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Nano Research 2023年第2期16卷 3320-3325页

作者： Mengting Jin Yanhao Wang mengyue gu Xuewen Zhao Rongzheng Zhao Yuhao Zhang Yonghong Cheng Jinying Zhang School of Electrical Engineering Xi’an Jiaotong UniversityXi’an 710049China

The control of crystal growth is important but challenging for multi-disciplinary *** phosphorus,the most stable phosphorus allotrope,has recently been produced as a unique semiconducting layered *** crystal orientation and morphology bring extra performance due to its unique structure and ***,the layered violet phosphorus has been controlled to grow along the c-axis to give tunable length up to centimeters with the assistance of tin,while the reported flat bulk ones with thickness are limited to *** as-produced needle-shaped violet phosphorus has also been demonstrated to significantly enhance the photocatalytic degradation of methyl orange pollutants due to its special crystallographic *** 98.6%of methyl orange pollutants with a concentration of 50 ppm were degraded within 80 min under visible light conditions by needle-shaped violet phosphorus,which is much more effective than that of amorphous red phosphorus with only 14.1%degradation.

关键词： crystal growth photocatalytic degradation red phosphorus tin violet phosphorus

Laser-ablated violet phosphorus/graphene heterojunction as ultrasensitive ppb-level room-temperature NO sensor

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Chinese Chemical Letters 2023年第9期34卷 248-253页

作者： Xiaohui Ye Ming Qi Hao Qiang Mengzhen Chen Xi Zheng mengyue gu Xuewen Zhao Yanling Yang Chaozheng He Jinying Zhang School of Material Science and Engineering Shaanxi University of Science and TechnologyXi’an 710021China Center of Nanomaterials for Renewable Energy(CNRE) School of Electrical EngineeringXi’an Jiaotong UniversityXi’an 710049China Institute of Environmental and Energy Catalysis School of Materials Science and Chemical EngineeringXi’an Technological UniversityXi’an 710021China

Two dimensional(2D)materials are promising gas sensing materials,but the most of them need to be heated to show promising sensing *** structures with high sensing performance at room-temperature are ***,another 2D material,violet phosphorus(VP)nanoflake is investigated as gas sensing *** VP nanoflakes have been effectively ablated to have layers of 1–5 layers by laser ablation in *** VP nanoflakes are combined with graphene to form VP/G heterostructuresbased NO *** ultra-high gauge factor of 3×10^(7)for ppb-level sensing and high resistance response of 59.21%with ultra-short recovery time of 6s for ppm-level sensing have been *** sensing mechanism is also analysed by density functional theory(DFT)*** adsorption energy of VP/G is calculated to be-0.788 e V,resulting in electrons migration from P to N to form a P-N bond in the gap between VP and graphene *** work provides a facile approach to ablate VP for mass *** as-produced structures have also provided potential gas sensors with ultrasensitive performance as ppb-level room-temperature sensors.

关键词： Laser ablation Violet phosphorus nanoflakes Heterostructures ppb level NO sensor

丙泊酚麻醉下脑氧供需平衡及脑血流自动调节范围的影响因素

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第三军医大学学报 2021年第4期43卷 335-341页

作者：辜梦月陈妍杨纯勇鲁开智陆军军医大学(第三军医大学)第一附属医院麻醉科重庆400038

目的探讨丙泊酚麻醉下脑氧供需平衡和脑血流自动调节(cerebral autoregulation,CA)范围的影响因素。方法纳入我院肝胆外科2019年8月至2020年1月在丙泊酚麻醉下行开腹手术的患者共66例。收集患者的一般资料。实时采集患者从入手术室至手... 详细信息

目的探讨丙泊酚麻醉下脑氧供需平衡和脑血流自动调节(cerebral autoregulation,CA)范围的影响因素。方法纳入我院肝胆外科2019年8月至2020年1月在丙泊酚麻醉下行开腹手术的患者共66例。收集患者的一般资料。实时采集患者从入手术室至手术结束期间的局部脑氧饱和度(regional cerebral oxygen saturation,rSO_(2))、局部脑组织血红蛋白浓度指数(tissue hemoglobin concentration index,THI)来评价脑氧供需平衡,并采集平均动脉压(mean arterial pressure,MAP)、心脏指数及动脉血气分析指标。然后分别通过计算rSO_(2)与MAP的pearson相关系数得到脑血氧测定指数(cerebral oximetry index,COx)、计算THI与MAP的pearson相关系数得到脑总血红蛋白反应指数(total hemoglobin reactivity index,THx)。根据COx和THx设立每位患者CA范围的上限和下限。通过单因素分析和多因素线性回归分析的方法,对患者的一般资料、术中监测数据和血气分析指标进行分析,分别筛选出rSO_(2)、THI以及由COx和THx所界定的CA范围上下限的影响因素。结果经单因素分析剔除混杂因素后,多因素线性回归分析显示rSO_(2)的影响因素包括手术时长、总血红蛋白浓度(P<0.05);THI的影响因素包括年龄(P<0.05);通过COx获得的CA范围上下限的影响因素包括高血压病史、术中MAP、PaO_(2)(P<0.05);通过THx获得的CA范围上下限的影响因素包括高血压病史、术中MAP(P<0.05)。结论在丙泊酚麻醉下,脑氧供需平衡的影响因素有年龄、手术时长、总血红蛋白浓度;脑血流自动调节范围的影响因素有高血压病史、术中MAP、PaO_(2)。

关键词：脑氧供需平衡脑血流自动调节脑氧饱和度脑血氧测定指数影响因素

五元杂环并嘧啶类MTH1抑制剂的设计、合成及生物活性评价

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中国药科大学学报 2018年第4期49卷 407-412页

作者：王蕾马俊顾梦月狄蓉蓉刘煜赖宜生中国药科大学新药研究中心南京210009 中国药科大学生命科学与技术学院南京210009

在MTH1抑制剂TH287的基础上,采用闭环、骨架跃迁和生物电子等排等药物设计策略,结合计算机辅助药物设计方法,设计并合成了17个五元杂环并嘧啶类目标化合物(I_(1~10),II_(1~7))。采用孔雀石绿显色法评价了目标化合物对MTH1酶活性的影响,... 详细信息

在MTH1抑制剂TH287的基础上,采用闭环、骨架跃迁和生物电子等排等药物设计策略,结合计算机辅助药物设计方法,设计并合成了17个五元杂环并嘧啶类目标化合物(I_(1~10),II_(1~7))。采用孔雀石绿显色法评价了目标化合物对MTH1酶活性的影响,结果表明该类化合物具有良好的MTH1抑制活性,其中7个化合物的(I_3,I_4,I_(7~9))IC_(50)低于1μmol/L,可以作为新型MTH1抑制剂开展进一步的研究。

关键词：五元杂环并嘧啶类 DNA氧化损伤 DNA修复 MTH1抑制剂合成抗肿瘤生物活性评价

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加巴喷丁治疗奥氮平致不宁腿综合征1例

四川精神卫生 2021年第3期34卷 277-279页

作者：顾梦阅狄东川邱俊翟金国济宁医学院山东济宁272000 济宁医学院第二附属医院山东济宁272000

本文目的是提示临床使用奥氮平过程中加强对不宁腿综合征(RLS)的识别与治疗。本文报道1例精神分裂症患者服用奥氮平期间出现夜间双下肢不适、控制不住地想要活动双腿、无法入睡等RLS症状,服用加巴喷丁后,患者症状明显改善。

关键词：奥氮平不宁腿综合征加巴喷丁

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu Zhen gu Hua Yan Dingding Shen Xiaosong gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang Yuan Liang Yixue gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

Brain-derived neurotrophic factor plays with TRiC:focus on synaptic dysfunction in Huntington’s disease

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Neural Regeneration Research 2025年第10期20卷 2919-2920页

作者： Yingli gu Kijung Sung Chengbiao Wu Department of Neurosciences University of California San DiegoLa JollaCAUSA

Brain-derived neurotrophic factor(BDNF)exerts pleiotropic effects on brain processes including psychiatric disorders,aging,neurodegeneration,and metabolic homeostasis.A simple PubMed search using the key word“BDNF,”to date,yields over 33,000 *** fundamental biology to potential therapeutic applications,BDNF has clearly garnered extensive and significant attention in the field of neurobiology research.

关键词： Huntington homeostasis therapeutic

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深部脑刺激术治疗抑郁障碍研究进展

济宁医学院学报 2021年第5期44卷 352-355页

作者：顾梦阅(综述) 翟金国(审校) 济宁医学院精神卫生学院济宁272013

深部脑刺激术(deep brain stimulation,DBS)是一种使用植入颅内的电极来调节神经活动的技术,已有多项试验证明其在抑郁障碍治疗领域的疗效。本文对DBS治疗抑郁障碍的最新研究进展做一综述,特别关注DBS靶点和临床疗效之间的关系。

关键词：抑郁障碍深部脑刺激术靶点

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看守所在押人员的自杀意念及相关因素

中国心理卫生杂志 2021年第9期35卷 758-763页

作者：顾梦阅狄东川彭吉军吉峰翟金国刘燕济宁医学院山东济宁272013 山东省戴庄医院山东济宁272051 济南市公安局济南250115

目的:了解看守所在押人员自杀意念流行现状并分析其相关因素。方法:于2020年1月1日-15日,选取某看守所在押人员1268名,使用自编一般情况调查表、自杀意念自评量表(SIOSS)、艾森克人格问卷(EPQ)进行调查。结果:在押人员过去1年内自杀意... 详细信息

目的:了解看守所在押人员自杀意念流行现状并分析其相关因素。方法:于2020年1月1日-15日,选取某看守所在押人员1268名,使用自编一般情况调查表、自杀意念自评量表(SIOSS)、艾森克人格问卷(EPQ)进行调查。结果:在押人员过去1年内自杀意念检出率为30.7%。心理压力较大(OR=2.97,95%CI:2.07,4.26)、自杀未遂史(OR=2.94,95%CI:2.10,4.13)、家庭关系缺乏温暖(OR=1.83,95%CI:1.31,2.56)、神经质(OR=1.08,95%CI:1.06,1.09)、精神质(OR=1.03,95%CI:1.02,1.04)是自杀意念的危险因素,外向是自杀意念的保护因素(OR=0.96,95%CI:0.95,0.98)。结论:约三分之一的在押人员有过自杀意念。有自杀未遂史、家庭关系不良、心理压力大及神经质、精神质人格特质的在押人员易产生自杀意念。

关键词：在押人员自杀意念横断面研究