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Higher cardiovascular risk scores and liver fibrosis risk estimated by biomarkers in patients with metabolic-dysfunction-associated fatty liver disease

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World Journal of Hepatology 2022年第8期14卷 1633-1642页

作者： Giovanni Alejandro Salgado Alvarez Samanta Mayanin Pinto Galvez Uriel Garcia Mora Ana Delfina Cano Contreras Cristina Durán Rosas Bryan Adrián Priego-Parra Arturo Triana Romero mercedes amieva balmori Federico Roesch Dietlen Sophia Eugenia Martinez Vazquez Ines Osvely Mendez Guerrero Luis Alberto Chi-Cervera Raúl Bernal Reyes Leonardo Alberto Martinez Roriguez Maria Eugenia Icaza Chavez Jose Maria Remes Troche Instituto de Investigaciones Médico-biologicas Universidad VeracruzanaVeracruz 91700VeracruzMexico Department of Gastroenterología Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMéxico 14080MéxicoMexico Clínica de Especialidades Gastrointestinales y Hepáticas Hospital Star MedicaMerida 97133YucatanMexico Department of Gastroenterologia Sociedad Española de BeneficenciaPachuca 42000HidalgoMexico Department of Gastroenterologia Clínica de Rehabilitación Metabólica Digestiva y HepáticaMexico 14080MexicoMexico Department of Gastroenterologia Hospital Star Médica de MéridaMerida 97133YucatanMexico

BACKGROUND The definition of metabolic-dysfunction-associated fatty liver disease(MAFLD)allows identification of metabolically complicated *** risk scores are related to cardiovascular risk(CVR)scores and could be useful for the identification of patients at risk of systemic *** To evaluate the relationship between MAFLD and CVR using the Framingham risk score in a group of Mexican *** Cross-sectional,observational and descriptive study carried out in a cohort of 585 volunteers in the state of Veracruz with MAFLD *** risk of liver fibrosis was calculated with aspartate aminotransferase-to-platelet ratio index,nonalcoholic fatty liver disease score and fibrosis-4,as well as with transient hepatic elastography with Fibroscan~?.The CVR was determined by the Framingham *** One hundred and twenty-five participants(21.4%)with MAFLD criteria were evaluated,average age 54.4 years,63.2%were women,body mass index 32.3 kg/m~*** Framingham CVR was high in 43 patients(33.9%).Transient elastography was performed in 55.2%of volunteers;39.1%with high CVR and predominance in advanced fibrosis(F3–F4).The logistic regression analysis showed that liver fibrosis,diabetes and hypertension independently increased *** One of every three patients with MAFLD had a high CVR,and in those with high fibrosis risk,the CVR risk was even greater.

关键词： Fatty liver Cardiovascular risk Hepatic steatosis Fibrosis Liver disease

Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique Santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

Reproductive biology of harvestmen(Arachnida:Opiliones):a review of a rapidly evolving research field

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Current Zoology 2024年第1期70卷 115-135页

作者： Glauco Machado mercedes Burns LAGE do Departamento de Ecologia Instituto de BiocienciasUniversidade de Sao PauloSao PauloBrazil Department of Biological Sciences University of MarylandBaltimore CountyBaltimoreMDUSA

Harvestmen are a major arachnid order that has experienced a dramatic increase in biological knowledge in the 21st *** publication of the book Harvestmen:The Biology of Opiliones in 2007 stimulated the development of many behavioral *** the book is relatively recent,our understanding of the reproductive biology of harvestmen is already outdated due to the fast accumulation of new *** goal is to provide an updated review of the subject to serve as a benchmark for the following *** the pre-copulatory phase,we explore the evolu-tion of facultative parthenogenesis,the factors that may affect the types of mating system,and the role of nuptial gifts in *** the copulatory phase,harvestmen are unique arachnids because they have aflagellate spermatozoa and a penis with complex *** discuss the implications of these two features for sperm competition and cryptic female *** the post-copulatory phase,we connect ovi-position site selection and climate conditions to the widespread occurrence of resource defense polygyny,alternative reproductive tactics,and sexual dimorphism in several clades of tropical ***,we present the different forms of parental care in the order,and discuss the benefits and costs of this behavior,which can be performed either by females or *** the review,we indicate gaps in our knowl-edge and subjects that deserve further ***,the information synthesized here will stimulate researchers worldwide to embrace harvestmen as a study system and to improve our effort to unravel the mysteries of their reproductive biology.

关键词： alternative reproductive tactics nuptial gifts parental care parthenogenesis resource defense polygyny sexual dimorphism.

Tailored optical propulsion forces for controlled transport of resonant gold nanoparticles and associated thermal convective fluid flows

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Light(Science & Applications) 2020年第1期9卷 256-266页

作者： Jose A.Rodrigo mercedes Angulo Tatiana Alieva Facultad de Ciencias Fisicas Ciudad Universitaria s/nUniversidad Complutense de Madrid28040 MadridSpain

Noble metal nanoparticles illuminated at their plasmonic resonance wavelength turn into heat *** phenomenon has prompted the development of numerous applications in science and *** optical manipulation of such resonant nanoparticles could certainly extend the functionality and potential applications of optothermal *** this article,we experimentally demonstrate optical transport of single and multiple resonant nanoparticles(colloidal gold spheres of radius 200 nm)directed by tailored transverse phase-gradient forces propelling them around a 2D optical *** show how the phase-gradient force can be designed to efficiently change the speed of the *** have found that multiple hot nanoparticles assemble in the form of a quasi-stable group whose motion around the laser trap is also controlled by such optical propulsion *** assembly experiences a significant increase in the local temperature,which creates an optothermal convective fluid flow dragging tracer particles into the ***,the created assembly is a moving heat source controlled by the propulsion force,enabling indirect control of fluid flows as a micro-optofluidic *** existence of these flows,probably caused by the temperature-induced Marangoni effect at the liquid water/superheated water interface,is confirmed by tracking free tracer particles migrating towards the *** propose a straightforward method to control the assembly size,and therefore its temperature,by using a nonuniform optical propelling force that induces the splitting or merging of the group of *** envision further development of microscale optofluidic tools based on these achievements.

关键词： thermal fluid transport

A note on the consistency of a behavioral play marker in piglets

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Journal of Animal Science and Biotechnology 2014年第2期5卷 245-250页

作者： Wendy mercedes Rauw Departamento de Mejora Genetica Animal Instituto Nacional de Investigaciony Tecnologia Agrariay AlimentariaCrtadela Corunakm 7.5Madrid 28040Spain

Background： Play behavior has been proposed as a new potential indicator of animal welfare. Animals play only if they are in a relaxed state. Play may improve adaptability to challenging environments which may be of interest in the breeding objective. Little information is available on play behavior in livestock species. The aim of the present study is to investigate whether play behavior in post-weaned piglets can be induced instantly in the presence of additional space and whether play markers are body weight, sex, and litter dependent, it is investigated whether playfulness is elicited by the moment or if this measure is consistent over different days. Methods： Thirty two piglets from four litters were released into a corridor and video recorded for eight min at 37, 41, 44 and 48 d of age. The first test was considered as an adjustment period and was not included in the analysis. In the second to the fourth test, joyful brusque movements （jumping, turning and running） were recorded with a camera and total number of movements （JOY#） and total time （JOYtime） were estimated individually. Animals were weighed at 41 d of age. Results： Females had higher scores of JOY# and JOYtime than males but this was significant only for JOY# at 41 d of age （P 〈 0.05）. The effect of age was highly significant both for JOY# and JOYtime （P 〈 0.01）. Animals with a higher JOY# and JOYtime also expressed a higher JOY# and JOYtime in the other tests, but this was significant only between 44 and 48 d of age （P〈 0.01）. Body weight at 41 d of age was not significantly related to JOY# and JQYtime in any of the tests. Conclusions： Locomotor play was induced instantly by the provision of increased space allowance. Litter origin had a significant effect on play behavior. In addition, locomotor play scores were consistent between two of the three tests.

关键词： Behavior Locomotor play Pigs Play marker Welfare

Tourism versus nature conservation: reconciliation of common interests and objectives——an analysis through Picos de Europa National Park

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Journal of Mountain Science 2018年第11期15卷 2505-2516页

作者： LóPEZ Iván PARDO mercedes Department of Psychology and Sociology University of Zaragoza Department of Social Analysis University Carlos Ⅲ of Madrid

Nature tourism and particularly tourism in national parks have acquired significant importance in contemporary societies. Post-Fordist consumers have reevaluated the meanings of ‘nature' and ‘natural spaces' and now avoid standardization to seek singularity. Tourism in national parks is a consequence of this tendency and has both positive and negative aspects. The purpose of this sociological research is to describe the most relevant conflicts in the Picos de Europa National Park(Spain) involving the park's conservation, local economic development,and tourism. Seven in-depth interviews and three focus groups were addressed to key local *** this research were identified three chief areas of existing or potential inter-related conflicts and the main actors interacting with them. The first is on population, particularly, the negative consequences of depopulations on the local socio-economic development and the environment. A second source of conflicts identified is caused by the difficult conciliation between commercial exploitation and conservation of the protected natural area. More precisely, this specific form of tourism positively contributes to the economy of local communities whilst problems can arise for the conservation goals of National Parks. Thirdly, in this research is also analyzed the institutional governance and the inter and intra-governmental conflicts as well as with the Park's management body. These findings provide important information for the improved management of tourism and conflicting interests in natural parks.

关键词： National parks Environmental conservation Nature tourism Mountain traditional economy Picos de Europa Spain

The Maximal Graded Left Quotient Algebra of a Graded Algebra

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Acta Mathematica Sinica,English Series 2006年第1期22卷 261-270页

作者： Gonzalo ARANDA PINO mercedes SILES MOLINA Departamcnto de Algebra Geometriay Topologia Universidad de Mdlaga 29071 Mdlaga Espana

We construct the maximal graded left quotient algebra of every graded algebra A without homogeneous total right zero divisors as the direct limit of graded homomorphisms （of left A-modules） from graded dense left ideals of A into a graded left quotient algebra of A. In the case of a superalgebra, and with some extra hypothesis, we prove that the component in the neutral element of the group of the maximal graded left quotient algebra coincides with the maximal left quotient algebra of the component in the neutral element of the group of the superalgebra.

关键词： graded algebra graded left quotient algebra maximal graded left quotient algebra left quotieat algebra maximal left quotient algebra superalgebra

The potential leaching and mobilization of trace elements from FGD-gypsum of a coal-fired power plant under water re-circulation conditions

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Journal of Environmental Sciences 2015年第6期27卷 72-80页

作者： Patricia Córdoba Iria Castro mercedes Maroto-Valer Xavier Querol Centre for Innovation on Carbon Capture and Storage Institute of Mechanical Process and Energy Engineering Heriot-Watt University Institute of Environmental Assessment and Water Research

Experimental and geochemical modelling studies were carried out to identify mineral and solid phases containing major, minor, and trace elements and the mechanism of the retention of these elements in Flue Gas Desulphurisation（FGD）-gypsum samples from a coal-fired power plant under filtered water recirculation to the scrubber and forced oxidation conditions. The role of the p H and related environmental factors on the mobility of Li, Ni, Zn, As, Se, Mo, and U from FGD-gypsums for a comprehensive assessment of element leaching behaviour were also carried out. Results show that the extraction rate of the studied elements generally increases with decreasing the p H value of the FGD-gypsum leachates. The increase of the mobility of elements such as U, Se, and As in the FGD-gypsum entails the modification of their aqueous speciation in the leachates; UO2SO4, H2 Se, and HAs O2 are the aqueous complexes with the highest activities under acidic *** speciation of Zn, Li, and Ni is not affected in spite of p H changes; these elements occur as free cations and associated to SO4 ^2 in the FGD-gypsum leachates. The mobility of Cu and Mo decreases by decreasing the p H of the FGD-gypsum leachates, which might be associated to the precipitation of Cu Se2 and Mo Se2, respectively. Time-of-Flight mass spectrometry of the solid phase combined with geochemical modelling of the aqueous phase has proved useful in understanding the mobility and geochemical behaviour of elements and their partitioning into FGD-gypsum samples.

关键词： Geochemical modelling studies Trace elements Leaching Landfills FGD-gypsum ToF mass spectrometry

Gastric mucosa-associated lymphoid tissue lymphomas and Helicobacter pylori infection:A Colombian perspective

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World Journal of Gastroenterology 2012年第7期18卷 685-691页

作者： Sally Yepes Maria mercedes Torres Carlos Saavedra Rafael Andrade Institute of Genetics Universidad Nacional de Colombia14490 Bogotá DCColombia Department of Pathology Fundación Santa Fe de Bogotá220246 Bogotá DCColombia Human Genetics Laboratory Universidad de los Andes4976 Bogotá DCColombia Faculty of Medicine Universidad Nacional de Colombia14490 Bogotá DCColombia

AIM： To assess the significance of chromosome translo- cation t（11;18）（q21;q21）, B-cell lymphoma 10 （BCL-10） protein and He/icobacter py/ori （H. py/on） infection in gastric mucosa-associated lymphoid tissue ... 详细信息

关键词： Mucosa-associated lymphoid tissue lympho-ma Helicobacter pylori Treatment t(11 18)(q21 q21 ) B-cell lymphoma 10