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Cardiomyocyte-targeted anti-inflammatory nanotherapeutics against myocardial ischemia reperfusion (IR) injury

Nano Research 2022年第10期15卷 9125-9134页

作者： Min Lan Mengying Hou Jing Yan Qiurong Deng Ziyin Zhao Shixian Lv Juanjuan Dang mengyuan yin Yong Ji Lichen yin Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Department of Cardiothoracic Surgery Wuxi People’s Hospital Affiliated to Nanjing Medical UniversityWuxi 214023China

Myocardial ischemia reperfusion(IR)injury is closely related to the overwhelming inflammation in the myocardium.Herein,cardiomyocyte-targeted nanotherapeutics were developed for the reactive oxygen species(ROS)-ultrasensitive co-delivery of dexamethasone(Dex)and RAGE small interfering RNA(siRAGE)to attenuate myocardial inflammation.PPTP,a ROSdegradable polycation based on PGE2-modified,PEGylated,ditellurium-crosslinked polyethylenimine(PEI)was developed to surface-decorate the Dex-encapsulated mesoporous silica nanoparticles(MSNs),which simultaneously condensed siRAGE and gated the MSNs to prevent the Dex pre-leakage.Upon intravenous injection to IR-injured rats,the nanotherapeutics could be efficiently transported into the inflamed cardiomyocytes via PGE2-assisted recognition of over-expressed E-series of prostaglandin(EP)receptors on the cell membranes.Intracellularly,the over-produced ROS degraded PPTP into small segments,promoting the release of siRAGE and Dex to mediate effective RAGE silencing(72%)and cooperative antiinflammatory effect.As a consequence,the nanotherapeutics notably suppressed the myocardial fibrosis and apoptosis,ultimately recovering the systolic function.Therefore,the current nanotherapeutics represent an effective example for the codelivery and on-demand release of nucleic acid and chemodrug payloads,and might find promising utilities toward the synergistic management of myocardial inflammation.

关键词： small interfering RNA(siRNA)delivery reactive oxygen species(ROS)responsiveness ditellurium-crosslinked polyethylenimine(PEI) myocardial ischemia reperfusion injury anti-inflammation

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基于GIS网络分析法的广州市保障性住房人群绿地可达性研究

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地理科学 2024年第3期44卷 483-491页

作者：骆雯尹梦媛祝明建栾博华南理工大学设计学院广东广州510006 北京大学深圳研究院绿色基础设施研究所广东深圳518057

城市绿地是推进空间资源合理分配的重要基础设施之一。以广州市已建成的保障性住房为研究对象,采用GIS网络分析法,分析居住在保障性住房中的居民在不同交通方式下到达不同规模等级绿地的可达性。研究发现:①保障性住房人群到区级绿地和... 详细信息

城市绿地是推进空间资源合理分配的重要基础设施之一。以广州市已建成的保障性住房为研究对象,采用GIS网络分析法,分析居住在保障性住房中的居民在不同交通方式下到达不同规模等级绿地的可达性。研究发现:①保障性住房人群到区级绿地和街道级绿地的可达性受交通方式影响较小。②通过核密度法和标准差椭圆法验证绿地与保障性住房的分布差异,结果表明保障性住房周边绿地覆盖范围小,各等级绿地的可达性较差。保障性住房的发展方向与绿地规划方向存在不一致,导致保障性住房处于绿地边缘位置。③地铁与公交或驾车的可达性高于地铁与步行的组合方式,主要因为绿地通常位于城市中心或繁忙地区较远的地方,且地铁与公交或驾车能覆盖更长的距离。本研究的结果对广州市在“十四五”规划中筹建新的保障性住房提供了有益参考,助力推动城市空间布局的优化。

关键词：保障性住房绿地可达性 GIS 广州市

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Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome

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Oncology Research 2024年第5期32卷 911-923页

作者： JINGJING CHEN DAN WANG ZEQUN WANG mengyuan HAN HOUQING yin WENTING ZHOU RIBAI YAN YAN PAN Department of Pharmacology School of PharmacyChangzhi Medical CollegeChangzhiChina2 Department of PharmacologySchool of Basic Medical SciencesHealth Science CenterPeking UniversityBeijingChina3 Beijing Key Laboratory of Tumor Systems BiologyPeking UniversityBeijingChina4 Department of PharmacologyXinjiang Medical UniversityUrumqiChina5 School of Pharmaceutical SciencesPeking UniversityBeijingChina

Photodynamic therapy(PDT)is a promising cancer treatment.This study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]−10,15,20-triphenyl-porphyrin(DTP)mediated PDT(DTP-PDT).Cell viability,reactive oxygen species(ROS),and apoptosis were measured with a Cell Counting Kit-8 assay,DCFH-DA fluorescent probe,and Hoechst staining,respectively.Cell apoptosis-and autophagy-related proteins were examined using western blotting.RNA sequencing was used to screen differentially expressed mRNAs(DERs),and bioinformatic analysis was performed to identify the major biological events after DTP-PDT.Our results show that DTP-PDT inhibited cell growth and induced ROS generation in MCF-7 and SGC7901 cells.The ROS scavenger N-acetyl-L-cysteine(NAC)and the P38 MAPK inhibitor SB203580 alleviated DTP-PDT-induced cytotoxicity.DTP-PDT induced cell apoptosis together with upregulated Bax and downregulated Bcl-2,which could also be inhibited by NAC or SB203580.The level of LC3B-Ⅱ,a marker of autophagy,was increased by DTP-PDT.A total of 3496 DERs were obtained after DTP-PDT.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses indicated that DERs included those involved in cytosolic ribosomes,the nuclear lumen,protein binding,cell cycle,protein targeting to the endoplasmic reticulum,and ribosomal DNA replication.Disease Ontology and Reactome enrichment analyses indicated that DERs were associated with a variety of cancers and cell cycle checkpoints.Protein-protein interaction results demonstrated that cdk1 and rps27a ranked in the top 10 interacting genes.Therefore,DTP-PDT could inhibit cell growth and induce cell apoptosis and autophagy,partly through ROS and the P38 MAPK signaling pathway.Genes associated with the cell cycle,ribosomes,DNA replication,and protein binding may be the key changes in DTP-PDT-mediated cytotoxicity.

关键词： Photodynamic therapy ROS Apoptosis Autophagy Bioinformatic analysis

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Influence of Sub-Cloud Secondary Evaporation Effects on the Stable Isotopes in Precipitation of Urumqi Glacier No.1,Eastern Tianshan

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Journal of Earth Science 2024年第1期35卷 177-189页

作者： mengyuan Song Zhongqin Li Feiteng Wang Xin Zhang State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-Environment and ResourcesTianshan Glaciological StationChinese Academy of SciencesLanzhou 730000China College of Geography and Environmental Science Northwest Normal UniversityLanzhou 730000China College of Sciences Shihezi UniversityShihezi 832000China

In arid regions,the stable hydrogen and oxygen isotopic composition in raindrops is often modified by sub-cloud secondary evaporation when they descend from cloud base to ground through the unsaturated air.As a result of kinetic fractionation,the slope and intercept of the δ^(2)H-δ^(18)O correlation equation decrease.The variation of deuterium excess from cloud base to the ground is often used to quantitatively evaluate the influence of secondary evaporation effect on isotopes in precipitation.Based on the event-based precipitation samples collected at Urumqi Glacier No.1,eastern Tianshan during four-year observation,the existence and impact of secondary evaporation effects were analyzed by the methods of isotope-evaporation model.Under high air temperature,small raindrop diameter and precipitation amount,and low relative humidity conditions,the remaining rate of raindrops is small and the change of deuterium excess is large relatively,and the slope and intercept of δ^(2)H-δ^(18)O correlation equation are much lower than those of Global Meteoric Water Line,which mean that the influence secondary evaporation on precipitation enhanced.While on the conditions of low air temperature,high relative humidity,heavy rainfall,and large raindrop diameter,the change of deuterium excess is small relatively and the remaining rate of raindrops is large,and the slope and intercept of δ^(2)H-δ^(18)O correlation equation increase,the secondary evaporation is weakened.The isotope-evaporation model described a good linear correlation between changes of deuterium excess and evaporation proportion with the slope of 0.90‰/%,which indicated that an increase of 1%in evaporation may result in a decrease of deuterium excess about 0.90‰.

关键词： stable isotopes meteoric water line deuterium excess sub-cloud secondary evaporation effect precipitation glaciers

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Micromechanics of Thermal Conductive Composites:Review,Developments and Applications

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Acta Mechanica Solida Sinica 2024年第2期37卷 215-237页

作者： Guannan Wang Yulin Huang mengyuan Gao Qiang Chen Department of Civil Engineering Zhejiang UniversityHangzhou310058China Center for Balance Architecture Zhejiang UniversityHangzhou310007China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an710049China

Micromechanics investigations of composites with fiber-shaped reinforcement are extensively applied in the engineering design and theoretical analysis of thermal composites in the aerospace engineering and high-tech industry.In this paper,a critical review of various classical micromechanics approaches is provided based on the classification framework and the development of micromechanics tools.Several numerical micromechanics tools have been developed to overcome limitations through exactly/approximately solving the internal governing equations of microstructures.The connections and limitations of those models are also investigated and discussed,based on which three recently developed numerical or semi-analytical models are explained,including finite-element micromechanics,finite-volume direct averaging micromechanics,and locally exact homogenization theory,as well as machine learning tools.Since it is almost inevitable to mention the interfacial effects on thermal behavior of fibrous composites,we review the new mathematical relations that interrupt the original continuity conditions due to the existence of interphase/interface within unit cells.Generally speaking,the interphase/interface is demonstrated to play a significant role in influencing the effective coefficients and localized thermal fields.The present work also briefly reviews the application of micromechanics tools in emerging engineered woven composites,natural fibrous composites,and ablative thermal protection composites.It is demonstrated that sophisticated micromechanics tools are always demanded for investigating the effective and localized responses of thermal fibrous composites.

关键词： Micromechanics models Thermal fibrous composites Microstructural detail-free models Semi-analytical and numerical methods Interfacial effects Woven composites Natural composites

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Synthesizing active and durable cubic ceria catalysts(<6 nm)for fast dehydrogenation of bio-polyols to carboxylic acids coproducing green H_(2)

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Green Energy & Environment 2024年第3期9卷 529-543页

作者： mengyuan Liu Puhua Sun Guangyu Zhang Xin Jin Chaohe Yang Honghong Shan State Key Laboratory of Heavy Oil Processing College of Chemical EngineeringChina University of PetroleumNo.66 Changjiang West RoadQingdaoShandong266580China SINOPEC Research Institute of Safety Engineering Co. Ltd.No.339 Songling RoadQingdaoShandong266000China

Dehydrogenation is considered as one of the most important industrial applications for renewable energy.Cubic ceria-based catalysts are known to display promising dehydrogenation performances in this area.Large particle size(>20 nm)and less surface defects,however,hinder further application of ceria materials.Herein,an alternative strategy involving lactic acid(LA)assisted hydrothermal method was developed to synthesize active,selective and durable cubic ceria of<6 nm for dehydrogenation reactions.Detailed studies of growth mechanism revealed that,the carboxyl and hydroxyl groups in LA molecule synergistically manipulate the morphological evolution of ceria precursors.Carboxyl groups determine the cubic shape and particle size,while hydroxyl groups promote compositional transformation of ceria precursors into CeO_(2) phases.Moreover,enhanced oxygen vacancies(Vo)on the surface of CeO_(2) were obtained owing to continuous removal of O species under reductive atmosphere.Cubic CeO_(2) catalysts synthesized by the LA-assisted method,immobilized with bimetallic PtCo clusters,exhibit a record high activity(TOF:29,241 h^(-1))and Vo-dependent synergism for dehydrogenation of bio-derived polyols at 200℃.We also found that quenching Vo defects at air atmosphere causes activity loss of PtCo/CeO_(2) catalysts.To regenerate Vo defects,a simple strategy was developed by irradiating deactivated catalysts using hernia lamp.The outcome of this work will provide new insights into manufacturing durable catalyst materials for aqueous phase dehydrogenation applications.

关键词： Cubic ceria Oxygen vacancy Dehydrogenation C-H bond activation

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Optimal Operation with Dynamic Partitioning Strategy for Centralized Shared Energy Storage Station with Integration of Large-scale Renewable Energy

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 359-370页

作者： Jianlin Li Zhijin Fang Qian Wang mengyuan Zhang Yaxin Li Weijun Zhang Beijing Future Technology Innovation Centre for Electrochemical Energy Storage System Integration North China University of Technology Beijing China State Grid Fujian Electric Power Research Institute Fuzhou China

As renewable energy continues to be integrated into the grid,energy storage has become a vital technique supporting power system development.To effectively promote the efficiency and economics of energy storage,centralized shared energy storage(SES)station with multiple energy storage batteries is developed to enable energy trading among a group of entities.In this paper,we propose the optimal operation with dynamic partitioning strategy for the centralized SES station,considering the day-ahead demands of large-scale renewable energy power plants.We implement a multi-entity cooperative optimization operation model based on Nash bargaining theory.This model is decomposed into two subproblems:the operation profit maximization problem with energy trading and the leasing payment bargaining problem.The distributed alternating direction multiplier method(ADMM)is employed to address the subproblems separately.Simulations reveal that the optimal operation with a dynamic partitioning strategy improves the tracking of planned output of renewable energy entities,enhances the actual utilization rate of energy storage,and increases the profits of each participating entity.The results confirm the practicality and effectiveness of the strategy.

关键词： Shared energy storage(SES) dynamic partitioning strategy optimal operation Nash bargaining theory actual utilization rate of energy storage

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Molecule configurations modulate packing array and charge transfer in cocrystal engineering

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Science China Chemistry 2024年第2期67卷 512-516页

作者： Shenglong An mengyuan Qiao Xin Jin Xuanying Chen Jianhua Su Lifang Guo Zhiyun Zhang Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CentreFrontiers Science Center for Materiobiology and Dynamic ChemistryEast China University of Science&TechnologyShanghai200237China

Organic cocrystal as an emerging assembly strategy has received increasing attention in constructing multiple functional materials,through continually screening suitable constituent monomers or changing their stoichiometry ratios.However,the role of molecule configuration in the cocrystal field is rarely explored despite the fascinating potential in regulating the packing mode.In this study,the N,N′-diphenyl-5,10-dihydrophenazine derivatives(DPPs) with the flexible scaffold and different methyl substitutions are selected as the donors bearing various molecular configurations.In a simple collaborative way,a series of cocrystals based on DPPs and OFN(octafluoronaphthalene) are fabricated,exhibiting two self-adaptive molecular stacking arrays.X-ray crystallographic analysis and theoretical calculation unveil their different π···π interactions and charge transfer characters,leading to the significant emission redshift up to 125 nm compared with individual DPPs.As a result,controllable molecule stacking structure,tunable emission,and charge transfer properties can be achieved.The study provides a new perspective to reveal the structure-property relationships at the molecular level by controlling the molecule configuration in cocrystal engineering,contributing to the development of cocrystal theoretical physics and organic functional materials.

关键词： cocrystals molecular configuration self-adaptive packing mode charge transfer

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Alpha-gal syndrome

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中华医学杂志(英文版) 2024年第10期137卷 2024 Mar 26页

作者： Zhan mengyuan Chen Shaohui Xu Tengda yin Jia Li Hao Pan Zhouxian Cui Ning Wen Liping Department of Allergy Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China State Key Laboratory of Complex Severe and Rare Diseases Beijing China National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID) Beijing China Department of Health Care Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China Department of Anesthesiology Chinese Academy of Medical College and Peking Union Medical College Hospital Beijing China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Diseases Beijing China The No.Hospital Xinyang Henan China

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Liquid Crystal Based Label-Free Optical Sensors forBiochemical Application

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Photonic Sensors 2024年第2期14卷 57-88页

作者： Jieyuan TANG Zhibin LI mengyuan XIE Yunhan LUO Jianhui YU Guojie CHEN Zhe CHEN School of Physics and Optoelectronic Engineering Foshan UniversityFoshan 528225China Guangdong-Hong Kong.Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology Foshan UniversiyFoshan 528225China Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes Jinan UniversityGuangzhou 510632.China Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510632China JiHua Laboratory Foshan 528200China

Biochemical sensors have important applications in biology,chemistry,and medicine.Nevertheless,many biochemical sensors are hampered by intricate techniques,cumbersome procedures,and the need for labeling.In the past two decades,it has been discovered that liquid crystals can be used to achieve the optical amplification of biological interactions.By modifying recognition molecules,a variety of label-free biochemical sensors can be created.Consequently,biochemical sensors based on the amplification of liquid crystals have become one of the most promising sensors.This paper describes in detail the optical sensing principle of liquid crystals,sensing devices,and optical detection technologies.Meanwhile,the latest research findings are elucidated.Finally,the challenges and future research directions are discussed.

关键词： Optical sensor biochemistry liquid crystal label-free

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