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Actin polymerization induces mitochondrial distribution during collective cell migration

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Journal of Genetics and Genomics 2023年第1期50卷 46-49页

作者： Chen Qu Yating Kan Hui Zuo mengqi wu Zhixiang Dong Xinyi Wang Qing Zhang Heng Wang Dou Wang Jiong Chen MOE Key Laboratory of Model Animals for Disease Study Model Animal Research CenterJiangsu Key Laboratory of Molecular MedicineMedical School of Nanjing UniversityNanjingJiangsu 210008China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Collective cell migration plays critical roles in various developmental,physiological,and pathological processes such as morphogenesis,wound healing,and tumor metastasis(Friedl and Gilmour,2009).During collective migration,each coherent group of associated cells needs to interpret external directional signal and convert it into a front-back asymmetry across a collective group(Rorth,2011).But the underlying mechanism for the establishment and maintenance of front-back asymmetry during collective migration is still not well understood.

关键词： healing collective wound

Highly insulating phase of Bi_(2)O_(2)Se thin films with high electronic performance

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Nano Research 2023年第2期16卷 3224-3230页

作者： Tao Wang Zhuokai Xu Ziye Zhu mengqi wu Zhefeng Lou Jialu Wang Wanghua Hu Xiaohui Yang Tulai Sun Xiaorui Zheng Wenbin Li Xiao Lin Department of Physics Fudan UniversityShanghai 200433China Key Laboratory for Quantum Materials of Zhejiang Province Department of PhysicsSchool of ScienceWestlake UniversityHangzhou 310024China Key Laboratory of 3D Micro/nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024China Center for Electron Microscopy State Key Laboratory Breeding Base of Green Chemistry Synthesis Technology and College of Chemical EngineeringZhejiang University of TechnologyHangzhou 310014China

Bi_(2)O_(2)Se is highly competitive as a candidate of next-generation high-performance semiconductors.Though dubbed as semiconductor,Bi_(2)O_(2)Se films exhibited high conductance,i.e.,metallic behavior,due to spontaneously ionized defects.Semiconducting/insulating films are of practical importance in broad applications based on low-power,high-performance electronics,the existence of which lacks firm evidence.Here,we synthesized highly insulating films in a controlled way,which exhibit semiconducting behavior with channel resistance up to 1 TΩ.The electron chemical potential lies within the band gap,in some cases,even below the charge neutrality level,signifying the trace of hole-type semiconducting.The performance of insulating devices remains high,comparable to high-quality devices previously.Especially,the threshold voltage(Vth)is positive,contrary to common negative values reported.Calculations indicate that our synthesis conditions suppress electron donors(Se vacancies(VSe))and promote the formation of compensating acceptors(Bi vacancies(VBi)),leading to insulating behaviors.Our work offers insights into electron dynamics of Bi_(2)O_(2)Se,moves one step further towards p-type transistors and provides a valuable playground for engineering ferroelectricity in high-performance semiconductors.

关键词： Bi_(2)O_(2)Se field effect transistor high performance layered semiconductor highly insulating phase in-gap state

How do Chinese medicines that tonify the kidney inhibit dopaminergic neuron apoptosis?

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Neural Regeneration Research 2013年第30期8卷 2820-2826页

作者： Shaogang Lin Shuifen Ye Jinmu Huang Yun Tian Yihui Xu mengqi wu Jingxia Wang Songying wu Jing Cai Hospital of Putian University Academy of Integrative Medicine Fujian University of Traditional Chinese Medicine College of Pharmaceutical Sciences Zhejiang University The Second People’s Hospital of Fujian University of Traditional Chinese Medicine

Wistar rats were intragastrical y perfused with Chinese medicines used for tonifying the kidney. These included 0.180 g/mL of Herba Epimedi （Epimedium）, Semen Cuscutae （Dodder Seed）, or Herba Cistanches （Desertliving Cistanche）, 0.04 mg/mL monoamine oxidase-B inhibitor selegiline, or distil ed water for 14 consecutive days to prepare drug-containing serum or blank serum. MES23.5 cells in the logarithmic phase were cultured in media supplemented with 15%drug-containing serum for 24 hours, fol owed by incubation in culture solution containing 100μmol/L H2O2 for 3 hours. 3-（4,5-Dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide （MTT） and flow tometry results showed that al drug-containing serums improved the survival rate of H 2 O 2-injured MES23.5 cells, inhibited pro-apoptotic FasL and caspase-3 expression, promoted anti-apoptotic Bcl-2 expression. However, drug-containing serums had little influence on Fas expression in H 2 O 2-injured MES23.5 cells. Enzyme-linked immunosorbent assay results showed that serum containing Herba Cistanches or Herba Epimedi increased the expression of nerve growth factor, brain-derived neurotrophic factor, and glial cellline-derived neurotrophic factor in injured MES23.5 cells;serum containing Semen Cuscutae only increased brain-derived neurotrophic factor expres-sion; while expression of the above neurotrophic factors remained the same in cells treated with serum containing selegiline. These findings indicate that Chinese medicines used to tonify the kid-ney can protect nerve cells by regulating the expression of apoptosis-related factors and neuro-trophic factors in MES23.5 cells.

关键词： neural regeneration traditional Chinese medicine drug-containing serum MES23.5 dopaminergicnerve cells neurotrophic factors apoptosis factors Parkinson＇s disease neuroprotection

准噶尔盆地北部含铀矿目的层白垩系岩相学及地球化学特征分析

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江西科学 2024年第2期42卷 297-302页

作者：吴梦绮王清东华理工大学地球科学学院南昌330013

以准噶尔盆地北部乌伦古坳陷含矿目的层红砾山组(K_(2)h)为主要研究对象,通过矿物学、地球化学和沉积环境体系等系统分析。结果表明,含矿目的层红砾山组砂岩主要为岩屑砂岩、岩屑长石砂岩和长石岩屑砂岩,少量落于长石砂岩和长石石英砂岩... 详细信息

以准噶尔盆地北部乌伦古坳陷含矿目的层红砾山组(K_(2)h)为主要研究对象,通过矿物学、地球化学和沉积环境体系等系统分析。结果表明,含矿目的层红砾山组砂岩主要为岩屑砂岩、岩屑长石砂岩和长石岩屑砂岩,少量落于长石砂岩和长石石英砂岩中;红砾山组(K_(2)h)下、中、上段沉积相分别为砾质辫状河沉积、砂质辫状河沉积和曲流河沉积;另外,研究区还原带中全铁含量最高,具较强的还原性,氧化带中发生明显的后生作用致使Fe^(3+)富集。

关键词：岩石学特征地球化学特征红砾山组准噶尔北部

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Macroporous 3D carbon-nitrogen(CN)confined MoO_(x) catalyst for enhanced oxidative desulfurization of dibenzothiophene

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Chinese Chemical Letters 2020年第10期31卷 2819-2824页

作者： Jinmei Ye Jie Wen Dongdong Zhao Peilun Zhang Airong Li Lianhong Zhang Hui Zhang mengqi wu Center for Computational Chemistry and Molecular Simulation College of Chemistry and Chemical EngineeringSouthwest Petroleum UniversityChengdu 610500China Department of Chemical and Biological Engineering Case Western Reserve UniversityClevelandOH 44120United States

Macroporous 3D carbon doped with nitrogen confined Mo catalyst(MoO_(x)@CN)had been prepared by a facile one-step pyrolysis technique using silica as a template and was employed for oxidative desulfurization(ODS)of dibenzothiophene(DBT)in model fuel with H2O_(2) as oxidant.The effect of different ope rating conditions(i.e.,reaction te mperature and time,catalyst dosage,H2O_(2)/DBT(O/S)molar ratio)were also systematic investigated.Under the optimal reaction condition,MoO_(x)@CN catalyst exhibited highly excellent ODS performance toward DBT,the highest sulfur removal efficiency can be up to 99.9%and sulfur content was wiped out from 800 ppm to 10 ppm.Due to the robust 3D structure promoting rapid transfer,in addition to the increased number of active sites induced by the Mo vacancies,the catalyst,prepared using chitosan and ammonium heptamolybdate in a mass ratio of 1:0.5,displayed rapid kinetics and low activation energy in the oxidation of dibenzothiophene.Moreover,it exhibited excellent recyclability after five cycles without any obvious decrease in catalytic activity for the oxidative desulfurization reaction.

关键词： O_(x)idation desulfurization Carbon-nitrogen confined MoO_(x) Mo vacancies Dibenzothiophene Nanoparticles

融合帧间时序关系的标准胎儿四腔心超声切面自动获取

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中国图象图形学报 2024年第3期29卷 782-797页

作者：徐光柱吴梦琦钱奕凡王阳刘蓉周军雷帮军湖北省水电工程智能视觉监测重点实验室(三峡大学) 宜昌443002 三峡大学计算机与信息学院宜昌443002 宜昌市中心人民医院超声科宜昌443003

目的超声医师手动探查与采集胎儿心脏切面图像时,常因频繁的手动暂停与截图操作而错失心脏切面最佳获取时机。而单纯采用深层视觉目标检测或分类网络自动获取切面时,因无法确保网络重点关注切面图像中相对较小的心脏区域的细粒度特征,... 详细信息

目的超声医师手动探查与采集胎儿心脏切面图像时,常因频繁的手动暂停与截图操作而错失心脏切面最佳获取时机。而单纯采用深层视觉目标检测或分类网络自动获取切面时,因无法确保网络重点关注切面图像中相对较小的心脏区域的细粒度特征,导致高误检率;另外,不同的心脏解剖部件的最佳成像时刻也常常不同步。针对上述问题,提出一种目标检测与分类网络相结合,同时融合关键帧间时序关系的标准四腔心(four-chamber,4CH)切面图像自动获取算法。方法首先,利用自行构建的胎儿心脏超声切面数据集训练目标检测网络,实现四腔心区域和降主动脉区域的快速准确定位。接着,当检测到在一定时间窗内的视频帧存在降主动脉区域时,将包含四腔心目标的候选区域提取后送入利用自建的标准四腔心区域图像集训练好的分类网络,进一步分类出标准四腔心区域。最后,通过时序关系确定出可靠的降主动脉区域,将可靠降主动脉的检测置信度及同一时间窗内各个切面图像中四腔心区域在分类模型中的输出,加权计算得到标准四腔心切面图像的得分。结果采用本文构建的数据集训练的YOLOv5x(you only look once version 5 extra large)和Darknet53模型,在四腔心区域和降主动脉区域的检测任务上分别达到94.0%的mAP@0.5和61.1%的mAP@[. 5∶. 95],以及69.5%的recall@0.5-0.95;在四腔心区域标准性分类任务上TOP-1准确率达到92.4%。将检测与分类模块结合后,系统对四腔心区域的误检率降低了29.38%。结论目标检测与分类网络相结合的策略及帧间时序信息的加入能够有效调和错检与漏检间的矛盾,同时大幅降低误检率。另外,所提算法除可自动获取标准的四腔心切面图像外,还可同时给出最佳切面,具有较好的实际应用价值。

关键词：深度学习卷积神经网络(CNN) 目标检测图像分类帧间时序关系

Corrigendum to“Actin polymerization induces mitochondrial distribution during collective cell migration”[Journal of Genetics and Genomics(2023)50 46-49]

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Journal of Genetics and Genomics 2023年第3期50卷 221-221页

作者： Chen Qu Yating Kan Xinyi Wang Hui Zuo mengqi wu Zhixiang Dong Qing Zhang Heng Wang Dou Wang Jiong Chen MOE Key Laboratory of Model Animals for Disease Study Model Animal Research CenterJiangsu Key Laboratory of Molecular MedicineMedical School of Nanjing UniversityNanjingJiangsu 210008China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

This erratum clarifies information in the Letter to the Editor“Actin polymerization induces mitochondrial distribution during collective cell migration”by Qu et al.(2023).In the section for the list of author names,“Chen Qu,Yating Kan,Hui Zuo,mengqi wu,Zhixiang Dong,Xinyi Wang,Qing Zhang,Heng Wang,Dou Wang,Jiong Chen”should be“Chen Qu,Yating Kan,Xinyi Wang,Hui Zuo,mengqi wu,Zhixiang Dong,Qing Zhang,Heng Wang,Dou Wang,Jiong Chen”.

关键词： collective distribution migration

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重叠血迹沉积顺序的形态特征分析

中国法医学杂志 2024年第3期39卷 299-303页

作者：钱尊磊张林迪邬孟奇王昊宇刘兆贾振军中国人民公安大学侦查学院北京100038 刑事科学技术北京市重点实验室北京100038 开封市祥符区公安局物证鉴定室河南开封475100 北京市公安局刑事侦查总队北京100054

目的探究重叠血迹的形态特征,判断血迹的沉积顺序。方法在瓷砖客体上模拟滴落状血迹与血鞋印形成的重叠血迹,分析6组重叠血迹的形态特征差异并筛选有效的指示性特征,统计受试者在经过形态特征指导前后对血迹沉积顺序判断的正确率。结... 详细信息

目的探究重叠血迹的形态特征,判断血迹的沉积顺序。方法在瓷砖客体上模拟滴落状血迹与血鞋印形成的重叠血迹,分析6组重叠血迹的形态特征差异并筛选有效的指示性特征,统计受试者在经过形态特征指导前后对血迹沉积顺序判断的正确率。结果受试者掌握重叠血迹的形态特征后,对沉积顺序判断的正确率由59.5%提升至89.0%,对初始血迹干湿情况判断的正确率由45.6%提升至65.3%。结论基于重叠血迹的形态特征不仅可以有效判断血迹的沉积顺序,还可以判断初始血迹的干湿情况,从而推断血迹沉积的时间间隔,为犯罪现场的分析与重建提供技术支撑。

关键词：法医物证学重叠血迹形态特征沉积顺序

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缅甸进口姜黄无机元素分析研究

中国无机分析化学 2024年第5期14卷 662-669页

作者：李秀林武梦琦梁建平刘汗青陈祖婷杨新周昆明海关技术中心昆明650000 瑞丽海关云南瑞丽678600 德宏州科学技术创新中心云南芒市678400 德宏师范高等专科学校民族医药研究所云南芒市678400

通过测定缅甸进口姜黄中26种无机元素,并对进口姜黄中重金属含量进行风险评价,为缅甸进口姜黄的质量控制奠定基础。采用微波消解-电感耦合等离子体质谱(ICP-MS)法对24批来自缅甸地区的姜黄中的26种无机元素进行测定,通过靶标危害系数(T... 详细信息

通过测定缅甸进口姜黄中26种无机元素,并对进口姜黄中重金属含量进行风险评价,为缅甸进口姜黄的质量控制奠定基础。采用微波消解-电感耦合等离子体质谱(ICP-MS)法对24批来自缅甸地区的姜黄中的26种无机元素进行测定,通过靶标危害系数(THQ)和总危害指数(HI)对Pb、Cd、Cu 3种元素进行非致癌风险评价,用终生致癌风险(R)对As进行致癌风险评价。结果表明,缅甸进口姜黄中含有24种无机元素,其中K、Na、Mg、Ca 4种营养元素含量占24种无机元素的92.39%。缅甸姜黄中均未检出Sn、Hg 2种金属元素,Pb、Cd、As、Cu、Hg 5种重金属元素含量均符合2020版《中国药典》限定值。经过缅甸姜黄中Cu、Pb、Cd 3种重金属元素健康风险评价,THQ和HI均小于1,表明人体通过缅甸姜黄摄入的Cu、Pb、Cd不会对人体造成非致癌伤害。经过对姜黄中As的致癌健康风险评价,致癌风险R为7.72×10-6,低于世界卫生组织建议的致癌风险值(1.00×10-5),通过缅甸姜黄摄入的总As不存在致癌风险。总体而言,缅甸进口姜黄重金属元素保持在较好水平。

关键词： ICP-MS 姜黄无机元素重金属健康风险评价