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Gut liver brain axis in diseases:the implications for therapeutic interventions

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Signal Transduction and Targeted Therapy 2024年第1期9卷 79-104页

作者： mengyao yan Shuli Man Benyue Sun Long Ma Lanping Guo Luqi Huang Wenyuan Gao State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyNational and Local United Engineering Lab of Metabolic Control Fermentation TechnologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&Technology300457 TianjinChina National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences100700 BeijingChina Tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityWeijin Road300072 TianjinChina

Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract,liver,and nervous *** the past few decades,breakthrough progress has been made in the gut liver brain axis,mainly through understanding its formation mechanism and increasing treatment *** this review,we discuss various complex networks including barrier permeability,gut hormones,gut microbial metabolites,vagus nerve,neurotransmitters,immunity,brain toxic metabolites,β-amyloid(Aβ)metabolism,and epigenetic regulation in the gut-liver-brain *** therapies containing antibiotics,probiotics,prebiotics,synbiotics,fecal microbiota transplantation(FMT),polyphenols,low FODMAP diet and nanotechnology application regulate the gut liver brain ***,some special treatments targeting gut-liver axis include farnesoid X receptor(FXR)agonists,takeda G protein-coupled receptor 5(TGR5)agonists,glucagon-like peptide-1(GLP-1)receptor antagonists and fibroblast growth factor 19(FGF19)*** gut-brain axis embraces cognitive behavioral therapy(CBT),antidepressants and tryptophan metabolism-related *** liver-brain axis contains epigenetic regulation and Aβmetabolism-related *** the future,a better understanding of gut-liver-brain axis interactions will promote the development of novel preventative strategies and the discovery of precise therapeutic targets in multiple diseases.

关键词： metabolism therapeutic immunity

2022—2023年承德市呼吸道合胞病毒的暴发流行及其临床特征研究

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中华微生物学和免疫学杂志 2024年第2期44卷 155-161页

作者：马倩格高姝畅郭心悦严梦瑶户祖熙谢广成李涛承德医学院第二临床学院儿科承德067000 承德医学院病原生物学教研室承德067000

目的确定呼吸道合胞病毒(respiratory syncytial virus,RSV)在承德市的流行情况及临床特征。方法收集2022年8月—2023年6月因呼吸道感染在承德市中心医院儿科住院治疗的患儿咽拭子478份及其临床信息,实时定量PCR检测A亚型和B亚型RSV的... 详细信息

目的确定呼吸道合胞病毒(respiratory syncytial virus,RSV)在承德市的流行情况及临床特征。方法收集2022年8月—2023年6月因呼吸道感染在承德市中心医院儿科住院治疗的患儿咽拭子478份及其临床信息,实时定量PCR检测A亚型和B亚型RSV的分子流行情况,对RSV感染患者的临床特征进行分析。结果67.57%(323/478)的住院患儿为RSV阳性,RSV呈暴发流行且均为RSV-A型,2022年11—12月和2023年5—6月为RSV-A型的2次感染高峰。RSV-A型阳性患儿中,86.07%(278/323)为合并其他病原体检出病例,其中与细菌共检出的例数最多,以肺炎链球菌为主,肺炎克雷伯菌次之。流感病毒A型是最常见的共检出病毒。与RSV-A型共检出患儿组相比,RSV-A型单独检出组的乳酸脱氢酶(Z=2.396,P=0.017)较高,且高于正常高值;RSV-A型共检出组的白细胞计数(Z=2.417,P=0.016)、中性粒细胞比例(Z=3.218,P=0.001)、C-反应蛋白(Z=1.998,P=0.046)和肌酐(Z=2.107,P=0.035)较高,淋巴细胞比例(Z=3.205,P=0.001)较低,但位于正常值范围。RSV-A型合并检出细菌或其他病毒的患儿临床特征无差异(P均>0.05)。结论RSV-A型是承德市2022—2023年呼吸道感染患儿的主要病原体,且多与细菌共检出。RSV-A型检测阳性患儿的临床特征与RSV-A型是否合并其他呼吸道病原体情况相关。

关键词：呼吸道合胞病毒流行特征临床特征儿童

基于文献计量学的贝林妥欧单抗治疗急性淋巴细胞白血病的研究现状分析

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肿瘤药学 2024年第3期14卷 360-367页

作者：李昭文何莉梅燕梦瑶中南大学湘雅医学院附属儿童医院/湖南省儿童医院药学部湖南长沙410007 中南大学湘雅护理学院湖南长沙410013

目的探讨近10年贝林妥欧单抗治疗急性淋巴细胞白血病的研究现状、趋势及热点。方法检索CNKI数据库、Web of Science核心合集数据库2014—2023年收录的贝林妥欧单抗治疗急性淋巴细胞白血病相关文献,运用CiteSpace 6.1.R6软件进行可视化... 详细信息

目的探讨近10年贝林妥欧单抗治疗急性淋巴细胞白血病的研究现状、趋势及热点。方法检索CNKI数据库、Web of Science核心合集数据库2014—2023年收录的贝林妥欧单抗治疗急性淋巴细胞白血病相关文献,运用CiteSpace 6.1.R6软件进行可视化分析。结果CNKI数据库共纳入中文文献8篇,发文量呈逐年上升趋势,但因纳入文献数量不足,未能进行可视化分析。Web of Science核心合集数据库共纳入英文文献784篇,涉及62个国家、331个机构。发文量最多的作者为Elias Jabbour,共37篇;发文量最多的国家是美国,共454篇;发文量最发文量最多的机构是美国MD安德森癌症中心,共97篇。排名第1的高频关键词为微小残留病灶,关键词突现显示目前儿童仍具有突现性。共被引频次排名前10的文献中,有4篇报道了贝林妥欧单抗治疗急性淋巴细胞白血病的疗效。共被引文献以关键词聚类形成8大主题,目前比较活跃的聚类是儿童和酪氨酸酶抑制剂。结论近10年贝林妥欧单抗治疗急性淋巴细胞白血病的研究主要集中于其在儿童群体中的有效性和安全性,目前的研究热点仍是儿童群体,未来的研究趋势为贝林妥欧单抗与奥加伊妥珠单抗、酪氨酸激酶抑制剂等联合用药。

关键词：贝林妥欧单抗急性淋巴细胞白血病研究现状

Pattern-reconfigurable antenna-assisted secret key generation from multipath fading channels

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Frontiers of Information Technology & Electronic Engineering 2023年第12期24卷 1803-1814页

作者： Zheng WAN mengyao yan Kaizhi HUANG Zhou ZHONG Xiaoming XU Yajun CHEN Fan WU PLA Strategic Support Force Information Engineering University Zhengzhou450001China Purple Mountain Laboratories for Network and Communication Security Nanjing210096China

Physical layer key generation(PKG)technology leverages reciprocal channel randomness to generate shared secret ***,multipath fading at the receiver may degrade the correlation between legitimate uplink and downlink channels,resulting in a low key generation rate(KGR).In this paper,we propose a PKG scheme based on the pattern-reconfigurable antenna(PRA)to boost the secret key ***,we propose a reconfigurable intelligent surface(RIS)based PRA architecture with the capability of flexible and reconfigurable antenna ***,we present the PRA-based PKG protocol to improve the KGR via mitigation of the effects of multipath ***,a novel algorithm for estimation of the multipath channel parameters is proposed based on atomic norm ***,a novel optimization method for the matching reception of multipath signals is formulated based on the improved binary particle swarm optimization(BPSO)***,simulation results show that the proposed scheme can resist multipath fading and achieve a high KGR compared to existing ***,our findings indicate that the increased degree of freedom of the antenna patterns can significantly increase the secret key capacity.

关键词： Physical layer security Secret key generation Reconfigurable intelligent surface Multipath fading Pattern-reconfigurable antenna

Prediction of Apple Fruit Quality by Soil Nutrient Content and Artificial Neural Network

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Phyton-International Journal of Experimental Botany 2023年第1期92卷 193-208页

作者： mengyao yan Xianqi Zeng Banghui Zhang Hui Zhang Di Tan Binghua Cai Shenchun Qu Sanhong Wang College of Horticulture Nanjing Agricultural UniversityNanjingChina College of Agriculture Nanjing Agricultural UniversityNanjingChina

The effect of soil nutrient content on fruit yield and fruit quality is very *** explore the effect of soil nutrients on apple quality we investigated 200 fruit samples from 40 orchards in Feng County,Jiangsu *** mineral elements and fruit quality were *** effect of soil nutrient content on fruit quality was analyzed by artificial neural network(ANN)*** results showed that the prediction accuracy was highest(R2=0.851,0.847,0.885,0.678 and 0.746)in mass per fruit(MPF),hardness(HB),soluble solids concentrations(SSC),titratable acid concentration(TA)and solid-acid ratio(SSC/TA),*** sensitivity analysis of the prediction model showed that soil available P,K,Ca and Mg contents had the greatest impact on the quality of apple *** surface method(RSM)was performed to determine the optimum range of the available P,K,Ca,and Mg contents in orchards In Feng County,which were 10∼20 mg⋅kg^(−1),170∼200 mg⋅kg^(−1),1000∼1500 mg⋅kg^(−1),and 80∼200 mg⋅kg^(−1),*** research also concluded that improving the content of available P and available Ca in orchard soil was crucial to improve apple fruit quality in Feng County,Jiangsu Province.

关键词： Apple soil nutrients fruit quality artificial neural network sensitivity analysis response surface methodology analysis

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中国妇女常见病筛查研究的现状与趋势分析

中国医学科学院学报 2024年第1期46卷 33-38页

作者：樊子暄严梦瑶裴晨阳雷潜润马晶刘远立中国医学科学院北京协和医学院卫生健康管理政策学院北京100730 清华大学医院管理研究院广东深圳518055

目的通过CiteSpace 6.1.R6对中国妇女常见病筛查的研究现状及热点进行可视化分析,为今后该领域研究的深入开展提供参考。方法基于中国知网数据库进行文献检索,时间限定为1992年1月1日至2022年12月31日,对年发文量、国家(地区)、机构、... 详细信息

目的通过CiteSpace 6.1.R6对中国妇女常见病筛查的研究现状及热点进行可视化分析,为今后该领域研究的深入开展提供参考。方法基于中国知网数据库进行文献检索,时间限定为1992年1月1日至2022年12月31日,对年发文量、国家(地区)、机构、作者合作网络、关键词共现、聚类、突现词进行分析。结果共纳入900篇符合标准的文献,发文量呈先上升后下降的趋势。跨机构的合作网络较为成熟。研究热点主要涵盖妇女保健、妇女病患病率、生殖健康和乳腺疾病等。热点演化由最初关注生殖保健,转向为妇科疾病管理,最终又发展为生殖健康以及全方面的妇女保健。结论未来应持续加强对妇女常见病筛查工作的关注,建议将妇女常见病筛查与宫颈癌和乳腺癌筛查同步进行,提高筛查覆盖率,促进疾病的早期发现和治疗,全面保障女性健康。

关键词：妇女常见病筛查影响因素妇女保健妇科疾病

The deteriorated degradation resistance of Mg alloy microtubes for vascular stent under the coupling effect of radial compressive stress and dynamic medium

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Journal of Magnesium and Alloys 2024年第2期12卷 573-585页

作者： mengyao Liu Yabo Zhang Qingyuan Zhang yan Wang Di Mei Yufeng Sun Liguo Wang Shijie Zhu Shaokang Guan School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Henan Key Laboratory of Advanced Magnesium Alloys Zhengzhou 450002China Key Laboratory of Advanced Materials Processing&Mold Ministry of Education Zhengzhou 450002China

The degradation of Mg alloys relates to the service performance of Mg alloy biodegradable *** order to investigate the degradation behavior of Mg alloys as vascular stent materials in the near service environment,the hot-extruded fine-grained Mg-Zn-Y-Nd alloy microtubes,which are employed to manufacture vascular stents,were tested under radial compressive stress in the dynamic Hanks'Balanced Salt Solution(HBSS).The results revealed that the high flow rate accelerates the degradation of Mg alloy microtubes and its degradation is sensitive to radial compressive *** results contribute to understanding the service performance of Mg alloys as vascular stent materials.

关键词： Mg alloy Microtubes Degradation behavior Radial compressive stress Dynamic conditions

Impacts of climate change and human activities on vegetation dynamics on the Mongolian Plateau, East Asia from 2000 to 2023

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Journal of Arid Land 2024年第8期16卷 1062-1079页

作者： yan Yujie CHENG Yiben XIN Zhiming ZHOU Junyu ZHOU mengyao WANG Xiaoyu School of Soil and Water Conservation Beijing Forestry UniversityBeijing 100083China Experimental Center of Desert Forestry Chinese Academy of ForestryDengkou 015200China Inner Mongolia Dengkou Desert Ecosystem National Observation Research Station National Forestry and Grassland AdministrationDengkou 015200China

The Mongolian Plateau in East Asia is one of the largest contingent arid and semi-arid areas of the *** the impacts of climate change and human activities,desertification is becoming increasingly severe on the Mongolian *** the vegetation dynamics in this region can better characterize its ecological *** this study,based on Moderate Resolution Imaging Spectroradiometer(MODIS)images,we calculated the kernel normalized difference vegetation index(kNDVI)on the Mongolian Plateau from 2000 to 2023,and analyzed the changes in kNDVI using the Theil-Sen median trend analysis and Mann-Kendall significance *** further investigated the impact of climate change on kNDVI change using partial correlation analysis and composite correlation analysis,and quantified the effects of climate change and human activities on kNDVI change by residual *** results showed that kNDVI on the Mongolian Plateau was increasing overall,and the vegetation recovery area in the southern region was significantly larger than that in the northern *** 50.99%of the plateau showed dominant climate-driven effects of temperature,precipitation,and wind speed on kNDVI *** analysis showed that climate change and human activities together contributed to 94.79%of the areas with vegetation *** human activities promoted the recovery of local vegetation,and climate change inhibited vegetation growth in the northern part of the Mongolian *** study provides scientific data for understanding the regional ecological environment status and future changes and developing effective ecological protection measures on the Mongolian Plateau.

关键词： kernel normalized difference vegetation index(kNDVI) human activities climate change partial correlation analysis composite correlation analysis residual analysis Mongolian Plateau

An overview of detecting gene-trait associations by integrating GWAS summary statistics and eQTLs

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Science China(Life Sciences) 2024年第6期67卷 1133-1154页

作者： yang Zhang mengyao Wang Zhenguo Li Xuan yang Keqin Li Ao Xie Fang Dong Shihan Wang Jianbing yan Jianxiao Liu National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Smart Farming for Agricultural Animals Huazhong Agricultural UniversityWuhan 430070China Hubei Key Laboratory of Agricultural Bioinformatics Huazhong Agricultural UniversityWuhan 430070China College of Informatics Huazhong Agricultural UniversityWuhan 430070China College of Life Sciences Nankai UniversityTianjin 300071China

Detecting genes that affect specific traits(such as human diseases and crop yields)is important for treating complex diseases and improving crop quality.A genome-wide association study(GWAS)provides new insights and directions for understanding complex traits by identifying important single nucleotide *** GWAS summary statistics data related to various complex traits have been gathered *** have shown that GWAS risk loci and expression quantitative trait loci(e QTLs)often have a lot of overlaps,which makes gene expression gradually become an important intermediary to reveal the regulatory role of *** this review,we review three types of gene-trait association detection methods of integrating GWAS summary statistics and e QTLs data,namely colocalization methods,transcriptome-wide association study-oriented approaches,and Mendelian randomization-related *** the theoretical level,we discussed the differences,relationships,advantages,and disadvantages of various algorithms in the three kinds of gene-trait association detection *** further discuss the performance of various methods,we summarize the significant gene sets that influence highdensity lipoprotein,low-density lipoprotein,total cholesterol,and triglyceride reported in 16 *** discuss the performance of various algorithms using the datasets of the four lipid *** advantages and limitations of various algorithms are analyzed based on experimental results,and we suggest directions for follow-up studies on detecting gene-trait associations.

关键词： gene-trait association GWAS eQTL colocalization transcriptome-wide association study(TWAS) Mendelian randomization(MR)

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