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An overview of detecting gene-trait associations by integrating GWAS summary statistics and eQTLs

Science China(Life Sciences) 2024年第6期67卷 1133-1154页

作者： yang Zhang mengyao Wang Zhenguo Li Xuan yang Keqin Li Ao Xie Fang Dong Shihan Wang Jianbing yan Jianxiao Liu National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Smart Farming for Agricultural Animals Huazhong Agricultural UniversityWuhan 430070China Hubei Key Laboratory of Agricultural Bioinformatics Huazhong Agricultural UniversityWuhan 430070China College of Informatics Huazhong Agricultural UniversityWuhan 430070China College of Life Sciences Nankai UniversityTianjin 300071China

Detecting genes that affect specific traits(such as human diseases and crop yields)is important for treating complex diseases and improving crop quality.A genome-wide association study(GWAS)provides new insights and directions for understanding complex traits by identifying important single nucleotide *** GWAS summary statistics data related to various complex traits have been gathered *** have shown that GWAS risk loci and expression quantitative trait loci(e QTLs)often have a lot of overlaps,which makes gene expression gradually become an important intermediary to reveal the regulatory role of *** this review,we review three types of gene-trait association detection methods of integrating GWAS summary statistics and e QTLs data,namely colocalization methods,transcriptome-wide association study-oriented approaches,and Mendelian randomization-related *** the theoretical level,we discussed the differences,relationships,advantages,and disadvantages of various algorithms in the three kinds of gene-trait association detection *** further discuss the performance of various methods,we summarize the significant gene sets that influence highdensity lipoprotein,low-density lipoprotein,total cholesterol,and triglyceride reported in 16 *** discuss the performance of various algorithms using the datasets of the four lipid *** advantages and limitations of various algorithms are analyzed based on experimental results,and we suggest directions for follow-up studies on detecting gene-trait associations.

关键词： gene-trait association GWAS eQTL colocalization transcriptome-wide association study(TWAS) Mendelian randomization(MR)

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Genome-wide association study of grain micronutrient concentrations in bread wheat

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Journal of Integrative Agriculture 2024年第5期23卷 1468-1480页

作者： Yongchao Hao Fanmei Kong Lili Wang Yu Zhao mengyao Li Naixiu Che Shuang Li Min Wang Ming Hao Xiaocun Zhang yan Zhao State Key Laboratory of Crop Biology/College of Agronomy Shandong Agricultural UniversityTai'an 271018China College of Resources and Environment Shandong Agricultural UniversityTai'an 271018China Jining Liangshan Ecological Environment Affairs Center Jining 272100China College of Forestry Shandong Agricultural UniversityTai'an 271018China

Bread wheat(Triticum aestivum)is a staple food crop *** genetic dissection of important nutrient traits is essential for the biofortification of wheat to meet the nutritional needs of the world's growing ***,45,298 single-nucleotide polymorphisms(SNPs)from 55K chip arrays were used to genotype a panel of 768 wheat cultivars,and a total of 154 quantitative trait loci(QTLs)were detected for eight traits under three environments by genome-wide association study(GWAS).Three QTLs(qMn-3B.1,qFe-3B.4,and qSe-3B.1/qFe-3B.6)detected repeatedly under different environments or traits were subjected to subsequent analyses based on linkage disequilibrium decay and the P-values of significant *** SNPs in the three QTL regions formed six haplotypes for qMn-3B.1,three haplotypes for qFe-3B.4,and three haplotypes for qSe-3B.1/*** analysis revealed significant differences among *** results indicated that the concentrations of several nutrient elements have been modified during the domestication of landraces to modern *** on the QTL regions,we identified 15 high-confidence genes,eight of which were stably expressed in different tissues and/or developmental ***3B02G046100 in qMn-3B.1 and TraesCS3B02G199500 in qSe-3B.1/qFe-3B.6 were both inferred to interact with metal ions according to the Gene Ontology(GO)***3B02G199000,which belongs to qSe-3B.1/qFe-3B.6,was determined to be a member of the WRKY gene ***,this study provides several reliable QTLs that may significantly affect the concentrations of nutrient elements in wheat grain,and this information will facilitate the breeding of wheat cultivars with improved grain properties.

关键词： bread wheat nutritional element GWAS domestication haplotype

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Current Status of Key Competencies among Medical Students: A Latent Profile Analysis

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Open Journal of Applied Sciences 2024年第2期14卷 450-465页

作者： mengyao Xiao Li yan Yongping Xia Li Liu School of Public Health Chongqing Medical University Chongqing China School of Medical Information Chongqing Medical University Chongqing China

The purpose of this study was to understand the overall level of key competencies of medical students and explore the potential profile of key competencies, promoting quality education, and improving the quality talent cultivation in medical colleges. A stratified random sampling method selected 734 medical students from four medical colleges in Chongqing Province of China. A general information questionnaire and a key competencies survey questionnaire were used to conduct the survey. The overall score and scores of each dimension of key competencies were analyzed. Latent profile analysis was conducted to classify the key competencies of medical students and compare the distribution differences of demographic variables among different categories. The results showed that 26% of medical students have never heard of the concept of key competencies, and 59% of them are not familiar with the content related to key competencies. The score of key competencies is 3.66 ± 0.60, with the highest score in the dimension of responsibility and the lowest score in the dimension of humanistic accomplishment. The latent profile analysis classified them into three categories: “low key competencies group (14.71%)”, “medium key competencies group (36.79%)”, and “high key competencies group (48.50%)”. The R3STEP regression analysis results showed statistically significant differences in educational level and whether they served as student cadres among different key competencies categories of medical students. This paper discusses three different potential key competencies categories among medical students, and the overall level of key competencies is relatively good. However, medical students lack a comprehensive and systematic understanding of key competencies. Humanistic accomplishment, healthy living, and practical innovation are the three dimensions with lower scores and should be given more attention. Medical colleges should integrate the concept of key competencies into teaching an

关键词： Sustainable Education Medical Students Key Competencies Latent Profile Analysis

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流动工人政治认同生成中的国家因素

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学海 2020年第5期 86-92页

作者：颜梦瑶刘伟中山大学广州510272 武汉大学政治与公共管理学院武汉430072 武汉大学地方政治研究中心

市场经济转型以来,工人的跨域流动已成为我国典型的社会现象。物质生活较为匮乏,利益易受侵害且缺少必要社会保障的流动工人,从一般经验上看更可能对政治系统表现出较低的认同感。然而,在对广东地区流动工人的调研中却发现,虽然确实存... 详细信息

市场经济转型以来,工人的跨域流动已成为我国典型的社会现象。物质生活较为匮乏,利益易受侵害且缺少必要社会保障的流动工人,从一般经验上看更可能对政治系统表现出较低的认同感。然而,在对广东地区流动工人的调研中却发现,虽然确实存在部分工人对政治体系表现出疏离现象,但大多数流动工人对国家及政治系统有着基本甚至较高的政治认同。结合对流动工人访谈记录的分析,探究流动工人政治认同的形成与国家整合及治理之间的关系,可以发现,国家通过制度安排的利益实现与价值吸引、意识形态的塑造以及治理绩效对具体诉求的回应,影响着工人对政治系统的感知和理解,从而使他们产生较为积极的政治认同。

关键词：流动工人政治认同生成机制国家治理

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融合拓扑信息与气象信息的空气质量预测网络

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中国环境监测 2023年第S1期39卷 80-90页

作者：严梦瑶林宣雄张旭西安交通大学电子与信息学部软件学院陕西西安710049 西安长天长软件股份有限公司陕西西安710065

通过空气质量监测数据对正在形成或即将到来的空气污染进行预测是一项具有重要意义的工作,而空气质量监测站只能检测其周围一定范围内的空气污染情况。为了衡量整个城市的空气污染情况,获取任意时间、任意位置的空气质量信息,结合交叉... 详细信息

通过空气质量监测数据对正在形成或即将到来的空气污染进行预测是一项具有重要意义的工作,而空气质量监测站只能检测其周围一定范围内的空气污染情况。为了衡量整个城市的空气污染情况,获取任意时间、任意位置的空气质量信息,结合交叉注意力机制,提出了一种融合拓扑信息与气象信息的空气质量预测网络(CGMIM)。将西安市空气质量监测数据与气象数据转换为图像拼接起来,作为输入信息。在高阶非线性时空动态神经网络(MIM)的基础上引入注意力机制,并增加拓扑图编码器模块,提高模型提取能力以及对空气质量监测数据中的空间特征的利用率。最后,使用时空损失函数替代传统的均方误差损失函数,提高模型对空间关系的关注。结果表明:CGMIM网络模型能够在准确预测的同时,对位置区域合理填充,能够有效提升空气质量监测数据的空间分辨率。

关键词：空气质量预测循环神经网络图卷积神经网络

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A near-infrared fluorescent probe for visualizing transformation pathway of Cys/Hcy and H2S and its applications in living system

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Chinese Chemical Letters 2024年第5期35卷 296-301页

作者： Yudi Cheng Xiao Wang Jiao Chen Zihan Zhang Jiadong Ou mengyao She Fulin Chen Jianli Li Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry&Materials ScienceNorthwest UniversityXi’an 710127China Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationBiomedicine Key Laboratory of Shaanxi ProvinceLab of Tissue Engineeringthe College of Life SciencesFaculty of Life Science&MedicineNorthwest UniversityXi’an 710069China

Sulfydryl-contained(-SH)substances including hydrogen sulfide(H_(2)S),cysteine(Cys),homocysteine(Hcy)and glutathione(GSH)play crucial roles in living systems,and their variations are closely associated with various ***,we developed a near-infrared intramolecular charge transfer(ICT)based fluorescent probe Y-NBD,achieving detection of Cys/Hcy and H_(2)S with different fluorescent signals(green-red for Cys/Hcy,red for H_(2)S),large Stokes shifts(∼100/105nm or 191 nm)and high signal-background-ratio,but not responding to GSH.Y-NBD was successfully applied to image exogenous/endogenous Cys/Hcy and H_(2)S in various living cancer cells(HeLa,A549,and HepG2)and in *** not only visualized the transformation pathway of several thiols in HepG2 cells but also verified that the intestine is the main site for the activation and metabolism of Y-NBD in zebrafish,as well as realized to evaluate the degree of drug-induced liver *** work provides a promising tool for imaging Cys/Hcy and H_(2)S in living systems and shows great potency in evaluating drug-induced liver injury and its treatment.

关键词： Fluorescent probe Near-infrared Hydrogen sulfide Cysteine/homocysteine Large Stokes shift Dicyanoisophorone Drug-induced liver injury

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Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2077-2096页

作者： Cheng Qian Yueke Zhou Teng Zhang Guanglu Dong mengyao Song Yu Tang Zhonghong Wei Suyun Yu Qiuhong Shen Wenxing Chen Jaesung P.Choi Juming yan Chongjin Zhong Li Wan Jia Li Aiyun Wang Yin Lu yang Zhao Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China School of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjing 210023China Centre for Inflammation Faculty of ScienceCentenary InstituteSchool of Life SciencesUniversity of Technology SydneySydney NSW 2050Australia Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogenic Biology and ImmunologyNational Experimental Demonstration Center for Basic Medicine EducationXuzhou Laboratory of Infection and ImmunityXuzhou Medical UniversityXuzhou 221004China Department of General Surgery Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China Macquarie Medical School Faculty of MedicineHuman Health SciencesMacquarie UniversitySydney NSW 2109Australia

Aberrant tumor blood vessels are prone to propel the malignant progression of tumors,and targeting abnormal metabolism of tumor endothelial cells emerges as a promising option to achieve vascular normalization and antagonize tumor ***,we demonstrated that salvianic acid A(SAA)played a pivotal role in contributing to vascular normalization in the tumor-bearing mice,thereby improving delivery and effectiveness of the chemotherapeutic *** was capable of inhibiting glycolysis and strengthening endothelial junctions in the human umbilical vein endothelial cells(HUVECs)exposed to ***,SAA was inclined to directly bind to the glycolytic enzyme PKM2,leading to a dramatic decrease in endothelial *** importantly,SAA improved the endothelial integrity via activating theβ-Catenin/Claudin-5 signaling axis in a PKM2-dependent *** findings suggest that SAA may serve as a potent agent for inducing tumor vascular normalization.

关键词： Salvianic acid A Tumor vascular normalization PKM2 β-Catenin Claudin-5 Endothelial glycolysis Tight junctions Doxorubicin

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人类命运共同体理念的审美政治阐释

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甘肃理论学刊 2023年第6期 5-12页

作者：鄢梦瑶中山大学马克思主义学院广州510275

“审美”作为人的有意义的存在方式,是政治理论的最高价值之一。作为21世纪马克思主义的重要时代成果,人类命运共同体理念旨在实现人的自由全面发展和美好生活,是一种蕴含美的理念和价值诉求的审美政治。首先,人类命运共同体理念与马克... 详细信息

“审美”作为人的有意义的存在方式,是政治理论的最高价值之一。作为21世纪马克思主义的重要时代成果,人类命运共同体理念旨在实现人的自由全面发展和美好生活,是一种蕴含美的理念和价值诉求的审美政治。首先,人类命运共同体理念与马克思审美政治具有一脉相承的内在联系,它继承了马克思审美政治的感性解放的审美理念、美的规律的审美尺度和自由王国的审美愿景。其次,人类命运共同体理念构筑了一个审美的政治共同体,它内含着“各美其美”的政治判断、“美人之美”的政治态度、“美美与共”的政治追求和“天下大同”的政治理想,具有丰富的审美政治面相。最后,人类命运共同体理念全面推动了社会、经济、政治、文化和生态层面的审美共同体建构,是一种五位一体的审美政治实践。

关键词：人类命运共同体审美政治马克思审美共同体

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柚皮素治疗消化系统疾病的药理作用及机制研究进展

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中草药 2024年第13期55卷 4622-4632页

作者：陈孟瑶乐音子颜帅南京中医药大学附属苏州市中医医院江苏苏州215009

柚皮素是一种广泛存在于柑橘类水果及药用植物中的天然黄酮类化合物,可通过调节肠道功能障碍、抗炎、抗氧化、抗纤维化、抗肿瘤、调节脂质代谢等多种药理活性对消化系统产生保护作用,有望成为治疗消化系统疾病的候选药物,具有广阔的开... 详细信息

柚皮素是一种广泛存在于柑橘类水果及药用植物中的天然黄酮类化合物,可通过调节肠道功能障碍、抗炎、抗氧化、抗纤维化、抗肿瘤、调节脂质代谢等多种药理活性对消化系统产生保护作用,有望成为治疗消化系统疾病的候选药物,具有广阔的开发应用前景。对近5年国内外相关文献进行查阅、比较与分析,通过归纳与整理,综述柚皮素治疗消化系统疾病的药理作用及机制研究进展,以期为其新用途开发提供参考。

关键词：柚皮素消化系统疾病调节肠道功能障碍抗炎抗氧化抗纤维化抗肿瘤调节脂质代谢

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TiO_(2)光催化联合低温等离子体技术处理氮氧化物的研究

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高压电器 2021年第5期57卷 29-35页

作者：杨国清杨宇凡王德意闫梦瑶刘菁陶凯西安理工大学西北旱区生态水利工程国家重点实验室西安710048 西安理工大学水电学院电力工程系西安710048

文中基于溶胶—凝胶法制备单面负载TiO_(2)薄膜的石英介质板,并采用NaOH液体电极,构建了光催化协同的气液两相介质阻挡放电系统,研究了0.2~1.4 mol/L NaOH溶液作用下,气液两相DBD的放电特性与NO处理率的变化及反应机理。研究发现,DBD中... 详细信息

文中基于溶胶—凝胶法制备单面负载TiO_(2)薄膜的石英介质板,并采用NaOH液体电极,构建了光催化协同的气液两相介质阻挡放电系统,研究了0.2~1.4 mol/L NaOH溶液作用下,气液两相DBD的放电特性与NO处理率的变化及反应机理。研究发现,DBD中产生的337.1~394.1 nm紫外辐射可有效激发TiO_(2),产生光生自由电子和空穴对,NaOH溶液可增加液相电极电导率及气液两相界面OH-离子浓度。而光生空穴及气液界面OH-离子可促进羟基的产生。结果表明,在气液两相DBD中引入320 nm厚度TiO_(2)薄膜及1 mol/LNaOH,NO去除率最高可达93.8%。

关键词：介质阻挡放电光催化二氧化钛氢氧化钠氮氧化物

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