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Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning li Yakun Gu Wei Ma Yuying Guan mengyuan Guo Qianqian Shao Xunming Ji Jia liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

A Modified Split⁃Ring Resonator Antenna for Radio Frequency Identification Tag

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Transactions of Nanjing University of Aeronautics and Astronautics 2021年第3期38卷 512-519页

作者： CHEN Weikang NIU Zhenyi li mengyuan XU Qian GU Changqing Key Laboratory of Radar Imaging and Microwave Photonics Ministry of EducationCollege of Electronic and Information EngineeringNanjing University of Aeronautics and AstronauticsNanjing 211106P.R.China

A compact antenna formed by three concentric split rings for ultra-high frequency(UHF)radio frequency identification(RFID)tag is proposed in this *** antenna is composed of two parts,an outer short-circuited ring modified from a traditional split-ring resonator(SRR)antenna and an inner SRR load,so the antenna can be regarded as a short-circuited ring loaded with *** to the transmission line theory,to conjugate match with the capacitive input-impedance of a tag chip,the length of the short-circuited ring isλg/4 shorter than that of an open-circuited dipole of a traditional SRR antenna,whereλg is the wavelengh of the operating ***,the size of the proposed antenna is more compact than that of the traditional SRR ***,the proposed antenna is simulated and optimized by ANSYS high-frequency structure simulator(HFSS).The impedance,efficiency,and mutual coupling of the fabricated antenna are tested in a reverberation chamber(RC).The results show that the size of the presented antenna is 83%smaller than that of the traditional SRR antenna and the proposed antenna can cover the whole UHF RFID operating frequency band worldwide(840—960 MHz).The measured read range of the tag exhibits maximum values of 45 cm in free space and 37 cm under dense tag environment.

关键词： radio frequency identification(RFID) compact antenna split-ring resonator(SRR) reverberation chamber(RC) dense tag environment

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青年女性腿型与裤装版型关系的研究

毛纺科技 2017年第3期45卷 48-51页

作者：李梦园浙江理工大学服装学院浙江杭州310018

针对青年女性腿型分类不够精细、裤装版型合体性不够的问题,分别对青年女性腿型分类和裤装版型的研究现状进行研究,从创新的角度提出了基于腿型分类的青年女性裤装版型的发展方向:运用人体数据采集技术建立完善的青年女性腿型规格库与... 详细信息

针对青年女性腿型分类不够精细、裤装版型合体性不够的问题,分别对青年女性腿型分类和裤装版型的研究现状进行研究,从创新的角度提出了基于腿型分类的青年女性裤装版型的发展方向:运用人体数据采集技术建立完善的青年女性腿型规格库与裤装样板数据库;将三维的人体模型与二维裤装样板自动匹配,构建裤装样板自动生成系统,并确定青年女性裤装版型个性化定制模式,以期为服装行业生产出符合年轻群体体型和审美的裤装提供新的思路。

关键词：腿型版型构建定制

聚乙烯醇生产中回收工段第三、第四精馏塔的模拟与优化

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化工进展 2023年第S01期42卷 113-123页

作者：李梦圆郭凡李群生北京化工大学化学工程学院北京100029 浙江华亿工程设计股份有限公司浙江绍兴312300

聚乙烯醇(PVA)是一种性能优良的聚合物材料,其回收工段的主要目的是对上游产生的富含醋酸甲酯(MeOAC)、甲醇(MeOH)等化工原料的醇解废液进行回收处理。其中回收工段第三精馏塔和第四精馏塔(以下简称TQ-603和TQ-604)主要分离任务是同时... 详细信息

聚乙烯醇(PVA)是一种性能优良的聚合物材料,其回收工段的主要目的是对上游产生的富含醋酸甲酯(MeOAC)、甲醇(MeOH)等化工原料的醇解废液进行回收处理。其中回收工段第三精馏塔和第四精馏塔(以下简称TQ-603和TQ-604)主要分离任务是同时处理来自回收二塔TQ-602的塔釜液、来自回收一塔TQ-601的塔釜液及聚合工段第三精馏塔TQ-302的塔釜液,其物料的主要组成均为甲醇与水的混合物。本文采用Aspen Plus化工流程模拟软件对10万吨/年PVA回收工段中回收三塔和四塔进行模拟优化,针对所分离的主要体系MeOH-H_(2)O体系进行了热力学方法的选择及参数回归,最终选用NRTL模型进行了模拟与优化。优化后得到单塔的最佳操作参数。在此基础上将双效精馏技术用于原工艺流程的节能改造并开展模拟优化,构建多塔供热流程,实现深度节能。

关键词：聚乙烯醇回收塔双效精馏模拟优化

明朝盐课提举司的地方运作与制度变迁——以云南五井盐课提举司为例

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中国边疆史地研究 2023年第3期33卷 86-95,242页

作者：李梦圆中山大学历史学系(珠海) 519082

明朝云南五井盐课提举司作为滇西北的最高盐务管理机构,其职权一度超出盐务范畴,深入到井地的民政、司法、文教等领域。嘉靖年间五井盐课提举司治所迁入云龙州,与云龙州治分驻于澜沧江东岸雒马井和西岸旧州。改土归流后,云龙知州接手了... 详细信息

明朝云南五井盐课提举司作为滇西北的最高盐务管理机构,其职权一度超出盐务范畴,深入到井地的民政、司法、文教等领域。嘉靖年间五井盐课提举司治所迁入云龙州,与云龙州治分驻于澜沧江东岸雒马井和西岸旧州。改土归流后,云龙知州接手了盐课提举的行政、司法和社会管控等“附加职能”,弱化了盐官对地方政务的影响。“盐官”终被州官完全取代,盐务与政务合于知州一人,云龙州实现了真正意义上的“州司合一”。

关键词：明朝云南盐课提举司盐井政区改土归流

矿物掺合料对胶凝材料浆体流变性能和触变性的影响

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硅酸盐学报 2019年第5期47卷 594-601页

作者：刘宇黎梦圆阎培渝清华大学土木工程系城市轨道交通绿色与安全建造技术国家工程实验室北京100084

基于大流态混凝土配合比,研究了各种矿物掺合料对胶凝材料浆体的流变性能和触变性的影响。结果表明:通过流变仪转速阶梯变化制度构建稳定的浆体流动状态,并利用转换方程可进行浆体流变性能参数的有效测量和计算。胶凝材料浆体的流变性... 详细信息

基于大流态混凝土配合比,研究了各种矿物掺合料对胶凝材料浆体的流变性能和触变性的影响。结果表明:通过流变仪转速阶梯变化制度构建稳定的浆体流动状态,并利用转换方程可进行浆体流变性能参数的有效测量和计算。胶凝材料浆体的流变性能符合Bingham模型。粉煤灰和粉煤灰微珠均能降低浆体的屈服应力、塑性黏度和触变性,粉煤灰微珠作用效果更为明显;硅灰能增大浆体的屈服应力、塑性黏度和触变性;磨细矿渣粉会降低浆体的屈服应力和触变性,提高浆体的塑性黏度。在进行大流态混凝土配合比设计时应综合考虑矿物掺合料对新拌混凝土流变性能的影响。

关键词：矿物掺合料胶凝材料浆体流变性能触变性 Bingham模型

Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4748-4764页

作者： Yingqiang liu Zhengsheng Zhan Zhuang Kang mengyuan li Yongcong Lv Shenglan li linjiang Tong Fang Feng Yan li Mengge Zhang Yaping Xue Yi Chen Tao Zhang Peiran Song Yi Su Yanyan Shen Yiming Sun Xinying Yang Yi Chen Shanyan Yao Hanyu Yang Caixia Wang Meiyu Geng Wenbin li Wenhu Duan Hua Xie Jian Ding Division of Antitumor Pharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Medicinal Chemistry Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Neuro-oncology Cancer CenterBeijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Shanghai Runshi Pharmaceutical Technology Co. Ltd.Shanghai 201218China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshan 528400China University of Chinese Academy of Sciences Beijing 100049China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China

Glioblastoma(GBM)is the most common and aggressive malignant brain tumor in adults and is poorly *** studies have shown that both macrophages and angiogenesis play significant roles in GBM progression,and co-targeting of CSF1R and VEGFR is likely to be an effective strategy for GBM ***,this study developed a novel and selective inhibitor of CSFIR and VEGFR,SYHA1813,possessing potent antitumor activity against ***1813 inhibited VEGFR and CSFIR kinase activities with high potency and selectivity and thus blocked the cell viability of HUVECs and macrophages and exhibited anti-angiogenetic effects both in vitro and in ***1813 also displayed potent in vivo antitumor activity against GBM in immune-competent and immune-deficient mouse models,including temozolomide(TMZ)insensitive ***,SYHA1813 could penetrate the blood-brain barrier(BBB)and prolong the survival time of mice bearing intracranial GBM ***,SYHA1813 treatment resulted in a synergistic antitumor efficacy in combination with the PD-1 *** a clinical proof of concept,SYHA1813 achieved confirmed responses in patients with recurrent GBM in an ongoing first-in-human phase I *** data of this study support the rationale for an ongoing phase I clinical study(ChiCTR2100045380).

关键词： Small molecule inhibitor Glioblastoma VEGFR CSF1R Angiogenesis Macrophage Tumor microenvironment Immune-checkpoint inhibitor

The Modelling and Verification of PLC Program Based on Interactive Theorem Proving Tool COQ

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The Modelling and Verification of PLC Program Based on Inter...

2011 International Conference on Computer Science and Information Technology(ICCSIT 2011)

作者： litian Xiao mengyuan li Ming Gu Jiaguang Sun National Laboratory for Information Science and Technology Key Laboratory for Information System Security Ministry of EducationDepartment of Computer Science and Technology School of Software Tsinghua University Beijing Special Engineering Design and Research Institute National Laboratory for Information Science and Technology Key Laboratory for Information System Security Ministry of Education Department of Computer Science and Technology School of Software Tsinghua University

COQ is an interactive theorem proving tool. The paper abstractly describes the feature of COQ, the architecture and working modes of PLC program with the example of typical PLC. It also introduces the first-order logic syntax and semantics of Intuitionistic Logic. It briefly introduces the main Gallina language syntax elements, the corresponding use methods and main theorem proving tactic on COQ. The work has modeled kernel data type and basic statements and and the denotational semantics of PLC program with Gallina. It has given the correctness proof of PLC program based on theorem proving, i.e. based on semantics function the relationship of configuration between the before codes execution and the after is proved. The main purpose is to prove whether a PLC program satisfies certain nature within a scan period.

关键词： PLC Program Embedded System Verification Denotational Semantics Theorem Proving COQ

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论高校图书馆与读者的互动

中共福建省委党校学报 2009年第4期 94-96页

作者：李萌远福建财会管理干部学院福建福州350108

文章探讨了图书馆开展互动服务的重要性,阐述了图书馆与读者互动的方式和内容。文章主张,不断提高馆员与读者的互动意识,共同提升图书馆的服务水平。

关键词：高校图书馆读者服务互动