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HMGB1 from Astrocytes Promotes EAE by Influencing the Immune Cell Infiltration-Associated Functions of BMECs in Mice

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Neuroscience Bulletin 2022年第11期38卷 1303-1314页

作者： Junyu Shi Yifan Xiao Na Zhang mengya jiao Xuhuan Tang Chan Dai Chenchen Wang Yong Xu Zheng Tan Feili Gong Fang Zheng Department of Immunology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Organ Transplantation Ministry of EducationNHC Key Laboratory of Organ TransplantationKey Laboratory of Organ TransplantationChinese Academy of Medical SciencesWuhan 430030China Department of Pathology and Pathophysiology School of MedicineJianghan UniversityWuhan 430056China

High mobility group box 1(HMGB1)has been reported to play an important role in experimental autoimmune encephalomyelitis(EAE).Astrocytes are important components of neurovascular units and tightly appose the endothelial cells of microvessels by their perivascular endfeet and directly regulate the functions of the blood-brain *** express more HMGB1 during EAE while the exact roles of astrocytic HMGB1 in EAE have not been well ***,using conditional-knockout mice,we found that astrocytic HMGB1 depletion decreased morbidity,delayed the onset time,and reduced the disease score and demyelination of ***,there were fewer immune cells,especially pathogenic T cells infiltration in the central nervous system of astrocytic HMGB1 conditional-knockout EAE mice,accompanied by up-regulated expression of the tight-junction protein Claudin5 and down-regulated expression of the cell adhesion molecules ICAM1 and VCAM1 in *** vitro,HMGB1 released from astrocytes decreased Claudin5 while increased ICAM1 and VCAM1 expressed by brain microvascular endothelial cells(BMECs)through TLR4 or *** together,our results demonstrate that HMGB1 derived from astrocytes aggravates EAE by directly influencing the immune cell infiltration-associated functions of BMECs.

关键词： HMGB1 Astrocytes Experimental autoimmune encephalomyelitis Blood-brain barrier

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Conditional knockout of HMGB1 in astrocytes improves experimental autoimmune encephalitis through reducing BBB damages

Conditional knockout of HMGB1 in astrocytes improves experim...

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第十四届全国免疫学学术大会

作者： Junyu Shi Na Zhang mengya jiao Xuhuan Tang Zhenggang Zhang Chan Dai Chenchen Wang Zheng Tan Fang Zheng Department of immunology School of Basic Medicine Tongji Medical College HuaZhong University of Science and Technology

Background: HMGB1, a nonhistone DNA-binding nuclear protein that can be released into extracellular space as a DAMP, has been discovered to play an important role in EAE, the animal model of autoimmune disease multiple sclerosis. Astrocytes are the most abundant cell populations in the CNS and are also important components of neurovascular units, where astrocytes can influence nearby cells directly. Astrocytes that expressed HMGB1 increased during EAE while the certain roles of HMGB1 derived from astrocytes have not been ***: To explore the roles astrocytic HMGB1 playing in the development of ***: *** HMGB1 conditionally knocked out mice were generated through injecting GFAP-CreERT2-HMGB1f/f mice with Tamoxifen. *** accepted immunization with MOG to develop EAE. The disease severity was assessed according to the EAE clinical score and the degree of demyelination with LFB. The infiltration of pathogenic immune cells in the CNS was detected with HE staining, immunohistochemistry and flow cytometry. Immunofluorescenece and western blot were carried out to detect the changes of blood brain barrier(BBB). 3. Primary brain microvascular endothelial cells(BMECs) were stimulated by HMGB1 to detect its influences on ***: On the whole, conditional knockout of HMGB1 in astrocytes decreased the morbidity, onset time and clinical score of EAE as well as spinal cord demyelination. Besides, there were less immune cells infiltration in the CNS, especially pathogenic T cells. While the number of T cells in the peripheral immune organ lymph nodes was increased. In terms of BBB, which can inhibit the entrance of immune cells to the CNS in normal physiological conditions, tight junction protein Claudin5 expressed in the BMECs was increased and the cell adhesion molecules ICAM1 and VCAM1 were decreased in the spinal cord of astrocytic HMGB1 conditionally knocked out mice. In vitro, HMGB1 stimulation also promoted the decrease of Claudin5 and t

关键词： astrocyte HMGB1 BBB EAE

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The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan jiao Lingyan Meng Kang Du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

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Systematic comparison of Kawasaki disease Z-score formulas:Enhancing diagnostic accuracy and clinical applicability across populations

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World Journal of Clinical Pediatrics 2025年第1期14卷 63-68页

作者： Yan Pan Fu-Yong jiao Department of Pediatrics The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina Shaanxi Kawasaki Disease Diagnosis and Treatment Center Children's HospitalShaanxi Provincial People's Hospital of Xi'anJiaotong UniveristyXi'an 710000Shaanxi ProvinceChina

This study aims to evaluate the performance of six distinct Z-score formulas in diagnosing coronary artery dilation in Kawasaki disease(KD)patients,with a focus on their clinical applicability across diverse populations.A retrospective analysis was conducted using comparative statistical methods to assess the sensitivity and specificity of each *** Kobayashi and Dallaire formulas demonstrated the highest sensitivity in China,particularly in younger patients with prolonged fever *** findings provide evidence-based recommend-ations for selecting Z-score formulas to optimize diagnostic precision in KD patients.

关键词： Kawasaki disease Early diagnosis Z-score Children

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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian jiao Lai Xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan Qi Robert Chunhua Zhao jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

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原花青素对H_2O_2诱导SH-SY5Y细胞氧化损伤的保护作用

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广东药科大学学报 2017年第6期33卷 768-772页

作者：杨霞胡苗何茵如焦萌亚梅寒芳广东药科大学基础学院/广东省生物活性药物研究重点实验室广东广州510006

目的观察原花青素对H_2O_2诱导SH-SY5Y细胞氧化损伤的保护作用,并初步探讨其保护机制。方法 MTT法筛选合适的原花青素作用浓度,用H_2O_2(400μmol/L)建立SH-SY5Y细胞氧化损伤模型,分别用质量浓度为6.25、12.5、25μg/mL原花青素预处理... 详细信息

目的观察原花青素对H_2O_2诱导SH-SY5Y细胞氧化损伤的保护作用,并初步探讨其保护机制。方法 MTT法筛选合适的原花青素作用浓度,用H_2O_2(400μmol/L)建立SH-SY5Y细胞氧化损伤模型,分别用质量浓度为6.25、12.5、25μg/mL原花青素预处理各组细胞,倒置显微镜观察SH-SY5Y细胞形态学的变化;MTT法检测细胞存活率;Western-blot检测各组细胞HSPA1L蛋白表达水平的变化。结果与模型组比较,各浓度原花青素组的细胞形态明显改善,细胞存活率明显升高,呈浓度依赖性;与模型组比较,12.5、25μg/mL原花青素组HSPA1L表达水平逐渐降低,其中25μg/mL组HSPA1L表达水平显著下降(P<0.01)。结论原花青素可缓解H_2O_2诱导的SH-SY5Y细胞氧化损伤,其机制可能与调节H_2O_2诱导的HSPA1L蛋白表达有关。

关键词：原花青素 H2O2 SH-SY5Y细胞 HSPA1L蛋白

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Imperative for long-term management and surveillance in Kawasaki disease

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World Journal of Clinical Cases 2025年第4期13卷 61-63页

作者： Yan Pan Fu-Yong jiao Department of Pediatrics The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina Shaanxi Kawasaki Disease Diagnosis and Treatment Center Children’s HospitalShaanxi Provincial People’s Hospital of Xi’an Jiaotong UniversityXi’an 710000Shaanxi ProvinceChina

Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery *** the effectiveness of initial treatments,such as intravenous immunoglobulin,KD patients can experience long-term cardiovascular issues,as evidenced by a recent case report of an adult who suffered a ST-segment elevation myocardial infarction due to previous KD in the World Journal of Clinical *** editorial emphasizes the critical need for long-term management and regular surveillance to prevent such *** drawing on recent research and case studies,we advocate for a structured approach to follow-up care that includes routine cardiac evaluations and preventive measures.

关键词： Kawasaki disease Long-term management Coronary artery aneurysm Surveillance Preventive care

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Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu Jing Wu Guang Yin Fan‑Zhen jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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Facile detection of pesticides using atmospheric pressure matrix-assisted laser desorption ionization mass spectrometry with multi-walled carbon nanotubes-based matrix

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Chinese Chemical Letters 2023年第1期34卷 569-573页

作者： Sijian Chen Huanxi Zhao Lili jiao Zhenhuan Wang mengya Zhao Lu Tian Yang Xiu Shuying Liu Jilin Ginseng Academy Changchun University of Chinese MedicineChangchun 130117China Changchun Institute of Applied Chemistry Chinese Academy of ScienceChangchun 130022China

A novel atmospheric pressure matrix-assisted laser desorption ionization mass spectrometry(AP-MALDIMS)method was established for the facile detection of pesticides in ambient *** kinds of multi-walled carbon nanotubes(MWCNTs)-based matrix were synthesized and utilized to enhance the ionization efficiency of ***,anilinopyrimidine,carbamate,triazine,triazole and benzimidazole pesticides were directly desorbed and ionized from MWCNTs-based matrix in ambient environment,showing clear background and good *** a comparison,Fe3O4-doped MWCNTs improved the intensity of pesticide ions more than the other three ***,MWCNTs-based matrix exhibited better performance than organic *** analysis of pesticides using APMALDI-MS was validated to be adequate linearity,repeatability and ***,AP-MALDI-MS combined with MWCNTs-based matrix enables the directly qualitative and quantitative analysis of pesticides in ambient environment.

关键词： Atmospheric pressure MALDI Pesticides MWCNTs-based matrix Ambient ionization

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