检索结果-南通市图书馆

Forest Ecosystems 2024年第2期11卷 247-254页

作者： mengping jian.jingyi yang College of Forestry Guizhou UniversityGuiyang550025China

Background:With the expansion of urban areas,the remnants of forested areas play a crucial role in preserving biodiversity in urban *** study aimed to explore the impact of spatiotemporal urban expansion on the networks of leaf traits in woody plants within remnant forest patches,thereby enhancing our understanding of plant adaptive strategies and contributing to the conservation of urban ***:Our study examined woody plants within 120 sample plots across 15 remnant forest patches in Guiyang,*** constructed leaf trait networks (LTNs) based on 26 anatomical,structural,and compositional leaf traits and assessed the effects of the spatiotemporal dynamics of urban expansion on these *** and conclusions:Our results indicate that shrubs within these patches have greater average path lengths and diameters than *** increasing urban expansion intensity,we observed a rise in the edge density of the ***,modularity within the networks of shrubs decreased as road density and urban expansion intensity increased,and increases in the average path length and average clustering coefficient for shrubs were observed with a rise in the composite terrain complexity ***,patches subjected to‘leapfrog’expansion exhibited greater average patch length and diameter than those experiencing edge *** traits were found to have high degree centrality within these networks,signifying their substantial contribution to multiple *** urban remnant forests,shrubs bolster their resilience to variable environmental pressures by augmenting the complexity of their leaf trait networks.

关键词： Urban remnant forest patch Woody plant Leaf trait network Plant adaptation strategy Spatiotemporal urban expansion

Efficacy and safety of single microneedle radiofrequency *** therapy on moderate-to-severe acne vulgaris:A prospective,randomized,controlled study

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第8期137卷 1006-1008页

作者： Chuchu Huang mengping Mao Yiran Peng Ben Wang Yuxuan Deng Hongfu Xie Dan jian Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Dermatology and Allergy and Christine Kühne-Center for Allergy Research and EducationUniversity Hospital of BonnD-53127BonnGermany

To the Editor:Acne vulgaris is a prevalent skin disorder affecting both physical and psychosocial health.[1]Although photodynamic therapy(PDT)exists for moderate-to-severe acne,due to its adverse reactions,we are still looking forward to a novel therapeutic option with fewer side ***,radiofrequency has been used to treat moderate acne.[2]In this study,we aimed to evaluate the efcacy and safety of moderate-to-severe acne treatment based on a single microneedle with radiofrequency(MRF)*** during three consecutive sessions through a prospective,randomized,and controlled trial study.

关键词： needle prospective randomized

Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2022年第3期16卷 442-458页

作者： mengping Xi Shanshan Guo Caicike Bayin Lijun peng Florent Chuffart Ekaterina Bourova-Flin Sophie Rousseaux Saadi Khochbin jian-Qing Mi Jin Wang Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Pôle de Recherches Sino-Français en Science du Vivant et Génomique Shanghai 200025China CNRS UMR 5309/INSERM U1209/UniversitéGrenoble Alpes/Institute for Advanced Biosciences 38706 La TroncheFrance

T-cell acute lymphoblastic leukemia(T-ALL)is one of the most dangerous hematological malignancies,with high tumor heterogeneity and poor *** than 60%of T-ALL patients carry NOTCH1 gene mutations,leading to abnormal expression of downstream target genes and aberrant activation of various signaling *** found that chidamide,an HDAC inhibitor,exerts an antitumor effect on T-ALL cell lines and primary cells including an anti-NOTCH1 *** particular,chidamide inhibits the NOTCH1-MYC signaling axis by down-regulating the level of the intracellular form of NOTCH1(NICD1)as well as MYC,partly through their ubiquitination and degradation by the proteasome *** also report here the preliminary results of our clinical trial supporting that a treatment by chidamide reduces minimal residual disease(MRD)in patients and is well *** results highlight the effectiveness and safety of chidamide in the treatment of T-ALL patients,including those with NOTCH1 mutations and open the way to a new therapeutic strategy for these patients.

关键词： T-cell acute lymphoblastic leukemia HDAC inhibitor chidamide NOTCH1 MYC ubiquitination

Alpha/beta-hydrolase domain-containing 6（ABHD6） negatively regulates the surface delivery and synaptic function of AMPA receptors

在线全文

学校读者我要写书评

暂无评论

Alpha/beta-hydrolase domain-containing 6（ABHD6） negatively...

中国神经科学学会第十二届全国学术会议

作者： mengping Wei jian Zhang Moye Jia Chaojuan yang Yunlong Pan Shuaiqi Li Yiwen Luo Junyuan Zheng jianguo Ji jianguo Chen Xinli Hu Jingwei Xiong Yun Shi Chen Zhang State Key Laboratory of Membrane Biology School of Life Sciences Peking University–IDG/McGovern Institute for Brain Research Peking University Institute of Molecular Medicine Peking University MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center of Nanjing University

In the brain, a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid（AMPA）-type glutamate receptors are major postsynaptic receptors at excitatory synapses that mediate fast neurotransmission and synaptic plasticity. α/β-Hydrolase domain containing 6（ABHD6）, a monoacylglycerol lipase, was previously found to be a component of AMPA receptor macromolecular complexes, but its physiological significance in the function of AMPA receptors（AMPARs） has remained unclear. The present study showed that overexpression of ABHD6 in neurons drastically reduced excitatory neurotransmission mediated by AMPA but not by N-methyl-D-aspartate receptors（NMDARs） at excitatory synapses. Inactivation of ABHD6 expression in neurons by either CRISPR/Cas9 or sh RNA knockdown methods significantly increased excitatory neurotransmission at excitatory synapses. Interestingly, overexpression of ABHD6 reduced glutamate-induced currents and the surface expression of Glu A1 in HEK293 T cells expressing Glu A1 and stargazin, suggesting a direct functional interaction between these two proteins. The C-terminal tail of Glu A1 was required for the binding between of ABHD6 and Glu A1. Mutagenesis analysis revealed a GFCLIPQ sequence in the GluA1C-terminus that was essential for the inhibitory effect of ABHD6. The hydrolase activity of ABHD6 was not required for the effects of ABHD6 on AMPAR function in either neurons or transfected HEK293 T cells. Thus, these findings reveal a novel and expected mechanism governing AMPAR trafficking at synapses through ABHD6.

关键词： ABHD6 AMPA receptor synapses receptor trafficking

Alpha/beta-hydrolase domain-containing 6（ABHD6） negatively regulates the surface delivery and synaptic function of AMPA receptors

在线全文

cnki会议

学校读者我要写书评

暂无评论

Alpha/beta-hydrolase domain-containing 6（ABHD6） negatively...

第九届海内外华人神经科学家研讨会

作者： mengping Wei jian Zhang Moye Jia Chaojuan yang Yunlong Pan Shuaiqi Li Yiwen Luo Junyuan Zheng jianguo Ji jianguo Chen Xinli Hu Jingwei Xiong Yun Shi Chen Zhang State Key Laboratory of Membrane Biology School of Life Sciences Institute of Molecular Medicine Peking University cMOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center of Nanjing University

In the brain, a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid（AMPA）-type glutamate receptors are major postsynaptic receptors at excitatory synapses that mediate fast neurotransmission and synaptic plasticity. α/β-Hydrolase domain containing 6（ABHD6）, a monoacylglycerol lipase, was previously found to be a component of AMPA receptor macromolecular complexes, but its physiological significance in the function of AMPA receptors（AMPARs） has remained unclear. The present study showed that overexpression of ABHD6 in neurons drastically reduced excitatory neurotransmission mediated by AMPA but not by N-methylD-aspartate receptors（NMDARs） at excitatory synapses. Inactivation of ABHD6 expression in neurons by either CRISPR/Cas9 or sh RNA knockdown methods significantly increased excitatory neurotransmission at excitatory synapses. Interestingly, overexpression of ABHD6 reduced glutamate-induced currents and the surface expression of GluA1 in HEK293 T cells expressing GluA1 and stargazin, suggesting a direct functional interaction between these two proteins. The Cterminal tail of GluA1 was required for the binding between of ABHD6 and GluA1. Mutagenesis analysis revealed a GFCLIPQ sequence in the Glu A1 C-terminus that was essential for the inhibitory effect of ABHD6. The hydrolase activity of ABHD6 was not required for the effects of ABHD6 on AMPAR function in either neurons or transfected HEK293 T cells. Thus, these findings reveal a novel and expected mechanism governing AMPAR trafficking at synapses through ABHD6.

关键词： ABHD6 AMPA receptor synapses receptor trafficking

应用生物信息学分析正常女性不同乳腺密度差异表达基因

在线全文

cnki会议

学校读者我要写书评

暂无评论

南京医科大学学报（自然科学版） 2021年第12期41卷 1747-1752,1773页

作者：徐文秀蒋梦萍王丹丹张建吴旸张薇唐金海南京医科大学第一附属医院普外科江苏南京210029

目的:应用生物信息学技术筛选高乳腺密度和低乳腺密度的正常女性的差异基因并分析其富集通路,为致密型乳腺女性乳腺癌早期诊断、靶向治疗和预后评估提供理论依据。方法:从GEO数据库获取GSE38506数据集,使用GEO2R筛选差异表达基因。使用D... 详细信息

目的:应用生物信息学技术筛选高乳腺密度和低乳腺密度的正常女性的差异基因并分析其富集通路,为致密型乳腺女性乳腺癌早期诊断、靶向治疗和预后评估提供理论依据。方法:从GEO数据库获取GSE38506数据集,使用GEO2R筛选差异表达基因。使用DAVID数据库进行GO、KEGG富集分析,并应用STRING及Cytoscape软件的CytoHubba插件进行蛋白相互作用网络分析,筛选出Hub基因。最后使用bc GenExMiner在线工具对这5个Hub基因进行预后分析。结果:从GSE38506基因芯片共筛选出830个显著差异表达基因,其中上调基因442个,下调基因388个。富集分析显示,差异表达基因主要涉及信号转导、GTP酶活性的正调控、固有免疫反应、细胞黏附、细胞质膜、细胞表面、细胞连接、ATP结合、肌动蛋白结合、转录因子结合等。共筛选出2个核心模块和5个Hub基因,包括EGFR、JUN、CDC42、SRC、RAC1,并且它们都与乳腺癌预后相关。结论:通过生物信息学筛选出了正常女性乳腺密度相关的5个核心基因,可能对乳腺癌的发生发展和预后存在一定影响,是潜在的致密型乳腺女性易患乳腺癌的分子学标志物和靶向治疗新位点。

关键词：乳房钼靶密度差异表达基因富集分析蛋白质互相作用网络 Hub基因

Prospetive study of Thalidomide maintenance therapy in high-risk diffuse large B-cell lymphoma

在线全文

学校读者我要写书评

暂无评论

Prospetive study of Thalidomide maintenance therapy in high-...

第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议

作者： Xiaojie Fang Xiaoting Lin He Huang Huangming Hong Chaoyong Liang Chengcheng Guo Ying Tian Tingzhi Liu mengping Zhang Xiaohong Fu Zhao Wang Xueying Li Shanshan Li jian Xiao Yabing Cao Tongyu Lin Sun Yat-sen university Cancer center

＜正＞Objective Patients with high-risk diffuse large B-Cell lymphoma（DLBCL）have a unfavourable clinical outcome even treated with *** inhibits angiogenesis and exerts complex immunomodulatory *** study aimed to exp...

关键词：

在线全文

cnki会议

学校读者我要写书评

暂无评论

煤矿湿润剂抑尘影响因素分析

现代矿业 2011年第3期27卷 40-43页

作者：谷孟平田冬梅姚建河北省安全生产监督管理局华北科技学院

通过室内实验选取了非离子型湿润剂和阴离子湿润剂进行复配,针对不同的变质程度煤样与除尘效率,湿润剂水溶液浓度与湿润时间的关系进行研究。实验表明非离子型湿润剂、阴离子湿润剂水溶液浓度为20%～40%最佳;同一种湿润剂随着煤的变质... 详细信息

通过室内实验选取了非离子型湿润剂和阴离子湿润剂进行复配,针对不同的变质程度煤样与除尘效率,湿润剂水溶液浓度与湿润时间的关系进行研究。实验表明非离子型湿润剂、阴离子湿润剂水溶液浓度为20%～40%最佳;同一种湿润剂随着煤的变质程度增加,非离子型湿润剂和阴离子湿润剂除尘效果越来越差。

关键词：粉尘湿润剂除尘湿润时间变质程度除尘效率

Extranodal natural killer T-Cell lymphoma,Nasal-Type: A new staging system from CSWOG: a multicenter study

在线全文

学校读者我要写书评

暂无评论

Extranodal natural killer T-Cell lymphoma,Nasal-Type: A new ...

第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议

作者： tongyu lin huangming hong chaoyong liang he huang chengcheng guo ying tian tingzhi liu mengping zhang xueying li xiaohong fu zhao wang xiaojie fang xiaoting lin shanshan li jiatian lin Raj Shrestha Prem sheng ye jiqun yi yanhong deng jian xiao Department of Medical Oncology Sun Yat-sen University Cancer Center Department of Medical Oncology Sun Yat-Sen University First Affiliated Hospital Department of Medical Oncology Guang Zhou Red Cross hospital Department of Medical Oncology The Sixth Affiliated Hospital of Sun Yat-sen University

＜正＞Objective Extranodal NK/T-cell lymphoma,nasal type（ENKTL）,is a rare and high aggressive disease with poor *** Ann Arbor staging system had been unable to define ENKTL staging in specific *** study conduct a ne...

关键词：

华西雨屏区不同发育阶段柳杉人工林枝叶4种矿质元素重吸收特征

在线全文

cnki会议

学校读者我要写书评

暂无评论

应用与环境生物学报 2023年第3期29卷 680-689页

作者：刘宣马孟平洪宗文熊仕臣赖明玥谭波李晗徐振锋张健游成铭冯秋红四川省林业科学研究院森林和湿地生态恢复与保育四川省重点实验室成都610081 长江上游林业生态工程四川省重点实验室/长江上游森林资源保育与生态安全国家林业和草原局重点实验室/华西雨屏区人工林生态系统研究长期科研基地/四川农业大学林学院成都611130 安徽省全椒县神山国有林场滁州239534

为探究不同发育阶段柳杉枝和叶的K、Ca、Na、Mg含量及其重吸收效率变化规律,以华西雨屏区幼龄林(6年)、中龄林(12年)、近熟林(23年)、成熟林(27、32年)和过熟林(46、52年)的柳杉(Cryptomeria japonica)人工林为研究对象,采用火焰原子吸... 详细信息

为探究不同发育阶段柳杉枝和叶的K、Ca、Na、Mg含量及其重吸收效率变化规律,以华西雨屏区幼龄林(6年)、中龄林(12年)、近熟林(23年)、成熟林(27、32年)和过熟林(46、52年)的柳杉(Cryptomeria japonica)人工林为研究对象,采用火焰原子吸收分光光度计法测定植物和凋落物枝、叶以及土壤的K、Ca、Na、Mg含量.结果表明:柳杉成熟叶的K、Na和Mg含量(3.36-5.80 g/kg、0.01-0.20 g/kg和0.96-1.83 g/kg)低于全球木本植物叶片的平均值,表明该区柳杉生长可能受到K、Na和Mg限制.发育阶段对柳杉枝和叶4种矿质元素含量及其重吸收效率均有显著影响.随发育阶段的增加,柳杉成熟枝、叶的K、Ca含量均呈“N”型变化,Mg含量呈先增后减的变化趋势;凋落枝、叶的K含量呈先减后增趋势,Ca、Mg含量呈增加趋势;枝、叶的K、Ca、Mg重吸收效率均表现为先增后减的趋势.器官对柳杉枝和叶的K、Ca、Na含量及其重吸收效率均有显著影响,成熟叶的Ca、Na含量显著高于成熟枝,凋落叶的K、Ca含量显著高于凋落枝,枝的K重吸收效率显著高于叶.枝、叶的矿质元素重吸收效率与植物的矿质元素含量呈显著正相关(K除外),与凋落物的矿质元素含量呈显著负相关(枝的Mg除外);并且,叶的K和Mg重吸收效率分别与土壤的K和Mg含量呈显著负相关.总体来看,矿质元素重吸收效率与植物和凋落物矿质元素含量的线性关系相较土壤更紧密.4种矿质元素间存在显著的异速关系,其异速指数大小受到器官、元素等因素的调控;本研究结果有助于深入认识不同发育阶段柳杉人工林的矿质元素限制格局和养分利用策略,可为柳杉人工林的科学经营和管理提供理论依据.

关键词：华西雨屏区柳杉人工林矿质元素养分重吸收效率异速关系