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World Journal of Stem Cells 2025年第1期17卷 6-21页

作者： wan-Yu Zhang Han-Bi wang Cheng-Yan Deng Department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Obstetrics and Gynecology Peking Union Medical College HospitalBeijing 100730China

Endometrial injury caused by repeated uterine procedures,infections,inflammation,or uterine artery dysfunction can deplete endometrial stem/progenitor cells and impair regeneration,thereby diminishing endometrial receptivity and evidently lowering the live birth,clinical pregnancy,and embryo implantation ***,safe and effective clinical treatment methods or gene-targeted therapies are unavailable,especially for severe endometrial *** cord mesenchymal stem cells and their extracellular vesicles are characterized by their simple collection,rapid proliferation,low immunogenicity,and tumorigenicity,along with their involvement in regulating angiogenesis,immune response,cell apoptosis and proliferation,inflammatory response,and fibrosis,Therefore,these cells and vesicles hold broad potential for application in endometrial *** article reviewed recent research on human umbilical cord mesenchymal stem cells as well as their extracellular vesicles in repairing endometrial injury.

关键词： Endometrial injury Umbilical cord mesenchymal stem cells Extracellular vesicles MicroRNA Biomaterial assemblies Regenerative repair

Carbapenem-resistant Klebsiella pneumoniae infections after liver transplantation:Drug resistance,risk factors and impact on prognosis

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World Journal of Gastroenterology 2025年第8期31卷 38-48页

作者： Tao-Hua Liu Li-Hua Chen Qi-Quan wan Department of Pediatrics The Third Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina Department of Laboratory Medicine The Third Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina Department of Transplant Surgery The Third Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina Engineering and Technology Research Center for Transplantation Medicine of National Health Commission The Third Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina

BACKGROUND Liver transplant(LT)recipients are susceptible to carbapenem-resistant Klebsiella pneumoniae(CRKP)*** research addressing the incidence,timing,infection sites,resistance patterns,treatment options,and associated risk factors among LT recipients with CRKP is now *** To assess the incidence,resistance,therapy,and risk factors of CRKP infections post-LT,and to evaluate the impact of them on *** A retrospective study was conducted,including 430 consecutive patients who underwent LT between January 2015 and June *** study aimed to investigate the risk factors for CRKP infections and their influence on outcomes using logistic regression *** Among the 430 patients who underwent LT,20(4.7%)experienced at least one documented CRKP infection within 3 months *** median time from LT to the onset of CRKP infections was 6.5 *** lungs and bloodstream were the most common sites of CRKP *** isolates were relatively susceptible to ceftazidime/avibactam(93.7%),polymyxin B(90.6%),and tigecycline(75.0%)***,all isolates were resistant to piperacillin/tazobactam,ceftazidime,cefepime,aztreonam,meropenem,and levofloxacin *** with CRKP infections had a mortality rate of 35%,the rate was 12.5%for those receiving ceftazidime/avibactam *** analysis identified female sex[odds ratio(OR)=3.306;95%confidence interval(CI):1.239-8.822;P=0.017],intraoperative bleeding≥3000 mL(OR=3.269;95%CI:1.018-10.490;P=0.047),alanine aminotransferase on day 1 post-LT≥1500 U/L(OR=4.370;95%CI:1.686-11.326;P=0.002),and post-LT mechanical ventilation(OR=2.772;95%CI:1.077-7.135;P=0.035)as significant variables associated with *** infections were related to an intensive care unit length(ICU)of stay≥7 days and 6-month all-cause mortality *** CRKP infections were frequent complications following LT,with poor associated *** factors for p

关键词： Liver transplantation Carbapenem-resistant Klebsiella pneumonia Antibiotic resistance Infection Immunosuppression Risk factors

Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第1期68卷 377-384页

作者： Shiwen Liu Xuerui wan Meng Zhao Jiaqi wang Weilan Wu Linlin You Yonggui Yuan Qian Xu Rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of EducationSchool of Public HealthSoutheast UniversityNanjing 210009China Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and DetectionSchool of Public HealthNanjing Medical UniversityNanjing 211166China Department of Psychosomatics and Psychiatry Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009China

The measurement of amino acid and monoamine neurotransmitters(NTs)in serum plays a central role in the identification and monitoring of clinical panic disorder(PD).However,the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely ***,we developed a strategy that integrated solid phase extraction based on magnetic Fe_(3)O_(4)coated with polydopamine(Fe_(3)O_(4)@PDA)and direct analysis of mass spectrometry in real time(DART-MS)for quantification of 10 *** systematically investigated the optimal conditions of this strategy to achieve good accuracy and *** with existing magnetic solid phase extraction methods for NTs detection in biological samples,this strategy could adsorb more targets while having similar adsorption efficiencies,and the total process time was reduced by an average of 69.42%.We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic *** addition,an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this *** results highlighted the potential ability of Fe_(3)O_(4)@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

关键词： neurotransmitters panic disorder magnetic solid phase extraction direct analysis of mass spectrometry in real time

Reduced Salinity Interacts with Enriched Nitrogen to Enhance the Photosynthetic Efficiency of Chlorophyta Ulva fasciata

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Journal of Ocean University of China 2025年第1期24卷 130-138页

作者： wan Mingyue BAI Lingling NI Guangyan LI Li TAN Yehui LI Gang Key Laboratory of Tropical Marine Bio-Resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510530China Daya Bay Marine Biology Research Station Chinese Academy of SciencesShenzhen 518121China University of Chinese Academy of Sciences Beijing 100049China School of Pharmaceutical Science Southern Medical UniversityGuangzhou 510515China Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems South China National Botanical GardenChinese Academy of SciencesGuangzhou 510650China

Macroalgae dominate nutrient dynamics and function as high-value foods for microbial,meio-and macrofaunal communities in coastal *** of this vital role,it is important to clarify the physiological information associated with environmental changes as it reflects their growth *** evaluate the effects of the changes in salinity and nutrients,the photosynthetic efficiency of a green macroalga Ulva fasciata from the Daya Bay was tested at a range of salinity(i.e.,31 to 10 psu)and nitrogen content(i.e.,5 to 60μmol L^(-1)).The results showed that cellular chlorophyll a(Chl a),carbohydrate and protein contents of *** were increased due to reduced salinity,and were decreased by interactive nitrogen *** a short culture period(i.e.,18 h),the reduced salinity decreased the maximum photosynthetic efficiency(rETRmax and Pmax)derived from the rapid light response curve and photosynthetic oxygen evolution rate versus irradiance curve,respectively,as well as the saturation irradiance(E_(K)).This reducing effect diminished with enlonged cultivation time and reversed to a stimulating effect after 24 h of *** nitrogen enrichment stimulated the rETRmax and Pmax,as well as the E_(K),regardless of salinity,especially within short-term cultivation period(i.e.,<24 h).In addition,our results indicate that seawater freshening lowers the photosynthetic efficiency of *** in the short term,which is mitigated by nitrogen enrichment,but stimulates it in the long term,providing insight into how macroalgae thrive in coastal or estuarine waters where salinity and nutrients normally covary strongly.

关键词： reduced salinity nitrogen enrichment photosynthetic efficiency Ulva fasciata Daya Bay

CMOS direct conversion X-ray detector coupled with fluorinated liquid

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Nuclear Science and Techniques 2025年第1期36卷 59-68页

作者： Shi-Hua Liu Chao-Song Gao Xin Zhang Xiang-Ming Sun Meng Wu Zhi-Hui Han Tong wan Yong-Shuai Ge Key Laboratory of Quark&Lepton Physics(MOE) Central China Normal UniversityWuhan 430079China Guizhou Education University Guiyang 550018China Research Center for Medical Artificial Intelligence Chinese Academy of SciencesShenzhen Institutes of Advanced TechnologyShenzhen 518055China

X-ray detectors show potential applications in medical imaging,materials science,and nuclear *** achieve high detection efficiency and spatial resolution,many conventional semiconductor materials,such as amorphous selenium,cadmium telluride zinc,and perovskites,have been utilized in direct conversion X-ray ***,these semiconductor materials are susceptible to temperature-induced performance degradation,crystallization,delamination,uneven lattice growth,radiation damage,and high dark *** study explores a new approach by coupling an FC40 electronic fluorinated liquid with a specialized high-resolution and high-readout-speed complementary metal-oxide-semiconductor(CMOS)pixel array,specifically the Topmetal II−chip,to fabricate a direct conversion X-ray *** fluorinated liquid FC40(molecular formula:C_(21)F_(48)N_(2))is an electronic medium that is minimally affected by temperature and displays no issues with uniform *** exhibits a low dark current and minimal radiation damage and enables customizable thickness in X-ray *** addresses the limitations inherent in conventional semiconductor-based *** this study,simple X-ray detector imaging tests were conducted,demonstrating the excellent coupling capability between FC40 electronic fluorinated liquid and CMOS chips by the X-ray detector.A spatial resolution of 4.0 lp/mm was measured using a striped line par card,and a relatively clear image of a cockroach was displayed in the digital radiography imaging *** test results indicated the feasibility of fabricating an X-ray detector by combining FC40 electronic fluorinated liquid and CMOS *** to the absence of issues related to chip-material coupling,a high spatial resolution could be achieved by reducing the chip pixel *** method presents a new avenue for studies on novel liquid-based direct conversion X-ray detectors.

关键词： FC40 electronic fluorinated liquid CMOS pixel chip X-ray detector Spatial resolution

Understanding and probing progression of localized corrosion on inner walls of steel pipelines:an overview

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Journal of Iron and Steel Research International 2025年第1期32卷 1-18页

作者： Ming-yu wang Hai-yuan Yao Yong-fei Liu Ye-sen Zhu wan-bin Chen Yun-ze Xu Yi Huang School of Naval Architecture and Ocean Engineering Dalian University of TechnologyDalian 116024LiaoningChina China National Offshore Oil Corporation Research Institute Co. Ltd.Beijing 100028China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024LiaoningChina

Corrosion poses a major threat to the safety of transportation ***,it is crucial to have an in-depth understanding of corrosion mechanisms in pipeline steels for the effective management of pipeline *** research on corrosion mechanisms relies on the use of efficient and reliable corrosion monitoring and analysis *** advancements in corrosion monitoring techniques specifically designed for the localized corrosion monitoring were aimed to be introduced,and a comprehensive overview of recent progress in understanding the localized corrosion mechanisms in pipeline steels was *** on the different corrosive environments encountered,the localized corrosion issues inside pipelines are classified into two categories:localized corrosion primarily influenced by electrochemical processes and localized corrosion controlled by both electrochemical and mechanical ***,a thorough analysis of the synergistic effects between micro-cell and macro-cell currents,as well as the interplay of mechanics and electrochemistry is ***,recommendations for future research on the mechanisms of internal localized corrosion in pipelines are provided.

关键词： Pipeline steel Localized corrosion Corrosion type Corrosion monitoring Corrosion mechanism

Recognition of a salivary effector by the TNL protein RCSP promotes effector-triggered immunity and systemic resistance in Nicotiana benthamiana

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Journal of Integrative Plant Biology 2025年第1期67卷 150-168页

作者： Weiwei Rao Tingting Ma Jiayuan Cao Yajun Zhang Sisi Chen Shu Lin Xiaoxiao Liu Guangcun He Li wan Key Laboratory of Plant Design CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China National Key Laboratory of Hybrid Rice College of Life SciencesWuhan UniversityWuhan 430072China University of Chinese Academy of Sciences Beijing 100049China

Insects secret chemosensory proteins(CSPs)into plant cells as potential effector proteins during *** molecular mechanisms underlying how CSPs activate plant immunity remain largely *** show that CSPs from six distinct insect orders induce dwarfism when overexpressed in Nicotiana ***-mediated transient expression of Nilaparvata lugens CSP11(NlCSP11)triggered cell death and plant dwarfism,both of which were dependent on ENHANCED DISEASE SUSCEPTIBILITY 1(EDS1),N requirement gene1(NRG1)and SENESCENCE-ASSOCIATED GENE 101(SAG101),indicating the activation of effector-triggered immunity(ETI)in *** of NlCSP11 led to stronger systemic resistance against Pseudomonas syringae DC3000 lacking effector HopQ1-1 and tobacco mosaic virus,and induced higher accumulation of salicylic acid(SA)in uninfiltrated leaves compared to another effector XopQ that is recognized by a Tollinterleukin-1 receptor(TIR)domain nucleotidebinding leucine-rich repeat receptor(TNL)called ROQ1 in ***,NlCSP11-induced dwarfism and systemic resistance,but not cell death,were abolished in *** transgenic line expressing the SA-degrading enzyme Nah *** large-scale virus-induced gene silencing screening,we identified a TNL protein that mediates the recognition of CSPs(RCSP),including aphid effector MP10 that triggers resistance against aphids in ***,bimolecular fluorescence complementation and Alpha Fold2 prediction unveiled an interaction between NlCSP11 and ***,RCSP does not contain the conserved catalytic glutamic acid in the TIR domain,which is required for TNL *** findings point to enhanced ETI and systemic resistance by a TNL protein via hyperactivation of the SA ***,RCSP is the first TNL identified to recognize an insect effector.

关键词： chemosensory protein effector effector-triggered immunity salicylic acid TIR-NBS-LRR

Bistable switch molecule DPACdCl_(4) showing four physical channels and high phase transition temperature

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Chinese Chemical Letters 2025年第1期36卷 591-596页

作者： Ying-Yu Zhang Jia-Qi Luo Yan Han wan-Ying Zhang Yi Zhang Hai-Feng Lu Da-Wei Fu Institute for Science and Applications of Molecular Ferroelectrics Key Laboratory of the Ministry of Education for Advanced Catalysis MaterialsZhejiang Normal UniversityJinhua 321004China Ordered Matter Science Research Center Jiangsu Key Laboratory for Science and applications of Molecular FerroelectricsSoutheast UniversityNanjing 211189China

Multiple switchable physical channels within one material or device,encompassing optical,electrical,thermal,and mechanical pathways,can enable multifunctionality in mechanical-thermal-opto-electronic *** integrated encryption and enhanced performance in storage and sensing presents a formidable challenge in the synthesis and functionality of new *** an effort to overcome the complexities associated with these multiple physical functions,this study investigates the large-size crystal of DPACdCl_(4)(DPA=diisopropylammonium),revealing significant features in rare multi-channel *** compound demonstrates the ability to switch between"OFF/0"and"ON/1"states in the mechanical-thermal-opto-electronic ***,DPACd Cl_(4)possesses four switchable physical channels,characterized by a higher phase transition temperature of 440.7 K and a competitive piezo-electric coefficient of 46 pC/***,solid-state NMR analysis indicates that thermally activated molecular vibrations significantly contribute to its multifunctional switching capabilities.

关键词： Organic-inorganic hybrid Phase transition Crystal Perovskite Piezoelectricity

Properties of the drip-line nucleus and mass relation of mirror nuclei

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Nuclear Science and Techniques 2025年第2期36卷 112-122页

作者： Meng-Ting wan Li Ou Min Liu Ning wang College of Physics and Technology Guangxi Normal UniversityGuilin 541004China Guangxi Key Laboratory of Nuclear Physics and Technology Guangxi Normal UniversityGuilin 541004China

The isospin asymmetry and quadrupole deformation value of drip-line nuclei are investigated using the Weizsäcker-Skyrme nuclear mass *** observe that for heavy nuclei at the neutron drip line,the Coulomb energy heightened by an aug-mented charge could not be mitigated completely by symmetry energy because of isospin asymmetry saturation but is resisted complementally by strong nuclear *** positions of saltation for the difference in proton numbers between two neighboring nuclei at the neutron drip line,and the isospin asymmetry of the neutron drip-line nucleus as a function of the neutron number distinctly correspond to the known magic numbers,which can serve as a reference to verify the undeter-mined neutron magic *** fitting of the binding energy difference between mirror nuclei(BEDbMN),a set of Coulomb energy coefficients with greater accuracy is obtained.A high-precision description of the BEDbMN is useful for accurately determining the experimentally unknown mass of the nucleus close to the proton drip line if the mass of its mirror nucleus is measured experimentally.

关键词： Nuclear mass formula Drip-line nucleus Magic number Mirror nuclei Coulomb energy

Carrier Recombination and Diffusion Dynamics in LiBr Passivated CsPbBr_(3) Perovskite Film with Poly(9-vinylcarbazole)Film Underneath

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Chinese Journal of Chemical Physics 2025年第1期38卷 17-24,I0006-I0018,I0055页

作者： Jianchang Lv Ao Liu Yan wan College of Chemistry Beijing Normal UniversityBeijing 100875China

The performance of cesium lead halide per-ovskite devices is seriously affected by grain boundaries and other charge traps in the poly-crystalline perovskite thin *** doping could effectively passivate defects in CsPbBr_(3) perovskite thin films,but it is still unclear that whether the passivation can help the carriers to diffuse across the grain *** we have studied the carrier recombina-tion and diffusion dynamics in LiBr passivat-ed CsPbBr_(3) perovskite film with poly(9-vinyl-carbazole)(PVK)film underneath by using ultrafast transient absorption spectroscopy and transient absorption *** photoluminescence imaging and transient absorption morphological imaging show that LiBr passivating has made the grain size larger and reduced grain boundaries in CsPbBr_(3) *** transient absorption spectroscopy and time-re-solved photoluminescence data indicate that LiBr passivating has slowed down the bimolecu-lar recombination rate and extended the carrier *** photoexcited hot holes in the perovskite layer would transfer to the PVK layer in the initial 2 *** the transient absorp-tion microscopy measurements reveal that the LiBr passivation can help the carriers to diffuse across the grain boundaries to the surrounding grains in the CsPbBr_(3) perovskite *** carrier diffusion time is around 100 ps when the distance between two grains is~0.9μm.

关键词： Perovskite Carrier diffusion Transient absorption microscopy