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Superior growth performance in broiler chicks fed chelated compared to inorganic zinc in presence of elevated dietary copper

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Journal of Animal Science and Biotechnology 2016年第4期7卷 561-569页

作者： Junmei Zhao Robert B. Shirley Julia J. Dibner Karen J. Wedekind Frances Yan Paula Fisher Thomas R. Hampton Joseph L. Evans mercedes Vazquez-Anon research and development novus international20 Research Park DriveSaint CharlesMO 63304USA current affiliation:poultry technical services adisseo usaAlpharettaGA 30022USA

background： The goal of this study was to compare the antagonism of elevated dietary Cu （250 mg/kg） from CuS04 on three different Zn sources （ZnS04. H20; [Zn bis（-2-hydroxy-4-（methylthio）butanoic acid）], Zn（HMTba）2 a chelated Zn methionine hydroxy analogue; and Zn-Methionine）, as measured using multiple indices of animal performance in ROSS 308 broilers. Methods： Three experiments were conducted in broiler chicks fed a semi-purified diet. All birds were fed a Zn-deficient diet （8.5 mg/kg diet） for 1 wk, and then provided with the experimental diets for 2 wks. Results： Experiment 1 was a 2 x 2 factorial design with two levels of Cu （8 vs. 250 mg/kg diet from CuSO4） and two Zn sources at 30 mg/kg [ZnSO4. H20 vs. Zn（HMTba）2]. Elevated Cu impaired growth performance only in birds fed ZnSO4. Compared to ZnSO4. H20, Zn（HMTba）2 improved feed intake （12 %; P 〈 0.001） and weight gain （12 %, P 〈 0.001） and the benefits were more pronounced in the presence of 250 mg/kg diet Cu. Experiment 2 was a dose titration of ZnSO4- H20 and Zn（HMTba）2 at 30, 4,5, 60, and 75 mg/kg diet in the presence of 250 mg/kg CuSO4. Feed：gain was decreased and tibia Zn was increased with increasing Zn levels from 30 to 75 mg/kg. Birds fed Zn（HMTba）2 consumed more food and gained more weight compared to birds fed ZnSO4, especially at lower supplementation levels （30 and 45 mg/kg; interaction P 〈 0,05）. Experiment 3 compared two organic Zn sources （Zn（HMTba）2 vs. Zn-Methionine） at 30 mg/kg with or without 250 mg/kg CuSO4. No interactions were observed between Zn sources and Cu levels on performance or tissue mineral concentrations. High dietary Cu decreased weight gain （P 〈 0.01）. Tibia Cu and liver Cu were significantly increased with 250 mg/kg dietary Cu supplementation （P 〈 0.01）. No difference was observed between the two Zn sources. Conclusions： Dietary 250 mg/kg Cu significantly impaired feed intake and weight gain in birds fed ZnSO4. H20, but had less impact in birds fed Zn（HMTba）2. No difference

关键词： Antagonism Broilers Chelates Growth MineraLs Organic Performance

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Association between the CYba and NOX4 genes of NADPH oxidase and its relationship with metabolic syndrome in non-alcoholic fatty liver disease in Brazilian population

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 330-335页

作者： Fabiola Rabelo Jose Tadeu Stefano Ana mercedes Cavaleiro Rodrigo Vieira Costa Lima Daniel Ferraz de Campos Mazo Flair Jose Carrilho Maria Lúcia Correa-Giannellac Claudia P.Oliveiraa Departamento de Gastroenterologia Faculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil Hospital das Clinicas HCFMUSP Departamento de GastroenterologiaLIM07Faculdade de MedicinaUniversidade de Sao PauloSao PauloSPBrazil Laboratório de Carboidratos e Radioimunensaio LIM18Hospital das Clinicas HCFMUSP(LIM07)Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Programa de Pos-Graduacao em Medicina Universidade Nove de Julho(UNINOVE)Sao PauloBrazil

background: Oxidative stress has been implicated in the progression of severe forms of non-alcoholic fatty liver disease(NAFLD). NADPH oxidase produces reactive oxygen species. In the present study, we investigated for the first time two single nucleotide polymorphisms(SNPs) in the regulatory region of genes encoding NADPH oxidase 4(NOX4) and p22 phox(CYba) in ***: A total of 207 biopsy-proven NAFLD patients [simple steatosis(n = 27); nonalcoholic steatohepatitis(NASH)(n = 180)] were evaluated. Genomic DNA was extracted from peripheral blood cells, and polymorphisms in CYba(unregistered) and NOX4(rs3017887) were determined by direct sequencing of ***: Associations of CYba-675 T/A with high-density lipoprotein(HDL)(TT vs TA vs AA; P ba and NOX4 genes encoding the NADPH oxidase system proteins and the presence of NASH. Regarding the clinical results, it was observed that the most advanced degrees of fibrosis occurred in patients diagnosed with type 2 diabetes mellitus(66.9% vs 37.5%, P ba-675 T/A CYba gene and a higher level of TGL and lower HDL in NASH patients. The presence of metabolic syndrome was associated with advanced degrees of fibrosis in NAFLD patients.

关键词： Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis Genetic polymorphism Metabolic syndrome

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DERMAOZONE品牌的品牌意识策略

DERMAOZONE品牌的品牌意识策略

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作者： JESSY mercedes QUINTERO MORENO 上海外国语大学

学位级别：硕士

人们对外表的追求使得满足这些需求的市场不断发展,其中包括定价合理的医疗、有机产品、外科手术和技术先进的产品。皮肤护理品牌Dermaozone属于最后一类,该品牌使用臭氧成分及一种可持续方法取得了独特的竞争优势。然而,即便具备这些... 详细信息

人们对外表的追求使得满足这些需求的市场不断发展,其中包括定价合理的医疗、有机产品、外科手术和技术先进的产品。皮肤护理品牌Dermaozone属于最后一类,该品牌使用臭氧成分及一种可持续方法取得了独特的竞争优势。然而,即便具备这些竞争优势,该品牌也并未赢得客户的芳心。造成这种情况的一大原因是它们没有线上渠道。此外,由于分销渠道存在一些限制,客户无法享受全渠道体验。这些因素导致该品牌在厄瓜多尔客户当中缺乏知名度。因此,主要应解决的问题是如何改善品牌,使其从竞争者中获得市场份额。为解决这一问题,本专题研究将分析该公司,包括组织结构和环境,从而了解哪些因素可以用作业务机会。此外,为了解环境意识等新行为趋势对厄瓜多尔消费者的影响,作者制定了不同的定性和定量方法。这些信息有助于清晰了解厄瓜多尔人的需求和冲动,从而进一步了解新一代消费者的购买过程。作者为Dermaozone提出了合适的细分和定位,从而重塑其形象。建议包括品牌推广策略和额外的销售渠道。此外,本文还提出一项实施计划,其中涉及建立职务和KPI明确的营销部门,同时也对管理、财务、人力资源和研发部门提出了要求。总而言之,本研究将指导公司赢取新一代具备环保意识的厄瓜多尔消费者,并建议其他公司利用该国的技术发展优势,在化妆品市场建立全方位渠道。本文将在项目期间指出研究的局限性,提供未来研究方向。

关键词：品牌意识绿色营销消费者行为全渠道护肤市场

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Reshaping International Development Cooperation ——China’s Foreign Aid in Latin America

Reshaping International Development Cooperation ...

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作者： Melissa mercedes Alvarez Silva 华中师范大学

学位级别：硕士

巴西、俄罗斯、印度、中国和南非等新兴经济体的快速发展,既改变了国际秩序,也改变了国际发展格局。从历史上看,西方的援助活动一直由经合组织-发展援助委员会（OECD-DAC）主导,并且这种援助带有特定的意图和方向。由于中国等国在南南... 详细信息

巴西、俄罗斯、印度、中国和南非等新兴经济体的快速发展,既改变了国际秩序,也改变了国际发展格局。从历史上看,西方的援助活动一直由经合组织-发展援助委员会（OECD-DAC）主导,并且这种援助带有特定的意图和方向。由于中国等国在南南合作中一直发挥着重要作用,西方援助国和西方援助机构对如何提供发展合作产生了争论。显然,西方的对外援助概念和中国的对外援助概念在不同领域存在着差异。因此,本文希望根据自己国家的发展经验,研究作为21世纪国际发展合作的新塑造者中国的对外援助,尤其是其对拉丁美洲援助的重大贡献。本研究旨在更好地实现和平发展,构建人类命运共同体。

关键词：经合组织-发展援助委员会中国的对外援助拉丁美洲和平发展构建人类命运共同体

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Eco-friendly Leather： Chromium Reduction in the Tanning Cycle

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Journal of Environmental Science and Engineering(A) 2017年第8期6卷 402-409页

作者： Elena Salernitano Alessandra Strafella mercedes Roig Alice Dall'Ara Laboratory of TEMAF (Materials Technologies Faenza) Italian National Agency for New Technologies Energy and Sustainable Economic Development (ENEA) Faenza 48018 Italy INESCOP Centre for Technology and Innovation Elda 03600 Spain

The leather manufacturing is traditionally responsible for high environmental pollution. Tannery effluent contains, indeed, large amounts of lime sludge, sulfides, acids, toxic metals salts, in particular chromium salts, which are toxic, non-biodegradable and hardly disposable. For this reason, great research efforts are addressed to establish a significantly eco-sustainable and convenient business for companies and to produce high quality leather products. The replacement of current commercial chemical and toxic products with innovative natural/naturalized products and technologies in some crucial phases of the tanning cycle （mainly bating and defatting）, can induce an eco-friendly reduction of the needed chromium amount. Leather samples, treated with innovative bating and defatting products and tanned by several different Cr contents, were characterized by SEM-EDS （Scanning Electron Microscopy equipped with Energy Dispersive X-Ray Spectroscopy） and TGA （Thermogravimetric Analysis）. SEM-EDS was used to observe the surface and cross-section morphology and to provide a semi-quantitative elemental analysis, while TGA to evaluate the thermal stability and decomposition phases. The compatibility of the innovative products was demonstrated and the environmental impact of the process, performed by the effluents characterization, was effectively improved as a result of a 20% Cr lowering. The use of innovative products and the chromium reduction did not affect the thermal stability, leather morphology and not involve significant differences in the composition.

关键词： Leather manufacturing tanning cycle Cr reduction natural/naturalized products.

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Evaluation of Ocimum basilicum *** Different Concentrations of K^(+)as an Inhibitor of Pathogenic bacterial Strains

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 533-541页

作者： mercedes Georgina Ramírez-Aragón Victoria Jared Borroel-García Ramón Valenzuela-Soto Ricardo David Valdez-Cepeda Francisco Javier Wong-Corral JoséLuis García-Hernández Universidad Politécnica de Gómez Palacio Gómez Palacio35120México Universidad Autónoma Chapingo Centro Regional Universitario Centro-NorteZacatecasZac.Universidad Autónoma de ZacatecasFacultad de MatemáticasZacatecas98053México Departamento de Investigación y Posgrado en Alimentos Universidad de SonoraHermosillo83000México Facultad de Agricultura y Zootecnia Universidad Juárez del Estado de DurangoGómez Palacio34000México

The extraction of bioactive compounds has become one of the most interesting areas of modern *** therapeutic reasons,it´s important to obtain antimicrobial agents from natural *** objective of the present study was to determine the inhibitory effect of ethanolic extract of basil(Ocimum basilicum *** Rubin)subjected to different concentrations of potassium(K^(+))on the activity of three bacterial strains that are pathogens in *** was evaluated by inhibition surface and these results were compared to two antibiotics:Gentamicin(GE)and Ciprofloxacin(CPF)for their efficacy against each bacterial *** variables presented significant difference(p≤0.05).According to the results,basil extract evaluated showed positive antibacterial activity against the three strains of Pseudomonas aeruginosa,Listeria monocytogenes and Staphylococcus aureus on Mueller Hinton *** was observed highest inhibition areas of different diameters(15.3 mm,21.3 mm and 21.6 mm respectively)when the extract used was obtained from the plants with the highest concentration of potassium(13 mmol L-1).These values were even superior to the highest values showed on the treatments with the antibiotic gentamicin.

关键词： basil inhibition potassium secondary metabolites antibiotics

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Laparoscopic approach in gastrointestinal emergencies

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World Journal of Gastroenterology 2016年第9期22卷 2701-2710页

作者： Rosa M Jimenez Rodriguez Juan José Segura-Sampedro mercedes Flores-Cortés Francisco López-Bernal Cristobalina Martín Verónica Pino Diaz Felipe Pareja Ciuro Javier Padillo Ruiz Department of Surgery Hospital Universitario Virgen del Rocio 41013 Sevilla Spain Hospital Universitario Son Espases 07010 Palma de Mallorca Spain

This review focuses on the laparoscopic approach to gastrointestinal emergencies and its more recent indications. Laparoscopic surgery has a specific place in elective procedures, but that does not apply in emergency situations. In specific emergencies, there is a huge range of indications and different techniques to apply, and not all of them are equally settle. We consider that the most controversial points in minimally invasive procedures are indications in emergency situations due to technical difficulties. Some pathologies, such as oesophageal emergencies, obstruction due to colon cancer, abdominal hernias or incarcerated postsurgical hernias, are nearly always resolved by conventional surgery, that is, an open approach due to limited intraabdominal cavity space or due to the vulnerability of the bowel. These technical problems have been solved in many diseases, such as for perforated peptic ulcer or acute appendectomy for which a laparoscopic approach has become a wellknown and globally supported procedure. On the other hand, endoscopic procedures have acquired further indications, relegating surgical solutions to a second place; this happens in cholangitis or pancreatic abscess drainage. This endoluminal approach avoids the need for laparoscopic development in these diseases. Nevertheless, new instruments and new technologies could extend the laparoscopic approach to a broader array of potentials procedures. There remains, however, a long way to go.

关键词： Minimally invasive surgery Gastrointestinal surgery Emergency surgery Digestive emergencies Abdominal emergencies

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Simultaneous Exact Controllability of Wave Sound Propagations in Multilayer Media

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Journal of Mathematics and System Science 2016年第8期6卷 323-329页

作者： Alexis Rodriguez Carranza Luis. J. Caucha Obidio Rubio mercedes National university of Trujillo Peru.

In this work we study one problem of mathematical interest for their applications in several topics in Applied Science. We study simultaneous controllability of a pair of systems which model the evolution of sound in a compressible flow considered as a transmission problem. We show the well posed of the problem. Furthermore provided appropriate conditions in the geometry of the domain are valid and suitable assumptions on the fluid, is possible to conduce the pair of systems to the equilibrium in a simultaneous way using only one control.

关键词： Controllability wave sound H.U.M

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Lower serum expression of miR-181c-5p is associated with increased plasma levels of amyloid-beta 1-40 and cerebral vulnerability in normal aging

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Translational Neurodegeneration 2019年第1期8卷 423-432页

作者： Marta Manzano-Crespo mercedes Atienza Jose L.Cantero Laboratory of Functional Neuroscience Pablo de Olavide UniversityCtra.de Utrera Km 141013 SevilleSpain CIBERNED Network Center for Biomedical Research in Neurodegenerative Diseases28031MadridSpain

background:Previous studies have shown that expression levels of miR-181c are downregulated by amyloid-β(Aβ)deposition and chronic cerebral hypoperfusion,both factors largely associated with the development of ***,reduced 2-[18F]fluoro-2-deoxy-D-glucose(FDG)-PET brain metabolism and volume loss of regions of the medial temporal lobe have been generally recognized as hallmarks of *** on this evidence,we have here investigated potential associations between serum levels of miR-181c-5p and these AD signatures in asymptomatic elderly ***:Ninety-five normal elderly subjects underwent clinical,cognitive,structural MRI,and FDG-PET *** expression levels of miR-181c-5p and plasma Aβ concentrations were further analyzed in this *** analyses were performed to assess associations between serum miR-181c-5p levels and cognitive functioning,plasma Aβ,structural and metabolic brain ***:Decreased serum expression of miR-181c-5p was associated with increased plasma levels of Aβ1–40,deficits in cortical glucose metabolism,and volume reduction of the entorhinal *** significant associations were found between lower miR-181c-5p levels and cognitive deficits or cortical ***:These findings suggest that deregulation of serum miR-181c-5p may indicate cerebral vulnerability in late life.

关键词： Aging Alzheimer’s disease Blood biomarkers microRNAs Amyloid-beta FDG-PET Entorhinal cortex

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Mixtures of Distributions and Volatility

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Journal of Statistical Science and Application 2016年第4期4卷 179-189页

作者： Juan Carlos Abril Maria de las mercedes Abril Carlos Ismael Martinez Universidad Nacional de Tucuman. Facultad de Ciencias Economicas and Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET). Tucuman. Argentina.

Using Monte Carlo methods we generate time series with the following features： a） series with distributions that are the mix of two normal distributions with different variances, b） series that satisfy volatility models, c） series that satisfy an AR（1） model but with contaminated errors that follow the same distribution as the mixes given in a） and d） series that follow the same distribution as the mixes given in a） but with conditional heterocedasticity. From the analysis we see that it is difficult to identify in practical situations the real generating process of the series. In fact, the processes that come from distribution mixes have many similar characteristics to the ones that satisfy the volatility scheme. We use the corresponding theoretical considerations and also the usual tools in the identifying process of any time series; that is, series graphs, histograms, the corresponding sampling distributions, correlograms and partial correlograms.

关键词： Autoregression Contaminated errors Distribution mixes AR(1) models ARCH models Volatility.

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