检索结果-南通市图书馆

Deficiency of Healthcare Accessibility of Elderly People Exposed to Future Extreme Coastal Floods:A Case Study of Shanghai,China

引用

International Journal of Disaster Risk Science 2023年第5期14卷 840-857页

作者： Xinmeng Shan Paolo Scussolini Jun Wang mengya li Jiahong Wen Lei Wang Key Laboratory of Geographic Information Science(Ministry of Education) East China Normal UniversityShanghai200241China Institute for National Safety and Emergency Management East China Normal UniversityShanghai200062China School of Geographic Sciences East China Normal UniversityShanghai200241China Institute for Environmental Studies Vrije Universiteit Amsterdam1081 HVAmsterdamThe Netherlands School of Public Management East China Normal UniversityShanghai200062China School of Environmental and Geographical Sciences Shanghai Normal UniversityShanghai200234China Department of Geography&Anthropology Louisiana State UniversityBaton RougeLA70803USA

Socioeconomic development,subsidence,and climate change have led to high flood risks in coastal cities,making the vulnerable,especially elderly people,more prone to floods.However,we mostly do not know how the accessibility of life-saving public resources for the elderly population will change under future scenarios.Using Shanghai as a case,this study introduced a new analytical framework to fill this gap.We integrated for the first time models of coastal flooding,local population growth,and medical resource supply-demand estimation.The results show that under an extreme scenario of coastal flooding in the year 2050,in the absence of adaptation,half of the elderly population may be exposed to floods,the supply of medical resources will be seriously insufficient compared to the demand,and the accessibility of emergency medical services will be impaired by flooding.Our methodology can be applied to gain insights for other vulnerable coastal cities,to assist robust decision making about emergency responses to flood risks for elderly populations in an uncertain future.

关键词： Coastal floods Elderly population Flood exposure analysis Healthcare accessibility Shanghai

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Using Multidisciplinary Analysis to Develop Adaptation Options against Extreme Coastal Floods

引用

International Journal of Disaster Risk Science 2022年第4期13卷 577-591页

作者： Xinmeng Shan Jun Wang Jiahong Wen Hengzhi Hu Lei Wang Jie Yin mengya li Key Laboratory of Geographic Information Science Ministry of EducationEast China Normal UniversityShanghai 200241China School of Geographic Sciences East China Normal UniversityShanghai 200241China Key Laboratory of Spatial-Temporal Big Data Analysis and Application of Natural Resources in Megacities Ministry of Natural ResourcesShanghai 200241China School of Environmental and Geographical Sciences Shanghai Normal UniversityShanghai 200234China Department of Hospitality Management Shanghai Business SchoolShanghai 200235China Department of Geography and Anthropology Louisiana State UniversityBaton RougeLA 70810USA

Long-term flood risk adaptation and decision making are complex because the future is full of deep uncertainties.Flexibility and robustness can be used to deal with future uncertainty.This study developed an integrated modeling framework that extends previous studies to the spatial domain to assess the future flood risks and the cost and benefit of three adaptation measures for four types of buildings in Shanghai.Real options analysis(ROA)and dynamic adaptive policy pathways(DAPP)were integrated to develop a dynamic adaptation pathway and identify robust adaptation options.The results show that:(1)Sea level rise and land subsidence will significantly exacerbate the flood risks in Shanghai;(2)Among the three flood control measures,wet-floodproofing has the best economic performance in terms of both the net present value and the benefit/cost ratio,followed by dry-floodproofing,and elevation;(3)Dryfloodproofing can be used at the beginning of the future period(2030–2100),and it can be replaced by wet-floodproofing in 2035–2042;the elevation measure also shows good performance at the beginning of implementation,but its performance will decline after 2041–2045;(4)The combined strategy of dry-and wet-floodproofing in 2044–2046and a hybrid strategy combining the three measures should be the optimal solution for reducing the flood risks in 2047–2051.The methodology developed in this study can provide insights for coastal cities to formulate cost-effective and feasible adaptation strategies in a deeply uncertain future.

关键词： Adaptation options Building-level measures Climate change Coastal floods Cost-benefit analysis Shanghai

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Metabolism, signaling, and transport of jasmonates

引用

Plant Communications 2021年第5期2卷 78-91页

作者： mengya li Guanghui Yu Congli Cao Pei liu Department of Ecology College of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193P.R.China These authors contributed equally to this article

Biosynthesis/metabolism,perception/signaling,and transport are three essential aspects of the actions of phytohormones.Jasmonates(JAs),including jasmonic acid(JA)and related oxylipins,are implicated in the regulation of a range of ecological interactions,as well as developmental programs to integrate these interactions.Jasmonoyl-isoleucine(JA-Ile)is the most bioactive JAs,and perception of JA-Ile by its coreceptor,the Skp1-Cullin1-F-box-type(SCF)protein ubiquitin ligase complex SCF^(COI1)-JAZ,in the nucleus derepresses the transcriptional repression of target genes.The biosynthesis and metabolism of JAs occur in the plastid,peroxisome,cytosol,endoplasmic reticulum,and vacuole,whereas sensing of JA-Ile levels occurs in the nucleus.It is increasingly apparent that a number of transporters,particularly members of the jasmonates transporter(JAT)family,located at endomembranes as well as the plasma membrane,constitute a network for modulating and coordinating the metabolic flux and signaling of JAs.In this review,we discuss recent advances in the metabolism,signaling,and especially the transport of JAs,focusing on intracellular compartmentation of these processes.The roles of transporter-mediated cell-cell transport in driving long-distance transport and signaling of JAs are also discussed.

关键词： jasmonates metabolism signaling transport cellular compartmentation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

我国东中西部地区及城乡社区人群心血管疾病发病率及病死率分析

引用

中华心血管病杂志 2024年第2期52卷 191-198页

作者：李小萌李梦雅韩国亮游凯金辉向全永李杨中国医学科学院北京协和医学院国家心血管病中心阜外医院医学统计部北京102308 北京市顺义区疾病预防控制中心北京101399 北京积水潭医院预防保健科北京102208 江苏省疾病预防控制中心南京210009

目的探讨我国东中西部地区城乡社区人群心血管疾病发病率及病死率情况。方法本研究基于前瞻性城乡流行病学研究(PURE)中国队列数据,选取其中基线年龄、性别资料齐全且至少完成1次随访的参与者,收集一般人口学、心血管危险因素、心血管... 详细信息

目的探讨我国东中西部地区城乡社区人群心血管疾病发病率及病死率情况。方法本研究基于前瞻性城乡流行病学研究(PURE)中国队列数据,选取其中基线年龄、性别资料齐全且至少完成1次随访的参与者,收集一般人口学、心血管危险因素、心血管疾病防治情况等信息。采用PURE全球研究统一的标准化病例报告表进行随访采集心血管疾病及死亡事件,以评估我国东中西部地区及城乡社区心血管疾病发病率及病死率。结果共纳入东中西部12个省份115个城乡社区的47262名参与者,年龄(51.1±9.6)岁,女性27529例(58.2%)。在11.9(9.5,12.6)年的随访期中,共记录了2686例死亡事件及5873例心血管事件,心血管疾病发病率为[11.90(95%CI:11.60~12.21)/1000人年]。不同地区心血管疾病发病率及病死率呈现出明显差异(P趋势<0.001)。西部地区心血管疾病发病风险最高[13.99(95%CI:13.33~14.65)/1000人年],东部地区次之[11.92(95%CI:11.52~12.33)/1000人年],中部地区最低[8.87(95%CI:8.25~9.50)/1000人年];而心血管疾病1年病死率呈现出从东到西依次递增的趋势[东部:10.20%(95%CI:6.95~14.73);中部:13.50%(95%CI:9.90~18.14);西部:18.62%(95%CI:14.95~22.94);P趋势<0.001]。农村地区主要心血管疾病发病率在东中西部地区均高于城市地区(东部P<0.001,中部P=0.01,西部P<0.001),1年病死率在东部(P<0.001)及西部(P=0.02)均高于城市地区。结论我国中老年人群心血管疾病发病率和病死率高,其中社会经济水平较低的西部地区以及农村地区尤为明显。

关键词：心血管疾病发病率病死率社会经济地区城乡社区

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Importers Drive Leaf-to-Leaf Jasmonic Acid Transmission in Wound-Induced Systemic Immunity

引用

Molecular Plant 2020年第10期13卷 1485-1498页

作者： mengya li Feifei Wang Shuangzhang li Guanghui Yu lijian Wang Qingqing li Xiangyu Zhu Zhen li lixing Yuan Pei liu Department of Ecology College of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193P.R.China State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193P.R.China Department of Plant Nutrition College of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193P.R.China

The transmission of mobile wound signals along the phloem pathway is essential to the activation of wound-induced systemic response/resistance,which requires an upsurge of jasmonic acid(JA)in the distal undamaged leaves.Among these mobile signals,the electrical signal mediated by the glutamate-dependent activation of several clade three GLUTAMATE RECEPTOR-liKE(GLR3)proteins is involved in the stimulation of JA production in distal leaves.However,whether JA acts as a mobile wound signal and,if so,how it is transmitted and interacts with the electrical signal remain unclear.Here,we show that JA was translocated from the local to distal leaves in Arabidopsis,and this process was predominantly regulated by two phloem-expressed and plasma membrane-localized jasmonate transporters,AtJAT3 and AtJAT4.In addition to the cooperation between AtJAT3/4 and GLR3.3 in the regulation of long-distance JA translocation,our findings indicate that importer-mediated cell-cell JA transport is important for driving the loading and translocation of JA in the phloem pathway in a self-propagating manner.

关键词： wound-induced systemic resistance jasmonate importers mobile signals phloem loading long-distance transmission self-propagation mode

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

不同回收渠道下的再制造模式对比研究

引用

系统管理学报 2024年第3期33卷 547-564页

作者：夏西强李梦雅路梦圆郑州大学商学院郑州450001 中山大学管理学院广州510275

为分析知识产权保护下两种再制造模式对不同回收渠道选择的影响,通过建立基于外包和授权再制造模式的原始制造商回收、再制造商回收和零售商回收3种回收渠道博弈模型,从环境和收益双重角度研究了不同再制造模式下最优回收渠道选择。研... 详细信息

为分析知识产权保护下两种再制造模式对不同回收渠道选择的影响,通过建立基于外包和授权再制造模式的原始制造商回收、再制造商回收和零售商回收3种回收渠道博弈模型,从环境和收益双重角度研究了不同再制造模式下最优回收渠道选择。研究发现:无论采取授权再制造还是外包再制造,不同回收渠道对新产品的批发和零售价格没有影响,主要通过影响授权费用、外包费用和再制造产品定价来调节两种产品的销售量。授权再制造模式下,原始制造商回收渠道实现了原始制造商、再制造商和零售商三者利润共赢,同时促进再制造产业发展、降低环境影响;外包再制造模式下,基于收益和环境双重考虑,再制造商回收渠道更具优势。授权再制造时选取原始制造商回收渠道与外包再制造时选取再制造商回收渠道对再制造产品销售量、环境和零售商利润的影响一样。然而,原始制造商和再制造商均倾向于选择自身回收渠道以实现最大利润。因此,在确定最优再制造模式和回收渠道时,需要考虑原始制造商和再制造商的回收能力。

关键词：回收渠道外包再制造授权再制造博弈模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characteristics of oil shale pyrolysis in a two-stage fluidized bed

引用

Chinese Journal of Chemical Engineering 2018年第2期26卷 407-414页

作者： Yong Tian mengya li Dengguo Lai Zhaohui Chen Shiqiu Gao Guangwen Xu State Key Laboratory of Multi-phase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of ChineseAcademy of Sciences Beijing 100049China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

Rapid pyrolysis of oil shale coupled with in-situ upgrading of pyrolysis volatiles over oil shale char was studied in a laboratory two-stage fluidized bed(TSFB) to clarify the shale oil yield and quality and their variations with operating conditions. Rapid pyrolysis of oil shale in fluidized bed(FB) obtained shale oil yield higher than the Fischer Assay oil yield at temperatures of 500-600 ℃. The highest yield was 12.7 wt% at 500 ℃ and was about1.3 times of the Fischer Assay oil yield. The heavy fraction(boiling point > 350 ℃) in shale oil at all temperatures from rapid pyrolysis was above 50%. Adding an upper FB of secondary cracking over oil shale char caused the loss of shale oil but improved its quality. Heavy fraction yield decreased significantly and almost disappeared at temperatures above 550 ℃, while the corresponding light fraction(boiling point light fraction yield, the optimal pyrolysis and also secondary cracking temperatures in TSFB were 600 ℃, at which the shale oil yield decreased by 17.74% but its light fraction yield of 7.07 wt% increased by 86.11% in comparison with FB pyrolysis. The light fraction yield was higher than that of Fischer Assay at all cases in TSFB. Thus, a rapid pyrolysis of oil shale combined with volatile upgrading was important for producing high-quality shale oil with high yield as well.

关键词：热分解油页岩流体化二阶特征页岩油油产量温度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transporter-Mediated Nuclear Entry of Jasmonoyl-lsoleucine Is Essential for Jasmonate Signaling

引用

Molecular Plant 2017年第5期10卷 695-708页

作者： Qingqing li Jian Zheng Shuaizhang li Guanrong Huang Stephen J. Skilling lijian Wang ling li mengya li lixing Yuan Pei liu Department of Ecology Department of Plant Nutrition College of Resources and Environmental Sciences China Agricultural University Beijing 100193 P. R. China

To control gene expression by directly responding to hormone concentrations, both animal and plant cells have exploited comparable mechanisms to sense small-molecule hormones in nucleus. Whether nuclear entry of these hormones is actively transported or passively diffused, as conventionally postulated, through the nuclear pore complex, remains enigmatic. Here, we identified and characterized a jasmonate transporter in Arabidopsis thaliana, AtJAT1/AtABCG16, which exhibits an unexpected dual localization at the nuclear envelope and plasma membrane. We show that AtJAT1/AtABCG16 controls the cytoplasmic and nuclear partition of jasmonate phytohormones by mediating both cellular efflux of jasmonic acid （JA） and nuclear influx of jasmonoyl-isoleucine （JA-Ile）, and is essential for maintaining a critical nuclear JA-Ile concentration to activate JA signaling. These results illustrate that transporter-mediated nuclear entry of small hormone molecules is a new mechanism to regulate nuclear hormone signaling. Our findings provide an avenue to develop pharmaceutical agents targeting the nuclear entry of small molecules.

关键词： jasmonate transporter jasmonic acid jasmonoyl-isoleucine nuclear import AtJAT1/AtABCG16

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

AECOPD机械通气病人下呼吸道感染风险预测Nomogram模型的构建

引用

循证护理 2024年第8期10卷 1469-1474页

作者：潘丹丹李梦娅无锡市第二人民医院江苏214000

目的:构建慢性阻塞性肺疾病急性加重(AECOPD)机械通气病人下呼吸道感染的风险预测Nomogram模型。方法:回顾性选取2019年1月—2022年12月在本院行机械通气的417例AECOPD病人,将所有病人按照2∶1比例随机分为训练集(278例)和验证集(139例... 详细信息

目的:构建慢性阻塞性肺疾病急性加重(AECOPD)机械通气病人下呼吸道感染的风险预测Nomogram模型。方法:回顾性选取2019年1月—2022年12月在本院行机械通气的417例AECOPD病人,将所有病人按照2∶1比例随机分为训练集(278例)和验证集(139例)。收集病人资料,统计AECOPD机械通气病人下呼吸道感染发生率,采用单因素分析和多因素Logistic回归分析AECOPD机械通气病人下呼吸道感染的影响因素,应用R软件构建下呼吸道感染风险预测Nomogram模型并进行验证。结果:下呼吸道感染发生率为51.80%(216/417);多因素Logistic回归分析结果显示,年龄、合并糖尿病、机械通气持续时间、气管插管、合并低蛋白血症、抗菌药物使用时间、抗菌药物使用种类≥2种均是AECOPD机械通气病人下呼吸道感染的独立影响因素(P0.05)均显示预测值和实际值具有良好一致性;决策曲线显示,当训练集阈概率在4%~90%、验证集阈概率在9%~78%时该模型的净收益高。结论:基于7项影响因素[年龄、合并糖尿病、机械通气持续时间、气管插管、合并低蛋白血症、抗菌药物使用时间、抗菌药物使用种类(≥2种)]构建的AECOPD机械通气病人下呼吸道感染的风险预测Nomogram模型具有良好区分度和一致性,且具有临床应用价值。

关键词：慢性阻塞性肺疾病急性加重机械通气下呼吸道感染 Nomogram模型护理影响因素

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

新型高丝氨酸脱氢酶的挖掘与改造研究

引用

食品与发酵工业 2024年第12期50卷 9-16页

作者：吴硕黄新燕李梦雅徐宁魏亮刘君中国科学院天津工业生物技术研究所天津300308 河北师范大学生命科学学院河北石家庄050024 南京农业大学生命科学学院江苏南京210000

高丝氨酸脱氢酶(homoserine dehydrogenase,HSD)是L-高丝氨酸和L-苏氨酸等天冬氨酸家族氨基酸生物合成的关键酶,然而由于其活性较低且受到L-苏氨酸等的反馈抑制作用,严重制约了L-高丝氨酸和L-苏氨酸等氨基酸的生物合成水平。该研究通过... 详细信息

高丝氨酸脱氢酶(homoserine dehydrogenase,HSD)是L-高丝氨酸和L-苏氨酸等天冬氨酸家族氨基酸生物合成的关键酶,然而由于其活性较低且受到L-苏氨酸等的反馈抑制作用,严重制约了L-高丝氨酸和L-苏氨酸等氨基酸的生物合成水平。该研究通过数据库检索,挖掘了8个不同来源的高丝氨酸脱氢酶。通过酶活测定分析法发现,来源于二穗短柄草(Brachypodium distachyon)的高丝氨酸脱氢酶BdHSD具有最高的催化活性,达到7.6 U/mg,且不受L-苏氨酸的反馈抑制,其催化最适pH值为10.5,最适催化温度为38℃。随后该研究进一步对BdHSD进行定向进化,提高BdHSD的催化活性。通过多轮筛选获得了3个具有更高催化活性的BdHSD突变体T186A、N283K、A137T/I188V,其中突变体T186A酶活性达到10.3 U/mg,比野生型提高了35.6%。通过L-高丝氨酸发酵分析发现,BdHSD突变体能有效提升L-高丝氨酸的合成水平。综上所述,该研究挖掘和改造了一个具有高效催化特性的高丝氨酸脱氢酶BdHSD,为L-高丝氨酸、L-苏氨酸和L-蛋氨酸等天冬氨酸家族氨基酸的高效生物合成提供了有力的催化元件。

关键词：高丝氨酸脱氢酶酶进化二穗短柄草 L-高丝氨酸抗苏氨酸

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：