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山东纺织科技 2024年第4期65卷 48-52页

作者：丁志慧张梦宇路作明青岛理工大学商学院山东青岛266520

基于价值链理论,以服装业为例,分析了人工智能与制造业融合的价值节点,论述了每个价值活动中智能技术的作用,并以现实案例详细阐述了应用过程。最后,对我国促进制造业与人工智能深度融合提出了政策建议。

关键词：高端制造业人工智能价值链理论政策体系服装业

高上林教授基于“脾胃和法”辨治消渴学术思想探析

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四川中医 2024年第1期42卷 14-18页

作者：张梦玉汪德芬赵田柴金金西安市中医医院内分泌科陕西西安710021 陕西省康复医院内分泌科陕西西安710065

高上林教授是国家级名老中医,对消渴病的临证治疗经验十分丰富。本文从“脾胃和法”思想出发,总结高上林教授从脾胃论治消渴病的学术思想。根据临床经验,高教授认为先天禀赋不足、饮食无度、情志失调和劳欲过度而致脾胃失和是消渴的病... 详细信息

高上林教授是国家级名老中医,对消渴病的临证治疗经验十分丰富。本文从“脾胃和法”思想出发,总结高上林教授从脾胃论治消渴病的学术思想。根据临床经验,高教授认为先天禀赋不足、饮食无度、情志失调和劳欲过度而致脾胃失和是消渴的病机关键,故以“和”立法,以“脾胃和法”为核心的基础法则辨治消渴:气机清升浊降、升降有序谓之升降和;补气益阴、理气和中谓之气阴和;滋阴温阳、阴平阳秘谓之阴阳和;治脾疏肝、气血同补谓之脏腑和,即升降同治、气血同养、阴阳相和、五脏同调,临床上取得了较好治疗效果,为消渴病的中医诊疗提出了一条崭新的思路。

关键词：高上林消渴病脾胃和法学术思想

脑卒中患者健康行为促进与障碍因素的质性研究

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中华行为医学与脑科学杂志 2024年第1期33卷 27-31页

作者：张孟羽郭丽娜郭园丽杨彩侠雷小雨张格格刘延锦郑州大学护理与健康学院郑州450001 郑州大学第一附属医院神经内科国家高级卒中中心郑州450052 郑州大学第一附属医院护理部郑州450052

目的探讨脑卒中患者健康行为的促进与障碍因素。方法采用目的抽样法,于2022年9月至2023年3月对16例脑卒中患者进行面对面半结构式访谈。根据理论域框架(theoretical domain framework,TDF)设计访谈提纲,运用定向内容分析法和归纳法分析... 详细信息

目的探讨脑卒中患者健康行为的促进与障碍因素。方法采用目的抽样法,于2022年9月至2023年3月对16例脑卒中患者进行面对面半结构式访谈。根据理论域框架(theoretical domain framework,TDF)设计访谈提纲,运用定向内容分析法和归纳法分析转录的文字资料并从中提炼主题。以TDF作为编码框架,将提炼的主题合并到最相关的域中,根据每个理论域中主题的数量、主题间的关系来确定理论域与脑卒中患者健康行为的对应关系。结果本研究确定了影响脑卒中患者健康行为的9个理论域:知识、技能、动机和目标、社会影响、社会/职业认同、环境与资源、能力信念、结果信念、行为调节。结论脑卒中患者健康行为复杂,受多种因素的影响,本研究所识别出的9个理论域将为今后脑卒中患者健康行为干预方案的制定提供依据。

关键词：脑卒中健康行为质性研究理论域框架

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脑卒中患者健康行为潜类别及其预测因素

中华行为医学与脑科学杂志 2024年第1期33卷 21-26页

作者：郭丽娜郭园丽张孟羽杨彩侠马珂珂张格格魏苗刘延锦郑州大学第一附属医院神经内科国家高级卒中中心郑州450052 郑州大学护理与健康学院郑州450001 郑州大学第一附属医院护理部郑州450052

目的探讨脑卒中患者健康行为的潜类别,并分析不同类别的预测因素。方法采用整群随机抽样法,于2022年9月采用一般情况调查表、改良版Rankin量表(modified Rankin scale,mRS)、脑卒中健康知识问卷(stroke prevention knowledge questionna... 详细信息

目的探讨脑卒中患者健康行为的潜类别,并分析不同类别的预测因素。方法采用整群随机抽样法,于2022年9月采用一般情况调查表、改良版Rankin量表(modified Rankin scale,mRS)、脑卒中健康知识问卷(stroke prevention knowledge questionnaire,SPKQ)、脑卒中健康行为问卷(health behavior scale for stroke patients,HBS-SP)以及脑卒中健康信念量表(short form-health belief model scale,SF-HBMS)对1186名脑卒中患者进行横断面调查。采用Mplus 8.3软件对脑卒中患者健康行为进行潜类别分析(latent class analysis,LCA),并采用SPSS 27.0软件进行无序多分类Logistic回归分析脑卒中患者健康行为各潜类别的预测因素。结果脑卒中患者健康行为可分为三个潜类别:健康行为较低-健康责任缺失组(66.9%,n=794)、健康行为中等-依从性欠佳组(11.9%,n=141)和健康行为良好-运动锻炼不足组(21.2%,n=251)。以健康行为良好-运动锻炼不足组为参照,较短受教育时间(B=-0.589,OR=0.555,P=0.036)、出血性卒中(B=0.082,OR=1.086,P<0.001)、较少并发症(B=-0.022,OR=0.978,P=0.026)、较高mRS得分(B=0.046,OR=1.047,P=0.004)、较低SPKQ得分(B=-0.055,OR=0.947,P=0.016)、较低SF-HBMS得分(B=-0.085,OR=0.919,P<0.001)更易进入健康行为中等-依从性欠佳组;而较短受教育时间(B=-0.026,OR=0.974,P=0.003)、农村(B=0.800,OR=2.225,P=0.004)、较少并发症(B=-0.056,OR=0.945,P<0.001)、较低SPKQ得分(B=-0.101,OR=0.904,P<0.001)、较低SF-HBMS得分(B=-0.071,OR=0.931,P<0.001)则更易进入健康行为较低-健康责任缺失组。结论脑卒中患者健康行为具有三个潜类别,应根据不同类别特点开展针对性干预,以提高其健康行为水平。

关键词：脑卒中健康行为潜类别分析预测因素

Clinical relevance of salivary pepsin detection in diagnosing gastroesophageal reflux disease subtypes

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Gastroenterology Report 2023年第1期11卷 446-453页

作者： mengyu zhang Tingting Wu Niandi Tan Songfeng Chen Qianjun Zhuang Yu Luo Yinglian Xiao Department of Gastroenterology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Gastroesophageal reflux disease(GERD)is heterogeneous with a varied symptom spectrum and reflux *** definite diagnosis often requires invasive tools including endoscopy or reflux *** aim of this study was to investigate the clinical relevance of salivary pepsin detection as a non-invasive screening tool to diagnose GERD of different ***:A total of 77 patients with suspected GERD symptoms and 12 asymptomatic controls were *** participants performed symptom evaluation,upper endoscopy,esophageal manometry,and 24-hour multichannel intraluminal impedance-dual pH probe *** was self-collected across three different time points:at early fasting,postprandially,and at symptom *** pepsin levels were measured via *** optimal threshold of salivary pepsin for diagnosing distal or proximal reflux was determined according to a receiver-operating characteristic ***:The average salivary pepsin concentration of suspected GERD patients was significantly higher than that of controls(100.63[68.46,141.38]vs 67.90[31.60,115.06]ng/mL,P=0.044),although no difference was found among patients with different symptom *** distal reflux group had a higher average pepsin concentration than non-reflux patients(170.54[106.31,262.76]vs 91.13[63.35,127.63]ng/mL,P=0.043),while no difference was observed between the distal reflux group and the proximal reflux *** optimal cut-off value of salivary pepsin concentration for diagnosing pathological distal reflux was 157.10 ng/mL,which was higher than that for diagnosing pathological proximal reflux(122.65 ng/mL).The salivary pepsin concentration was significantly correlated with distal and proximal reflux ***:Salivary pepsin measurement can help in identifying true GERD with pathological distal reflux or proximal reflux,regardless of different symptom spectrums.A higher threshold should be applied for diagnosing distal reflu

关键词： salivary pepsin gastroesophageal reflux disease laryngopharyngeal reflux screening and diagnosis

Current complementary and alternative therapy for gastroesophageal reflux disease

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Gastroenterology Report 2023年第1期11卷 171-181页

作者： Dianxuan Jiang Qianjun Zhuang Xingyu Jia Songfeng Chen Niandi Tan mengyu zhang Yinglian Xiao Department of Gastroenterology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Gastroesophageal reflux disease(GERD)is a widely prevalent gastrointestinal disorder,affecting13.3%of the global *** are shortages and limitations of current GERD treatment modalities,and complementary and alternative therapy(CAT)is a promising option to fill in the *** and lifestyle modifications might play an important and complementary role in alleviating GERD *** Chinese medicine and brain–gut behavior therapy,particularly transcutaneous electrical acustimulation and diaphragmatic breathing therapy were shown to be useful adjuncts or alternatives in treating *** may help to relieve GERD symptoms,minimize medication dosage,and slow the demand for *** aim of this review was to summarize the existing evidence of some common CATs in treating symptomatic GERD,including dietary modification,lifestyle change,traditional Chinese medicine,and brain–gut behavior therapy.

关键词： GERD complementary therapies alternative therapies lifestyle traditional Chinese medicine behavior intervention

Flexural behavior of textile reinforced mortar-autoclaved lightweight aerated concrete composite panels

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Frontiers of Structural and Civil Engineering 2024年第5期18卷 776-787页

作者： Liying GUO Mingke DENG Wei zhang Tong LI Yangxi zhang mengyu CAO Xian HU Department of Civil Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Key Lab of Structural Engineering and Earthquake Resistance Ministry of Education(XAUAT)Xi’an 710055China Scene engineering design institute Xi’an 710016China Dahua Group Shang hai 200062China

To improve the deficiencies of prefabricated autoclaved lightweight aerated concrete(ALC)panel such as susceptibility to cracking and low load-bearing capacity,a textile-reinforced mortar-autoclaved lightweight aerated concrete(TRM-ALC)composite panel was developed in this *** group of reference ALC panels and five groups of TRM-ALC panels were fabricated and subjected to four-point flexural *** was applied on the tensile side of the ALC panels to create *** variable parameters were the plies of textile(one or two),type of textile(basalt or carbon),and whether the matrix(without textile)was applied on the compression side of *** results showed that a bonding only 8-mm-thick TRM layer on the surface of the ALC panel could increase the cracking load by 180%−520%.The flexural capacity of the TRM-ALC panel increased as the number of textile layers *** reinforcement of the matrix on the compressive side could further enhance the stiffness and ultimate loadbearing capacity of the TRM-ALC *** panels with basalt textile failed in flexural mode,with the rupture of fabric *** with carbon textile failed in shear mode due to the ultra-high tensile strength of *** addition,analytical models related to the different failure modes were presented to estimate the ultimate load-carrying capacity of the TRM-ALC panels.

关键词： prefabricated autoclaved lightweight aerated concrete panel textile-reinforced mortar cracking load flexural capacity stiffness

Coordination environments build up and tune a superior synergistic “genome” toward novel trifunctional (TM-N_(x)O_(4−x))@g- C_(16)N_(3)-H_(3): High-throughput inspection of ultra-high activity for water splitting and oxygen reduction reactions

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Nano Research 2024年第4期17卷 2337-2351页

作者： Chunyao Fang Xian Wang Qiang zhang Xihang zhang Chenglong Shi Jingcheng Xu mengyu Yang Department of Physics University of Shanghai for Science and TechnologyShanghai 200093China School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China

Emerging as a prominent area of focus in energy conversion and storage technologies,the development of highly active metal-based single-atom catalysts(SACs)holds great signiﬁcance in searching alternatives to replace precious metals toward the efficient,stable,and low-cost hydrogen evolution reaction(HER),as well as the oxygen evolution reaction(OER)and the oxygen reduction reaction(ORR).Combining the tremendous tunability of ligand and coordination environment with rich metal-based electrocatalysts can create breakthrough opportunities for achieving both high stability and ***,we propose a novel and stable holey graphene-like carbon nitride monolayer g-C_(16)N5(N_(4)@g-C_(16)N_(3))stoichiometries interestingly behaving as a natural substrate for constructing SACs((TM-N_(4))@g-C_(16)N_(3)),whose evenly distributed holes map rich and uniform nitrogen coordination positions with electron-rich lone pairs for anchoring transition metal(TM)***,we employed density functional theory(DFT)calculations to systematically investigate the electrocatalytic activity of(TM-N_(4))@g-C_(16)N_(3) toward HER/OER/ORR,meanwhile considering the synergistic modulation of H-loading and O-coordination((TM-N_(x)O_(4-x))@g-C_(16)N_(3)^(-)H_(3),x=0–4).Together a“four-step procedure”screening mechanism with the first-principles high-throughput calculations,we find that(Rh-N_(4))and(Ir-N_(2)O_(2)-II)distributed on g-C_(16)N_(3)^(-)H_(3) can modulate the adsorption strength of the adsorbates,thus achieving the best HER/OER/ORR performance among 216 candidates,and the lowest overpotential of 0.098/0.3/0.46 V and 0.06/0.48/0.45 V,***,the d-band center,crystal orbital Hamilton population(COHP),and molecular orbitals are used to reveal the OER/ORR activity ***,the Rh/Ir-d orbital is dramatically hybridized with the O-p orbital of the oxygenated adsorbates,so that the lone-electrons incipiently locate at the antibonding orbital pair up and popula

关键词： single atom catalysts loading and coordination hydrogen evolution reaction oxygen evolution reaction oxygen reduction reaction

siRNA-functionalized lanthanide nanoparticle enables efficient endosomal escape and cancer treatment

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Nano Research 2022年第10期15卷 9160-9168页

作者： Chanchan Yu Kun Li Lin Xu Bo Li Chunhui Li Shuai Guo Ziyue Li Yuquan zhang Abid Hussain Hong Tan mengyu zhang Yongxiang Zhao Yuanyu Huang Xing-Jie Liang School of Life Science Advanced Research Institute of Multidisciplinary ScienceSchool of Medical Technology(Institute of Engineering Medicine)Key Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy ResearchGuangxi Medical UniversityNanning 530021China

Attaching DNA/RNA to nanomaterials is the basis for nucleic acid-based assembly and drug ***,we report that small interfering RNA(siRNA)effectively coordinates with ligand-free lanthanide nanoparticles(NaGdF4 NPs),and forms siRNA/NaGdF4 spherical nucleic acids(SNA).The coordination is primarily attributed to the interaction between Gd and phosphate backbone of the ***,an efficient encapsulation and rapid endosomal escape of siRNA from the endosome/lysosome were achieved,due to its flexible ability to bound to phospholipid head of endosomal membrane,thereby disrupting the membrane *** to the dual properties of NaGdF4 NPs,siRNA loading,and endosomal escape,siRNA targeting programmed cell death-ligand 1(siPD-L1)/NaGdF4 SNA triggers significant gene silencing in vitro and in vivo,and effectively represses the tumor growth in both CT26 tumor model and 4T1 orthotopic murine model.

关键词： coordination chemistry nuclei acid lanthanide nanomaterials small interfering RNA(siRNA)delivery endosome escape

The molecular pathogenesis of achalasia:a paired lower esophageal sphincter muscle and serum 4D label-free proteomic study

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Gastroenterology Report 2023年第1期11卷 340-349页

作者： Songfeng Chen Xiangbin Xing Xun Hou Qianjun Zhuang Niandi Tan Yi Cui Jinhui Wang mengyu zhang Shixian Hu Yinglian Xiao Department of Gastroenterology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Gastrointestinal Surgery Center The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Institute of Precision Medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Achalasia is a primary esophageal motility disorder with potential molecular pathogenesis remaining *** study aimed to identify the differentially expressed proteins and potential pathways among achalasia subtypes and controls to further reveal the molecular pathogenesis of ***:Paired lower esophageal sphincter(LES)muscle and serum samples from 24 achalasia patients were *** also collected 10 normal serum samples from healthy controls and 10 normal LES muscle samples from esophageal cancer *** 4D label-free proteomic analysis was performed to identify the potential proteins and pathways involved in ***:Analysis of Similarities showed distinct proteomic patterns of serum and muscle samples between achalasia patients and controls(both P<0.05).Functional enrichment analysis suggested that these differentially expressed proteins were immunity-,infection-,inflammation-,and *** mfuzz analysis in LES specimens showed that proteins involved in the extracellular matrix–receptor interaction increased sequentially between the control group,type III,type II,and type I *** 26 proteins altered in the same directions in serum and muscle ***:This first 4D label-free proteomic study of achalasia indicated that there were specific protein alterations in both the serum and muscle of achalasia,involving immunity,inflammation,infection,and neurodegeneration *** protein clusters between types I,II,and III revealed the potential molecular pathways associated with different disease *** of proteins changed in both muscle and serum samples highlighted the importance of further studies on LES muscle and revealed potential autoantibodies.

关键词： achalasia proteomics serum lower esophageal sphincter