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Alterations of Blood Immune Cells in Elderly Patients with COVID-19 and with or without Pre-Existing Type 2 Diabetes

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Open Journal of Immunology 2022年第2期12卷 41-63页

作者： susana salva Yanina Kolling Nicolás Argañaraz María Pía Rocchia Novillo María del Milagro Rocchia Novillo Leonardo Albarracin Jacqueline Charubi Alejandra Casen Nadia Gobbato Mirta Rachid susana Alvarez Haruki Kitazawa Julio Villena Juan Carlos Valdez Laboratory of Immunobiotechnology Reference Centre for Lactobacilli (CERELA-CONICET) Tucuman Argentina Laboratory of Immunology Faculty of Biochemistry Chemistry and Pharmacy National University of Tucuman Tucuman Argentina Hospital Centro de salud “Zenon santillan” Tucuman Argentina Instituto de Maternidad “Ntra. sra. De las mercedes” Tucuman Argentina Food and Feed Immunology Group Laboratory of Animal Food Function Graduate School of Agricultural Science Tohoku University Sendai Japan Livestock Immunology Unit International Education and Research Center for Food and Agricultural Immunology (CFAI) Graduate School of Agricultural Science Tohoku University Sendai Japan

Elderly individuals, especially those with pre-existing conditions like type 2 diabetes mellitus (T2DM), have a high risk for developing severe cases of COVID-19. The aim of this work was to characterize the alterations of blood immune cells (BIC) in patients with symptomatic COVID-19 and confirmed sARs-CoV-2 infection, ≥60 years and who needed hospitalization in the Centro de salud Hospital of Tucuman, Argentina, during the second peak of the pandemic in Argentina. Ten patients were enrolled from December 2020 to May 2021. Blood samples were taken at the time of admission (day 0) and five days after (day 5) for routine laboratory tests and the characterization of BIC by flow cytometry. Most of the patients were men (70%) aged between 60 and 78 years. The 70% of patients had T2DM while 50% had arterial hypertension. At day 0, all the patients had increased neutrophils and inflammatory markers (C reactive protein and D-dimers) and reduced numbers of lymphocytes, HLA-DRsup>hisup> monocytes, CD16sup>+sup>CD56sup>+sup> NK cells, CD3sup>+sup>HLAsup>−sup>DRsup>+sup>CD25sup>+sup> cells, CD4sup>+sup> and CD8sup>+sup> T cells in blood. Patients received a standard treatment for COVID-19 care (Osub>2sub>, corticosteroids and antibiotics). The hospital treatment normalized the levels of BIC (day 5) in 30% of patients who were those with no comorbidities. In patients with T2DM, BIC recovery was variable. In T2DM patients who required administration of plasma (30%), prolonged Osub>2sub> therapy (40%) or referral to the intensive care unit (10%) significant reductions of CD16sup>+sup>CD56sup>+sup>, CD3sup>+sup>HLAsup>−sup>DRsup>+sup>CD25sup>+sup>, CD4sup>+sup> and CD8sup>+sup> cells were observed between days 0 and 5. In line with previous studies, our results show that absolute counts of major lymphocyte subsets in blood are significantly and substantially decreased during the course of severe COVID-19 disease

关键词： COVID-19 sARs-CoV-2 Diabetes Elderly Blood Leukocytes Immune Response

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肝部分切除术理想的手术切口:mercedes型切口远期并发症较扩大右肋缘下切口增加

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中华肝胆外科杂志 2006年第8期12卷 573-573页

作者： D＇Angelica M Maddineni s Fong Y 黄辉不详解放军总医院第二附属医院北京市100091

　　该研究主要是对比肝部分切除术采用两种不同腹部切口的早期和远期并发症的不同.……

关键词：肝部分切除术远期并发症肋缘下切口手术切口理想腹部切口

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BAF和PRC2复合物亚基Dpf2和Eed拮抗调控Tbx3控制胚胎干细胞分化

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科学新闻 2020年第2期 62-62页

作者：张文胜 Constantinos Chronis 陈曦 Heyao Zhang Rapolas spalinskas mercedes Pardo Liangliang Chen 吴光明朱哲鑫余勇 Lu Yu Jyoti Choudhary Jennifer Nichols Mana M.Parast Boris Greber Pelin sahle'n Kathrin Plath 苏州大学医学部剑桥苏大基因组资源中心 sanger研究所马谱生物分子医学研究所伦敦癌症研究所剑桥大学干细胞研究所加州大学圣迭戈分校瑞典皇家理工学院加州大学洛杉矶分校

文章简介BAF(Brg or Brahma-associated factors)染色质重塑复合物利用其ATP酶亚基水解ATP产生的能量改变组蛋白和DNA的作用,调控转录因子同DNA的结合而调节基因的表达,参与多种生物学过程。BAF复合物由多至15个不同的亚基组成,但对这... 详细信息

文章简介BAF(Brg or Brahma-associated factors)染色质重塑复合物利用其ATP酶亚基水解ATP产生的能量改变组蛋白和DNA的作用,调控转录因子同DNA的结合而调节基因的表达,参与多种生物学过程。BAF复合物由多至15个不同的亚基组成,但对这些亚基功能的研究多局限于显示失活特定亚基而导致的表型缺陷,缺乏深入的作用机制的研究。

关键词：干细胞分化 Eed 复合物 BAF

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A Comparative Analysis between the spanish and Portuguese seismic Codes: Application to a Border RC Primary school

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Journal of Mechanics Engineering and Automation 2020年第3期10卷 87-97页

作者： María-Victoria Requena-Garcia-Cruz Antonio Morales-Esteban María-Luisa segovia-Verjel Emilio Romero-sánchez Jaime De-Miguel-Rodríguezand João Manuel Carvalho Estêvão Department of Building structures and Geotechnical Engineering University of SevilleAv.Reina Mercedes 2Seville 41012Spain Department of Civil Engineering ISEUniversity of AlgarveFaro 8005-139Portugal

The Iberian Peninsula is close to the Eurasia-Africa plate boundary resulting in a considerable seismic *** fact,the southwestern Iberian Peninsula is affected by far away earthquakes of long-return period with large-very large magnitude.A project named PERsIsTAH(Projetos de Escolas Resilientes aos sIsmos no Território do Algarve e de Huelva,in Portuguese)aims to cooperatively assess the seismic vulnerability of primary schools located in the Algarve(Portugal)and Huelva(spain).Primary schools have been selected due to the considerable amount of similar buildings and their seismic *** Portugal,the Decreto Lei 235/83(RsAEEP)is mandatory while in spain,the mandatory code is the seismic Building Code(NCsE-02).In both countries,the Eurocode-8(EC-8)is *** the fact that both regions would be equally affected by an earthquake,both seismic codes are significantly *** research compares the seismic action of Ayamonte(Huelva)and Vila Real de santo António(Portugal).Both towns are very close and located at both sides of the ***,they share the same *** analysis has been applied considering a reinforced concrete(RC)primary school building located in *** do so,the performance-based method has been *** seismic action and the damage levels are compared and *** results have shown considerable differences in the seismic actions designation,in the performance point values and in the damage *** values considered in the Portuguese code are significantly more *** agreement between codes should be made for border regions.

关键词： Performance-based method seismic code seismic behaviour nonlinear analysis Iberian Peninsula RC building

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