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3D placement of unmanned aerial vehicles and partially overlapped channel assignment for throughput maximization

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Digital Communications and Networks 2021年第2期7卷 214-222页

作者： Chengming Zou Xiaoxiao Li Xing Liu mengya zhang Hubei Key Laboratory of Transportation Internet of Things Wuhan University of TechnologyWuhan430070China School of Computer Science and Technology Wuhan University of TechnologyWuhan430070China Peng Cheng Laboratory Shenzhen518055China Logistics Engineering School Wuhan University of TechnologyWuhan430070China

This paper investigates a wireless system with multi-Unmanned Aerial Vehicles(UAVs)for improving the overall *** contrast to previous studies that optimize the locations of UAVs and channel assignment separately,this paper considers the two issues jointly by exploiting Partially Overlapped Channels(POCs).The optimization problem of maximizing network throughput is formulated as a non-convex and non-linear *** order to find a practical solution,the problem is decomposed into two subproblems,which are iteratively ***,the optimal locations of UAVs are determined under a fixed channel assignment scheme by solving the mixed-integer second-order cone ***,an efficient POC allocation scheme is determined via the proposed channel assignment *** results show that the proposed approach not only significantly improves system throughput and service reliability compared with the cases in which only orthogonal channels and stationary UAVs are considered,but also achieves similar performance using the exhaustive search algorithm with lower time complexity.

关键词： Unmanned aerial vehicle Partially overlapped channel Throughput maximization Channel assignment

Targeting macrophagic 17β-HSD7 by fenretinide for the treatment of nonalcoholic fatty liver disease

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Acta Pharmaceutica Sinica B 2023年第1期13卷 142-156页

作者： Xiaoyu Dong Yiting Feng Dongqin Xu mengya zhang Xiao Wen Wenhao Zhao Qintong Hu Qinyong zhang Hui Fu Jie Ping Department of Pharmacology School of Basic Medical SciencesWuhan UniversityWuhan 430071China Department of Anatomy School of Basic Medical SciencesWuhan UniversityWuhan 430071China

Nonalcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide and macrophage polarization plays an important role in its ***,which molecule regulates macrophage polarization in NAFLD remains ***,we showed NAFLD mice exhibited increased 17β-hydroxysteroid dehydrogenase type 7(17β-HSD7)expression in hepatic macrophages concomitantly with elevated M1 ***-cell RNA sequencing on hepatic non-parenchymal cells isolated from wild-type littermates and macrophage-17β-HSD7 knockout mice fed with high fat diet(HFD)for 6 weeks revealed that lipid metabolism pathways were notably ***,17β-HSD7 deficiency in macrophages attenuated HFD-induced hepatic steatosis,insulin resistance and liver ***,17β-HSD7 triggered NLRP3 inflammasome activation by increasing free cholesterol content,thereby promoting M1 polarization of macrophages and the secretion of pro-inflammatory *** addition,to help demonstrate that 17β-HSD7 is a potential drug target for NAFLD,fenretinide was screened out from an FDA-approved drug library based on its 17β-HSD7 dehydrogenase inhibitory *** dose-dependently abrogated macrophage polarization and pro-inflammatory cytokines production,and subsequently inhibited fat deposition in hepatocytes co-cultured with *** conclusion,our findings suggest that blockade of 17β-HSD7 signaling by fenretinide would be a drug repurposing strategy for NAFLD treatment.

关键词： Nonalcoholic fatty liver disease 17β-HSD7 Macrophage Cholesterol Insulin resistance Fenretinide

Patent Application, Grant and Patent Law Amendment in China

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Innovation and Development Policy 2020年第2期 126-137页

作者： Gupeng zhang Sen Du mengya zhang School of Public Policy and Management University of Chinese Academy of SciencesBeijing 100049China

This study employs 920,108 invention patents from the State Intellectual Property of China(SIPO)to examine the impact of two patent law amendments,which occurred in 1993 and 2001 respectively,on the patent *** first patent law amendment in 1993 led to less strict criteria for patent *** the second patent law amendment,which occurred in 2001,showed a similar positive impact on patenting as *** is more likely that the first patent law amendment encouraged foreign applicants to make patent application,because their applications and grant share started to rise after *** contrast,the second patent law amendment played an opposite role by motivating Chinese applicants to make patent application,which is reflected by a rise of application and grant share by Chinese applicants in post-2001 *** grant is viewed as one of the key indicators for judging the patent *** find that foreign applicants from the U.S.,Japan and European Union have higher patent grant rate than that of Chinese applicants,suggesting that patents held by foreign applicants may have higher potential value than those held by Chinese *** types of applicants may differ from each other in terms of the patent grant rate,where research institutes have higher patent grant rate than that of corporations and *** the filed patents in China can enjoy a provisional protection for 3 years at most,some applicants do not request their *** an examination of the novelty,inventiveness and practicality of patent,the patent office determines whether to grant *** using a bivariate probit model,we make an econometric analysis of this *** result confirms the positive impact of both patent law amendments in 1993 and 2001 on the patent *** also find other determinants of the patent grant,for example,R&D human capital investment,applicant’s competitive technology advantage in the patent’s field,and applicant’s research ability,play positi

关键词： patent application patent grant patent law examination request bivariate probit model

Tongue-coating microbiome reflects cardiovascular health and determines outcome in blood pressure intervention

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Journal of Genetics and Genomics 2023年第10期50卷 803-806页

作者： Hairong Chen Yue Ma Min Li Qingwei Li mengya zhang Zixiong Wang Hongmei Liu Jun Wang Xiaolin Tong Yixin Zeng CAS Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Department of Endocrinology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China University of Chinese Academy of Sciences Beijing 100049China Rehabilitation Hospital Affiliated to National Rehabilitation Aids Research Center Beijing 100176China

Tongue-coating microbiome,as a part of oral microbiome,is an important part of commensal microbes in human *** technical difficulties in gaining functional insights using metagenomic approaches due to high levels of host DNA contaminations,a number of diseases have been found to be closely related to the alteration of oral microbial communities,including periodontal and caries diseases,cardiovascular disease,diabetes,rheumatoid arthritis.

关键词： cardiovascular diseases coating

Metabolically healthy obesity increase risk for hypertension,T2DM and the metabolic syndrome:A community-based cohort study

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广西医科大学学报 2018年第6期35卷 794-799页

作者： Huixia Lin Qingfeng Song mengya zhang Wei Xiao Meiqi Zhao Ying Cui Department of Medical Research Affiliated Tumor Hospital of Guangxi Medical University

Objective:To investigate the prevalence of metabolically healthy obesity(MHO)and its relationship with incidence of metabolic syndrome(MetS),type 2diabetes mellitus(T2DM)and hypertension in individuals in the city of ***:We studied 1,666 participants,aged over18years at baseline,with free of components of the MetS except waist *** were divided into three groups based on body mass index(Ibm):lean/normal weight(Ibm<23kg/m2),overweight(Ibm,23-24.9kg/m2),obesity(Ibm≥25 kg/m2).The cumulative incidence of MetS,T2DM and hypertension over 5.21years among groups was ***:The prevalence of MHO was 19.5%in the baseline *** an average 5.21year follow-up,the cumulative incidence of MetS,T2DM and hypertension in1,666participants were 16.4%,19.1%and 3.9%,*** obesity group had a significantly higher cumulative incidence of MetS(16.4%vs.3.2%,P<0.001),hypertension(19.1%vs.3.7%,P<0.001),and T2DM(3.9%vs.1.6%,P<0.001)compared to the lean/normal weight *** kg/m2 of Ibm carried increased risk for T2DM(19%),hypertension(11%)and MetS(13%).Conclusion:Metabolically healthy obesity individuals confer increased risk for hypertension,T2DM and the MetS than their non-obese counterparts.

关键词：医疗卫生行业治疗方法临床分析理论分析

Regulation of miR-30b on Nav1.6 participates oxaliplatin-induced neuropathic pain as a regulator of DRG neuronal excitability

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Regulation of miR-30b on Nav1.6 participates oxaliplatin-ind...

Cold Chain Logistics Information Monitoring Platform Based on Internet of Vehicles

中国解剖学会2019年年会

作者： zhang Jingjing zhang mengya Shao Jinping Cao Jing Zang Weidong Department of Human Anatomy School of Basic Medical SciencesZhengzhou University

＜正＞Anti-cancer chemotherapy is usually associated with neurotoxicity,which may cause severe pain *** previous study found,in DRG of oxaliplatin （OXA）-treated rats, a significant increase in Nav1.6 expression mediated by ***,we further studied the functional significance of Nav1.6expression change in OXA-induced neuropathic *** currents and neuronal activity in rat DRG neurons was

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Cold Chain Logistics Information Monitoring Platform Based o...

作者： Liu Dan Cao Xin Zhou Xinghai zhang mengya Dept.of Computer Science and Technology Neusoft Institute of Information Dalian Hi-Think Computer Technology Corp.

With the development of specialized lowtemperature food and division of labor in logistics field in China,Cold Chain Logistics which uses low-temperature transportation has become *** the face of more and more refrigerated transportation market,the application of Internet-of-Vehicles（IoV） technology in cold chain logistics is a new technology which is developing vigorously in the field of *** paper describes the IoV technology feasibility in cold chain logistics industry,the necessity and importance,builds a cold chain logistics information monitoring platform based on IoV,which including the cold chain logistics vehicle real-time positioning,vehicle trajectory monitoring,the freezer temperature and humidity monitoring and early warning function etc.

关键词： Sensors Cold chain logistics Internet-of-Vehicles Monitoring Platform

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激光烧蚀材料过程中的热效应分析

光学学报 2024年第19期44卷 343-353页

作者：施舜泽张梦伢李凌上海理工大学能源与动力学院上海200093

建立二维柱坐标系下的热力耦合模型,研究激光加工反应材料时材料内部的传热过程和热应力特性,分析各应力沿径向和轴向的变化规律,在此基础上进一步探讨激光功率对热应力的产生以及变化特性的影响。结果表明,热应力最大值在不同方向上的... 详细信息

建立二维柱坐标系下的热力耦合模型,研究激光加工反应材料时材料内部的传热过程和热应力特性,分析各应力沿径向和轴向的变化规律,在此基础上进一步探讨激光功率对热应力的产生以及变化特性的影响。结果表明,热应力最大值在不同方向上的变化趋势并不相同。沿半径方向,径向应力和环向应力的最大值先增加而后又逐渐减小,而轴向应力最大值则不断增加;沿轴向方向,三种应力最大值都是先增大后减小,并逐渐趋于平缓。研究结果有助于推进激光在加工反应材料中的应用。

关键词：超快光学激光光学激光烧蚀热力耦合模型传热特性应力分布

考虑间歇效应的循环荷载下软黏土刚度软化特性

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哈尔滨工业大学学报 2020年第11期52卷 88-96页

作者：郑晴晴夏唐代张孟雅浙江大学建筑工程学院杭州310058 浙江大学城市和滨海岩土研究中心杭州310058 中国电力工程顾问集团东北电力设计院有限公司长春130000

天然软土地基在地铁运营期受到周期性振动和间歇的反复作用,间歇期内软土力学特性的变化将影响其刚度软化,但以往关于交通荷载下软土刚度软化的研究大多忽视发车间歇的影响.为此,考虑不同动应力比、单位间歇时长和振动时长,设计不排水... 详细信息

天然软土地基在地铁运营期受到周期性振动和间歇的反复作用,间歇期内软土力学特性的变化将影响其刚度软化,但以往关于交通荷载下软土刚度软化的研究大多忽视发车间歇的影响.为此,考虑不同动应力比、单位间歇时长和振动时长,设计不排水连续和停振循环三轴试验,对试样采用真实K 0固结,研究原状淤泥质软黏土在列车非连续荷载下的长期刚度软化规律.通过对比连续振动和间歇振动试验结果,发现间歇对刚度软化有削弱作用,可减少大循环周数下残余软化指数,缩短快速软化期经历的循环周数.基于试验结果深入分析间歇的影响机制,发现加载初期软土受激振作用影响,土体结构动态调整滞后至间歇期,导致孔压持续增长,软土软化,平均软化速率提高;一定循环周数后,软土由于在前期间歇和振动阶段集中对结构进行调整,土体结构提前进入稳定状态,间歇期消散部分孔压,恢复部分刚度,导致下一次振动软化速率降低,间歇期恢复的刚度随振动次数增加而累积,致使最终残余软化指数显著提高;同等条件下,间歇时长越长,初期软化速率越大,软化速率随振动次数增加的衰减也越显著,导致进入稳定期所需的振动周数越少,整体软化程度削弱越明显.

关键词：间歇性循环加载间歇效应刚度软化 K0固结原状软黏土软化速率