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Journal of Pharmaceutical Analysis 2021年第2期11卷 183-190页

作者： Yuan Li mengqi wan Guosheng Yan Ping Qiu Xiaolei wang Department of Chemistry Nanchang UniversityNanchang330031China Jiangxi Province Key Laboratory of Modern Analytical Science Nanchang UniversityNanchang330031China Institute of Translational Medicine Nanchang UniversityNanchang330088China

A highly sensitive and selective method was developed for both UVevis spectrophotometric and fluorimetric determination of organophosphorus pesticides(OPs). This method used silver nanoparticles(AgNPs) modified with graphitic carbon nitride(g-C_3N_4). The AgNPs reduced the fluorescence intensity of g-C_3N_4. Acetylthiocholine(ATCh) could be catalytically hydrolyzed by acetylcholinesterase(AChE) to form thiocholine, which induces aggregation of the AgNPs. This aggregation led to the recovery of the blue fluorescence of g-C_3N_4, with excitation/emission peaks at 310/460 nm. This fluorescence intensity could be reduced again in the presence of OPs because of the inhibitory effect of OPs on the activity of AChE. The degree of reduction was found to be proportional to the concentration of OPs, and the limit of fluorometric detection was 0.0324 mg/L(S/N=3). In addition, the absorption of the g-C_3N_4/AgNPs at 390 nm decreased because of the aggregation of the AgNPs, but was recovered in presence of OPs because of the inhibition of enzyme activity by OPs. This method was successfully applied to the analysis of parathion-methyl in real samples.

关键词： Organophosphorus pesticides Dual-signal g-C_3N_4/AgNPs Fluorescence UVevis spectrophotometry

A hygro-thermo-mechanical constitutive model for shape memory polymers filled with nano-carbon powder

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International Journal of Smart and Nano Materials 2021年第3期12卷 286-306页

作者： Jianping Gu Xiaopeng Zhang Hao Duan mengqi wan Huiyu Sun Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of TechnologyNanjingChina State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjingChina

The nano-carbon powders are often used as fillers to endow the shape memory polymers(SMPs)with *** has been found that the shape memory effects(SMEs)of SMPs filled with nano-carbon powder can be triggered both by temperature and by *** reveal the driving mechanism of SMEs,a constitutive model for describing the thermally activated and moisture activated SMEs of these shape memory polymer composite(SMPCs)is developed *** both of the SMEs share the same driving mechanism,the variable moisture is incorporated into the framework of a thermo-mechanical modeling approach to disclose the effect of moisture on the thermoviscoelastic *** SMPCs are regarded as isotropic materials and the effect of carbon powder on the mechanical properties of the matrix is also considered in the *** the complete recovery may not be reached even they are exposed to the stimulus environment long enough,the blocking mechanism is also considered *** is the mainly new contribution compared to the early *** the method of parameter determination presented here,the effectiveness of the proposed hygro-thermo-mechanical constitutive model is confirmed by comparing the model results with the test data of uniaxial deformation from the literature.

关键词： Shape memory polymer composites nano-carbon powder hygro-thermomechanical constitutive model thermodynamics internal state variables

Enhanced Photocatalytic Performance of Anatase TiO_(2) by Deposition-Precipitation Treatment

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Chinese Journal of Chemical Physics 2024年第4期37卷 531-538,I0094页

作者： mengqi wan Qian Wen Mengyi Ci wangyang Li Zhen Zhang Key Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education Institutes Department of Chemical PhysicsUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Deposition-precipitation(DP)method is commonly used to prepare the supported metal *** this study,the modification effect of the mild DP method on the photocatalytic performance of TiO_(2)was *** TiO_(2)samples with DP treatment,as well as Au/TiO_(2)prepared under the same conditions,showed enhanced photocatalytic performance of the degradation of methylene blue(MB).·OH generated by photoexcited holes is identified as the main intermediate reactive species during the degradation reaction.X-ray photoelectron spectroscopy(XPS)and Fourier transform infrared spectroscopy(FTIR)show that TiO_(2)(A)-17 after DP treatment has the most amount of surface OH^(-)_(ad)*** presence of surface OH^(-)_(ad)species not only changes the surface zeta potential,favoring the attraction of cationic MB;but also depresses the electron-hole recombination,favoring photodegradation of MB by hole-produced·*** implication of these findings is that the modification of support properties should be taken into account while preparing supported metal catalysts using DP methods.

关键词： TiO_(2) Photocatalysis ·OH Deposition-precipitation method

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冷弯C形钢蒙古包刚架抗震性能分析

建筑钢结构进展 2020年第3期22卷 12-21页

作者：万梦琦陈明内蒙古科技大学土木工程学院内蒙古包头014010

随着对作为蒙古族特色房屋的蒙古包适用性、功能性要求的不断提升,对其结构的受力性能也提出了新的要求。考虑到绿色、安装便捷等现代房屋建造要求,在双肢冷弯C形钢门式刚架的基础上提出新的陶脑构造,设计出一种装配式蒙古包刚架。运用A... 详细信息

随着对作为蒙古族特色房屋的蒙古包适用性、功能性要求的不断提升,对其结构的受力性能也提出了新的要求。考虑到绿色、安装便捷等现代房屋建造要求,在双肢冷弯C形钢门式刚架的基础上提出新的陶脑构造,设计出一种装配式蒙古包刚架。运用ANSYS有限元软件考察了此类新型刚架的抗震性能,并以C形钢厚度、柱翼缘宽度、节点板厚度、梁腹板高度、屋面坡度和陶脑直径为参数,对双肢冷弯C形钢蒙古包刚架进行了抗震性能影响因素分析。结果表明:该新型刚架结构陶脑构造对刚架受力性能有所提升,此结构具有良好的抗震性能。设计中建议节点板厚度不应小于6mm,C形钢厚度不应小于2.5mm。

关键词：冷弯C形钢蒙古包刚架陶脑构造有限元分析抗震性能

多层级治理—政治系统理论视角下的欧盟难民政策研究——以两次难民问题为例

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欧洲研究 2019年第1期37卷 126-146,I0006页

作者：杨娜万梦琪南开大学周恩来政府管理学院

20世纪90年代,东欧剧变引发西欧难民潮,欧洲共同体出台了一系列较为有效的难民政策。2015年以来,中东北非的大批难民涌入,导致欧盟再次爆发难民危机,其难民政策却未能取得显著效果。对比两次难民问题及欧盟决策过程的异同,发现当下难民... 详细信息

20世纪90年代,东欧剧变引发西欧难民潮,欧洲共同体出台了一系列较为有效的难民政策。2015年以来,中东北非的大批难民涌入,导致欧盟再次爆发难民危机,其难民政策却未能取得显著效果。对比两次难民问题及欧盟决策过程的异同,发现当下难民问题未能妥善解决的原因是:此次制定难民政策的决策主体较前次更多元,除欧盟及其成员国外,还有次国家层级和跨国家层级的行为体;行为体的增加直接导致决策流程更为烦冗,决策过程中"输入—输出—反馈"的循环次数增多;从冷战结束到全球化时代,难民问题所处的决策环境更为复杂。若要有效应对此次难民问题,欧盟还需促进各层级的良性互动、妥善安置及遣返境内难民、加强与联盟外第三国的合作等。

关键词：多层级治理政治系统理论欧盟难民政策决策过程成员国

Acute Liver Failure Attenuative Effects of Tamoxifen through Anti-Oxidative Stress Action

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Acute Liver Failure Attenuative Effects of Tamoxifen through...

第十届全国免疫学学术大会

作者： Mansheng Luo Peng Zhang Surong Wu mengqi wan Siying Xu Yan Jiang Kangwen Peng Medical school of Jinggangshan University Jinggangshan University Dispensary

Background:Acute liver failure(ALF)is a severe hepatic syndrome in clinic,which signifies by acute hepatic injury,and eventual *** to now,aside from supportive therapy and surgical operation no other anti-ALF strategies are *** confirm that ALF has close association with TNFαinduced hepatic ***,reactive oxygen species,are implicated ***,oxidative stress has become a promising target for ALF ***:We aim to discern whether TAM could alleviate D-Ga IN/LPS induced ALF and reveal its ***:Mice were given TAM once a day for three times.12 h after the last treatment,they were co-administered with D-Ga IN/LPS(i.p).Ten mice were monitored for the mortality until 12 *** was collected 2 h,5 h for serum TNFαand alanine transaminase measurements,*** specimen sampled 5 h was used for H&E and TUNEL *** homogenates were examined for MDA,GSH/***:In this study,D-Ga IN/LPS induced mice ALF was alleviated by TAM *** contrast to model group,TAM significantly protected mice from ALF evidenced by improved survival,decreased sera TNFα,and moderate alanine transaminases(p<0.05).Mice pretreated by TAM displayed better hepatic structure,less neutrophil infiltration and hemorrhage than model and ICI *** group performed obvious hepatocellular apoptosis diminished remarkably by *** ICI was administered with TAM altogether,the latter’s ALF antagonism was not blocked *** to moderate MDA and GSSG increase in TAM group,model group showed statistic difference compared to normal control(p<0.05);but ICI group didn’t have the similar ***:This investigation demonstrated that TAM could prevent or attenuate D-Ga IN/LPS induced ALF effectively,probably through hepatocellular apoptosis antagonism which results from its anti-oxidative stress ***,it also didn’t preclude other binding molecule other than estrogen receptor on he

关键词： acute liver failure oxidative stress Tamoxifen

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电解水过程ZnO电极表面氢物种行为的表征

Chinese Journal of Chemical Physics 2023年第3期36卷 313-318,I0100页

作者：袁路凤李汪阳徐广远万梦奇张镇中国科学技术大学化学与材料科学学院化学物理系安徽省教育厅表界面化学与能源催化重点实验室合肥230026

ZnO表面氢物种能够显著改变ZnO的性能并参与催化化学反应,研究氢物种在ZnO表面的行为对提高ZnO的催化活性至关重要.本文利用电化学分析方法并结合扫描电镜、原位拉曼光谱和光致发光光谱研究了电解水过程中ZnO表面氢物种行为.结果表明,... 详细信息

ZnO表面氢物种能够显著改变ZnO的性能并参与催化化学反应,研究氢物种在ZnO表面的行为对提高ZnO的催化活性至关重要.本文利用电化学分析方法并结合扫描电镜、原位拉曼光谱和光致发光光谱研究了电解水过程中ZnO表面氢物种行为.结果表明,在较负的电势下水在ZnO电极表面还原生成氢物种并扩散进入ZnO晶格占据晶格间隙位和氧缺陷位,两种氢物种具有不同的氧化电势.利用扫描电镜、原位拉曼光谱和光致发光光谱研究了氢物种对ZnO的形貌结构和电子结构的影响.结果有助于理解ZnO表面与氢相关的催化及电催化过程.

关键词：电催化 ZnO 水还原间隙氢

乳酸经Akt信号途径促进胃癌细胞中高迁移率族蛋白盒1的磷酸化及释放

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中华肿瘤杂志 2023年第11期45卷 919-925页

作者：陈雪雷葛菲万梦琪齐世美戚之琳皖南医学院生物化学与分子生物学教研室芜湖241002 皖南医学院药学院芜湖241002

目的探讨乳酸诱导胃癌细胞高迁移率族蛋白盒1(HMGB1)释放的分子机制。方法将胃癌HGC-27细胞分为对照组和乳酸处理6 h组,通过酶联免疫吸附试验(ELISA)检测细胞培养液中HMGB1的水平,激光共聚焦和核质分离实验分别检测HMGB1的胞内定位及核... 详细信息

目的探讨乳酸诱导胃癌细胞高迁移率族蛋白盒1(HMGB1)释放的分子机制。方法将胃癌HGC-27细胞分为对照组和乳酸处理6 h组,通过酶联免疫吸附试验(ELISA)检测细胞培养液中HMGB1的水平,激光共聚焦和核质分离实验分别检测HMGB1的胞内定位及核转位,免疫共沉淀检测HMGB1磷酸化和乙酰化,Western blot检测Akt和蛋白激酶C的磷酸化。以Akt抑制剂LY294002与乳酸联合作用HGC-27细胞后,采用免疫共沉淀和Western blot分别检测HMGB1和Akt的磷酸化,激光共聚焦检测HMGB1的胞内定位,EdU实验检测细胞的增殖能力,Transwell实验检测细胞的迁移能力。将HGC-27细胞注射于BALB/C裸鼠腋部皮下建立移植瘤模型。乳酸组小鼠隔天腹腔注射乳酸(0.2 g/kg),对照组小鼠隔天腹腔注射等量PBS,连续20 d。ELISA法检测裸鼠内眦静脉血HMGB1含量,免疫共沉淀和Western blot检测肿瘤组织中HMGB1和Akt的磷酸化。结果乳酸作用6和12 h,HMGB1的释放量分别为(2995.00±660.91)pg/ml和(696.33±22.03)pg/ml,均高于对照组[(485.00±105.83)pg/ml,P值分别为<0.001和0.028]。乳酸处理6 h后,HGC-27细胞的细胞质中HMGB1蛋白的相对表达量为1.13±0.09,高于对照组(0.83±0.07,P=0.001),而细胞核中HMGB1的相对表达量为0.79±0.06,低于对照组(1.07±0.06,P=0.007);HMGB1的磷酸化水平达1.41±0.09,高于对照组(0.97±0.10,P=0.031);Akt的磷酸化水平为11.16±0.06,高于对照组(0.91±0.022,P=0.002)。抑制Akt活化后,乳酸诱导的HMGB1磷酸化水平降低,HMGB1核转位明显减少,细胞增殖和迁移能力亦下降。体内实验显示,乳酸组小鼠外周血中HMGB1的含量为(1280.70±389.66)pg/ml,高于对照组[(595.11±44.75)pg/ml,P=0.008],肿瘤组织中HMGB1和Akt的磷酸化水平明显增强。结论乳酸通过激活Akt信号通路增强胃癌细胞中HMGB1的磷酸化,促进HMGB1释放。

关键词：胃肿瘤乳酸高迁移率族蛋白盒1 核转位 Akt

双层波形钢板内填混凝土组合剪力墙稳定性研究

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建筑结构 2019年第6期49卷 43-48,60页

作者：陈明万梦琦王玉生内蒙古科技大学土木工程学院包头014010 浙江中南建设集团钢结构有限公司杭州310000

设计了一个一字形双层波形钢板内填混凝土组合剪力墙试件,并对其进行轴压试验,结果发生伴有局部屈曲的整体失稳破坏。运用ABAQUS有限元软件建立双层波形钢板内填组合剪力墙模型,分析其高宽比、钢板厚度、墙体厚度等参数对组合墙稳定承... 详细信息

设计了一个一字形双层波形钢板内填混凝土组合剪力墙试件,并对其进行轴压试验,结果发生伴有局部屈曲的整体失稳破坏。运用ABAQUS有限元软件建立双层波形钢板内填组合剪力墙模型,分析其高宽比、钢板厚度、墙体厚度等参数对组合墙稳定承载力的影响。研究结果表明:双层波形钢板内填混凝土组合剪力墙具有较高的稳定承载力。当组合墙的高宽比在1.5～3.0范围内时,对其稳定承载力影响较小;当钢板的厚度从3mm增加到4mm时,其稳定承载力提高比较明显。最后拟合出表征双层波形钢板内填混凝土组合剪力墙整体稳定性的φ-λ曲线及公式,可用于实际工程设计。

关键词：双层波形钢板组合剪力墙整体稳定性参数分析

芦荟苷可抑制胃癌细胞的增殖和迁移:基于下调STAT3/HMGB1信号通路

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南方医科大学学报 2023年第5期43卷 702-709页

作者：葛菲万梦琪程振宇陈雪雷陈芊伊戚之琳皖南医学院基础医学院生物化学与分子生物学教研室安徽芜湖241002 皖南医学院活性生物大分子安徽省重点实验室安徽芜湖241002 皖南医学院药学院安徽芜湖241002 皖南医学院临床学院安徽芜湖241002

目的通过体内外实验探讨芦荟苷抑制胃癌细胞增殖和迁移的分子机制。方法胃癌MGC-803细胞分为对照组、不同浓度芦荟苷(100、200和300μg/mL)处理组。CCK-8、EdU和Transwell实验分别检测细胞活力、细胞增殖和迁移能力;RT-qPCR检测HMGB1 m... 详细信息

目的通过体内外实验探讨芦荟苷抑制胃癌细胞增殖和迁移的分子机制。方法胃癌MGC-803细胞分为对照组、不同浓度芦荟苷(100、200和300μg/mL)处理组。CCK-8、EdU和Transwell实验分别检测细胞活力、细胞增殖和迁移能力;RT-qPCR检测HMGB1 mRNA的表达水平;Western blot检测HMGB1,Cyclin B1/E1,E-cadherin,MMP-2/9的表达以及STAT3的磷酸化。JASPAR数据库预测STAT3与HMGB1启动子的结合。MGC-803细胞(2×106/只)注射于BALB/c-Nu小鼠腋下进行皮下植瘤,裸鼠随机分为对照组和芦荟苷组(n=5)。实验组使用芦荟苷50 mg/kg/d腹腔注射,对照组注射等量PBS。每日测量瘤体大小和小鼠质量;提取肿瘤组织蛋白,Western blot检测HMGB1,Cyclin B1/E1,E-cadherin,MMP-2/9和p-STAT3的表达。HE染色检测肝、肺组织中肿瘤转移情况。结果芦荟苷能够浓度依赖性的抑制胃癌细胞活力(P<0.05),不同浓度芦荟苷处理组EdU阳性染色细胞与对照组相比显著减少(P<0.01),芦荟苷处理的胃癌细胞转移能力明显较对照组减弱(P<0.01)。芦荟苷能够浓度依赖性的下调HMGB1 mRNA和蛋白表达(P<0.01),下调Cyclin B1,E1,MMP-2/9,上调E-cadherin,明显抑制p-STAT3。JASPAR数据库预测STAT3能够与HMGB1启动子区域相结合。芦荟苷处理组瘤体大小和质量明显低于对照组(P<0.01)。芦荟苷处理组Cyclin B1/E1,MMP-2/9,HMGB1和p-STAT3的表达与对照组相比明显降低,E-cadherin的表达则显著增强(P<0.01)。结论芦荟苷通过抑制p-STAT3/HMGB1信号途径,抑制胃癌细胞的增殖和迁移。

关键词：芦荟苷高迁移族盒蛋白1 胃癌增殖迁移

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