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A pathological joint-liver axis mediated by matrikine-activated CD4^(+)T cells

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2679-2693页

作者： Junzhi Yi Hui Zhang Fangyuan Bao Zhichu Chen Yuliang Zhong Tianning Ye Xuri Chen Jingyi Qian mengya Tian Min Zhu Zhi Peng Zongyou Pan Jianyou Li Zihao Hu Weiliang Shen Jiaqi Xu Xianzhu Zhang Youzhi Cai Mengjie Wu Hua liu Jing Zhou Hongwei Ouyang Department of Sports Medicine of the Second Affiliated Hospital and Liangzhu LaboratoryZhejiang University School of MedicineHangzhouChina Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine Zhejiang University School of MedicineHangzhouChina Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesHangzhouChina The MOE Key Laboratory of Biosystems Homeostasis&Protection The Key Laboratory of Cancer Molecular Cell Biology of Zhejiang ProvinceLife Sciences InstituteZhejiang UniversityHangzhouChina Department of Orthopedics Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhouChina China Orthopedic Regenerative Medicine Group(CORMed) HangzhouChina Department of Orthopedics The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina

The knee joint has long been considered a closed *** pathological effects of joint diseases on distant organs have not been ***,our clinical data showed that post-traumatic joint damage,combined with joint bleeding(hemarthrosis),exhibits a worse liver function compared with healthy *** mouse model,hemarthrosis induces both cartilage degeneration and remote liver ***,we found that hemarthrosis induces the upregulation in ratio and differentiation towards Th17 cells of CD4^(+)T cells in peripheral blood and *** of CD4^(+)T cells reverses hemarthrosis-induced liver *** of cartilage matrix induced by hemarthrosis upregulates serological type Ⅱ collagen(COL Ⅱ),which activates CD4^(+)T *** application of a COL Ⅱ antibody blocks the ***,bulk RNAseq and single-cell qPCR analysis revealed that the cartilage Akt pathway is inhibited by blood ***-articular application of Akt activator blocks the cartilage degeneration and thus protects against the liver impairment in mouse and pig *** together,our study revealed a pathological joint-liver axis mediated by matrikine-activated CD4^(+)T cells,which refreshes the organ-crosstalk axis and provides a new treatment target for hemarthrosis-related disease.

关键词： degeneration damage inhibited

Microtopography Attenuates Endothelial Cell Proliferation by Regulating MicroRNAs

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Journal of Biomaterials and Nanobiotechnology 2017年第3期8卷 189-201页

作者： Dan Wang mengya liu Shuangying Gu Yue Zhou Song Li School of Biomedical Engineering and Med-X Research Institution Shanghai Jiao Tong University Shanghai China Department of Bioengineering and Department of Medicine University of California Los Angeles CA USA

Endothelial cell (EC) morphology can be regulated by the micro/nano topography in engineered vascular grafts and by hemodynamic forces in the native blood vessels. However, how EC morphology affects miRNA and thus EC functions is not well understood. In this study, we addressed this question by using human umbilical vein endothelial cells (HUVECs) cultured on microgrooves as a model. HUVECs were grown on either microgrooved (with 10 μm width/spacing and 3 μm depth) or smooth surfaces. HUVECs on microgrooved surface had elongated and bipolar morphology, while HUVECs on smooth surface showed cobble stone shape or non-polar morphology. EdU staining indicated that HUVECs with elongated morphology had lower proliferation rate compared to their counterpart cultured on smooth surface. Quantitative PCR analysis demonstrated that the expression of the specific microRNAs (miR-10a, miR-19a, miR-221) that targeted proliferation-related genes was all up-regulated. Consistently, the mRNA levels of their respective target genes, mitogen-activated protein kinase kinase kinase 7, Cyclin D1 and c-kit were significantly reduced by a fold change of 0.12 ± 0.01 (p < 0.01), 0.70 ± 0.23 (p 0.05) and 0.76 ± 0.21 (p < 0.05). Other miRNAs such as miR-126 and miR-181a were up-regulated as well, leading to the repression of their targets vascular cell adhesion molecule-1 and prospero homeobox-1. Our results suggested that microgrooved surface may regulate microRNA levels and thus EC functions. These results provide insight into the modulation of EC functions by microtopographic cues, and will facilitate the rational design of microstructured materials for cell and tissue engineering.

关键词： Microgroove PDMS MicroRNA Endothelial Cell

Frequency Regulation of VSC-MTDC System with Offshore Wind Farms

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 275-286页

作者： Haoyu liu Chongru liu North China Electric Power University Beijing 102206China

Frequency regulation of voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC)system with offshore wind farms enhances the frequency stability by compensating the power for a disturbed AC ***,it is difficult to reasonably allocate frequency-regulation resources due to a lack of coordination mechanisms between wind farms and the MTDC ***,it is difficult for the frequency control of the wind farms to manage changes in wind speed;and the risk of wind-turbine stalls is ***,based on the kinetic energy of wind turbines and the power margin of the converters,the frequency-regulation capability of wind turbines is evaluated,and a dynamic frequency-support scheme considering the real-time frequency-support capability of the wind turbines and system frequency evolution is proposed to improve the frequency-support performance.A power adaptation technique at variable wind speeds is developed;the active power in the frequency-support stage and restoration stage is switched according to the wind speed.A hierarchical zoning frequency-regulation scheme is designed to use the frequency-regulation resources of different links in the MTDC system with wind *** simulation results show that the novel frequency-regulation strategy maintains frequency stability with wind-speed changes and avoids multiple frequency dips.

关键词： Wind generation voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC) frequency regulation cooperative control adaptive control variable wind speed

基于PI3K/AKT/Caspase-9通路研究富氢水在急性放射性脑损伤中的作用及机制

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环境与职业医学 2023年第3期40卷 246-253页

作者：王永陈小曼刘梦雅罗浩王永丽刘晓明秦秀军山西医科大学法医学院山西太原030001 中国辐射防护研究院放射医学与环境医学研究所药物毒理与放射损伤药物山西省重点实验室/中核放射毒理与放射性药物临床前评价重点实验室山西太原030006

[背景]目前,放射治疗广泛应用于临床肿瘤的治疗,射线在杀伤肿瘤细胞的同时也会损伤正常组织。有研究表明氢是一种具有前景的治疗相关疾病的方法。[目的]探究磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(AKT)/半胱氨酸天冬氨酸特异性蛋白酶9(Caspa... 详细信息

[背景]目前,放射治疗广泛应用于临床肿瘤的治疗,射线在杀伤肿瘤细胞的同时也会损伤正常组织。有研究表明氢是一种具有前景的治疗相关疾病的方法。[目的]探究磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(AKT)/半胱氨酸天冬氨酸特异性蛋白酶9(Caspase-9)信号通路在富氢水对急性放射性脑损伤中的作用及机制。[方法]将40只雄性SD大鼠随机分为对照组、单纯照射(IR)组、高剂量富氢水干预(IR+HHRW)组、低剂量富氢水干预(IR+LHRW)组,每组10只。除对照组外,其余组动物均接受单次20 Gy全脑照射。各组动物均在照射前3 d至照射后7 d内,每天灌胃1次,对照组和IR组给予纯净水(20 mL·kg^(−1)),IR+HHRW组和IR+LHRW组给予富氢水(20 mL·kg^(−1)、10 mL·kg^(−1))。照射7 d后每组各取5只大鼠进行Morris水迷宫实验检测行为学变化;剩余动物麻醉后剖杀、采血、取脑组织检测血液指标变化,进行TUNEL染色观察神经细胞凋亡情况,苏木精和伊红(HE)染色观察组织病理学变化,酶联免疫吸附试验(ELISA)检测氧化应激指标的变化,采用实时荧光定量PCR和Western blotting法检测PI3K、AKT、细胞色素C(Cytc)、Caspase-9的mRNA和蛋白的表达。[结果]照后第7天,与对照组相比,各照射组大鼠体重均降低(P<0.05),并且出现了不同程度的弓背、精神萎靡等症状,IR+HHRW组大鼠较IR组大鼠以上症状明显更轻。行为学检测结果显示:第2~5天IR+HHRW组或IR+LHRW组大鼠相对于IR组逃避潜伏期缩短(P<0.05),且IR+HHRW组大鼠在第6天撤去平台后到达平台原来位置所用时间减少(P<0.05)。血液学检测结果显示,IR组红细胞(RBC)计数、血红蛋白(HGB)量、白细胞(WBC)计数均降低(P<0.05),IR+HHRW组RBC、HGB、WBC指标均有所改善(P<0.05)。HE染色结果显示:IR+HHRW组较IR组的异常神经细胞数量以及碎裂、溶解的细胞核明显减少,损伤程度更轻。氧化应激指标检测结果显示:IR组抑制自由基能力降低,丙二醛(MDA)水平增高(P<0.01);LHRW干预后,MDA水平降低(P<0.05);HHRW干预后,SOD活力升高(P<0.05)。TUNEL染色结果显示:IR+HHRW组凋亡信号较IR组稀疏。实时荧光定量PCR结果显示:与IR组相比,IR+HHRW组和IR+LHRW组PI3K、AKT的mRNA表达水平升高(P<0.05),而Cytc和Caspase-9的mRNA表达水平降低(P<0.05)。Western blotting结果显示:与IR组相比,IR+HHRW组磷酸化AKT(pAKT)表达量增加(P<0.05),而Caspase-9和Cytc蛋白表达量降低(P<0.05)。[结论]富氢水干预可显著减轻急性放射性脑损伤引起的炎症和氧化应激反应,并减轻神经细胞凋亡,其机制可能与调控PI3K/AKT/Caspase-9信号通路有关。

关键词：富氢水电离辐射磷脂酰肌醇3-激酶/蛋白激酶B/半胱氨酸天冬氨酸特异性蛋白酶9信号通路神经细胞凋亡

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七水合硫酸镁微胶囊对HMX的安全性能影响

兵器装备工程学报 2022年第4期43卷 278-283页

作者：徐聪刘梦雅马静静侯聪花中北大学环境与安全工程学院太原030051

为研究水合盐材料对HMX的性能影响,选择七水合硫酸镁微胶囊作为改性剂。采用溶液-水悬浮法,以Estane5703,F_(2602)为黏结剂、Span-80为表面活性剂制备HMX基PBX。采用扫描电子显微镜、X射线衍射仪和差示扫描量热仪对样品进行了表征和热分... 详细信息

为研究水合盐材料对HMX的性能影响,选择七水合硫酸镁微胶囊作为改性剂。采用溶液-水悬浮法,以Estane5703,F_(2602)为黏结剂、Span-80为表面活性剂制备HMX基PBX。采用扫描电子显微镜、X射线衍射仪和差示扫描量热仪对样品进行了表征和热分析;并测试样品的机械感度。结果表明:以F_(2602)为黏结剂制备的样品表面光滑,颗粒密实,形貌好;制备的样品晶型未发生改变;使用F_(2602),Estane5703制备的样品热爆炸临界温度较HMX分别下降了2.58℃,5.66℃,水合盐微胶囊的加入使HMX放热量有一定的增加;以F_(2602)为黏结剂制备的样品特性落高较HMX提高42.06 cm,摩擦荷重较HMX提高96 N。

关键词：七水合硫酸镁微胶囊 HMX 溶液-水悬浮法机械感度

小儿重度喉软化症临床特点及手术疗效影响因素分析

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临床耳鼻咽喉头颈外科杂志 2022年第4期36卷 258-264页

作者：刘燕魏萍寇巍胡思洁武小芳刘萌雅陈成姚红兵重庆医科大学附属儿童医院耳鼻咽喉头颈外科国家儿童健康与疾病临床医学研究中心儿童发育疾病研究教育部重点实验室儿科学重庆市重点实验室重庆400014 重庆佑佑宝贝妇儿医院耳鼻咽喉科

目的:探讨重度喉软化症患儿的临床特点及影响手术疗效的因素。方法:回顾性分析2015年1月-2019年5月在重庆医科大学附属儿童医院进行声门上成形术的重度喉软化症患儿的临床资料,探讨重度喉软化症患儿的临床特点,评估术后不同时期主要症... 详细信息

目的:探讨重度喉软化症患儿的临床特点及影响手术疗效的因素。方法:回顾性分析2015年1月-2019年5月在重庆医科大学附属儿童医院进行声门上成形术的重度喉软化症患儿的临床资料,探讨重度喉软化症患儿的临床特点,评估术后不同时期主要症状的改善情况,分析手术年龄和医学共病对手术疗效的影响。结果:在重症喉软化的解剖分型中,Ⅳ型所占比例最高(37例,66.1%),Ⅰ型最少(2例,3.6%);所有患儿均存在喉鸣和呼吸困难,其次是喂养困难(46例,82.1%)和生长发育不良(38例,67.9%)。56例重度喉软化症患儿中,伴有医学共病的患儿35例(62.5%),先天性心脏疾病22例(39.3%),发病率最高。不伴医学共病的重度喉软化症手术有效率为100.0%,伴一种类型共病的手术有效率为96.0%,伴多种类型共病的手术有效率为30.0%(P0.05);手术年龄>3个月,无论是否伴有共病,术后1、3、6个月的手术有效率均为100.0%。不伴共病患儿的手术失败率和再手术率均为0,而伴共病患儿的手术失败率和再手术率分别为22.9%和20.0%,两者比较差异有统计学意义(P<0.05),其中伴多种共病患儿的手术失败率及再手术率显著高于伴一种共病的患儿(70.0%和4.0%,60.0%和4.0%),两者比较差异有统计学意义(P<0.01)。重度喉软化症总体手术成功率为85.7%。结论:大部分重度喉软化症患儿伴有不同类型和数量的共病,有着更复杂的解剖分型。声门上成形术可改善绝大部分患儿的喉鸣、呼吸困难、喂养困难及生长发育不良,手术成功率高;手术疗效不受手术年龄的影响;多种共病的存在是手术失败和再手术的主要原因。

关键词：儿童喉软化症医学共病声门上成形术治疗效果

A Novel Design of a Pre-separation Panel Structure to Protect Against the Impact of an Explosion in an Aircraft Plenum Chamber

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Acta Mechanica Solida Sinica 2024年第1期37卷 166-180页

作者： Zongxing liu Xiang Yang Jun liu School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China COMAC Shanghai Aircraft Design and Research Institute Shanghai 201210China

To reduce the damage of the pressurizing panel structure of a fuselage caused by an explosion at the“least risk bomb location”in an aircraft structure,a new pre-separation panel structure was designed to resist blast ***,the dynamic strain response and morphology of impact damage of the new pre-separation panel were measured in an impact damage ***,the commercial software LS-DYNA was used to calculate the propagation of the blast shock wave,and the results were compared with empirical equations to verify the rationality of the numerical calculation ***,the fluid–structure coupling method was used to calculate the damage process of the pre-separation panel structure under the impact of an explosion wave and an impact *** calculated results were in good agreement with the test results,which showed the rationality of the calculation method and the *** residual strength of the damaged pre-separation panel was significantly higher than that of the original damaged *** results show that the new pre-separation panel structure is reasonable and has certain significance for guiding the design of plenum chambers with strong resistance to implosion for aircraft fuselages.

关键词： Pre-separation panel structure Explosive response Residual strength Aircraft plenum chamber Least risk bomb location

Effectiveness and safety of acupuncture in treatment of pregnancyrelated symptoms:a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 16-26页

作者： liu Tingting liu Tongou liu Mingfu School of Traditional Chinese Medicine Clinical Medicine Hubei University of Traditional Chinese MedicineWuhan 430000China First Clinical College of Hubei University of Traditional Chinese Medicine Wuhan 430000China Department of Acupuncture and Tuina Affiliated Hospital of Hubei University of Traditional Chinese MedicineHubei Provincial Hospital of Traditional Chinese MedicineWuhan 430000China

OBJECTIVE:To systematically evaluate the efficacy and safety of acupuncture(AM)in the treatment of pregnancyrelated symptoms such as acute vomiting during ***:We comprehensively searched the available literature up to November 2021,including Pub Med,Embase,Cochrane Library,Chinese Biomedical Literature Database,and China National Knowledge Infrastructure Database,for randomized controlled trials(RCTs)on AM for the treatment of severe vomiting,insomnia,pharyngeal and pelvic pain,mood abnormalities,and dyspepsia during ***:Sixteen RCTs with a cumulative sample size of 1178 cases were *** these,964 patients were included in the *** Meta-analysis results showed that AM was more efficient than Western medicine in treating discomfort during pregnancy[odds ratio(OR)=1.19,95%confidence interval(CI)(1.11,1.28),P<0.01].AM was better than the control group in improving the visual analog scale scores[standard mean difference(SMD)=0.62,95%CI(0.53,0.71),P<0.01].AM was superior to the control group in improving Numerical Rating Scale(NRS)symptom scores[OR=7.31,95%CI(3.36,15.94),P<0.01].There was no significant difference in adverse effects between the AM and sham-AM groups and the analgesic drug group[OR=0.70,95%CI(0.39,1.28),P=0.25],but the treatment and control groups had mild adverse effects with a low ***:AM is more effective than other treatments or pharmacotherapy alone in the treatment of pregnancy-related symptoms,and is relatively ***,the quality of the included trials was rather poor,and high-quality studies are required to confirm our findings.

关键词： acupuncture pregnancy nausea vomiting sleep initiation and maintenance disorders low back pain pelvic pain mood abnormalities Meta-analysis systematic review

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护理人员对老年痴呆患者态度的研究进展

中国临床护理 2022年第8期14卷 525-528页

作者：刘梦雅张楠商丘工学院医学院河南商丘476000

文章总结了国内外护理人员对老年痴呆患者态度的研究现状,从痴呆态度的概念、评估工具、影响因素和干预措施等方面进行综述。当前适用于评估护士痴呆态度的量表主要包括痴呆态度量表、阿尔茨海默病态度量表和痴呆态度问卷。护士痴呆态... 详细信息

文章总结了国内外护理人员对老年痴呆患者态度的研究现状,从痴呆态度的概念、评估工具、影响因素和干预措施等方面进行综述。当前适用于评估护士痴呆态度的量表主要包括痴呆态度量表、阿尔茨海默病态度量表和痴呆态度问卷。护士痴呆态度的影响因素主要有社会人口学因素、工作因素和患者疾病因素三方面,相关干预措施主要以专业教育培训为主。护士作为干预措施的直接实施者,其痴呆态度水平影响着痴呆患者的护理质量。目前国内缺乏有关护士痴呆态度的相关研究,未来应引进或开发适合我国国情的护士痴呆态度评估工具,了解我国护理人员对老年痴呆患者的态度水平,为临床护理管理和干预提供理论参考。

关键词：护士痴呆态度综述