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Analysis of bacitracin and its related substances by liquid chromatography tandem mass spectrometry

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Journal of Pharmaceutical Analysis 2017年第1期7卷 48-55页

作者： Suleiman Ahmed Suleiman Fan Song mengxiang Su Taijun Hang Min Song Department of Pharmaceutical Analysis China Pharmaceutical University Nanjing 210009 China

A suitable liquid chromatography quadrupole time-of-flight mass spectrometric(LC–Q-TOF–MS) method was developed for separation and characterization of related substances in bacitracin test drug. The separation was performed on li Chrospher RP-18 column using methanol as mobile phase A and 0.2% ammonium acetate buffer solution as mobile phase B in gradient elution. A total of 12 related substances were detected through high resolution mass spectrometric determination in a positive electrospray ionization mode. They were identified as co-existing active components and degradation products of bacitracin through the analysis and elucidation of both the protonated parents and the product ions of all the related substances and their fragmentation pathways were also proposed.

关键词： Bacitracin Degradation products Fragmentation pathways Related substances LC–Q-TOF–MS

Research on coal staged conversion poly-generation system based on fluidized bed

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International Journal of Coal Science & Technology 2014年第1期1卷 39-45页

作者： Mingjiang Ni Chao li mengxiang Fang Qinhui Wang Zhongyang Luo Kefa Cen State Key Laboratory on Clean Energy Utilization Zhejiang UniversityHangzhou 310027China

A new coal staged conversion poly-generation system combined coal combustion and pyrolysis has been developed for clean and high efficient utilization of *** is the first pyrolysed in a fluidized *** pyrolysis gas is then purified and used for chemical product or liquid fuel *** is collected during purification and can be processed to extract high value product and to make liquid fuels by ***-coke from the pyrolysis reactor is burned in a circulating fluidized bed(CFB)combustor for heat or power *** system can realize coal multiproduct generation and has a great potential to increase coal utilization value.A 1 MW poly-generation system pilot plant and a 12 MW CFB gas,tar,heat and power poly-generation system was *** experimental study focused on the two fluidized bed operation and characterization of gas,tar and char yields and *** results showed that the system could operate stable,and produce about 0.12 m^(3)/kg gas with 22 MJ/m^(3)heating value and about 10 wt%tar when using Huainan bituminous coal under pyrolysis temperature between 500 and 600℃.The produced gases were mainly H_(2),CH_(4),CO,CO_(2),C_(2)H_(4),C_(2)H_(6),C_(3)H_(6)and C_(3)H_(8).The CFB combustor can burn semi-coke *** application prospect of the new system was discussed.

关键词： Poly-generation Coal pyrolysis Tar utilization Combustion Gas conversion

Hepatic retinaldehyde deficiency is involved in diabetes deterioration by enhancing PCK1-and G6PC-mediated gluconeogenesis

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Acta Pharmaceutica Sinica B 2023年第9期13卷 3728-3743页

作者： Hanyu Yang mengxiang Su Ming liu Yun Sheng liang Zhu Lu Yang Ruijing Mu Jianjun Zou Xiaodong liu li liu State Key Laboratory of Natural Medicines Key Laboratory of Drug Metabolism and PharmacokineticsChinaPharmaceutical UniversityNanjing 210009China Department of Pharmacology School of PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Pharmaceutical Analysis School of PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Clinical Pharmacology Nanjing First HospitalNanjing Medical UniversityNanjing 210006China

Type 2 diabetes(T2D) is often accompanied with an induction of retinaldehyde dehydrogenase 1(RALDH1 or ALDH1A1) expression and a consequent decrease in hepatic retinaldehyde(Rald)levels. However, the role of hepatic Rald deficiency in T2D progression remains unclear. In this study, we demonstrated that reversing T2D-mediated hepatic Rald deficiency by Rald or citral treatments, or liverspecific Raldh1 silencing substantially lowered fasting glycemia levels, inhibited hepatic glucogenesis,and downregulated phosphoenolpyruvate carboxykinase 1(PCK1) and glucose-6-phosphatase(G6PC)expression in diabetic db/db mice. Fasting glycemia and Pck1/G6pc mRNA expression levels were strongly negatively correlated with hepatic Rald levels, indicating the involvement of hepatic Rald depletion in T2D deterioration. A similar result that liver-specific Raldh1 silencing improved glucose metabolism was also observed in high-fat diet-fed mice. In primary human hepatocytes and oleic acidtreated HepG2 cells, Rald or Rald + RALDH1 silencing resulted in decreased glucose production and downregulated PCK1/G6PC mRNA and protein expression. Mechanistically, Rald downregulated direct repeat 1-mediated PCK1 and G6PC expression by antagonizing retinoid X receptor a, as confirmed by luciferase reporter assays and molecular docking. These results highlight the link between hepatic Rald deficiency, glucose dyshomeostasis, and the progression of T2D, whilst also suggesting RALDH1 as a potential therapeutic target for T2D.

关键词： Type 2 diabetes Retinaldehyde Retinaldehyde dehydrogenase 1 Gluconeogenesis Retinoid X receptor Oleic acid Glucose-6-phosphatase Phosphoenolpyruvate carboxykinase 1

Analysis of Terrain Height Effects on the Asymmetric Precipitation Patterns during the Landfall of Typhoon Meranti (2010)

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Atmospheric and Climate Sciences 2019年第3期9卷 331-345页

作者： Jinqing liu Ziliang li mengxiang Xu College of Oceanic and Atmospheric Sciences Ocean University of China Qingdao China Hunan Meteorological Observatory Changsha China

The predictions of heavy rainfall in an accurate and timely fashion are some of the most important challenges in disastrous weather forecast when a typhoon passes over land. Numerical simulations using the advanced weather research and forecasting (WRF) model are performed to study the effect of terrain height and land surface processes on the rainfall of landfall typhoon Meranti (2010). The experimental results indicate that terrain height could enhance convection and precipitation. The heavy rainfall is concentrated on the west side of typhoon track, which is mainly associated with the distribution of deep convection. The terrain height exacerbated the asymmetric distribution of heavy rainfall. The most striking feature is that enhanced rainfall is mainly caused by secondary circulation, which is induced by terrain height and can be explained by a highly simplified theoretical model. Finally, it is worth pointing out that perturbation potential temperature or buoyancy processes forced by terrain height could be taken as an indicator for accurate prediction of heavy rainfall during the landfall of a tropical cyclone.

关键词： Typhoon Asymmetry Topography The Secondary Circulation

Phytochemistry, quality control and biosynthesis in ginseng research from 2021 to 2023: A state-of-the-art review concerning advances and challenges

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Chinese Herbal Medicines 2024年第4期16卷 505-520页

作者： mengxiang Ding Huizhen Cheng Xiaohang li Xue li Min Zhang Dianxin Cui Yijin Yang Xiaojin Tian Hongda Wang Wenzhi Yang State Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China

Panax L.(Araliaceae) has a long history of medicinal and edible use due to its significant tonifying effects,and ginseng research has been a hot topic in natural products research and food science. In continuation of our recent ginseng review, we highlighted the advances in ginseng research from 2021 to 2023 with 157 citations, which exhibited the increasingly systematic, collaborative, and intelligent *** this review, we firstly updated the progress in phytochemistry involving the ginsenosides and polysaccharides and summarized the researches on the active components. Then, some specific applications by feat of the multidimensional chromatography, mass spectrometry imaging, DNA barcoding, and metabolomics, were analyzed, which could provide rich information supporting the multi-component characterization, authentication, and quality control of ginseng and the versatile products. Finally, the recent biosynthesis studies concerning ginsenosides were retrospected. Additionally, the current challenges and future trends with respect to ginseng research were discussed.

关键词： biosynthesis metabolomics Panax phytochemistry quality control

Graphene controlled solid-state growth of oxygen vacancies riched V2O5 catalyst to highly activate Fenton-like reaction

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Chinese Chemical Letters 2024年第12期35卷 384-387页

作者： mengxiang Zhu Tao Ding Yunzhang li Yuanjie Peng Ruiping liu Quan Zou Leilei Yang Shenglei Sun Pin Zhou Guosheng Shi Dongting Yue Shanghai Applied Radiation Institute State Key Lab.Advanced Special Steel Shanghai University Center for Soil Protection and land scape Design Chinese Academy of Environmental Planning Zhejiang Grearth Ecological Co. Ltd. International Trade Center Office Building Institute of Balsalt Fiber in Eco-Application School of Environmental Science and Engineering Qingdao University Research Center of secondary Resources and Environment Changzhou Institute of Technology

Fenton-like process based on metal oxide presents one of the most hoping strategies to generate reactive oxygen species to treat refractory pollutants. The introduction of oxygen vacancies（OVs） can enhance the catalytic performance of metal oxides in Fenton-like reaction. In this paper, a one-step all solid-state synthesis strategy is proposed to induce oxygen defects in V2O5, which uses graphene to engineer the crystallization process of V-based crystals. Such approach employs graphene as a solid-catalyst to promote growth of V-based crystals owing to the ions-π interactions between graphene and VCl3. The electrondonor OVs in V2O5@graphene can not only active H2O2for the·OH generation, but also accelerate the reduction of V5+)and V4+, thereby ensuring defective V2O5@graphene/H2O2system is 14.3, 28.2, and 17.3times higher than that of graphene/H2O2, pure V2O5/H2O2and graphene+V2O5/H2O2（mechanical mixed system）, respectively. Our study provides a novel synthetic strategy to design and prepare OVs-riched transition metal catalysts for developing advanced oxidation technologies toward higher sustainability and practicality.

关键词： Oxygen vacancies Fenton-like Catalysis Solid-state synthesis

Development of Customized Production Machine for Flue-cured Tobacco Formula Nutritional Soil

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Asian Agricultural Research 2021年第5期13卷 43-47页

作者： Jianyong li Jianwen WANG mengxiang PENG lili Jiongjiong ZHAO liangjiao liU Dewu ZENG liuyang Branch of Changsha Tobacco Company Changsha 410302 China

On the basis of full investigation and repeated trials,nutritional soil composed of cake fertilizer,mushroom residue,cow dung and calcium magnesium phosphate fertilizer was determined as an alternative for traditional flue-cured tobacco fired ash *** accordance with the feed grinding,mixing and processing integrated principle,processing machine for flue-cured tobacco nutritional soil was *** clogging problem of mixing box was solved by improving grinding and stirring method of mixing *** and large-scale production and commercialized supply of flue-cured tobacco nutritional soil was piloted to simplify the production process and reduce the production cost of nutritional soil for flue-cured tobacco and meet the needs of green development of tobacco production,thereby creating good social and economic benefits.

关键词： Flue-cured tobacco Nutritional soil Formula Processing machinery

Indirubin-30 -monoxime-loaded PLGA-PEG nanoparticles for potential Alzheimer's disease treatment

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Medicine in Novel Technology and Devices 2022年第3期15卷 91-97页

作者： lingli Jin Qiyao Wang mengxiang Yang Jiaying Zhang Hongze liang Hui Tan Zhenjiang liang Xiaopeng Ma Junying liu Haiyan li Xiaodong Cai Wei Cui lingling Zhao Faculty of Materials Science and Chemical Engineering Ningbo UniversityNingbo315211China Ningbo Key Laboratory of Behavioral Neuroscience Zhejiang Provincial Key Laboratory of PathophysiologySchool of MedicineNingbo UniversityNingbo315211China Department of Respiratory Shenzhen Children's HospitalShenzhen518038China Department of Endocrinology The First Affiliated HospitalShenzhen UniversityShenzhen518035China Department of Neurosurgery The First Affiliated HospitalShenzhen UniversityShenzhen518035China

Alzheimer's disease(AD)is an irreversible neurodegenerative disorder,which is pathologically characterized by the deposits of β-amyloid(Aβ),and plays an important role in neuronal ***-30-monoxime(I3M)showed neuroprotective effects against Aβ-induced neuronal ***,the use of I3M in AD treatment is limited due to its low ***,PLGA-PEG nanoparticles were synthesized for I3M loading.I3M could release sustainedly sustain release from the I3M-loaded PLGA-PEG nanoparticles(PLGA-PEG-I3M NPs)without obvious burst ***'s more,the PLGA-PEG-I3M NPs could significantly promote the uptake of I3M by PC12 cells through nanoparticle-mediated transport,and improve the efficacy of I3M on the inhibition of Aβfibrillization and oligomerization as well as the neuroprotective activity of I3M on Aβoligomers-induced neuronal ***,the PLGA-PEG-I3M NPs may be a promising platform for AD therapy.

关键词： Nanoparticles Alzheimer's disease Drug delivery Indirubin-30 -monoxime

高可控非稳态对冲扩散火焰的实现及其时变流场特征

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西安交通大学学报 2023年第2期57卷 49-56页

作者：余超李国柱周梦祥王宇武汉理工大学汽车工程学院武汉430070 先进汽车零部件技术湖北省重点实验室武汉430070

为研究火焰拉伸变化对流场、碳烟生成的瞬态效应,进一步完善层流火焰面模型在湍流火焰中的应用,设计并搭建了一个高可控的声激励对冲火焰燃烧器及其流场和碳烟浓度场的测量系统,利用相位锁定的粒子图像测速和激光诱导白炽光技术,测量了... 详细信息

为研究火焰拉伸变化对流场、碳烟生成的瞬态效应,进一步完善层流火焰面模型在湍流火焰中的应用,设计并搭建了一个高可控的声激励对冲火焰燃烧器及其流场和碳烟浓度场的测量系统,利用相位锁定的粒子图像测速和激光诱导白炽光技术,测量了简谐振荡的对冲火焰中流场以及碳烟生成随时间的变化特性。结果表明:设计的声激励对冲燃烧器喷嘴出口速度为非均匀分布;非稳态工况下,施加的声激励电压信号幅值与出口速度振幅呈线性关系,频率为40 Hz的乙烯和丙烷火焰出口速度分别滞后电压信号0.09、0.14周期;随着电压信号频率的增加,速度的滞后程度也随之扩大。此外,40 Hz频率下乙烯火焰的碳烟体积分数滞后准稳态值0.35周期,具有明显的瞬态效应。研究成果可为非稳态层流火焰面模型开发提供理论依据。

关键词：声激励对冲燃烧器碳烟生成粒子图像测速激光诱导白炽光