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SmartMat 2022年第4期3卷 533-564页

作者： Changli Chen mengru sun Kaixuan Wang Yujing Li Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications Experimental Center of Advanced MaterialsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijingChina

Dual-metal single-atom catalysts(DACs),featuring high atomic utilization efficiency,excellent selectivity,and stability originating from the atomically dispersed nature,have emerged as a new frontier in heterogeneous electrocatalysis due to the synergistic effect between diversified metal active sites in promoting their catalytic *** this review,the recent progress and development on the syntheses,characterizations,theoretical uniqueness,and applications for various catalytic reactions and devices(oxygen reduction reaction,oxygen evolution reaction,hydrogen evolution reaction,CO_(2) reduction reaction,N2 reduction reaction,proton exchange membrane fuel cells)are summarized and ***,the synergistic effect between the two metal centers and electronic structures of catalysts is systematically ***,the future challenges and prospects in developing practical DACs are proposed as a possible direction for further investigation.

关键词： dual-metal single-atomic catalyst electrocatalysis proton exchange membrane fuel cells

Rational design of Fe-N-C electrocatalysts for oxygen reduction reaction:From nanoparticles to single atoms

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Nano Research 2022年第3期15卷 1753-1778页

作者： mengru sun Changli Chen Menghao Wu Danni Zhou Zhiyi sun Jianling Fan Wenxing Chen Yujing Li Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications Experimental Center of Advanced MaterialsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Department of Physics and Engineering Technology Guilin Normal CollegeGuilin 541199China

As an alternative energy,hydrogen can be converted into electrical energy via direct electrochemical conversion in fuel *** important drawback of full cells is the sluggish oxygen reduction reaction(ORR)promoted by the high-loading of platinum-group-metal(PGM)***-N-C family has been received extensive attention because of its low cost,long service life and high oxygen reduction reaction activity in recent *** order to further enhance the ORR activity,the synthesis method,morphology regulation and catalytic mechanism of the active sites in Fe-N-C catalysts are *** paper reviews the research progress of Fe-N-C from nanoparticles to single *** structure-activity relationship and catalytic mechanism of the catalyst are studied and discussed,which provide a guidance for rational design of the catalyst,so as to promote the more reasonable design of Fe-N-C materials.

关键词： nanoparticle catalyst controlled structure regulation single atomic catalyst local atomic regulation synergistic effect

Surface Molecular Encapsulation with Cyclodextrin in Promoting the Activity and Stability of Fe Single-Atom Catalyst for Oxygen Reduction Reaction

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Energy & Environmental Materials 2023年第2期6卷 303-310页

作者： Changli Chen Haijing Li Jingzhao Chen Dong Li Wenxing Chen Juncai Dong mengru sun Yujing Li Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications Experimental Center of Advanced MaterialsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Clean Nano Energy Center State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China

Fe single-atom catalysts(Fe-SACs)have been extensively studied as a highly efficient electrocatalyst toward the oxygen reduction reaction(ORR).Nonetheless,they suffer from stability issue induced by dissolution of Fe metal center and the OH^(−)***,a surface molecular engineering strategy is developed by usingβ-cyclodextrins(CDs)as a localized molecular *** CD-modified Fe-SAC(Fe-SNC-β-CD)shows obviously improved activity toward the ORR with 0.90 V,4.10 and 4.09 mA cm^(-2)for E_(1/2),J_(0)and Jk0.9,***,the Fe-SNC-β-CD shows the excellent long-term stability against aggressive stress and the *** is confirmed through electrochemical investigation that modification ofβ-CD can,on one hand,regulate the atomic Fe coordination chemistry through the interaction between the CD and FeN_(x) moiety,while on the other mitigate the strong adsorption of OH^(−)and function as protective barrier against the poisoning molecules leading to enhanced ORR activity and stability for the *** molecular encapsulation strategy demonstrates the uniqueness of post-pyrolysis surface molecular engineering for the design of single-atom catalyst.

关键词： oxygen reduction reaction singe atom catalyst stability surface molecular engineering

Functional annotation map of natural compounds in traditional Chinese medicines library: TCMs with myocardial protection as a case

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Acta Pharmaceutica Sinica B 2023年第9期13卷 3802-3816页

作者： Xudong Xing mengru sun Zifan Guo Yongjuan Zhao Yuru Cai Ping Zhou Huiying Wang Wen Gao Ping Li Hua Yang State Key Laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China

The chemical complexity of traditional Chinese medicines(TCMs) makes the active and functional annotation of natural compounds challenging. Herein, we developed the TCMs-Compounds Functional Annotation platform(TCMs-CFA) for large-scale predicting active compounds with potential mechanisms from TCM complex system, without isolating and activity testing every single compound one by one. The platform was established based on the integration of TCMs knowledge base, chemome profiling, and high-content imaging. It mainly included:(1) selection of herbal drugs of target based on TCMs knowledge base;(2) chemome profiling of TCMs extract library by LC-MS;(3) cytological profiling of TCMs extract library by high-content cell-based imaging;(4) active compounds discovery by combining each mass signal and multi-parametric cell phenotypes;(5) construction of functional annotation map for predicting the potential mechanisms of lead compounds. In this stud TCMs with myocardial protection were applied as a case study, and validated for the feasibility and utility of the platform. Seven frequently used herbal drugs(Ginseng, etc.) were screened from 100,000 TCMs formulas for myocardial protection and subsequently prepared as a library of 700 extracts. By using TCMs-CFA platform, 81 lead compounds, including 10 novel bioactive ones, were quickly identified by correlating 8089mass signals with 170,100 cytological parameters from an extract library. The TCMs-CFA platform described a new evidence-led tool for the rapid discovery process by data mining strategies, which is valuable for novel lead compounds from TCMs. All computations are done through Python and are publicly available on GitHub.

关键词： Knowledge discovery Metabolomics High content screening Cell phenotype Ginseng Ginsenosides

Rationally engineered IR-783 octanoate as an enzyme-activatable fluorogenic tool for functional imaging of h Notum in living systems

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Chinese Chemical Letters 2024年第11期35卷 442-447页

作者： Lilin Song mengru sun Yuqing Song Feng Zhang Bei Zhao Hairong Zeng Jinhui Shi Huixin Liu Shanshan Zhao Tian Tian Heng Yin Guangbo Ge Liaoning Provincial Key Laboratory of Carbohydrates Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Re-searchShanghai University of Traditional Chinese MedicineShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Health Sciences Institute China Medical UniversityShenyang 110122China Department of Gynecology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital&InstituteShenyang 110042China

As a vital negative regulator of Wnt signaling pathway,human Notum(hNotum)plays a crucial regulatory role in the progression of many human *** the relevance of h Notum to human diseases requires practical and reliable tools for visualizing h Notum activity in living ***,an enzyme-activatable fluorogenic tool(IR-783 octanoate)was rationally engineered for sensing and imaging h Notum activity in living systems by integrating computer-aided molecular design and biochemical ***-783 octanoate showed good optical properties,excellent specificity and high binding-affinity towards h Notum(K_(m)=0.98μmol/L).IR-783 octanoate could be well up-taken into the cancerous cells or tumors that over-expressed organic anion transporting polypeptides(OATPs),and then hydrolyzed by cellular h Notum to release free IR-783 ketone,which created brightly fluorescent signals around 646 *** investigations showed that IR-783 octanoate achieved a good performance for in-situ functional imaging of h Notum in both living cells,cancerous tissues and *** was also found that some SW620cells with multipolar spindles could be stained by IR-783 octanoate to emit extremely bright signals,suggesting that this agent could be used as a novel visualizing tool for tracing the cells undergoing abnormal cell ***,this study devises a highly specific fluorogenic tool for in-situ functional imaging of hNotum in living systems,which offers a practical and reliable tool to dynamically track the changes in h Notum activity under various conditions.

关键词： hNotum Optical substrate Computer-aided molecular design In-situ functional imaging Cancer diagnosis

The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells

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Science China(Life Sciences) 2014年第4期57卷 412-421,1-3页

作者： CHEN JinYan sun mengru WANG XingHua LU Jing WEI Yan TAN Yan LIU Ying GTZ Jürgen HE RongQiao HUA Qian Beijing University of Chinese Medicine Clem Jones Centre for Ageing Dementia Research Queensland Brain Institute The University of QueenslandBrisbane Institute of Biophysics Chinese Academy of Sciences

The herbal medicine Tong Luo Jiu Nao （TLJN） contains geniposide （GP） and ginsenoside Rgl at a molar ratio of i0：1. Rgl is the major component of another herbal medicine, panax notoginseng saponin （PNS）. TLJN has been shown to strengthen brain function in humans, and in animals it improves learning and memory. We have previously shown that TLJN reduces amyloi- dogenic processing in Alzheimer＇s disease （AD） mouse models. Together this suggests TLJN may be a potential treatment for patients with dementia. Because chronic damage of the central nervous system by formaldehyde （FA） has been presented as a risk factor for age-associated cognitive dysfunction, in the present study we investigated the protective effect of both TLJN and GP in neuron-like cells exposed to FA. FA-exposed murine N2a neuroblastoma cells were incubated with TLJN, its main in- gredient GP, as well as PNS, to measure cell viability and morphology, the rate of apoptosis and expression of genes encoding Akt, FOXO3, Bcl2 and p53. The CCK-8 assay, cytoskeletal staining and flow cytometry were used to test cell viability, mor- phology and apoptosis, respectively. Fluorescent quantitative real-time PCR （qRT-PCR） was used to monitor changes in gene expression, and HPLC to determine the rate of FA clearance. Treatment of N2a cells with 0.09 mmol L-1 FA for 24 h signifi- cantly reduced cell viability, changed cell morphology and promoted apoptosis. Both TLJN and GP conferred neuroprotection to FA-treated N2a cells, whereas PNS, which had to be used at lower concentrations because of its toxicity, did not. Our data demonstrate that TLJN can rescue neuronal damage caused by FA and that its main ingredient, GP, has a major role in this ef- ficacy. This presents purified GP as a drug or lead compound for the treatment of AD.

关键词： Alzheimer's disease apoptosis formaldehyde geniposide neuroprotection panax notoginseng saponin Tong Luo Jiu Nao

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创新数字新闻理论以促进数字文明

社会科学战线 2024年第6期348卷 200-209,282页

作者：吴飞孙梦如浙江大学国际传播研究中心浙江杭州310058

数字新闻理论范式的创新可以围绕两条研究线索展开:一是从社会与理论背景出发,紧扣数字社会与数字文明两个核心概念,审视新闻理论创新与其背景的同构性;二是探索新闻学及新闻理论演变的内生逻辑。要不断丰富和发展数字新闻学的理论体系... 详细信息

数字新闻理论范式的创新可以围绕两条研究线索展开:一是从社会与理论背景出发,紧扣数字社会与数字文明两个核心概念,审视新闻理论创新与其背景的同构性;二是探索新闻学及新闻理论演变的内生逻辑。要不断丰富和发展数字新闻学的理论体系,研究数字文明的特点与规律、数字叙事方式、媒介融合实践、公众参与互动模式以及数字新闻领域伦理法规等问题,为建构数字文明提供理论支撑和实践指导。

关键词：数字新闻数字社会数字文明理论范式新闻理论创新

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基于模糊综合评判的剩余油分布定量描述

油气地质与采收率 2005年第2期12卷 52-54页

作者：孙梦茹胜利油田有限公司胜利采油厂

针对高含水后期非均质严重的油藏剩余油分布难以确定的问题,综合分析了影响剩余油分布的因素。在数值模拟基础上,基于模糊综合评判理论,建立了模糊评判模型,提出了用于定量预测剩余油的新方法。结合胜坨油田二区沙二段74单元的地质和... 详细信息

针对高含水后期非均质严重的油藏剩余油分布难以确定的问题,综合分析了影响剩余油分布的因素。在数值模拟基础上,基于模糊综合评判理论,建立了模糊评判模型,提出了用于定量预测剩余油的新方法。结合胜坨油田二区沙二段74单元的地质和开发资料,该方法在该区剩余油定量描述中得以成功应用,得到了各韵律层剩余油分布的概率图。该方法具有推广至相似性质油藏的价值。

关键词：剩余油分布定量描述模糊综合评判理论模糊评判模型高含水后期综合分析数值模拟定量预测胜坨油田非均质沙二段概率图韵律层油藏

高强冷成型钢开口截面轴压构件的高温后数值仿真与承载力研究

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建筑钢结构进展 2021年第9期23卷 61-71,90页

作者：张佳慧孙梦茹上海理工大学环境与建筑学院上海200093

冷成型钢构件在经历火灾(高温)后,力学性能可能发生衰减,需要关注其承载力的变化并做出准确评估。因此,在现有高强冷成型钢过火后材性与构件测试结果的基础上,通过数值仿真模拟预测构件经历不同温度后的力学行为。通过参数分析,开展开... 详细信息

冷成型钢构件在经历火灾(高温)后,力学性能可能发生衰减,需要关注其承载力的变化并做出准确评估。因此,在现有高强冷成型钢过火后材性与构件测试结果的基础上,通过数值仿真模拟预测构件经历不同温度后的力学行为。通过参数分析,开展开口截面承压构件过火后性能分析,研究高温后的构件长细比、截面形式对承载力和破坏模式的影响,评估常温构件设计方法的适用性。有限元建模和参数分析的结果表明:(1)冷成型钢构件材性的衰减不是影响其过火后性能的唯一因素,在特定温度段须考虑重量折减;(2)高温后长细比与构件破坏模式的关系与常温构件相似;(3)纵向加劲,特别是腹板加劲能够显著改善常温及过火后构件的承载能力;(4)常温构件承载力计算方法(直接强度法)整体上过高地估计了高温后构件的承载力,需引入高温后的构件几何缺陷。

关键词：高强冷成型钢开口截面高温后加劲数值仿真承载能力

健康传播视角下公共卫生事件中公众风险感知与行为的研究路径

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浙江大学学报（人文社会科学版） 2020年第3期50卷 116-129页

作者：孙梦如蒋莉郭沁浙江大学传媒与国际文化学院浙江杭州310028 香港城市大学媒体与传播系香港999077 浙江工业大学人文学院浙江杭州310023

风险感知是指人们对风险的态度和主观判断,受个人心理认知及社会文化因素的共同影响。在健康传播视角下,从公众这个核心主体出发,以风险传播和沟通为主要切入点,公共卫生事件中的公众风险感知与行为具有如下五个研究路径:多学科和多种... 详细信息

风险感知是指人们对风险的态度和主观判断,受个人心理认知及社会文化因素的共同影响。在健康传播视角下,从公众这个核心主体出发,以风险传播和沟通为主要切入点,公共卫生事件中的公众风险感知与行为具有如下五个研究路径:多学科和多种方法结合建立研究范式、在个体层面探究公共卫生事件中的个体心理机制、在群体共性层面探究公共卫生事件中的群体行为、从社会文化角度探究公共卫生事件、引导公众情绪和行为的策略。未来的研究应围绕这五个研究路径,在理论、研究方法和应用领域三个方面进行创新和完善:用跨学科的视角整合宏观微观机制;结合大数据、心理学实证及计算机仿真方法进行综合性实证研究;以重大问题导向和全球化为视角,拓宽应用领域。

关键词：公共卫生事件公众风险感知情绪健康传播