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Association of Blastocystis hominis with colorectal cancer:A systematic review of in vitro and in vivo evidences

World Journal of Gastrointestinal Oncology 2022年第3期14卷 734-745页

作者： Vinoth Kumarasamy Wahib Mohammed Atroosh Deepa Anbazhagan Mona Mohamed Ibrahim Abdalla meram azzani Department of Microbiology and Parasitology Faculty of MedicineBioscience and NursingMAHSA UniversityJenjarom 42610SelangorMalaysia Department of Preclinical Sciences Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanKajang 43000SelangorMalaysia Department of Parasitology Faculty of MedicineUniversiti MalayaKuala Lumpur 50603Wilayah PersekutuanMalaysia Department of Microbiology and Parasitology Faculty of Medicine and Health SciencesUniversity of AdenAden 00Yemen Human Biology Department International Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia Department of Community Medicine Faculty of MedicineBioscience and NursingMAHSA UniversityJenjarom 42610SelangorMalaysia

BACKGROUND Recently,there have been several findings that showed intestinal colonisation of Blastocystis hominis(Blastocystis)as a risk factor to the worsening of colorectal cancer(CRC).However,studies have shown controversial results in the pathogenicity of Blastocystis.AIM To review systematically the evidence available on the association between CRC and Blastocystis and the prevalence of Blastocystis in CRC patients and to investigate cytopathic and immunological effects of Blastocystis in in vitro and in vivo studies.METHODS PRISMA guidelines were utilised in conducting this systematic review.Original articles published before February 2,2020 were included.PubMed,Science Direct,Scopus and Google scholar databases were searched.Manual searching was carried out to find articles missed during the online search.RESULTS Out of 12 studies selected for this systematic review,seven studies confirmed the prevalence of Blastocystis and found it to be between 2%-28%in CRC patients,whereby subtype 1 and subtype 3 were predominantly seen.A total of four studies employing in vitro human colorectal carcinoma cell line study models showed significant cytopathic and immunological effects of Blastocystis.In addition,one in vivo experimental animal model study showed that there was a significant effect of infection with Blastocystis on exacerbation of colorectal carcinogenesis.CONCLUSION Blastocystis is a commonly identified microorganism in CRC patients.These studies have provided supportive data that Blastocystis could exacerbate existing CRC via alteration in host immune response and increased oxidative damage.Future studies of CRC and Blastocystis should attempt to determine the various stages of CRC that are most likely to be associated with Blastocystis and its relationship with other intestinal bacteria.

关键词： Blastocystis hominis Colorectal cancer Cytopathic effect Immunological effect

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