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Abnormal Alterations of Cortical Thickness in 16 Patients with Type 2 Diabetes Mellitus： A Pilot MRI Study

Chinese Medical Sciences Journal 2017年第2期32卷 75-82页

作者： ZhiyeChen XiujuanZang mengqiliu MengyuLiu JinfengLi ZhaoyanGu LinMa Department of Radiology Chinese PLA General Hospital Beijing 100853 China Department of Radiology 4Department of Endocrinology Hainan Branch of Chinese PLA General Hospital Sanya Hainan 572013 China Department of Radiology The Fifth People's Hospital Shizuishan Ningxia 753000 China

Objective The aim of this study is to investigate the cerebral cortical thickness changes in type 2 diabetes mellitus （T2DM） using a whole brain cortical thickness mapping system based on brain magnetic resonance imaging （MRI）. Methods High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 16 patients with T2DM, as well as from 16 normal controls. The whole brain cortical thickness maps were generated, and the cortical thickness of each brain region was calculated according to gyral based regions of interest （ROI） using an automated labeling system by the Freesurfer software. We compared mean cortical thickness at each brain region by the analysis of covariance with age and sex as covariates. The regional difference of the cortical thickness over the whole brain was compared by the analysis of surface-based cortical thickness. Results Mean cortical thicknesses analysis showed bilateral cerebrum in the patients with T2DM （left： 2.52±0.07 mm; right： 2.51±0.08 mm） were significant thinner than those in the normal controls （left： 2.56±0.09 mm; right： 2.56±0.09 mm）（both P〈0.05）. Regional cortical thinning in T2DM was demonstrated in the paracentral lobule, postcentral gyrus, lateral occipital gyrus, lingual gyrus, precuneus, superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus and posterior cingulate gyrus, compared to the normal controls. The cortical thickness of left middle cingulate and right inferior temporal gyrus were negatively correlated with the disease course. Conclusion A widespread cortical thinning was revealed in patients with T2DM by the analysis of brain cortical thickness on MR. Our finding supports the idea that T2DM could lead to subtle diabetic brain structural changes.

关键词： type 2 diabetes mellitus brain cerebral cortex cortical thickness magnetic resonance imaging

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