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Peripheral origin exosomal micro RNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment

药学学报:英文版 2023年第7期13卷 2817-2825页

作者： Lin Zhang Dongna Li Pengrong Yi Jiangwei Shi mengqing guo Qingsheng Yin Dingbin Liu Pengwei Zhuang Yanjun Zhang State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300193China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300193China State Key Laboratory of Medicinal Chemical Biology Research Center for Analytical Sciencesand Tianjin Key Laboratory of Molecular Recognition and BiosensingCollege of ChemistryNankai UniversityTianjin 300071China

Cognitive dysfunction is one of the common central nervous systems(CNS)complications of diabetes mellitus,which seriously affects the quality of life of patients and results in a huge economic burden.The glymphatic system dysfunction mediated by aquaporin-4(AQP4)loss or redistribution in perivascular astrocyte endfeet plays a crucial role in diabetes-induced cognitive impairment(DCI).However,the mechanism of AQP4 loss or redistribution in the diabetic states remains unclear.Accumulating evidence suggests that peripheral insulin resistance target tissues and CNS communication affect brain homeostasis and that exosomal miRNAs are key mediators.Glucose and lipid metabolism disorder is an important pathological feature of diabetes mellitus,and skeletal muscle,liver and adipose tissue are the key target insulin resistance organs.In this review,the changes in exosomal miRNAs induced by peripheral metabolism disorders in diabetes mellitus were systematically reviewed.We focused on exosomal miRNAs that could induce low AQP4 expression and redistribution in perivascular astrocyte endfeet,which could provide an interorgan communication pathway to illustrate the pathogenesis of DCI.Furthermore,the mechanisms of exosome secretion from peripheral insulin resistance target tissue and absorption to the CNS were summarized,which will be beneficial for proposing novel and feasible strategies to optimize DCI prevention and/or treatment in diabetic patients.

关键词： Diabetic cognitive impairment AQP4 Peripheral-central communication Exosomal miRNAs Central nervous system Glymphatic system Diabetes mellitus Astrocyte

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Innovations in metallurgical and materials processes:advancing liquid theory and honoring Prof.Han-jie guo's contributions to physical chemistry in metallurgy

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Journal of Iron and Steel Research(International) 2024年第1期31卷 1-2页

作者： Shuai Liu Jing guo Han-jie guo School of Artificial Intelligence Beijing Technology and Business UniversityBeijing100048China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China

Spanning three decades,Prof.Han-jie guo's research group has dedicated itself to exploring the fundamental theories and practical applications of physical chemistry within the realm of metallurgy.Operating under the a... 详细信息

关键词： chemistry liquid complexes

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Krill oil attenuates obesity-induced skeletal muscle atrophy in mice

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Food Science and Human Wellness 2024年

作者： mengqing Zhou Yuhong Yang Yan Zheng Zijian Wu Chen Chen Qijian Liang Yu Yang Hao Wu Xin guo Lei Du School of Food Science and Engineering Qilu University of Technology (Shandong Academy of Sciences) School of Public Health Cheeloo College of Medicine Shandong University Research Center of Translational Medicine Jinan Central Hospital Shandong University

Obesity is associated with skeletal muscle mass loss and physical dysfunction. Krill oil (KO) has been shown to be beneficial in human health. However， the effect of KO on obesity-induced skeletal muscle atrophy is still unclear. In this study， the male C57BL/6J mice were fed a high-fat diet (HFD) for 12 weeks to induce obesity， and then were intragastric administration with 400 mg/kg bw KO for an additional 6 weeks. The results showed that KO treatment reduced body weight， fat accumulation and serum pro-inflammatory cytokines in HFD-induced obese mice. Importantly， KO treatment attenuated skeletal muscle atrophy in HFD-fed mice， as evidenced by preserving skeletal muscle mass， average myofiber cross-sectional area and grip strength. KO administration also mitigated obesity-induced ectopic lipid deposition and inflammatory response in skeletal muscle. Additionally， KO treatment inhibited the transcriptional activities of nuclear factor-kappa B (NF-κB) p65 and forkhead box O 3a (FoxO3a)， and then down-regulated muscle atrophy F-box (MAFbx) and muscle-specific RING finger protein 1 (MuRF1) protein levels in skeletal muscle from HFD-fed mice. KO administration also improved obesity-induced impaired muscle protein synthesis via activating PI3K/Akt pathway. Furthermore， KO treatment enhanced muscle mitochondrial biogenesis in HFD-induced obese mice via activating PGC-1α pathway. Collectively， KO might be developed as a potential nutritional supplement for the prevention and treatment of obesity-induced skeletal muscle atrophy.

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Light People:Prof.Eric Mazur speaks about ultrafast optics and education

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Light(Science & Applications) 2024年第3期13卷 402-406页

作者： Chenzi guo Yang Li Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina State Key Laboratory of Precision Measurement Technology and Instrument Department of Precision InstrumentTsinghua UniversityBeijingChina

Prof.Eric Mazur is a great influencer over and beyond the optics community.As a physicist,he is a pioneer of ultrafast optics and was one of the inventors of colliding-pulse mode-locked laser.As an educator,he not only gave talks to thousands,but also revolutionized teaching with his globally renowned methodology“Peer Instruction”.As a leader and entrepreneur,he co-founded several companies and was President of Optica(formerly the Optical Society)and currently is the Chair of the Optica Foundation.Here,Light:Science&Applications talked with Prof.Eric Mazur about his opinions on research,education and industry.The full interview video can be found in the Supplementary File.

关键词： optics education companies

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Emerging direct current triboelectric nanogenerator for high-entropy mechanical energy harvesting

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Science China(Technological Sciences) 2024年第5期67卷 1297-1316页

作者： CHEN Jie guo RuiLong guo HengYu College of Physics and Electronic Engineering Chongqing Normal UniversityChongqing 401331China Department of Applied Physics Chongqing UniversityChongqing 401331China

In the era of the Internet of Things(IoT),the provision of sustainable power to distributed,mobile,and low-power-consumption electronic devices is a critical challenge.To overcome this challenge,the triboelectric nanogenerator(TENG),a highly efficient high-entropy mechanical energy harvesting device,was developed in 2012.This device enables the direct conversion of irregular and low-frequency mechanical energy into pulsed alternating current(AC)signals.However,the incompatibility of most electronic devices with AC signals necessitates rectifier circuits or generators that deliver direct current(DC)signals.In recent years,DC-TENGs have undergone extensive development,achieving significant milestones in various application fields while also facing crucial challenges that require solutions.In this review,three categories of DC-TENG devices with distinct operating mechanisms are comprehensively explored:multiphase coupling,mechanical rectification,and air breakdown.Their typical structures and working mechanisms are thoroughly discussed,and specific output performance limitations,along with corresponding optimization strategies,are identified.Furthermore,the applications of DC-TENGs in various scenarios are summarized.Finally,the challenges faced by DC-TENGs and potential solutions are analyzed to guide further advancements in this technology.

关键词： TENG direct current working mechanisms output performance limitations optimization strategies

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Light People:Prof.Kei May Lau,newly elected US NAE member in Hong Kong,talks about future of photonics and women in science

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Light(Science & Applications) 2024年第4期13卷 602-608页

作者： Yating Wan Chenzi guo Electrical and Computer Engineering the ComputerElectrical and Mathematical Sciences and Engineering DivisionKing Abdullah University of Science and Technology23955-6900 ThuwalSaudi Arabia Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina

Editorial Photonics technology remains a driving force in today’s scientific landscape,marked by continuous innovation and crossdisciplinary relevance.In an enlighting conversation with Light:Science&Applications,Prof.Kei May Lau,a pioneer in photonics research,shares her deep insights on the evolution of technologies of LEDs,lasers,challenges of hetero-epitaxy,and the future of micro-LEDs and quantum dot lasers.Recently honored as a member of the US National Academy of Engineering(NAE)for her significant contributions to photonics and electronics using III-V semiconductors on silicon,Prof.Lau stands out as the sole Hong Kong scholar inducted into the NAE this year,joining 114 new and 21 international members.In this exclusive Light People interview,Prof.Lau shares her journey as a pioneering woman in engineering,her commitment to mentorship and academia,and her perspective on advancing female representation in science.The summary provided is distilled from Prof.Lau’s thoughtful responses during the interview.For a deeper exploration of Prof.Lau’s experiences and advice,the full interview is available in the Supplementary material.

关键词： interview lighting driving

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Improving benzene catalytic oxidation on Ag/Co_(3)O_(4) by regulating the chemical states of Co and Ag

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Journal of Environmental Sciences 2024年第9期143卷 201-212页

作者： Hao guo Tao guo Mengqi Zhao Yaxin Zhang Wenfeng Shangguan Yinnian Liao State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources Xinjiang UniversityXinjiang 830017China Xinjiang Key Laboratory of Coal Clean Conversion&Chemical Engineering Process Xinjiang UniversityXinjiang 830017China School of Chemical Engineering and Technology Xinjiang UniversityXinjiang 830017China Research Center for Combustion and Environmental Technology Shanghai Jiao Tong UniversityShanghai 200240China School of Applied Chemistry and Materials Zhuhai College of Science and TechnologyGuangdong 519041China

Silver(9 wt.%)was loaded on Co_(3)O_(4)-nanofiber using reduction and impregnation methods,respectively.Due to the stronger electronegativity of silver,the ratios of surface Co^(3+)/Co^(2+) on Ag/Co_(3)O_(4) were higher than on Co_(3)O_(4),which further led to more adsorbed oxygen species as a result of the charge compensation.Moreover,the introducing of silver also obviously improved the reducibility of Co_(3)O_(4).Hence the Ag/Co_(3)O_(4) showed better catalytic performance than Co_(3)O_(4) in benzene oxidation.Compared with the Ag/Co_(3)O_(4) synthesized via impregnation method,the one prepared using reduction method(named as Ag Co-R)exhibited higher contents of surface Co^(3+) and adsorbed oxygen species,stronger reducibility,as well as more active surface lattice oxygen species.Consequently,Ag Co-R showed lowest T_(90) value of 183℃,admirable catalytic stability,largest normalized reaction rate of1.36×10^(-4)mol/(h·m^(2))(150℃),and lowest apparent activation energy(E_(a))of 63.2 kJ/mol.The analyzing of in-situ DRIFTS indicated benzene molecules were successively oxidized to phenol,o-benzoquinone,small molecular intermediates,and finally to CO_(2) and water on the surface of Ag Co-R.At last,potential reaction pathways including five detailed steps were proposed.

关键词： Reduction method Co_(3)O_(4)-supported Ag catalyst,VOCs Benzene oxidation Reaction mechanism

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Physicochemical principles of hydrogen metallurgy in blast furnace

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Journal of Iron and Steel Research(International) 2024年第1期31卷 46-63页

作者： Han-jie guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing100083China

Based on the stoichiometric method and the free energy minimization method,an ideal model for the reduction of iron oxides by carbon and hydrogen under blast furnace conditions was established,and the reduction efficiency and theoretical energy consumption of the all-carbon blast furnace and the hydrogen-rich blast furnace were compared.The results show that after the reduction reaction is completed at the bottom of the blast furnace,the gas produced by reduction at 1600℃still has a certain excessive reduction capacity,which is due to the hydrogen brought in by the hydrogen-rich blast as well as the excess carbon monoxide generated by the reaction of the coke and the oxygen brought in by the blast.During the process of the gas with excessive reduction capacity rising from the bottom of the blast furnace and gas reduction process,the excessive reduction capacity of the gas gradually decreases with the increase in the dydrogen content in the blast.In the all-carbon blast furnace,the excess gas reduction capacity is the strongest,and the total energy consumption per ton of iron reduction is the lowest.This shows that,for the current operation mode of the blast furnace,adding hydrogen in the blast furnace cannot reduce the consumption of carbon required for reduction per ton of iron,but rather increases the consumption of carbon.

关键词： Hydrogen metallurgy Excess gas reduction capacity Theoretical energy consumption Hydrogen-rich blast furnace Thermodynamic model Gibbs minimum free energy method

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Control Strategies for Digital Twin Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 170-180页

作者： guo-Ping Liu IEEE the Center for Control Science and Technology Southern University of Science and TechnologyShenzhen 518055China

With the continuous breakthrough in information technology and its integration into practical applications, industrial digital twins are expected to accelerate their development in the near future. This paper studies various control strategies for digital twin systems from the viewpoint of practical applications.To make full use of advantages of digital twins for control systems, an architecture of digital twin control systems, adaptive model tracking scheme, performance prediction scheme, performance retention scheme, and fault tolerant control scheme are proposed. Those schemes are detailed to deal with different issues on model tracking, performance prediction, performance retention, and fault tolerant control of digital twin systems. Also, the stability of digital twin control systems is analysed. The proposed schemes for digital twin control systems are illustrated by examples.

关键词： Digital twin control systems fault tolerant control model tracking performance prediction performance retention

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Molecular classification of small cell lung cancer subtypes:Characteristics,prognostic factors,and clinical translation

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Chinese Medical Journal 2024年第2期137卷 130-139页

作者： Hanfei guo Wenqian Li Ye guo Naifei Chen Jiuwei Cui Cancer Center The First Hospital of Jilin UniversityChangchunJilin 130021China

Small cell lung cancer(SCLC)is a highly malignant tumor with a very poor prognosis;therefore,more effective treatments are urgently needed for patients afflicted with the disease.In recent years,emerging molecular classifications based on key transcription factors of SCLC have provided more information on the tumor pathophysiology,metastasis,immune microenvironment,and acquired therapeutic resistance and reflected the intertumoral heterogeneity of the various SCLC phenotypes.Additionally,advances in genomics and single-cell sequencing analysis have further revealed the high intratumoral heterogeneity and plasticity of the disease.Herein,we review and summarize these recent lines of evidence and discuss the possible pathogenesis of SCLC.

关键词： Small cell lung carcinoma Molecular classification Tumor heterogeneity Drug resistance Transcription factors Genomics Phenotype Prognosis

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