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Determination of Double Beta Decay Half-Life of 136Xe with the PandaX-4T Natural Xenon Detector

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Research 2023年第2期2022卷 33-41页

作者： Lin si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yujun Mao Yue Meng Nasir Shaheed Xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Changsong Shang Guofang Shen Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang siguang Wang Wei Wang Xiuli Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Zhe Yuan Dan Zhang Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou IMOE Key Laboratory for Particle Astrophysics and Cosmology Shanghai Key Laboratory for Particle Physics and Cosmology School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China sichuan Research Institute Shanghai Jiao Tong UniversityChengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-sen UniversityGuangzhou 510275China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao266237 ShandongChina Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao266237 ShandongChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China School of Physics Nankai UniversityTianjin 300071China Key Laboratory NuclearPyics and Ionampplication(MOE)Instituteof ModenPysics Fun Universty Shanghai 200433China School of Physics Peking UniversityBeijing 100871China Schol of Physics Beihang UniversityBejing 100191China International Research Center for Nuclei and Particles in the Cosmos Beijing key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai200093China Department of Physics University of MarylandCollge ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratoryof Particle Detetion and Electronics University of Scienceand Technology of ChinaHefei230026China Department of Modern Physics University of Science and Technology of ChinaHefei230026China SJTU ParisElite Instute of Technology Shanghai Jiao Tong UniversityShanghai 200240China

Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta *** report the measurement of DBD half-life of 136xe using the Pandax-4T dual-phase Time Projection Chamber(TPC)with 3.7-tonne natural xenon and the first 94.9-day physics data release.

关键词： decay double Determination

毛萼乙素调控lncRNA CPS1-IT1表达抑制膀胱癌T24细胞增殖、迁移、侵袭的机制研究

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河北医药 2022年第5期44卷 650-654页

作者：熊涛王慧黄梦婷陈铮锐重庆市荣昌区人民医院泌尿外科 402460 重庆市荣昌区人民医院神经内科 402460 重庆市荣昌区人民医院重症医学科 402460

目的考察毛萼乙素(Eriocalyxin)是否通过调控长链非编码RNA(lncRNA)CPS1 intronic transcript 1(CPS1-IT1)的表达影响膀胱癌T24细胞的增殖、迁移、侵袭。方法四甲基偶氮唑蓝(MTT)测定法检测(2.5μmol/L、5μmol/L、10μmol/L)毛萼乙素作用于T24细胞的增殖,免疫印迹法(Western blot)测定Ki-67、基质金属蛋白酶(MMP)-2和MMP-9蛋白表达,Transwell法评估T24细胞的迁移、侵袭;实时荧光定量PCR(qRT-PCR)分析lncRNA CPS1-IT1表达。T24细胞转染pcDNA-CPS1-IT1、或转染si-CPS1-IT1并给予10μmol/L毛萼乙素,考察T24细胞的增殖、迁移、侵袭变化。结果(2.5μmol/L、5μmol/L、10μmol/L)毛萼乙素增加T24细胞的增殖抑制率和lncRNA CPS1-IT1表达量,减少迁移、侵袭细胞数、Ki-67、MMP-2、MMP-9蛋白的表达量,呈一定的浓度依赖性,差异均有统计学意义(P<0.05)。lncRNA CPS1-IT1过表达提高T24细胞的抑制率,降低迁移、侵袭细胞数、Ki-67、MMP-2和MMP-9蛋白表达量,差异均有统计学意义(P<0.05)。抑制lncRNA CPS1-IT1表达逆转了毛萼乙素(10μmol/L)对T24细胞增殖、迁移、侵袭的影响。结论毛萼乙素通过上调lncRNA CPS1-IT1表达,抑制膀胱癌T24细胞的增殖、迁移、侵袭。

关键词：毛萼乙素膀胱癌 lncRNA CPS1-IT1 增殖迁移侵袭

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A Search for Solar Axions and Anomalous Neutrino Magnetic Moment with the Complete Panda X-Ⅱ Data

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Chinese Physics Letters 2021年第1期38卷 30-34页

作者： Xiaopeng Zhou Xinning Zeng Xuyang Ning Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Di Huang Yan Huang Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Huaxuan Liu Jianglai Liu Xiaoying Lu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Kaixiang Ni Jinhua Ning Xiangxiang Ren Changsong Shang Guofang Shen Lin si Andi Tan Anqing Wang Hongwei Wang Meng Wang Qiuhong Wang siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Pengwei Xie Binbin Yan Jijun Yang Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou INPAC School of Physics and AstronomyShanghai Jiao Tong Universityand Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China School of Physics Beihang UniversityBeijing 100191China Shanghai Jiao Tong University sichuan Research Institute Chengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China School of Physics Nankai UniversityTianjin 300071China Key Laboratory of Nuclear Physics and Ion-Beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Peking UniversityBeijing 100871China International Research Center for Nuclei and Particles in the Cosmos&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Physics University of MarylandCollege ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Physics and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityJinan 250100China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Center for High Energy Physics Peking UniversityBeijing 100871China

We report a search for new physics signals using the low energy electron recoil events in the complete data set from PandaX-Ⅱ,in light of the recent event excess reported by XENON1 *** data correspond to a total exposure of 100.7 ton·day with liquid *** robust estimates of the dominant background spectra,we perform sensitive searches on solar axions and neutrinos with enhanced magnetic *** is found that the axionelectron coupling gAe<4.6×10^(-12) for an axion mass less than 0.1 keV/c^(2) and the neutrino magnetic moment μv<4.9×10^(-11)μB at 90%confidence *** observed excess from XENON1 T is within our experimental constraints.

关键词： moment. excess estimates

激光熔覆制备siC-Ni包覆型复合粉体涂层及性能研究

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科教文汇 2016年第18期 178-180页

作者：徐梦婷李微微高向向台州学院机械工程学院浙江台州318000

为使粉体混合均匀,采用化学镀法制备si C-Ni包覆型粉体。再激光熔覆制备含量不同的镍基合金si C-Ni复合粉体涂层。结果表明,加入适量的si C-Ni包覆型粉体后,熔覆涂层硬度和耐磨性都大大提高。

关键词：激光熔覆 siC-Ni包覆型粉体性能研究

Results of dark matter search using the full PandaX-Ⅱ exposure

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Chinese Physics C 2020年第12期44卷 184-200页

作者： Qiuhong Wang Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Di Huang Yan Huang Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Huaxuan Liu Jianglai Liu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Kaixiang Ni Jinhua Ning Xuyang Ning Xiangxiang Ren Changsong Shang Lin si Guofang Shen Andi Tan Anqing Wang Hongwei Wang Meng Wang siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Pengwei Xie Binbin Yan Jijun Yang Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Xinning Zeng Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou INPAC and School of Physics and Astronomy Shanghai Jiao Tong UniversityMOE Key Lab for Particle PhysicsAstrophysics and CosmologyShanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Jiao Tong University sichuan Research Institute Chengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Tsung-Dao Lee Institute Shanghai 200240China School of Physics Nankai UniversityTianjin 300071China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Peking UniversityBeijing 100871China School of Physics Beihang UniversityBeijing 100191China International Research Center for Nuclei and Particles in the Cosmos&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Physics University of MarylandCollege ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Physics and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityJinan 250100China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Center for High Energy Physics Peking UniversityBeijing 100871China

We report the dark matter search results obtained using the full 132 ton·day exposure of the PandaX-II experiment,including all data from March 2016 to August *** significant excess of events is identified above the expected *** limits are set on the spin-independent dark matter-nucleon *** lowest 90%confidence level exclusion on the spin-independent cross section is 2.2×10−46 cm2 at a WIMP mass of 30 GeV/c2.

关键词： dark matter direct detection liquid xenon

Study of background from accidental coincidence signals in the PandaX-Ⅱexperiment

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Chinese Physics C 2022年第10期46卷 11-24页

作者： Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Di Huang Yan Huang Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Huaxuan Liu Jianglai Liu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Kaixiang Ni Jinhua Ning Xuyang Ning Xiangxiang Ren Changsong Shang Lin si Guofang Shen Andi Tan Anqing Wang Hongwei Wang Meng Wang Qiuhong Wang siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Pengwei Xie Binbin Yan Jijun Yang Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Xinning Zeng Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou School of Physics and Astronomy Shanghai Jiao Tong UniversityMOE Key Laboratory for Particle Astrophysics and CosmologyShanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China Shanghai Jiao Tong University sichuan Research Institute Chengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Tsung-Dao Lee Institute Shanghai 200240China School of Physics Nankai UniversityTianjin 300071China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Peking UniversityBeijing 100871China School of Physics Beihang UniversityBeijing 102206China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing102206China School of Physics and Microelectronics Zhengzhou UniversityZhengzhouHenan 450001China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Physics University of MarylandCollege ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Physics and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityJinan 250100China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Center for High Energy Physics Peking UniversityBeijing 100871China

Ⅰ.INTRODUCTION The direct detection of dark matter particles,especially the weakly interacting massive particles(WIMPs),is being actively carried out by a couple of experiments worldwide[1].In recent years,the PandaX-Ⅱ experiment located in the China Jinping Underground Laboratory(CJPL)[1-3],which uses the technology of dual phase liquid xenon time projection chambers(TPCs),has pushed the limits of the cross section between WIMPs and nucleons to a new level for most of the possible WIMP masses;other experiments of the same type are also being performed[4–10].

关键词： dark matter xenon detector background accidental coincidence machine learning

Yb^(3+)/Al^(3+)/Ce^(3+)/F~–掺杂石英玻璃的结构与性质（英文）

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硅酸盐学报 2019年第1期47卷 1-12页

作者：邵冲云王璠郭梦婷杨佳慧张海波李吉豪王世凯于春雷任进军胡丽丽中国科学院上海光学精密机械研究所上海201800 中国科学院大学北京100049 布鲁克(北京)科技有限公司北京100192 中国科学院上海应用物理研究所上海201800

采用溶胶–凝胶法结合高温真空烧结制备不同F含量的Yb^(3+)/Al^(3+)/Ce^(3+)/F–掺杂石英玻璃。系统研究了F含量变化对这些玻璃的折射率、光谱性质、耐辐射特性的影响,并联用多种结构解析手段从玻璃微观结构变化角度研究其影响机理。通... 详细信息

采用溶胶–凝胶法结合高温真空烧结制备不同F含量的Yb^(3+)/Al^(3+)/Ce^(3+)/F–掺杂石英玻璃。系统研究了F含量变化对这些玻璃的折射率、光谱性质、耐辐射特性的影响,并联用多种结构解析手段从玻璃微观结构变化角度研究其影响机理。通过Fourier转换红外光谱(FTIR)测定玻璃的假想温度(Tf),该温度与玻璃的结构混乱度有关;采用固态核磁共振(NMR)和Raman光谱研究玻璃的网络结构变化;用脉冲电子顺磁共振(EPR)技术研究Yb^(3+)离子的局部环境;采用连续波EPR和光学吸收谱鉴定γ射线辐射诱导玻璃形成的硅相关(si-E'、NBOHC)、铝相关(Al-E'、Al-ODC、Al OHC)和镱相关(Yb2+)色心。研究结果表明,掺F不但能有效降低玻璃折射率和提高玻璃的耐辐射特性,且不会明显恶化Yb^(3+)离子的光谱性质;FTIR测试表明,掺F急剧降低了玻璃的Tf和结构混乱度;Raman和NMR测试表明,随着F含量增加,三元环和四元环结构下降,六配位铝(AlVI)明显增加;脉冲EPR测试表明,F原子进入Yb^(3+)的局部环境。这些结构解析有助于解释F含量变化对Yb^(3+)/Al^(3+)/Ce^(3+)/F-掺杂石英玻璃宏观性质的影响机理,为制备低数值孔径且抗辐射的掺Yb^(3+)石英光纤提供了参考。

关键词：掺氟石英玻璃结构弛豫耐辐射稀土局域结构

Determination of responses of liquid xenon to low energy electron and nuclear recoils using a PandaX-Ⅱ detector

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Chinese Physics C 2021年第7期45卷 273-282页

作者： Binbin Yan Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Di Huang Peiyao Huang Yan Huang Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Jianglai Liu Zhuoqun Lei Wenbo Ma Yugang Ma Yajun Mao Yue Meng Kaixiang Ni Jinhua Ning Xuyang Ning Xiangxiang Ren Changsong Shang Lin si Guofang Shen Andi Tan Anqing Wang Hongwei Wang Meng Wang Qiuhong Wang siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Pengwei Xie Rui Yan Jijun Yang Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Jianfeng Yue Xinning Zeng Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou School of Physics and Astronomy Shanghai Jiao Tong UniversityMOE Key Laboratory for Particle Astrophysics and CosmologyShanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Jiao Tong University sichuan Research Institute Chengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Tsung-Dao Lee Institute Shanghai 200240China School of Physics Nankai UniversityTianjin 300071China School of Physics Peking UniversityBeijing 100871China School of Physics Beihang UniversityBeijing 100191China International Research Center for Nuclei and Particles in the Cosmos&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Physics University of MarylandCollege ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Physics and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityJinan 250100China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Center for High Energy Physics Peking UniversityBeijing 100871China

We present a systematic determination of the responses of PandaX-Ⅱ,a dual phase xenon time projection chamber detector,to low energy *** electron recoil(ER) and nuclear recoil(NR) responses are calibrated,respectively,with injected tritiated methane or 220Rn source,and with 241Am-Be neutron source,in an energy range from 1-25 keV(ER) and 4-80 keV(NR),under the two drift fields,400 and 317 V/*** empirical model is used to fit the light yield and charge yield for both types of *** best fit models can describe the calibration data *** systematic uncertainties of the fitted models are obtained via statistical comparison to the data.

关键词： dark matter liquid xenon time projection chamber calibration electron recoil nucleon recoil NEST2.0

五虎汤通过干预炎症记忆对咳嗽变异性哮喘小鼠的治疗作用

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湖南中医药大学学报 2021年第4期41卷 512-517页

作者：江智豪胡燕王孟清丁伊邓弈駃邓梦婷湖南中医药大学湖南长沙410208 湖南中医药大学第一附属医院湖南长沙410007

目的探讨五虎汤对咳嗽变异性哮喘(cough variant asthma, CVA)小鼠可能的作用机制。方法将70只BALB/c小鼠分为空白组、CVA组、CVA再激发组、地塞米松组和五虎汤低、中、高剂量组,每组10只。除空白组外,其余各组采用鸡卵蛋白(ovalbumin, ... 详细信息

目的探讨五虎汤对咳嗽变异性哮喘(cough variant asthma, CVA)小鼠可能的作用机制。方法将70只BALB/c小鼠分为空白组、CVA组、CVA再激发组、地塞米松组和五虎汤低、中、高剂量组,每组10只。除空白组外,其余各组采用鸡卵蛋白(ovalbumin, OVA)致敏法激发建立CVA模型。休息30 d后,空白组与CVA组用生理盐水进行新一轮雾化,其余组用OVA进行新一轮雾化激发。五虎汤低、中、高剂量组分别灌胃1.6、3.2、6.4 g/kg五虎汤,地塞米松组腹腔注射1.82 mg/kg地塞米松,空白组、CVA组、CVA再激发组灌胃等体积生理盐水,1次/d,连续10 d后处理小鼠。分离肺组织制作病理切片,行HE及PAS染色;采集肺泡灌洗液进行细胞计数;并用ELISA法检测血清IgE、IFN-γ及IL-4、IL-5、IL-23的含量;流式细胞术检测肺组织中记忆T细胞CD4+Tm亚群的比例。结果肺组织HE及PAS病理染色显示:空白组小鼠肺部无炎性细胞浸润;CVA组小鼠肺部有少许的炎性细胞浸润;CVA再激发组小鼠气道炎症、官腔狭窄表现更为明显;五虎汤各剂量组及地塞米松组小鼠的气道炎症均有不同程度的缓解。肺泡灌洗中细胞计数结果显示:CVA组较空白组升高;CVA再激发组较CVA组升高;五虎汤各剂量组及地塞米松组降低,差异均有统计学意义(P0.05)。ELISA检测结果显示:CVA组的IL-4、IL-5、IL-23、IgE水平较空白组上升(P0.05);五虎汤各剂量组及地塞米松组与CVA再激发组比较,出现各细胞因子水平的回调,差异均有统计学意义(P0.05)。流式细胞术检测肺部组织CD4+Tm亚群结果显示:记忆性T细胞的占比情况,CVA组与空白组比较,差异无统计学意义(P>0.05);CVA再激发组与CVA组相比则明显上升,差异有统计学意义(P0.05)。结论五虎汤可通过降低记忆性T细胞、减少IgE和炎性细胞因子的分泌、纠正细胞因子失衡,从而调控炎症记忆而发挥治疗CVA的作用。

关键词：咳嗽变异性哮喘五虎汤 T细胞炎症记忆