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基于搅拌摩擦加工技术的镁基复合材料研究进展

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机械工程学报 2024年第8期60卷 48-64页

作者：蹇文轩丛孟启雷卫宁江苏理工学院江苏省先进材料设计与增材制造重点实验室常州213001 江苏理工学院机械工程学院常州213001 江苏理工学院材料工程学院常州213001

镁与镁合金具有密度较小、比强度高和易加工等优点,随着科技水平的不断进步,航空航天等领域对镁合金的性能要求越来越高,镁基复合材料的发展与研究日益受到高度重视。而搅拌摩擦加工技术(Friction stir processing,FSP)由于具有低成本... 详细信息

镁与镁合金具有密度较小、比强度高和易加工等优点,随着科技水平的不断进步,航空航天等领域对镁合金的性能要求越来越高,镁基复合材料的发展与研究日益受到高度重视。而搅拌摩擦加工技术(Friction stir processing,FSP)由于具有低成本、高效率与绿色节能等独特优势,在航空航天与汽车等领域有着广阔的应用前景,已成为复合材料制造领域热门研究之一。近年来国内外研究人员尝试通过搅拌摩擦加工技术对不同类型的增强体与镁合金进行加工从而制备出了许多性能优异的复合材料。目前,主要增强体分为颗粒、纤维、石墨烯等,针对镁基复合材料搅拌摩擦加工的国内外研究进展展开综述,对适用于镁基复合材料的搅拌摩擦加工技术及其基础问题研究、加工工艺对复合材料组织与性能的影响等方面的重要研究成果进行举例和分析,进一步提出了镁基复合材料搅拌摩擦加工技术研究的发展方向,以期为搅拌摩擦技术在镁基材料加工领域的研究和应用发展起到指导作用。

关键词：镁基复合材料搅拌摩擦加工增强体复合增强

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不同路径下电弧增材制造单层多道热力学分析

热加工工艺 2024年第7期53卷 16-22页

作者：吴超雷卫宁李小平丛孟启江苏理工学院机械工程学院江苏常州213100 江苏理工学院材料工程学院江苏常州213100 江苏省先进材料设计与增材制造重点实验室江苏常州213100

在增材制造过程中,金属内部的温度、应力演变对成型件质量有着重要影响。本文对电弧增材制造单层多道成型件进行堆焊实验与有限元分析,研究了单层多道成型件的热力演变规律,及沿长边单向、沿长边往复、沿短边单向扫描路径的温度场和应... 详细信息

在增材制造过程中,金属内部的温度、应力演变对成型件质量有着重要影响。本文对电弧增材制造单层多道成型件进行堆焊实验与有限元分析,研究了单层多道成型件的热力演变规律,及沿长边单向、沿长边往复、沿短边单向扫描路径的温度场和应力场规律。结果表明,熔覆层表面的纵向应力释放能力优异,而横向应力数值相对稳定并在一定区域高于纵向应力;沿长边单向扫描的成型件表面散热效果最好,沿长边往复扫描次之,沿短边单向扫描最低;往复扫描可有效避免单向扫描息弧端处的应力集中,沿短边扫描的纵向应力小于沿长边扫描的,横向应力相反。在进行单层多道路径规划时,应权衡好纵向应力与横向应力的应力释放程度。

关键词：电弧增材制造扫描路径温度场应力场

Molecular mechanisms underlying microglial sensing and phagocytosis in synaptic pruning

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Neural Regeneration Research 2024年第6期19卷 1284-1290页

作者： Anran Huo Jiali Wang Qi Li mengqi Li Yuwan Qi Qiao Yin Weifeng Luo Jijun Shi Qifei cong Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow UniversityInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases Soochow University Department of Neurology and Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow University

Microglia are the main non-neuronal cells in the central nervous system that have important roles in brain development and functional connectivity of neural circuits. In brain physiology, highly dynamic microglial processes are facilitated to sense the surrounding environment and stimuli. Once the brain switches its functional states, microglia are recruited to specific sites to exert their immune functions, including the release of cytokines and phagocytosis of cellular debris. The crosstalk of microglia between neurons, neural stem cells, endothelial cells, oligodendrocytes, and astrocytes contributes to their functions in synapse pruning, neurogenesis, vascularization, myelination, and blood-brain barrier permeability. In this review, we highlight the neuron-derived “find-me,” “eat-me,” and “don’t eat-me” molecular signals that drive microglia in response to changes in neuronal activity for synapse refinement during brain development. This review reveals the molecular mechanism of neuron-microglia interaction in synaptic pruning and presents novel ideas for the synaptic pruning of microglia in disease, thereby providing important clues for discovery of target drugs and development of nervous system disease treatment methods targeting synaptic dysfunction.

关键词： complement immune signals microglia molecular signal synapse elimination synapse formation synapse refinement synaptic pruning

基于响应曲面法的等离子喷涂Ni60CuMo涂层质量优化

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材料导报 2024年第3期38卷 182-187页

作者：楚佳杰韩冰源李仁兴高祥涵丛孟启吴海东徐文文杜伟江苏理工学院汽车与交通工程学院江苏常州213001 陆军装甲兵学院装备再制造技术国防科技重点实验室北京100072

采用表面工程技术对废旧铝合金活塞进行再制造,可有效延长铝合金活塞服役寿命,同时实现资源的节约与环境污染的降低。为此采用等离子喷涂技术在铝合金109(ZL109)表面制备了Ni60CuMo防护涂层,结合Box-Behnken响应曲面法设计实验对涂层质... 详细信息

采用表面工程技术对废旧铝合金活塞进行再制造,可有效延长铝合金活塞服役寿命,同时实现资源的节约与环境污染的降低。为此采用等离子喷涂技术在铝合金109(ZL109)表面制备了Ni60CuMo防护涂层,结合Box-Behnken响应曲面法设计实验对涂层质量进行优化,以孔隙率为响应值,分析了喷涂距离(D)、送粉速率(R)和喷涂功率(P_(1))对涂层孔隙率(P)的影响规律。结果表明:送粉速率对孔隙率的影响最大,在较低的送粉速率、较大的喷涂距离与较小的喷涂功率下涂层孔隙、裂纹更少,涂层质量更优。同时建立的孔隙率响应曲面模型有效,可以用于等离子喷涂Ni60CuMo涂层的质量优化。最低孔隙率的预测参数:喷涂距离D=131.58 mm,送粉速率R=37.01 g·min^(-1)和喷涂功率P 1=31.09 kW,能获得的最小孔隙率为2.5%。

关键词：等离子喷涂镍基涂层孔隙率响应曲面法

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热喷涂制备氧化钛复合涂层研究现状

江苏理工学院学报 2024年第2期30卷 27-40页

作者：吴海东燕玉林崔方方丛孟启高祥涵楚佳杰韩冰源江苏理工学院汽车与交通工程学院江苏常州213001 军事科学院战略评估咨询中心北京100091

氧化钛复合涂层具有优异的耐磨、耐腐蚀性能,常用于关键机械零部件的表面防护。根据国内外相关文献,总结了喷涂工艺和喷涂参数对涂层综合服役性能、力学性能的影响;阐述了氧化钛复合粉体制备方式与涂层质量的关系,分析了氧化钛(TiO_(2)... 详细信息

氧化钛复合涂层具有优异的耐磨、耐腐蚀性能,常用于关键机械零部件的表面防护。根据国内外相关文献,总结了喷涂工艺和喷涂参数对涂层综合服役性能、力学性能的影响;阐述了氧化钛复合粉体制备方式与涂层质量的关系,分析了氧化钛(TiO_(2))与氧化物(Al_(2)O_(3)、Cr_(2)O_(3)、ZrO_(2))、碳(CNT、GN)及碳化物(SiC、WC)等复合后对涂层综合性能提升的影响。得出如下结论:TiO_(2)颗粒在喷涂过程中可以抑制α-Al_(2)O_(3)向γ-Al_(2)O_(3)的转变,从而提升涂层耐磨耐腐蚀性能;TiO_(2)可以细化涂层晶粒使涂层韧性提升,并减少因应力集中而引起的微裂纹;TiO_(2)熔点较低,受热后熔融充分,可以起到封孔作用,从而提升涂层致密性、降低孔隙率。针对氧化钛复合涂层的性能特点,对涂层性能提升的发展方向进行了探讨。

关键词：表面技术等离子喷涂陶瓷涂层氧化钛摩擦磨损

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Structure,ligands,and roles of GPR126/ADGRG6 in the development and diseases

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Genes & Diseases 2024年第1期11卷 294-305页

作者： Qi Li Anran Huo mengqi Li Jiali Wang Qiao Yin Lumiao Chen Xin Chu Yuan Qin Yuwan Qi Yang Li Hengxiang Cui Qifei cong Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases Soochow UniversitySuzhouJiangsu215123China Department of Neurology and Clinical Research Center of Neurological Disease The Second Affliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Department of Nephrology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Department of Emergency Center The Second Affiliated Hospital of Nantong UniversityNantongJiangsu226001China Department of Neurology Huzhou Central HospitalThe Affiliated Huzhou HospitalZhejiang University School of MedicineHuzhouZhejiang 313000China Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China

Adhesion G protein-coupled receptors(aGPCRs)are the second largest diverse group within the GPCR superfamily,which play critical roles in many physiological and patho-logical processes through cell-cell and cell-extracellular matrix interactions.The adhesion GPCR Adgrg6,also known as GPR126,is one of the better-characterized aGPCRs.GPR126 was previously found to have critical developmental roles in Schwann cell maturation and its mediated myelination in the peripheral nervous system in both zebrafish and mammals.Current studies have extended our understanding of GPR126-mediated roles during develop-ment and in human diseases.In this review,we highlighted these recent advances in GPR126 in expression profile,molecular structure,ligand-receptor interactions,and associated physiological and pathological functions in development and diseases.

关键词： Adhesion G protein-coupled receptor Function GPR126/Adgrg6 Ligand Structure

Reliability of a Multicomponent Stress-strength Model Based on a Bivariate Kumaraswamy Distribution with Censored Data

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 478-507页

作者： cong-hua CHENG School of Mathematics and Statistics Zhaoqing UniversityZhaoqing 526061China

In this paper,we consider a system which has k statistically independent and identically distributed strength components and each component is constructed by a pair of statistically dependent elements with doubly type-II censored scheme.These elements(X1,Y1),(X2,Y2),…,(Xk,Yk)follow a bivariate Kumaraswamy distribution and each element is exposed to a common random stress T which follows a Kumaraswamy distribution.The system is regarded as operating only if at least s out of k(1≤s≤k)strength variables exceed the random stress.The multicomponent reliability of the system is given by Rs,k=P(at least s of the(Z1,…,Zk)exceed T)where Zi=min(Xi,Yi),i=1,…,k.The Bayes estimates of Rs,k have been developed by using the Markov Chain Monte Carlo methods due to the lack of explicit forms.The uniformly minimum variance unbiased and exact Bayes estimates of Rs,k are obtained analytically when the common second shape parameter is known.The asymptotic confidence interval and the highest probability density credible interval are constructed for Rs,k.The reliability estimators are compared by using the estimated risks through Monte Carlo simulations.

关键词： stress-strength model bivariate Kumaraswamy distribution multicomponent reliability doubly Type-II censored scheme interval estimation

Microglia in drug addiction:A perspective from neuroimmunopharmacology

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Zoological Research 2024年第3期45卷 704-706页

作者： cong Lin Xiaohui Wang Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunJilin 130022China Beijing National Laboratory for Molecular Sciences Beijing 100190China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefeiAnhui 230026China

Drug addiction refers to a state of dependence that arises from habitual drug intake and can result in specific withdrawal symptoms upon cessation.The most commonly abused substances include psychostimulants,cannabinoids,and opioids.When drugs are consumed,they stimulate the release of dopamine,a neurotransmitter crucial for the pleasure and reward centers of the brain.With repeated drug use,the brain undergoes various changes,leading to tolerance,dependence,and addiction(Lüscher et al.,2020).The mechanisms involved in drug addiction are highly complex and involve diverse cell types within the brain.

关键词： addiction drugs intake

Recent advances in the study of epitopes,allergens and immunologic cross-reactivity of edible mango

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Food Science and Human Wellness 2024年第3期13卷 1186-1194页

作者： Honglei Guo Yanjun cong Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Food and HealthBeijing Technology and Business UniversityBeijing 100048China

Mango(Mangifera indica L.)is a tropical fruit that is widely consumed as both fresh fruits and processed products around the world.The high incidence of mango allergy,on the other hand,has sparked widespread concern.Therefore,a summary and analysis of the current status and issues in mango allergen research can guide in-depth study on the mechanism of mango allergy and reveal effective desensitization methods.We described the incidence of fruit allergy,as well as the mechanism and clinical symptoms of mango allergy,in this review.We also looked into the structural properties of mango allergens,the effect of processing methods on mango allergens,prediction methods for mango allergen epitopes,and the current state of research on mango cross-reactive allergens and preventive measures.Finally,the research directions and ideas for the future are proposed and discussed.

关键词： Mango Allergen Epitope Immunocross-reactivity Prospects