检索结果-南通市图书馆

Timp1 Deletion Induces Anxiety-like Behavior in Mice

Neuroscience Bulletin 2024年第6期40卷 732-742页

作者： Xiaotong Wang wei Zheng Ziyi Zhu Biyu Xing weijie Yan Ke Zhu Lingli Xiao Chaojuan Yang mengping wei Lei Yang Zi-Bing Jin Xueyun Bi Chen Zhang State Key Laboratory of Neurology and Oncology Drug Development Nanjing210000China School of Basic Medical Sciences Wenzhou Medical UniversityWenzhou325035China School of Basic Medical Sciences Beijing Key Laboratory of Neural Regeneration and RepairAdvanced Innovation Center for Human Brain ProtectionBeijing Laboratory of Oral HealthCapital Medical UniversityBeijing100069China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing100005China Chinese Institute for Brain Research Beijing102206China Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing100191China

The hippocampus is essential for learning and memory,but it also plays an important role in regulating emotional behavior,as hippocampal excitability and plasticity affect anxiety and *** synaptic plasticity may be regulated by tissue inhibitor of matrix metalloproteinase 1(TIMP1),a known protein inhibitor of extracellular matrix(ECM),and the expression of TIMP1 in the hippocampus can be induced by neuronal excitation and various ***,the involvement of Timp1 in fear learning,anxiety,and hippocampal synaptic function remains to be *** study of Timp1 function in vivo revealed that Timp1 knockout mice exhibit anxiety-like behavior but normal fear *** results suggested that Timp1 knockout mice showed hyperactivity in the ventral CA1 region,but the basic synaptic transmission and plasticity were normal in the Schaffer collateral *** together,our results suggest that deletion of Timp1 in vivo leads to the occurrence of anxiety behaviors,but that Timp1 is not crucial for fear learning.

关键词： Timp1 Anxiety Fear Synaptic transmission Synaptic plasticity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Noninvasive Tracking of Every Individual in Unmarked Mouse Groups Using Multi-Camera Fusion and Deep Learning

引用

Neuroscience Bulletin 2023年第6期39卷 893-910页

作者： Feng Su Yangzhen Wang mengping wei Chong Wang Shaoli Wang Lei Yang Jianmin Li Peijiang Yuan Dong-Gen Luo Chen Zhang Department of Neurobiology School of Basic Medical SciencesBeijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijing100069China Chinese Institute for Brain Research Beijing102206China State Key Laboratory of Translational Medicine and Innovative Drug Development Nanjing210000China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing100871China School of Life Sciences Tsinghua UniversityBeijing100084China School of Biological Science and Medical Engineering Beihang UniversityBeijing100191China The Key Laboratory of Developmental Genes and Human Disease Institute of Life SciencesSoutheast UniversityNanjing210096JiangsuChina Institute for Artificial Intelligence the State Key Laboratory of Intelligence Technology and SystemsBeijing National Research Center for Information Science and TechnologyDepartment of Computer Science and TechnologyTsinghua UniversityBeijing100084China School of Mechanical Engineering and Automation Beihang UniversityBeijing100191China

Accurate and efficient methods for identifying and tracking each animal in a group are needed to study complex behaviors and social *** tracking methods(e.g.,marking each animal with dye or surgically implanting microchips)can be invasive and may have an impact on the social behavior being *** overcome these shortcomings,video-based methods for tracking unmarked animals,such as fruit flies and zebrafish,have been ***,tracking individual mice in a group remains a challenging problem because of their flexible body and complicated interaction *** this study,we report the development of a multi-object tracker for mice that uses the Faster region-based convolutional neural network(R-CNN)deep learning algorithm with geometric transformations in combination with multi-camera/multi-image fusion *** system successfully tracked every individual in groups of unmarked mice and was applied to investigate chasing *** proposed system constitutes a step forward in the noninvasive tracking of individual mice engaged in social behavior.

关键词： Noninvasive tracking Deep learning Multi-camera Mouse group Social interaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The complex genetics in autism spectrum disorders

引用

中国科学：生命科学英文版 2015年第10期58卷 933-945页

作者： HUA Rui wei mengping ZHANG Chen State Key Laboratory of Membrane Biology School of Life Sciences PKU-IDG/Mc Govern Institute for Brain Research Peking University

Autism spectrum disorders(ASD) are a pervasive neurodevelopmental disease characterized by deficits in social interaction and nonverbal communication, as well as restricted interests and stereotypical behavior. Genetic changes/heritability is one of the major contributing factors, and hundreds to thousands of causative and susceptible genes, copy number variants(CNVs), linkage regions, and micro RNAs have been associated with ASD which clearly indicates that ASD is a complex genetic disorder. Here, we will briefly summarize some of the high-confidence genetic changes in ASD and their possible roles in their pathogenesis.

关键词：遗传变化谱系 microRNA 孤独 ASD 神经疾病易感基因遗传疾病

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

核苷(酸)类似物抗病毒治疗对乙型肝炎病毒相关肝细胞癌患者临床特征及预后的影响

引用

中华传染病杂志 2023年第2期41卷 144-151页

作者：魏梦平马路园苏佩华赵彩彦河北医科大学第三医院感染科石家庄050051

目的分析采用核苷(酸)类似物(NAs)抗病毒治疗对乙型肝炎病毒(HBV)相关肝细胞癌(HCC)患者临床特征及预后的影响。方法回顾性分析2015年1月至2021年1月在河北医科大学第三医院首次确诊的450例HBV相关HCC患者的病历资料,其中持续NAs治疗组... 详细信息

目的分析采用核苷(酸)类似物(NAs)抗病毒治疗对乙型肝炎病毒(HBV)相关肝细胞癌(HCC)患者临床特征及预后的影响。方法回顾性分析2015年1月至2021年1月在河北医科大学第三医院首次确诊的450例HBV相关HCC患者的病历资料,其中持续NAs治疗组193例,HCC后NAs治疗组257例,采用倾向评分匹配均衡两组的基线资料。采用Kaplan-Meier法计算两组无复发生存率,采用Cox比例风险回归模型分析HCC复发的危险因素,采用Spearman相关性分析探究持续NAs治疗组患者HCC临床特征与HBV DNA载量的关系。结果匹配前,持续NAs治疗组中有肝硬化、体重指数≥25.0 kg/m2、单发肿瘤、肿瘤最大径≤5 cm、Child-Pugh分级A级、中国肝癌分期方案Ⅰ期的比例分别为93.8%(181/193)、45.1%(87/193)、70.5%(136/193)、82.4%(159/193)、74.6%(144/193)、74.6%(144/193),分别高于HCC后NAs治疗组的87.5%(225/257)、44.0%(113/257)、61.1%(157/257)、55.3%(142/257)、63.8%(164/257)、56.0%(144/257);持续NAs治疗组有饮酒史、发生门静脉癌栓的比例分别为12.4%(24/193)和3.1%(6/193),分别低于HCC后NAs治疗组的33.9%(87/257)和10.5%(27/257);差异均有统计学意义(χ^(2)=4.86、7.58、4.27、36.63、8.15、21.05、27.21、8.88,均P<0.05)。匹配后,持续NAs治疗组和HCC后NAs治疗组患者的中位无复发生存期分别为388 d和277 d,5年累积无复发生存率分别为50.0%和37.5%,差异有统计学意义(χ^(2)=5.30,P=0.021)。多因素分析显示,HCC前未行抗病毒治疗、多发肿瘤、肿瘤最大径≥5 cm、姑息治疗是影响HBV相关HCC复发的独立危险因素(风险比为1.509、1.491、0.446、1.472,均P<0.05)。匹配后,持续NAs治疗组的肿瘤最大径(r=0.175,P=0.042)、发生门静脉癌栓(r=0.210,P=0.014)、HBV相关HCC复发(r=0.178,P=0.038)与HBV DNA载量均呈正相关。结论尽早启动NAs抗病毒治疗能一定程度上改善患者进展至HBV相关HCC的肿瘤学特征,提高无复发生存率,而确诊HCC前未行抗病毒治疗、多发肿瘤、肿瘤最大径≥5 cm、姑息治疗则是影响HBV相关HCC复发的独立危险因素。

关键词：核苷(酸)类似物癌,肝细胞预后

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于树种谱系的林木种间竞争分析

引用

森林与环境学报 2024年第4期44卷 414-422页

作者：姜鹏博窦啸文韦新良罗海豪汤孟平省部共建亚热带森林培育国家重点实验室浙江杭州311300 浙江农林大学环境与资源学院、碳中和学院浙江杭州311300

为探究针阔混交林中竞争木与对象木的亲缘性对林木种间竞争的影响,以浙江省天目山国家级自然保护区的针阔混交林为研究对象,将树种谱系引入Hegyi竞争指数,构建树种谱系竞争指数(G_Hegyi竞争指数)。对Hegyi种间竞争指数、G_Hegyi种间竞... 详细信息

为探究针阔混交林中竞争木与对象木的亲缘性对林木种间竞争的影响,以浙江省天目山国家级自然保护区的针阔混交林为研究对象,将树种谱系引入Hegyi竞争指数,构建树种谱系竞争指数(G_Hegyi竞争指数)。对Hegyi种间竞争指数、G_Hegyi种间竞争指数与胸径的相关性,胸高断面积生长量、胸高断面积生长率与Hegyi种间竞争指数、G_Hegyi种间竞争指数的相关性进行比较分析。同时,对Hegyi种间竞争指数比值、G_Hegyi种间竞争指数比值与林木生长之间的关系进行对比研究。结果表明:两种种间竞争指数与胸径均表现为极显著负相关(P<0.01),均呈幂函数关系;胸高断面积生长量与两种种间竞争指数均表现为极显著负相关,且均符合对数函数关系。胸高断面积生长率与两种种间竞争指数均为极显著正相关,均服从幂函数分布。G_Hegyi种间竞争指数与胸径的决定系数(R^(2))、相关系数的绝对值及胸高断面积生长量、胸高断面积生长率与G_Hegyi种间竞争指数的R2、相关系数的绝对值均大于Hegyi种间竞争指数。G_Hegyi种间竞争指数比值较Hegyi种间竞争指数比值更能准确地反映林木生长与种间竞争的关系。G_Hegyi种间竞争指数在分析林木种间竞争方面优于Hegyi种间竞争指数,更适用于林木生长的相关研究。

关键词：树种谱系 Hegyi竞争指数 G_Hegyi竞争指数种间竞争针阔混交林

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

玉米地植保无人机施药对草地贪夜蛾的防治效果研究

引用

陕西农业科学 2023年第8期69卷 73-77页

作者：潘丽香覃帅韦华艳韦孟萍韦建赳兰加永河池市金城江区农业农村局广西河池547000 河池市发展和改革委员会广西河池547000

为探究防治草地贪夜蛾的有效方法,本次研究以河池市金城江区虫害玉米地为研究对象,使用喷施甲氨基阿维菌素苯甲酸盐微乳剂以及甲氨基阿维菌素苯甲酸盐-金龟子绿僵菌CQMa421混合药剂两种药剂、无人机和人工背负式喷施两种施药方式进行试... 详细信息

为探究防治草地贪夜蛾的有效方法,本次研究以河池市金城江区虫害玉米地为研究对象,使用喷施甲氨基阿维菌素苯甲酸盐微乳剂以及甲氨基阿维菌素苯甲酸盐-金龟子绿僵菌CQMa421混合药剂两种药剂、无人机和人工背负式喷施两种施药方式进行试验。结果表明,人工喷施见效较快,但在喷施10 d后人工和无人机喷药的防治效果均高于94%,且没有显著性差异,无人机喷药成本远低于人工成本;喷施混合药剂的防治效果略高于只喷施甲氨基阿维菌素苯甲酸盐微乳剂。推荐生产实践中采用无人机喷施混合药剂的方式防治玉米地草地贪夜蛾。

关键词：草地贪夜蛾玉米无人机农药防治效果

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mechanism and effect of stress granule formation in cancer and its potential roles in breast cancer therapy

引用

Genes & Diseases 2022年第3期9卷 659-667页

作者： Taobo Hu wei Hou Enhua Xiao mengping Long Department of Breast Surgery Peking University People’s HospitalBeijing 100044PR China Department of Pathology Peking University Cancer HospitalBeijing 100142PR China Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011PR China

Stress granules are non-membranous cytoplasmic foci induced by various stress *** is a protective strategy used by cells to suppress overall translation during *** cancer cells,it was thought that the formation of stress granules could protect them from apoptosis and induces resistance towards anti-cancer drugs or radiation treatment which makes the stress granules a potential target for cancer ***,most of our understanding of stress granules are still in the stage of molecular and cell biology,and a transitional gap for its actual effect on clinical settings *** this review,we summarize the mechanism and effect of stress granules formation in cancer and try to illuminate its potential applications in cancer therapy,using breast cancer as an example.

关键词： Apoptosis Breast cancer Drug resistance Stress granules Translation initiation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Alpha/beta-hydrolase domain-containing 6（ABHD6） negatively regulates the surface delivery and synaptic function of AMPA receptors

Alpha/beta-hydrolase domain-containing 6（ABHD6） negatively...

引用

中国神经科学学会第十二届全国学术会议

作者： mengping wei Jian Zhang Moye Jia Chaojuan Yang Yunlong Pan Shuaiqi Li Yiwen Luo Junyuan Zheng Jianguo Ji Jianguo Chen Xinli Hu Jingwei Xiong Yun Shi Chen Zhang State Key Laboratory of Membrane Biology School of Life Sciences Peking University–IDG/McGovern Institute for Brain Research Peking University Institute of Molecular Medicine Peking University MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center of Nanjing University

In the brain, a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid（AMPA）-type glutamate receptors are major postsynaptic receptors at excitatory synapses that mediate fast neurotransmission and synaptic plasticity. α/β-Hydrolase domain containing 6（ABHD6）, a monoacylglycerol lipase, was previously found to be a component of AMPA receptor macromolecular complexes, but its physiological significance in the function of AMPA receptors（AMPARs） has remained unclear. The present study showed that overexpression of ABHD6 in neurons drastically reduced excitatory neurotransmission mediated by AMPA but not by N-methyl-D-aspartate receptors（NMDARs） at excitatory synapses. Inactivation of ABHD6 expression in neurons by either CRISPR/Cas9 or sh RNA knockdown methods significantly increased excitatory neurotransmission at excitatory synapses. Interestingly, overexpression of ABHD6 reduced glutamate-induced currents and the surface expression of Glu A1 in HEK293 T cells expressing Glu A1 and stargazin, suggesting a direct functional interaction between these two proteins. The C-terminal tail of Glu A1 was required for the binding between of ABHD6 and Glu A1. Mutagenesis analysis revealed a GFCLIPQ sequence in the GluA1C-terminus that was essential for the inhibitory effect of ABHD6. The hydrolase activity of ABHD6 was not required for the effects of ABHD6 on AMPAR function in either neurons or transfected HEK293 T cells. Thus, these findings reveal a novel and expected mechanism governing AMPAR trafficking at synapses through ABHD6.

关键词： ABHD6 AMPA receptor synapses receptor trafficking

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Alpha/beta-hydrolase domain-containing 6（ABHD6） negatively regulates the surface delivery and synaptic function of AMPA receptors

Alpha/beta-hydrolase domain-containing 6（ABHD6） negatively...

引用

第九届海内外华人神经科学家研讨会

作者： mengping wei Jian Zhang Moye Jia Chaojuan Yang Yunlong Pan Shuaiqi Li Yiwen Luo Junyuan Zheng Jianguo Ji Jianguo Chen Xinli Hu Jingwei Xiong Yun Shi Chen Zhang State Key Laboratory of Membrane Biology School of Life Sciences Institute of Molecular Medicine Peking University cMOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center of Nanjing University

In the brain, a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid（AMPA）-type glutamate receptors are major postsynaptic receptors at excitatory synapses that mediate fast neurotransmission and synaptic plasticity. α/β-Hydrolase domain containing 6（ABHD6）, a monoacylglycerol lipase, was previously found to be a component of AMPA receptor macromolecular complexes, but its physiological significance in the function of AMPA receptors（AMPARs） has remained unclear. The present study showed that overexpression of ABHD6 in neurons drastically reduced excitatory neurotransmission mediated by AMPA but not by N-methylD-aspartate receptors（NMDARs） at excitatory synapses. Inactivation of ABHD6 expression in neurons by either CRISPR/Cas9 or sh RNA knockdown methods significantly increased excitatory neurotransmission at excitatory synapses. Interestingly, overexpression of ABHD6 reduced glutamate-induced currents and the surface expression of GluA1 in HEK293 T cells expressing GluA1 and stargazin, suggesting a direct functional interaction between these two proteins. The Cterminal tail of GluA1 was required for the binding between of ABHD6 and GluA1. Mutagenesis analysis revealed a GFCLIPQ sequence in the Glu A1 C-terminus that was essential for the inhibitory effect of ABHD6. The hydrolase activity of ABHD6 was not required for the effects of ABHD6 on AMPAR function in either neurons or transfected HEK293 T cells. Thus, these findings reveal a novel and expected mechanism governing AMPAR trafficking at synapses through ABHD6.

关键词： ABHD6 AMPA receptor synapses receptor trafficking

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

社区老年人多维度衰弱现状及影响因素研究

引用

中国老年保健医学 2024年第2期22卷 76-80页

作者：赵薇戴梦萍郜司蓉梅佳孙秀娜承德医学院 067000

目的调查社区老年人衰弱的现状,并分析其影响因素。方法2023年6月至9月采用便利抽样法抽取742名社区老年人作为调查对象。基于整合概念模型,采用一般资料量表、老年衰弱筛查量表、肌少症筛查量表、口腔健康评估量表、口腔健康自我效能... 详细信息

目的调查社区老年人衰弱的现状,并分析其影响因素。方法2023年6月至9月采用便利抽样法抽取742名社区老年人作为调查对象。基于整合概念模型,采用一般资料量表、老年衰弱筛查量表、肌少症筛查量表、口腔健康评估量表、口腔健康自我效能量表对调查对象进行问卷调查,明确社区老年人多维度衰弱现状,并对社区老年人多维度衰弱的影响因素进行相关性分析。结果社区老年人多维度衰弱发生率为16.3%。年龄、性别、文化程度、职业、个人收入、婚姻状况、患慢性病个数、肌少症状况、口腔健康评分是社区老年人衰弱的影响因素(P<0.05)。结论社区老年人多维度衰弱发生率较高,高龄、男性、文化程度低、职业收入低、婚姻状况不佳、有肌少症状况、慢性病共病、口腔健康情况差的老年人发生衰弱的风险较高。护理人员应定期检查社区老年人的健康状况,及时发现潜在衰弱人群,并针对老年人的不同特征,提供个体化、综合性的健康保健指导,以预防或延缓衰弱的发生和发展。

关键词：整合概念模型社区老年人多维度衰弱影响因素

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：