI = 2.7 - 85, 95;p = 0.000). Conclusion: Our study reveals that a set of factors contribute to the occurrence of spontaneous abortions in the second trimester of pregnancy in our context.

关键词： Spontaneous Abortion Second Trimester Associated Factors Laquintinie

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Forensic interrogation of diabetic endothelitis in cardiovascular diseases and clinical translation in heart failure

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World Journal of Cardiology 2020年第8期12卷 409-418页

作者： merlin C Thomas Pupalan Iyngkaran Department of Diabetes Monash UniversityMelbourne 3004VictoriaAustralia Werribee Mercy Sub School School of Medicine SydneyUniversity of Notre DameNorthcote 3070VictoriaAustralia

Diabetic heart disease(DHD)can be classified as a primary consequence from several pathophysiological manifestation of diabetes mellitus(DM)on cardiac tissues or secondarily in extracardiac tissues and is encountered as either primary or secondary complications of *** is inflammation of the vascular endothelium and is likely to be seen in the majority of patients who start to manifest an end organ complication of DM in this case *** is a leading cause for many cardiovascular syndromes and diseases including congestive heart failure(CHF)however much remains unknown about the transition from diagnosed DM to clinical state and the contribution of the various mechanical and counterregulatory systems in the manifested *** heart failure or heart failure with preserved ejection fraction(DHF/HFpEF),accounts for half of all CHF presentations,has DM as a major contributor,however,there remain large gaps in clinical and pathophysiological *** review aims to explore the microscopic aspects in diabetic endothelitis and provide a clinical link to with context to HFpEF.

关键词： Cardiovascular disease Diabetic heart disease Diabetes mellitus Diastolic heart failure Endothelitis Heart failure with preserved ejection fraction Inflammation

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Variation in mantle lithology and composition beneath the Ngao Bilta volcano,Adamawa Massif,Cameroon volcanic line,West-central Africa

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Geoscience Frontiers 2020年第2期11卷 665-677页

作者： Robert Temdjim merlin Patrick Njombie Wagsong Arnold Julien Nzakou Tsepeng Stephen Foley Department of Earth Sciences Faculty of SciencesUniversity of Yaounde IP.O.Box.812 YaoundeCameroon Department of Earth and Planetary Sciences and ARC Centre of Excellence for Core to Crust Fluid Systems Macquarie UniversityNorth RydeNSW2109Australia

Mantle peridotites entrained as xenoliths in the lavas of Ngao Bilta in the eastern branch of the continental Cameroon Line were examined to constrain mantle processes and the origin and nature of melts that have modified the upper mantle beneath the Cameroon *** xenoliths consist mainly of lherzolite with subordinate harzburgite and *** commonly contain olivine,orthopyroxene,clinopyroxene and spinel although the dunite is *** is an essential constituent in the *** chemistry differs between the three types of peridotite:olivines have usual mantle-like Mg#of around 90 in lherzolites,but follow a trend of decreasing Mg#(to 82)and NiO(to 0.06 wt.%)that is continuous in the *** also contain orthopyroxenes and/or clinopyroxenes with low-Mg#,indicating a reaction that removes Opx and introduces Cpx,olivine,amphibole and *** is attributed to reaction with a silica-undersaturated silicate melt such as nephelinite or basanite,which originated as a low-degree melt from a depleted source as indicated by low Al2O3 and Na2O in Cpx and high Na2O/K2O in *** estimates place the xenoliths at pressures of 11–15 kbar(35–50 km)and temperatures of 863–957C,along a dynamic rift geotherm and shallower than the region where carbonate melts may *** melt/rock reactions exhibited by the Ngao Bilta xenoliths are consistent with their peripheral position in the eastern branch of the Cameroon Volcanic Line in an area of thinned crust and lithosphere beneath the Adamawa Uplift.

关键词： Cameroon volcanic line Adamawa volcanic massif Peridotite xenoliths Partial melting Melt-rock reactions

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