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Effects of the viability of Lactobacillus rhamnosus GG on rotavirus infection in neonatal rats

World Journal of Gastroenterology 2012年第41期18卷 5925-5931页

作者： Hanna Ventola Liisa Lehtoranta Mari Madetoja Marja-Leena Simonen-Tikka Leena Maunula merja roivainen Riitta Korpela Reetta Holma Institute of Biomedicine PharmacologyUniversity of HelsinkiFI-00014 HelsinkiFinland Toxis Ltd Oy Lemmink isenkatu 14-18 CFI-20520 TurkuFinland Intestinal Viruses Unit National Institute for Health and WelfareFI-00271 HelsinkiFinland Department of Food Hygiene and Environmental Health University of HelsinkiFI-00014 HelsinkiFinland

AIM:To study the effects of live and dead Lactobacillus rhamnosus GG(GG) on rotavirus infection in a neonatal rat ***:At the age of 2 d,suckling Lewis rat pups were supplemented with either live or dead GG and the treatment was continued daily throughout the *** the age of 5 and 6 d the pups received oral rotavirus(RV) SA-11 *** pups were sacrificed at the age of 7 or 8 d by *** gastrointestinal tract was removed and macroscopic observations were *** consistency of feces in the colon was classified using a four-tier *** was detected from the plasma,small intestine,colon and feces by real-time quantitative polymerase chain reaction(PCR).RESULTS:In this neonatal rat model,RV induced a mild-to-moderate diarrhea in all except one pup of the RV-inoculated *** moderately reduced body weight development from day 6 *** day 7,after 2 d of RV infection,live and dead GG groups gained significantly more weight than the RV group without probiotics [36%(P = 0.001) and 28%(P = 0.031),respectively].In addition,when compared with the RV control group,both live and dead GG reduced the weight ratio of colon/animal body weight to the same level as in the healthy control group,with reductions of 22%(P = 0.002) and 28%(P < 0.001),*** increased moderately in both GG ***,the diarrhea incidence and severity in the GG groups were not statistically significantly different as compared with the RV control ***,observed diarrhea did not provoke weight loss or *** RV control group had the largest amount of RV PCR-positive samples among the RV-infected groups,and the live GG group had the smallest *** receiving live GG had significantly less RV in the colon(P = 0.027) when compared with the RV control *** GG was also more effective over dead GG in reducing the quantity of RV from plasma(P = 0.047).CONCLUSION:Both live and dead GG have beneficial effects in RV *** may

关键词： Diarrhea lactobacillus rhamnosus GG Neonatal rat Rotavirus Viability

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