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Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats

World Journal of Gastroenterology 2009年第33期15卷 4156-4162页

作者： Leyla Ozel M Sefa Ozel Ahmet Burak Toros Melih Kara Kemal Sirri Ozkan Gurkan Tellioglu Osman Krand meral koyuturk Ibrahim Berber Haydarpasa Numune Education and Research Hospital Department of General Surgery Haydarpasa Numune Education and Research Hospital Department of Orthopedics and Traumatology Istanbul Education and Research Hospital Department of Gastroenterology Acibadem Hospital Department of General Surgery Istanbul Bilim University Faculty of MedicineDepartment of Histology and Embryology

AIM： To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil （5-FU） to rats with colonic ***： Sixty Albino-Wistar male rats （median weight, 235 g） were used in this study. The rots were fed with standard laboratory food and given tap water ad libitum. The animals were divided into three groups： Group 1： Control group （chemotherapy was not administered）, Group 2： Intraperitoneally （IP） administered 5-FU group （chemotherapy was administered IP to animals at a dose of 20 mg/kg daily during the 5 d preceeding surgery）, Group 3： Intravenously （IV） administered 5-FU group. Chemotherapy was administered v/a the penil vein, using the same dosing scheme and duration as the second group. After a 3-d rest to minimize the side effects of chemotherapy, both groups underwent surgery. One centimeter of colon was resected 2 cm proximally from the peritoneal reflection, then sutured intermittently and subsequently end-to-end anastomosed. In each group, half the animals were given anaesthesia on the 3rd postoperative （PO） day and the other half on the 7th PO day, for in vivo analytic procedures. The abdominal incisions in the rats were dissected, all the new and old anastomotic segments were clearly seen and bursting pressures of each anastomotic segment, tissue hydroxyproline levels and DNA content were determined to assess the histologic tissue repair process. RESULTS： When the IV group was compared with the IP group, bursting pressures of the anastomotic segments on the 3rd and 7th PO days, were found to be significantly decreased, hydroxyproline levels at the anastomotic segment on the 7th PO day were significantly decreased （P 〈 0.01）. CONCLUSION： In this study, we conclude that early preoperative 5-FU, administered IV, negatively affects wound healing. However, IP administered 5-FU does not negatively affect wound healing.

关键词： 5-fluorouracil Neoadjuvant therapy Rats Wound healing

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<i>In vivo</i>effect of 17-β-estradiol, progesterone, hCG and expression of P53 and P21 in endometrial Ishikawa cells

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Open Journal of Obstetrics and Gynecology 2013年第1期3卷 105-110页

作者： Faruk Ab?ke Canan Aslan Gokhan K?l?c meral koyuturk Gozde Koksal Nedret Alt?ok Melike Ersoz Department of Obstetrics and Gynecology Florence Nightingale Kadikoy Hospital Istanbul Turkey Division of Gynecology Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston USA Istanbul Bilim University Institute of Health Sciences Department of Histology & Embryology Istanbul Turkey

The following article has been retracted due to the investigation of complaints received against it. The Editorial Board found that the first author published the paper without other authors’ consent and approval. The scientific community takes a very strong view on this matter, and the OJOG treats such behavior seriously. This paper published in Vol. 3 No. 1, 105-110 (pages), 2013, has been removed from this site.

关键词： Ishikawa cells 17-β-estradiol Progesterone hCG P53 P21 Endometrium

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Castle architecture in Anatolia： Fortifications of Diyarbakir

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Frontiers of Architectural Research 2013年第2期2卷 209-221页

作者： Fatma meral Halifeosiu Department of Architecture Dicle University Diyarbakir 21280 Turkey

The ancient wails of Diyarbakir are the city＇s most important urban etement, exhibiting an artistic grace through the arrangement of the towers, architectural values, dimensions, materiats, and decorations. Diyarbakir is located at the crossroads of important trade routes, one connecting the Western World to the Far East and the other connecting North to South. Architecturally, its defensive waits and towers make it one of the most important surviving casttes. In this study, the history, location, architectural and building properties of fortifications of Diyarbakir were explained and technical dimensioning typology studies on towers and city watts were submitted.

关键词： Diyarbakir Fortifications ofDiyarbakir Castte Citadel Tower ptans Typotosy

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Effect of hypercholesterolemia on experimental colonic anastomotic wound healing in rats

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World Journal of Gastroenterology 2006年第8期12卷 1225-1228页

作者： meral ■en A Ziya Anadol Mehmet O■uz Department of Surgery School of MedicineFatih University06500 AnkaraTurkey Department of Surgery School of MedicineOndokuz Mayis University55139 SamsunTurkey Department of Surgery School of MedicineGazi University06500 AnkaraTurkey

AIM： To evaluate the mechanical and biochemical parameters of colonic anastomotic healing in hypercholesterolemic rats. METHODS： Sixty rats were divided into two groups of 30 each according to their dietary regimens. The test group was fed with a high cholesterol-containing diet for two months while the control group had standard diet. These two groups were further divided into three subgroups consisting of ten rats each. After hypercholesterolemia was established, left colon resection and anastomosis were performed in both groups and samples from liver and abdominal aorta were taken to evaluate the systemic effects of hypercholesterolemia. Anastomotic wound healing, blow-out pressures and tissue hydroxyproline levels were evaluated. RESULTS： The test group had a significant weight gain in two months. Microscopic examination of the abdominal aorta revealed no atherosderotic change in none of the groups, but liver tissue specimens showed significant steatosis in the test group. Tissue hydroxyproline levels and anastomotic blow-out pressures were significantly lower in the test group than in the controls. CONCLUSION： Hypercholesterolemia not only increases hydroxyproline levels and blow-out pressures but also worsens anastomotic wound healing.

关键词： Hypercholesterolemia Colonic anastomosis Anastomotic wound healing

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Can 5-aminosalicylic acid suppository decrease the pain after rectal band ligation?

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World Journal of Gastroenterology 2008年第22期14卷 3523-3525页

作者： Burcak Kayhan Digdem Ozer meral Akdogan Ersan Ozaslan Osman Yuksel Ankara Numune Training and Education Hospital Department of Gastroenterology Ankara 06443 Turkey Ankara Güven Hospital Department of Internal Disease Ankara 06443 Turkey Turkiye Yüksek htisas Hospital Department of Gastroenterology Ankara 06443 Turkey

AIM: To investigate the effect of 5-aminosalicylic acid (5-ASA) suppositories on rectal band ligation-induced pain. METHODS: Sixty patients were randomized into two treatment groups. RESULTS: Our results showed that there was no difference between 5-ASA suppository group and the control group for pain control. CONCLUSION: 5-ASA may be an alternative treatment for hemorrhoids; however, it does not affect the rectal band ligation-induced pain.

关键词： Hemorrhoid Pain 5-aminosalicylic acid Rectal band ligation

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Hepatic fibrosis in biliary-obstructed rats is prevented by Ginkgo biloba treatment

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World Journal of Gastroenterology 2005年第35期11卷 5444-5449页

作者： Gksel pener Levent Kabasakal meral Yüksel Nursal Gedik Ynci Alican Department of Pharmacology Marmara University School of Pharmacy Istanbul Turkey Marmara University Vocational School of Health Related Professions Istanbul Turkey Division of Biochemistry Kas(?)mpasa Military Hospital Istanbul Turkey Department of Physiology School of Medicine Marmara University Istanbul Turkey

AIM： To assess the antioxidant and antifibrotic effects of long-term Ginkgo biloba administration on liver fibrosis induced by biliary obstruction in rats. METHODS： Liver fibrosis was induced in male Wistar albino rats by bile duct ligation and scission （BDL）. Ginkgo biloba extract （EGb 761, 50 mg/*** d） or saline was administered for 28 d. At the end of the treatment period, all rats were killed. Serum aspartate aminotransferase （AST）, alanine aminotransferase （ALT）, and lactate dehydrogenase （LDH） levels were determined to assess liver functions and tissue damage, respectively. Tumor necrosis factor-α （TNF-α） was also assayed in serum samples. Liver tissues were taken for determination of the hepatic malondialdehyde （MDA） and glutathione （GSH） levels, myeloperoxidase （MPO） activity and collagen content. Production of reactive oxidants was monitored by chemiluminescence （CL） assay. Serum AST, ALT, LDH, and TNF-α levels were elevated in the BDL group as compared to control group and were significantly decreased by EGb treatment. RESULTS： Hepatic GSH level, depressed by BDL, was elevated back to control level in EGb-treated BDL group. Increase in tissue MDA level, MPO activity and collagen content due to BDL were also attenuated by EGb treatment. Furthermore, luminol and lucigenin CL values in BDL group increased dramatically compared to control and reduced by EGb treatment. CONCLUSION： Our results suggest that Ginkgo biloba protects the liver from oxidative damage following BDL in rats. This effect possibly involves the inhibition of neutrophil infiltration and lipid peroxidation; thus, restoration of oxidant and antioxidant status in the tissue.

关键词： Ginkgo biloba, Bile duct ligation Hepatic fibrosis Oxidant

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Etiology and portal vein thrombosis in Budd-Chiari syndrome

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World Journal of Gastroenterology 2008年第18期14卷 2858-2862页

作者： Oguz Uskudar meral Akdogan Nurgul Sasmaz Sevinc Yilmaz Muharrem Tola Burhan Sahin Turkiye Yuksek htisas Hospital clinics of gastroenterology Ankara 06010 Turkey Turkiye Yuksek htisas Hospital hematology unit Ankara 06010 Turkey Turkiye Yuksek htisas Hospital clinics of radiology Ankara 06010 Turkey

AIM: To research the etiology, portal vein thrombosis and other features of Budd-Chiari syndrome (BCS) patients prospectively. METHODS: A total of 75 patients (40 female, 35 male) who were diagnosed between January 2002 and July 2004 as having BCS were studied prospectively. Findings from on physical examination, ultrasonography, duplex ultrasonography and venography were analyzed. Hemogram and blood chemistry were studied at the time of diagnosis and on each hospital visit. Bone marrow examination and immune phenotyping were performed by a hematologist when necessary. Protein C, S, antithrombin Ⅲ, activated protein C resistance, and anticardiolipin antibodies, antinuclear antibodies, and anti ds-DNA were studied twice. The presence of ascite, esophageal varices, and portal thrombosis were evaluated at admission and on every visit. RESULTS: At least one etiological factor was determined in 54 (72%) of the patients. The etiology could not be defined in 21 (28%) patients. One etiological factor was found in 39, 2 factors in 14 and 3 factors in 1 patient. The most common cause was the web (16%), the second was Hydatid disease (11%), the third was Behcet’s disease (9%). Portal vein thrombosis was present in 11 patients and at least one etiology was identified in 9 of them (82%). CONCLUSION: Behcet’s disease and hydatid disease are more prominent etiological factors in Turkey than in other countries. Patients with web have an excellent response to treatment without signs of portal veinthrombosis while patients having thrombofilic factors more than one are prone to develop portal vein thrombosis with worse clinical outcome.

关键词： Budd-Chiari syndrome Etiology Web Behcet's disease Portal thrombosis

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Extensive hepatic-portal and mesenteric venous gas due to sigmoid diverticulitis

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World Journal of Gastroenterology 2009年第7期15卷 879-881页

作者： meral Sen Ayhan Akpinar Aydin Snan Mete Sisman Cenap Dener Kayihan Akin Fatih University School of Medicine General Surgery Department06510 AnkaraTurkey Fatih University School of Medicine Radiology Department06510 AnkaraTurkey

Hepatic portal venous gas is most often associated with extensive bowel necrosis due to mesenteric *** exceeds 75% with this *** most common precipitating factors include ischemia,intra-abdominal abscesses and inflammatory bowel *** this report,we present a 75-year-old woman with extensive hepatic portal and mesenteric venous gas due to colonic *** had a 10-year history of type diabetes mellitus and *** was treated by sigmoid resection and Hartmann's procedure and discharged from the hospital without any complications.

关键词： Hepatic portal vein Gas Sigmoid diverticulitis Computed tomography

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Proton magnetic resonance spectroscopy of the anterior cingulate gyrus and caudate nucleus in schizophrenia patients versus healthy controls

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Neural Regeneration Research 2011年第6期6卷 467-473页

作者： Lutfi Incesu meral Baydin Kerim Aslan Baris Diren Huseyin Sahin Omer Boke Senol Dane Department of Radiology Medical FacultyOndokuz Mayis University Department of Radiology Gazi State Hospital Department of Radiology Ataturk State Hospital Department of Radiology Medicana International Hospital Department of Psychiatry Medical FacultyOndokuz Mayis University Department of Physiology Medical FacultyFatih University

Proton magnetic resonance spectroscopy （^1 H-MRS） permits the assessment of cerebral neurometabolites, such as N-acetylaspartate, choline, and creatine, in vivo and has been used to study schizophrenia. The present study used ^1H-MRS to compare the spectroscopy change of N-acetylaspartate, creatine, and choline metabolite levels in the anterior cingulate and caudate nucleus of both schizophrenia patients and healthy controls, as well as between the left and right cerebral hemispheres in the schizophrenia patients. Results showed that N-acetylaspartate and creatine metabolite levels in the left anterior cingulate gyrus were significantly lower in the schizophrenia patients than in the healthy controls, indicating hypometabolism. In addition, choline concentration in the left caudate nucleus of schizophrenia patients was significantly lower than in the right caudate nucleus, indicating that it is necessary to study the cerebral lateralization of ^1H-MRS in schizophrenia patients.

关键词： schizophrenia magnetic resonance spectroscopy anterior cingulate gyrus caudate nucleus neurocognitive test

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Adsorption and desorption behavior of silver ions onto valonia tannin resin

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Transactions of Nonferrous Metals Society of China 2012年第11期22卷 2846-2854页

作者： meral YURTSEVER .Ayhan SENGL Department of Environmental Engineering Engineering Faculty Sakarya University

Valonia tannin （VT） was gelated through polymerization with formaldehyde to prepare an adsorbent, which was found effective to remove Ag＋ from aqueous solution. The adsorption-desorption behaviors of valonia tannin resin （VTR） were investigated under various initial Ag＋ concentrations, solution temperatures, pH values etc. The applicability of empirical kinetic models was also studied. The pseudo-second-order model studies revealed the Ag＋ sorption was very rapid. VT and VTR were characterized using FTIR and SEM before and after adsorption. The Ag＋ biosorption on VTR increased with a rise in initial concentration of Ag＋ and with a decrease in temperature. Desorption experiments were conducted at low pH values and the solutions of H2SO4, HNO3 and HCl were used for desorption. The VTR shows high adsorption capacity to Ag＋ in a wide pH range of 2.0-7.0, and a maximum adsorption capacity of 97.08 mg/g was obtained at pH 5.0 and 296 K when the initial concentration of Ag＋ was 100.0 mg/L. Ag＋ ion desorption could reach 99.6% using 1 mol/L HCl＋1% thiourea （NH2CSNH2） solution. By utilizing such characteristics of VTR, it is expected that it can be applied to recovering Ag＋ efficiently and simply with low cost.

关键词： biosorption desorption kinetics silver Ag+ ions absorbent valonia tannin resin

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