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Effect of foot reflexology on pain and physiological indicators in postoperative patients:A systematic review and meta-analysis

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TMR Integrative Nursing 2021年第1期5卷 8-20页

作者： li Tian mengyuan li ling Yan School of Nursing Tianjin University of Traditional Chinese MedicineTianjinChina Department of Brain Cancer Tianjin Medical University Cancer Institute&HospitalTianjinChina Department of Nursing Tianjin Medical University Cancer Institute&HospitalTianjinChina

Aim:To determine the effect of foot reflexology intervention on pain and physiological indicators in postoperative *** resources:The Cochrane library,PubMed,EMBASE,MEDliNE,SCOPUS,CINAHL,China National Knowledge Infrastructure(CNKI),VIP,and Wan Fang Data were searched from inception until *** methods:Studies were screened according to the PICOS *** methodological quality was assessed with Cochrane Risk of Bias ***-analysis was performed using RevMan 5.3 ***:5 randomized clinical trials involving 318 participants were included in the *** were significant differences in pain and heart rate in postoperative patients between the two ***:The foot reflexology intervention decrease the postoperative pain and heart rate for the postoperative *** can be considered to be an effective non-pharmaceutical therapy to reduce the postoperative pain and heart *** evidence is not enough to prove the effectiveness of reducing postoperative blood pressure,respiratory rate,pulse rate and oxygen saturation using the foot reflexology.

关键词： Footreflexology Postoperativepatients Pain Physiological indicators Nursing Systematic review and meta-analysis

Underwater Bessel-like beams with enlarged depth of focus based on fiber microaxicon

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Chinese Optics Letters 2022年第7期20卷 36-40页

作者： Xiaoying He mengyuan li Lan Rao School of Electronic Engineering Beijing Key Laboratory of Space-Ground Interconnection and Convergenceand State Key Laboratory of Information Photonics and Optical CommunicationsBeijing University of Posts and TelecommunicationsBeijing 100876China

Underwater optical wireless communication,which is useful for oceanography,environmental monitoring,and underwater surveillance,suffers the limit of the absorption attenuation and Mie–Rayleigh scattering of the ***,Bessel-like beams generated by a fiber microaxicon is utilized for underwater wireless ***,the cone angle for generating Bessel-like beams starts from 46°,which is smaller than that in air for Bessel-like *** the cone angle of the fiber microaxicons is about 140°,the depth of focus underwater,which is four times as long as the depth of focus in air,has enlarged about 28μm,36.12μm,and 50.7μm for 470 nm,520 nm,and 632 nm visible *** transmission distance of the Bessel beams for visible lights has been simulated by using Henyey–Greenstein–Rayleigh phase function methods and spectral absorption by bio-optical model due to Monte Carlo *** results show that the propagation distance could reach 4000 m,which overcome the limit of the Mie–Rayleigh scattering and absorption attenuation underwater.

关键词： Bessel-like beams depth of focus underwater optical wireless communication

Novel spontaneous myelodysplastic syndrome mouse model

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Animal Models and Experimental Medicine 2021年第2期4卷 169-180,I0002页

作者： Weisha li lin Cao mengyuan li Xingjiu Yang Wenlong Zhang Zhiqi Song Xinpei Wang lingyan Zhang Grant Morahan Chuan Qin Ran Gao NHC Key Laboratory of Human Disease Comparative Medicine Beijing Engineering Research Center for Experimental Animal Models of Human Critical DiseasesInstitute of Laboratory Animal SciencesChinese Academy of Medical Sciences(CAMS)and Comparative Medicine CenterPeking Union Medical College(PUMC)BeijingChina

Background:Myelodysplastic syndrome(MDS)is a group of disorders involving he-mopoietic dysfunction leading to *** recently progress has been made in identifying underlying genetic mutations,many questions still *** models of MDS have been produced by introduction of specific ***,there is no spontaneous mouse model of MDS,and an animal model to simulate natu-ral MDS pathogenesis is urgently ***:In characterizing the genetically diverse mouse strains of the Collaborative Cross(CC)we observed that one,designated JUN,had abnormal hematological *** strain was thus further analyzed for phenotypic and pathological iden-tification,comparing the changes in each cell population in peripheral blood and in bone ***:In a specific-pathogen free environment,mice of the JUN strain are rela-tively thin,with healthy ***,in a conventional environment,they become lethargic,develop wrinkled yellow hair,have loose and light stools,and are prone to *** found that the mice were cytopenic,which was due to abnor-mal differentiation of multipotent bone marrow progenitor *** are common characteristics of ***:A mouse strain,JUN,was found displaying spontaneous myelodysplas-tic *** strain has the advantage over existing models in that it develops MDS spontaneously and is more similar to human MDS than genetically modified mouse *** mice will be an important tool for pathogenesis research of MDS and for evaluation of new drugs and treatments.

关键词： myelodysplastic syndrome(MDS) spontaneous mouse model The Collaborative Cross Mice

TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1814-1827页

作者： Qiang Qiu Yuanyuan Sun linyu Yang Qingqing li Yunyu Feng mengyuan li Yuexia Yin li Zheng Ning li Huandi Qiu Xue Cui Wei He Bochuan Wang Cong Pan Zi Wang Juan Huang Klarke MSample Zhihui li Yiguo Hu Department of Thyroid Surgery National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuanChina State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation Center for BiotherapyChengduSichuanChina Department of Oncology Guizhou Provincial People’s HospitalGuiyangGuizhouChina Sichuan Provincial People’s Hospital ChengduSichuanChina Institute of life Science eBond Pharmaceutical Technology Ltd.ChengduChina Laboratory of thyroid and parathyroid disease Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengduSichuanChina Department of Thyroid Surgery West China HospitalSichuan UniversityChengduSichuanChina

We report herein that TSPAN32 is a key node factor for Philadelphia (Ph+) leukemia pathogenesis. We found that TSPAN32expression was repressed by BCR-ABL and ectopic TSPAN32 expression upon Imatinib treatment inhibited the proliferation of Ph+cell lines. Tspan32 overexpression significantly prevented BCR-ABL induced leukemia progression in a murine model and impairedleukemia stem cell (LSC) proliferation. LSCs represent an obstacle for chronic myeloid leukemia (CML) elimination, which continuallyreplenish leukemia cells and are associated with disease relapse. Therefore, the identification of essential targets that contribute tothe survival and self-renewal of LSCs is important for novel curative CML. Mechanistically, TSPAN32 was shown to interact withPTEN, increased its protein level and caused a reduction in PI3K-AKT signaling activity. We also found that TSPAN32 was repressedby BCR-ABL via the suppression of an important transcription factor, TAL1. Ectopic expression of TAL1 significantly increasedTSPAN32 mRNA and protein level, which indicated that BCR-ABL repressed TSPAN32 transcription by decreasing TAL1 ***, we identified a new signaling axis composed of “BCR-ABL-TAL1-TSPAN32-PTEN-PI3K-AKT”. Our findings furthercomplement the known mechanisms underlying the transformation potential of BCR-ABL in CML pathogenesis. This new signalingaxis also provides a potential means to target PI3K-AKT for CML treatment.

关键词： pathogenesis impaired inhibited

Structure， properties， bioactivities and structure-activity relationships of polysaccharides from Nostoc flagelliforme grown under three different culture conditions

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Food Science and Human Wellness 2024年

作者： Yanru li Shigang Shen Longfei Wang mengyuan li Yan Zhang Shiru Jia Ruiying Zhu Peipei Han State Key Laboratory of Food Nutrition and Safety， Key Laboratory of Industrial Fermentation Microbiology， Ministry of Education， College of Biotechnology， Tianjin University of Science and Technology

The physicochemical properties， structural characteristics， antioxidant， radioprotective and lipid-lowering activities， as well as the underlying structure-activity relationships of polysaccharides extracted from Nostoc flagelliforme grown under normal （WL-EPS-1）， salt stress （NaCl-EPS-1） and mixotrophic culture conditions （Glu-EPS-1） were studied. The results demonstrated that WL-EPS-1， NaCl-EPS-1 and Glu-EPS-1 were heteropolysaccharides comprising different proportions of monosaccharides and uronic acid， with different average molecular weights of 0.99 × 103， 1.09 × 103and 1.18 × 103kDa， respectively. Their intrinsic viscosity values were significantly different， at 24.72 dL/g， 29.98 dL/g and 41.06 dL/g， respectively. The functional groups of polysaccharides were not greatly affected， but the chemical composition， triple-helix structure， chain length and surface morphology were significantly influenced by culture conditions. In vitro bioactivity assays showed that the antioxidant activity generally increased in the order of WL-EPS-1 lipid-lowering effect. In addition， the structure-activity relationship of the polysaccharides was analyzed by Partial Least Squares （PLS）， which revealed that the most important factors affecting the antioxidant， radioprotective and lipid-lowering activities of polysaccharides were viscosity and molecular weight. This study provides a strategy for obtaining high-bioactivity polysaccharides by appropriate regulation of culture conditions， as well as opening new directions for the molecular modification of polysaccharides.

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Anti-apoptotic protein BCL-XL as a therapeutic vulnerability in gastric cancer

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Animal Models and Experimental Medicine 2023年第3期6卷 245-254页

作者： Yumin Wei liping Zhang Chao Wang Zefeng li Mingjie Luo Guomin Xie Xingjiu Yang mengyuan li Shuyue Ren Dongbing Zhao Ran Gao Jia-Nan Gong National Human Diseases Animal Model Resource Center The Institute of Laboratory Animal ScienceChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina NHC Key Laboratory of Human Disease Comparative Medicine Beijing Engineering Research Center for Experimental Animal Models of Human Critical DiseasesBeijingChina Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases BeijingChina Department of Pancreatic and Gastric Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-Sen UniversityGuangzhouChina

Background: New therapeutic targets are needed to improve the outcomes for gastric cancer(GC) patients with advanced disease. Evasion of programmed cell death(apoptosis) is a hallmark of cancer cells and direct induction of apoptosis by targeting the pro-survival BCL2 family proteins represents a promising therapeutic strategy for cancer treatment. Therefore, understanding the molecular mechanisms underpinning cancer cell survival could provide a molecular basis for potential therapeutic interventions. Method: Here we explored the role of BCL2L1 and the encoded anti-apoptotic BCL-XL in GC. Using Droplet Digital PCR(ddPCR) technology to investigate the DNA amplification of BCL2L1 in GC samples and GC cell lines, the sensitivity of GC cell lines to selective BCL-XL inhibitors A1155463 and A1331852, pan-inhibitor ABT-263, and VHL-based PROTAC-BCL-XL was analyzed using(CellTiter-Glo) CTG assay in vitro. Western Blot(WB) was used to detect the protein expression of BCL2 family members in GC cell lines and the manner in which PROTAC-BCL-XL kills GC cells. Coimmunoprecipitation(Co-IP) was used to investigate the mechanism of A1331852 and ABT-263 kills GC cell lines. DDPCR, WB, and real-time PCR(RTPCR) were used to investigate the correlation between DNA, RNA, protein levels, and drug activity. Results: The functional assay showed that a subset of GC cell lines relies on BCL-XL for survival. In gastric cancer cell lines, BCL-XL inhibitors A1155463 and A1331852 are more sensitive than the pan BCL2 family inhibitor ABT-263, indicating that ABT-263 is not an optimal inhibitor of BCL-XL. VHL-based PROTAC-BCL-XL DT2216 appears to be active in GC cells. DT2216 induces apoptosis of gastric cancer cells in a time-and dose-dependent manner through the proteasome pathway. Statistical analysis showed that the BCL-XL protein level predicts the response of GC cells to BCL-XL targeting therapy and BCL2L1 gene CNVs do not reliably predict BCL-XL ***: We identified BCL-XL

关键词： apoptosis BCL2L1(BCL-XL) gastric cancer(GC) PROTAC-BCL-XL selective BCL-XL inhibitors

Research on the Work-for-Relief Policy within the Scope of Comprehensive Rural Revitalization:Quantitative Analysis of Policy Texts Based on 71 Policy Documents

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Proceedings of Business and Economic Studies 2024年第3期7卷 212-219页

作者： mengyuan li Minzhen li Zhaoxian Wang Yuyu Chen Jiaxin Di College of Humanities Tianjin Agricultural UniversityTianjin 300384China College of Economics and Management Tianjin Agricultural UniversityTianjin 300384China

Work-for-relief plays a unique role in China’s journey toward *** the perspectives of policy tools and interest analysis,this paper uses quantitative analysis of policy texts and integrates grounded theory to build a policy expression analysis model to discuss the current work-for-relief policy *** study found that China’s use of the work-for-relief policy is unbalanced,and it is necessary to enhance the involvement of non-governmental sectors,as well as to fully consider the policy’s target groups and the social issues that need addressing.

关键词： Work-for-relief Policy analysis Policy tools

Weakened tanning ability is an important mechanism for evolutionary skin lightening in East Asians

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Journal of Genetics and Genomics 2024年第7期51卷 703-713页

作者： Youwei Pu Siyu Pu Yanyan Chen Qinghong Kong Xuyang liu Qi Zhao Ke Xu Jiuming liu mengyuan li Xiaoyu Xu Xiaoyang Qiao Bing Su Jing Chen Zhaohui Yang Tianjian Laboratory of Advanced Biomedical Sciences Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450052China Department of Pediatric Surgery and Laboratory of Pediatric Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines Zunyi Medical UniversityZunyiGuizhou 563000China Yunnan Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunmingYunnan 650500China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China

The evolution of light-skin pigmentation among Eurasians is considered as an adaptation to the high-latitude *** Asians are ideal populations for studying skin color evolution because of the complex environment of East ***,we report a strong selection signal for the pigmentation gene phenylalanine hydroxylase(PAH)in light-skinned Han Chinese *** intron mutation rs10778203 in PAH is enriched in East Asians and is significantly associated with skin color of the back of the hand in Han Chinese males(Plity in East Asians,suggesting a unique genetic mechanism for evolutionary skin lightening in East Asians.

关键词： East Asians PAH Skin pigmentation Natural selection Genetic adaptation

加热方法对紫甘蓝花色苷组分及其清除自由基活性的影响

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中国食品学报 2016年第6期16卷 231-240页

作者：任虹李婷李强李梦媛北京工商大学食品学院北京市食品风味化学重点实验室食品添加剂与配料北京高校工程研究中心北京100048

目的:研究蒸汽加热和微波加热处理对紫甘蓝花色苷及其清除自由基活性的影响。方法:采用HPLC-MS法分析花色苷组分,ORAC法评价其清除自由基活性。结果:紫甘蓝花色苷主要有7种组分:矢车菊素-3-槐糖苷-5-葡萄糖苷(组分Ⅰ)、矢车菊素-3-槐糖... 详细信息

目的:研究蒸汽加热和微波加热处理对紫甘蓝花色苷及其清除自由基活性的影响。方法:采用HPLC-MS法分析花色苷组分,ORAC法评价其清除自由基活性。结果:紫甘蓝花色苷主要有7种组分:矢车菊素-3-槐糖苷-5-葡萄糖苷(组分Ⅰ)、矢车菊素-3-槐糖苷(组分Ⅱ)、芥子酰矢车菊素-3-槐糖苷-5-葡萄糖苷(组分Ⅲ)、芥子酰矢车菊素-3-槐糖苷(组分Ⅳ)、p-香豆酰阿魏酰芥子酰芍药素-3-槐糖苷-5-葡萄糖苷(组分Ⅴ)、芥子酰矢车菊素-3-槐糖苷-5-葡萄糖苷(组分Ⅵ)、二芥子酰矢车菊素-3-槐糖苷-5-葡萄糖苷(组分Ⅶ),其中,组分Ⅰ、Ⅲ、Ⅵ、Ⅶ含量较高。蒸汽加热和微波加热对紫甘蓝花色苷组分种类均无明显影响,而对其相对含量有所影响,微波加热较蒸汽加热对两种花色苷组分Ⅵ和Ⅶ影响显著。蒸汽加热,花色苷组分Ⅵ和Ⅶ分别增加4.46%和10.25%;微波加热,花色苷组分Ⅵ和Ⅶ分别增加10.90%和28.60%。加热后花色苷组分Ⅰ和Ⅲ相对含量有所减少,蒸汽加热两者分别减少2.15%和13.32%,微波加热分别减少6.07%和35.10%。两种加热处理对花色苷组分Ⅱ和Ⅳ相对含量无明显影响。ORAC评价结果表明,微波加热和蒸汽加热对花色苷清除自由基活性有一定的影响,对照组、微波组和蒸汽组的ORAC值分别为0.329±0.030,0.326±0.027,0.293±0.021μmol Trolox/m L。结论:蒸汽加热和微波加热影响紫甘蓝花色苷各组分的相对含量及其清除自由基活性。

关键词：紫甘蓝花色苷微波加热蒸汽加热高效液相色谱-质谱法清除自由基活性