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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing Qiu mengting Yang Danfeng Gong Haiying Liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

Artificial Intelligence-Empowered Resource Management for Future Wireless Communications: A Survey

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China Communications 2020年第3期17卷 58-77页

作者： mengting Lin Youping Zhao School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China

How to explore and exploit the full potential of artificial intelligence(AI)technologies in future wireless communications such as beyond 5G(B5G)and 6G is an extremely hot inter-disciplinary research topic around the *** the one hand,AI empowers intelligent resource management for wireless communications through powerful learning and automatic adaptation *** the other hand,embracing AI in wireless communication resource management calls for new network architecture and system models as well as standardized interfaces/protocols/data formats to facilitate the large-scale deployment of AI in future B5G/6G *** paper reviews the state-of-art AI-empowered resource management from the framework perspective down to the methodology perspective,not only considering the radio resource(e.g.,spectrum)management but also other types of resources such as computing and *** also discuss the challenges and opportunities for AI-based resource management to widely deploy AI in future wireless communication networks.

关键词： 5G beyond 5G(B5G) 6G artificial intelligence(AI) machine learning(ML) network slicing resource management

Optimized interval 2-tuple linguistic aggregation operator based on PGSA and its application in MAGDM

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Journal of Systems Engineering and Electronics 2019年第6期30卷 1192-1201页

作者： ZONG mengting SHEN Tian CHEN Xi School of Business Nanjing UniversityNanjing 210000China School of Education Nanjing University of Traditional Chinese MedicineNanjing 210000China

This study proposes a multiple attribute group decisionmaking(MAGDM)approach on the basis of the plant growth simulation algorithm(PGSA)and interval 2-tuple weighted average operators for uncertain linguistic weighted aggregation(ULWA).We provide an example for illustration and verification and compare several aggregation operators to indicate the optimality of the assembly *** addition,we present two comparisons to demonstrate the practicality and effectiveness of the proposed *** method can be used not only to aggregate MAGDM problems but also to solve multi-granularity uncertain linguistic *** high reliability,easy programming,and high-speed calculation can improve the efficiency of ULWA ***,the proposed method has the exact characteristics for linguistic information processing and can effectively avoid information distortion and loss.

关键词： multiple attribute group decision making(MAGDM) in terval 2-tuple plant growth simulation algorithm(PGSA) weighted Steiner point.

Superconducting X-ray detectors

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Science China(Information Sciences) 2020年第8期63卷 91-109页

作者： Can YANG mengting SI Lixing YOU State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology (SIMIT)Chinese Academy of Sciences CAS Center for Excellence in Superconducting Electronics (CENSE) Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Zhejiang Photon Technology Co.Ltd. Guigu Science Park

Owing to their high sensitivity and low noise, superconducting detectors are used for photon detection from microwave to high-energy particles. X-ray detection plays an important role in materials analysis, astronomy, and medical radiography, which require high efficiency as well as high energy resolution. However, traditional semiconducting detectors cannot fulfill these requirements. In this article, we review superconducting quantum detectors for X-ray detection, including transition-edge sensor(TES), superconducting tunneling junctions(STJs), kinetic inductance detectors(KIDs) and superconducting nanowire single-photon detectors(SNSPDs), and introduce the physical structures, working mechanisms, and device behaviors of these detectors. We also review their performances regarding X-ray detection and analyze their respective characteristics. According to recent progress and the requirements of various applications, possible improvement of superconducting detectors for X-rays are discussed.

关键词： superconducting X-ray detectors transition-edge sensors superconducting tunneling junctions kinetic inductance detectors superconducting nanowire single-photon detector

Rethinking resolution estimation in fluorescence microscopy: from theoretical resolution criteria to super-resolution microscopy

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Science China(Life Sciences) 2020年第12期63卷 1776-1785页

作者： mengting Li Zhen-Li Huang Britton Chance Center for Biomedical Photonics.Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology Wuhan 430074.China MoE Key Laboratory for Biomedical Photonics Collaborative Innovation Center for Biomedical Engineering.School of Engineering Sciences.Huazhong University of Science and TechnologyWuhan 430074China School of Biomedical Engineering Hainan UniversityHaikou 570228China

Resolution is undoubtedly the most important parameter in optical microscopy by providing an estimation on the maximum resolving power of a certain optical microscope. For centuries, the resolution of an optical microscope is generally considered to be limited only by the numerical aperture of the optical system and the wavelength of light. However, since the invention and popularity of various advanced fluorescence microscopy techniques, especially super-resolution fluorescence microscopy, many new methods have been proposed for estimating the resolution, leading to confusions for researchers who need to quantify the resolution of their fluorescence microscopes. In this paper, we firstly summarize the early concepts and criteria for predicting the resolution limit of an ideal optical system. Then, we discuss some important influence factors that deteriorate the resolution of a certain fluorescence microscope. Finally, we provide methods and examples on how to measure the resolution of a fluorescence microscope from captured fluorescence images. This paper aims to answer as best as possible the theoretical and practical issues regarding the resolution estimation in fluorescence microscopy.

关键词： fluorescence microscopy super-resolution microscopy Abbe limit Rayleigh criterion image resolution

Lightweight axiom pinpointing via replicated driver and customized SAT-solving

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Frontiers of Computer Science 2023年第2期17卷 121-133页

作者： Dantong OUYANG mengting LIAO Yuxin YE College of Computer Science and Technology Jilin UniversityChangchun 130012China Key Laboratory of Symbolic Computation and Knowledge Engineering(Jilin University) Ministry of EducationChangchun 130012China

In description logic,axiom pinpointing is used to explore defects in ontologies and identify hidden justifications for a logical *** recent years,SAT-based axiom pinpointing techniques,which rely on the enumeration of minimal unsatisfiable subsets(MUSes)of pinpointing formulas,have gained increasing *** with traditional Tableau-based reasoning approaches,SAT-based techniques are more competitive when computing justifications for consequences in large-scale lightweight description logic *** this article,we propose a novel enumeration justification algorithm,working with a replicated *** replicated driver discovers new justifications from the explored justifications through cheap literals resolution,which avoids frequent calls of SAT ***,when the use of SAT solver is inevitable,we adjust the strategies and heuristic parameters of the built-in SAT solver of axiom pinpointing *** adjusted SAT solver is able to improve the checking efficiency of unexplored *** proposed method is implemented as a tool named *** experimental results show that RDMinA outperforms the existing axiom pinpointing tools on practical biomedical ontologies such as Gene,Galen,NCI and Snomed-CT.

关键词： axiom pinpointing description logic SAT solver

Ensemble data assimilation and prediction of typhoon and associated hazards using TEDAPS:evaluation for 2015-2018 seasons

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Frontiers of Earth Science 2019年第4期13卷 733-743页

作者： Hong LI Jingyao LUO mengting XU Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China Key Laboratory of Numerical Modeling for Tropical Cyclones China Meteorological AdministrationShanghai 200030China

The initial condition accuracy is a major concern for tropical cyclone(TC)numerical *** ensemble-based data assimilation techniques have shown great promise to initialize TC *** addition to initial condition uncertainty,representing model errors(*** deficiencies)is another important issue in an ensemble forecasting *** improve TC prediction from both deterministic and probabilistic standpoints,a Typhoon Ensemble Data Assimilation and Prediction System(TEDAPS)using an ensemble-based data assimilation scheme and a multi-physics approach based on Weather Research and Forecasting(WRF)model,has been developed in Shanghai Typhoon Institute and running realtime since *** of TED APS in the prediction of track,intensity and associated disaster has been evaluated for the Western North Pacific TCs in the years of 2015-2018,and compared against the NCEP *** APS produces markedly better intensity forecast by effectively reducing the weak biases and therefore the degree of underdispersion compared to *** errors of TED APS track forecasts are comparative with(slightly worse than)those of GEFS at longer(shorter)forecast *** ensemble-mean exhibits advantage over deterministic forecast in track forecasts at long lead times,whereas this superiority is limited to typhoon or weaker TCs in intensity forecasts due to systematical *** case-studies for three landfalling cyclones and one recurving cyclone demonstrate the capacities of TEDAPS in predicting some challenging TCs,as well as in capturing the forecast uncertainty and the potential threat from TC-associated hazards.

关键词： ensemble data assimilation ensemble forecasting tropical cyclones

藤黄酸下调蛋白C受体表达杀伤三阴性乳腺癌干细胞的作用机制

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中国组织工程研究 2025年第23期29卷 4888-4898页

作者：李溯王清华达梦婷杨蕊陈道桢南京医科大学附属无锡妇幼保健院优生优育医学遗传研究所江苏省无锡市214002 江南大学附属妇产医院优生优育医学遗传研究所江苏省无锡市214002 青海大学附属医院乳腺疾病诊疗中心青海省西宁市810000 青海省海东市第二人民医院院长办公室青海省海东市810600

背景:藤黄酸对乳腺癌具有很强的细胞毒性,可有效杀伤三阴性乳腺癌干细胞,但潜在的机制尚不清楚。目的:探讨藤黄酸对三阴性乳腺癌干细胞的杀伤作用及可能的机制。方法:使用PharmMapper数据库预测藤黄酸的靶点蛋白,使用String网站构建各... 详细信息

背景:藤黄酸对乳腺癌具有很强的细胞毒性,可有效杀伤三阴性乳腺癌干细胞,但潜在的机制尚不清楚。目的:探讨藤黄酸对三阴性乳腺癌干细胞的杀伤作用及可能的机制。方法:使用PharmMapper数据库预测藤黄酸的靶点蛋白,使用String网站构建各药物靶点蛋白互作网络关系,使用Cytoscape软件构建活性成分-作用靶点网络,通过R语言软件对潜在靶点进行KEGG信号通路富集分析。采用CCK-8法检测不同浓度藤黄酸对人乳腺癌细胞株MDA-MB-231活力的影响,筛选适宜的作用浓度。采用细胞球培养法富集MDA-MB-231细胞干细胞,经过不同浓度(0,0.5,1.0,2.0μmol/L)藤黄酸作用24 h,TUNEL荧光染色与流式细胞仪检测干细胞凋亡,qPCR与Western blot检测蛋白C受体表达,Western blot检测p-PI3K、p-AKT、Caspase-3和Cleaved Caspase-3蛋白表达;将干细胞分4组培养:空白对照组(干细胞不做任何处理)、siRNA-NC组、siRNA-蛋白C受体组和siRNA-蛋白C受体+PI3K激动剂组,培养36 h后,采用Western blot法检测p-PI3K、p-AKT、Caspase-3和Cleaved Caspase-3蛋白表达。结果与结论:(1)网络药理学发现,三阴性乳腺癌干细胞标志物蛋白C受体是藤黄酸的作用靶点之一;KEGG富集分析涉及细胞凋亡、上皮生长因子受体、RAS和PI3K-AKT信号通路等;(2)CCK-8检测结果显示,藤黄酸可抑制MDA-MB-231细胞活力,半数抑制浓度IC50值为(1.18±0.34)μmol/L,因此后续实验选择浓度0.5,1.0,2.0μmol/L;(3)TUNEL荧光染色和流式细胞术检测证实,藤黄酸以剂量依赖的方式诱导三阴性乳腺癌干细胞凋亡(P <0.05);qPCR和Western blot检测证实,藤黄酸可下调蛋白C受体mRNA和蛋白表达,下调Caspase-3、p-PI3K和p-AKT蛋白表达,上调Cleaved Caspase-3蛋白表达(P <0.05);siRNA-蛋白C受体转染实验也进一步证实,敲低三阴性乳腺癌干细胞蛋白C受体表达可提升Cleaved Caspase-3蛋白表达(P <0.05)、下调PI3K/AKT信号通路磷酸化水平(P <0.05),而应用PI3K激动剂740 Y-P能够降低Cleaved Caspase-3蛋白表达(P <0.05)、提升p-PI3K和p-AKT的磷酸化水平(P <0.05),一定程度上改善细胞凋亡情况;(4)结果表明,藤黄酸可能通过下调蛋白C受体来发挥三阴性乳腺癌及干细胞杀伤及诱导凋亡作用,进一步的分子机制可能和PI3K/AKT信号通路抑制有关。

关键词：三阴性乳腺癌干细胞网络药理学藤黄酸分子机制信号通路